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Knowledge, Attitude, and Practices towards Covid-19 in the Midst of Pandemics among Jakarta Residents Tan, Christine; Kurniawan, Andree; Halim, Devina Adella; Wijovi, Felix; Jovita, Jovita; Agatha, Cindy Monika; Soputri, Christin; Maria, Eva; Winata, Sharleen
Journal of Epidemiology and Public Health Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (32.769 KB)

Background: Jakarta, capital city of Indonesia, had been extremely hit by the COVID-19 pandemic. Public consistence with control measures was important, which was greatly affected by knowledge, attitudes and practices towards COVID-19. This study aimed to investtigate knowledge, attitudes and practices of Jakarta residents for COVID-19.Subjects and Method: This was an analytic observational study with a cross-sectional design. Sample was gathered online from 221 Jakarta residents, range in age 10 to 60 years, which use self-reported questionnaires consisting of consent, questions about sociodemographics, knowledge, attitudes and practices relevant to COVID-19 and analyzed using t-test and ANOVA. A linear regression analysis was conducted to identify factors associated with knowledge, attitude and practice. Results: Participants showed moderate level of knowledge (mean= 71.20; SD= 8.37), positive attitudes (mean= 53.47; SD= 5.10) and moderate practice (mean= 78.63; SD= 12.73). Results demonstrated that women have better knowledge (mean= 72.1; SD= 9.0; p= 0.360), optimistic attitudes (mean= 55.1; SD = 6.2; p= 0.005) and great practices (mean= 80.1; SD= 11.6; p= 0.316) towards COVID-19 than men. Elderly have better knowledge (mean= 75.6; SD= 5.0; p= 0.001), optimistic attitude (mean= 56.3; SD= 3.8; p= 0.033) and good practices (mean= 82.4; SD= 14.3; p= 0.301) than younger individuals.Conclusion: Directed approaches in health promotion should be integrated for vulnerable populations, such as men, younger people, and low-income earners who would be at greater risk of COVID-19.Keywords: COVID-19, knowledge, attitude, practiceCorrespondence: Andree Kurniawan. Department of Internal Medicine, Faculty of Medicine Pelita Harapan University. Boulevard Jenderal Sudirman, Karawaci, Tangerang, Banten, Indonesia 15811. Email: andree.kurniawan@uph.edu. Mobile: +62-815-8891-655.Journal of Epidemiology and Public Health (2020), 05(04): 477-488https://doi.org/10.26911/jepublichealth.2020.05.04.10

Factors related to Post Traumatic Stress Symptoms in Indonesian adults during quarantine of the COVID-19 pandemic Evangelista, Nadya Nathalia; Wijovi, Felix; Orlin, Sisilia; Angelina, Stella; Halim, Devina Adella; Jodhinata, Claudia; Hamdoyo, Audrey; Cipta, Darien Alfa; Kurniawan, Andree; Lugito, Nata Pratama Hardjo
Public Health of Indonesia Vol. 8 No. 1 (2022): January - March
Publisher : YCAB Publisher & IAKMI SULTRA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/phi.v8i1.564

Background: COVID-19 is an unprecedented public health event. It started from Wuhan, China, in late December of 2019 and later spread worldwide. During the pandemic, negative impacts on mental health were found in all groups, including adults of their productive age. Objective: This study aimed to search for factors related to Post Traumatic Stress Symptoms (PTSS) during the quarantine due to the COVID-19 pandemic in Indonesia, specifically about the demographic background of respondents and its relation to PTSS. Methods: This study employed a cross-sectional design involving 257 Indonesian adults aged 26-67 years from 26 out of 34 provinces in Indonesia. The questionnaire used in this study consists of demographic questions and an Indonesian version of the Impact of Event Scale-Revised (IESR). The questionnaire was distributed through a link attached to the social media platform from 17 September to 5 October 2020. Data were analyzed using t-test, one-way ANOVA, and multiple linear regression using SPSS 25.0. Results: The data analysis showed a significant relationship between age and mean IES-R score during quarantine time in Indonesia (p-value 0.001). Other demographic factors such as gender, education level, marital status, work from home, income during the pandemic, and pandemic effects to income showed no significant relation to the IES-R score of the respondents. Adults aged 25-44 years old tend to have higher IES-R scores than those aged 45-64 and 65+ years old. Conclusion: Age was related to the IES-R score, while the other five independent variables included in the linear regression analysis were found to be confounders in this study.

The Role of Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma Patients: A Literature Review Giselvania, Angela; Sekarutami, Sri Mutya; Munandar, Arie; Halim, Devina Adella; Wijovi, Felix
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1190

Background: Globally, hepatocellular carcinoma (HCC) is the most prevalent kind of primary liver cancer. Treatment options for HCC include radiotherapy, immunotherapy, surgery, targeted therapy, transarterial chemoembolization, and hepatic arterial infusion chemotherapy. Limited efficacy was observed since 70-80% of cases are diagnosed late and unresectable. Growing evidence reported that SBRT is a viable option for locoregional treatments like radiofrequency ablation (RFA) or transarterial chemoembolization (TACE) for patients who did not respond to those treatments. Methods: A thorough search of electronic databases including PubMed, Cochrane Library, and Embase was conducted for studies on Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma published in English over the past 10 years. The review process followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to ensure a systematic approach. Inclusion criteria encompassed studies focusing on SBRT use in HCC treatment, with extracted data synthesized to provide a comprehensive overview of current evidence. Any discrepancies during the review were resolved through consultation with a third reviewer when necessary. Results: In comparison to conventional radiation therapy, Stereotactic Body Radiation Therapy (SBRT) offers precise administration of the high dose of radiotherapy, given in fewer fractions, and may be used in conjunction with other therapy modalities. Global guidelines, including in Indonesia, have proposed the implementation of SBRT. Local control was reportedly achieved in around 90–95% of HCC patients. Multimodal therapies, combined with TACE, showed superior results regarding the local control and overall survival. SBRT may eventually become the definitive treatment for early-stage HCC patients and has a critical role as a transitional therapy for patients awaiting liver transplantation. Improved outcomes and quality of life were also observed in patients with portal vein thrombosis (PVT) and extrahepatic metastases who underwent SBRT. Conclusions: SBRT results in promising local control, raises overall survival, and improves the quality of life in HCC patients with various stages.

A Systematic Review of Coronavirus Disease 2019 with Respiratory Distress Syndrome in Adult: Focus on Risk Factors, Mechanism, Diagnosis, and Treatment Jodhinata, Claudia; Kurniawan, Andree; Halim, Devina Adella
Medicinus Vol 10, No 1 (2020): October:2020
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v8i2.3442

Context: Coronavirus disease 2019 (COVID-19) is a newly discovered disease, caused by SARS-CoV-2 and currently has become a pandemic. Acute respiratory distress syndrome (ARDS) is the most common complication in COVID-19. There were numerous conflicting results among articles related to it. The aim of this study is to ascertain the most compelling evidence about ARDS in COVID-19.Evidence Acquisition: This systematic review was registered in PROSPERO (CRD42020180379). A systematic search was conducted in PubMed, PubMed central, and Google Scholar on April 16, 2020. Two reviewers independently searched and selected the articles. The risk of bias was evaluated using the Newcastle-Ottawa Quality assessment tool.Results: A total of 1,647 articles were screened, 9 articles were included. Patients were classified as having various degrees of ARDS, the diagnosis of COVID-19 was confirmed by PCR nasopharyngeal swab. Risk factors of ARDS in COVID-19 reported were older age, male gender, and pre-existing medical conditions. Cytokine storm was thought to play a role in the mechanism of ARDS. The main treatment for COVID-19 was supportive and symptomatic. To date, there is no antiviral treatment recommended for COVID-19 and the given treatment for ARDS in COVID-19 was similar to other pneumonia-induced ARDS. No additional therapy specific for ARDS in COVID-19 has been proposed.Conclusion: Our synthesis of the literature showed that there was no good evidence in the mechanism and treatment of ARDS. Further translation research in the mechanism of ARDS and continuing with clinical trials evaluating drug efficacy for ARDS in COVID-19 is needed.

Psychometric Properties of the Indonesian Version of Impact of Event Scale-Revised Questionnaire During COVID-19 Pandemic Wijovi, Felix; Kurniawan, Andree; Lugito, Nata Pratama Hardjo; Agung, Fransisca Handy; Cipta, Darien Alfa; Angelina, Stella; Halim, Devina Adella; Jodhinata, Claudia; Orlin, Sisilia; Hamdoyo, Audrey; Evangelista, Nadya Nathalia
Medicinus Vol 11, No 1 (2021): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v9i2.4703

Background: COVID-19 is a respiratory infection caused by SARS CoV-2. A health-related disaster may result in a wide range of mental consequences, including PTSD. IES-R is a self-reported instrument, and it corresponds to DSM-IV symptoms of PTSD. However, there were scarce data about the validation of the Indonesian version of IESR.Aim: The purpose of this study was to validate the IES-R in the Indonesian adult population by comprehensively and systematically assessing the epidemiological evidence about PTSS during the COVID-19 pandemic.Methods: This was a cross-sectional study. The IES-R questionnaire was translated from English to Indonesian, back-translated. All health workers were excluded to avoid the biased result. Pearson correlation and Cronbach's alpha coefficients to determine the validity and reliability of the questionnaire.Results: A total of 234 Indonesian-speaking adults completed the survey. The Indonesian IES-R had proven to be a valid (r= 0.756 -0.938, p= 0.000) and reliable (alpha coefficient: 0.858-0.868) measure for PTSS in a sample of Indonesian adults during the COVID-19 pandemic. In addition, the final model which consisted of 3 subscales with 20 items demonstrated acceptable factor loadings.Conclusion: The results of this study suggested IESR is valid and reliable to be used in the Indonesian population especially during pandemics.

Management of Autoimmune Hemolytic Anemia in the Midst of Coronavirus Disease 2019 Pandemic: A Case Report Kurniawan, Andree; Halim, Devina Adella
Medicinus Vol 9, No 2 (2020): February : 2020
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i7.2761

Introduction : The novel coronavirus disease 2019 (COVID-19) has become a pandemic involving all people and can be severe and life-threatening in a certain population such as those with comorbidity. Autoimmune hemolytic anemia (AIHA) is an autoimmune hematologic disease characterized with antibodies production that binds to red cell surface antigens. In this pandemic, several concerns have been raised by autoimmune disease clinicians and patients regarding the use of immunosuppressive drugs. In this case report, we illustrate the problems of autoimmune hemolytic anemia patient when she got active case.Case Illustration : A 28 years old lady was admitted to the hospital owing to fatigue and tiredness during exercise for two weeks. She had been diagnosed with autoimmune hemolytic anemia before and did not comply with the treatment. This patient has been reevaluated of having AIHA from the symptoms of fatigue, enlarged spleen, low hemoglobin, increased reticulocytes, signs of hemolytic in blood smear examination, increased indirect bilirubin, LDH and the Combs’ test result was given positive. She received methylprednisolone 2 mg/kg of body weight intravenously, washed packed red cells (PRC), calcium and proton pump inhibitor. She was discharged at the seventh day since admission and she was prescribed oral methylprednisolone equal to 1 mg/kg body weight.Conclusion : This is an educated case of non-compliance of AIHA that should be given high dose steroid and blood transfusion during hospitalization amid the COVID-19 pandemic. The recommendation of treatment for AIHA was still the same as before the pandemic occured.

Development and Validation of a “Pelita Harapan” Questionnaire Assessing Knowledge, Attitude, and Practice Toward Coronavirus Disease 2019 Among Young People in Indonesia Winata, Sharleen; Kurniawan, Andree; Agung, Fransisca Handy; Hardjo Lugito, Nata Pratama; Jodhinata, Claudia; Halim, Devina Adella; Angelina, Stella; Agatha, Cindy Monika
Medicinus Vol 10, No 2 (2021): February : 2021
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v8i3.3769

Introduction: Coronavirus Disease 2019 (COVID-19) has become a pandemic. Much false information was circulating especially through social media and affected individual’s knowledge, attitude, practice (KAP) towards COVID-19. Currently, there is lack of validated questionnaires to assess KAP about COVID-19 especially in Indonesian young people.Aim: To develop and validate a new COVID-19 KAP questionnaire for young people population in Indonesian language.Methods: Some literature review was done to look for the concept to generate a new questionnaire. Open-ended questions were generated to know the baseline knowledge. Then, close-ended questions were formulized for knowledge, attitude, and practice area. The experts and several respondents were asked to give their opinions about the contents of the questionnaire. The validity was examined using Cronbach's alpha coefficient. For reliability, internal consistency was examined by using Pearson or Spearmen correlation test.Results: A total of 59 subjects with median ages 21 (16-24) years old of non-medical individuals were included in this validation process. More than half were male, mostly held bachelor’s degree/diploma, and were dominated with students. This Indonesian COVID-19 KAP questionnaire for young people consists of 10 knowledge, 8 attitude, and 7 practice questions. The Cronbach’s alpha coefficient of knowledge, attitude, and practice areas were 0.87, 0.82, and 0.91, respectively.Conclusions: A questionnaire of KAP towards COVID-19 in Indonesian language had been developed and the results showed good validity.

Knowledge, Attitude, and Practices towards Covid-19 in the Midst of Pandemics among Jakarta Residents Tan, Christine; Kurniawan, Andree; Halim, Devina Adella; Wijovi, Felix; Jovita, Jovita; Agatha, Cindy Monika; Soputri, Christin; Maria, Eva; Winata, Sharleen
Journal of Epidemiology and Public Health Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Jakarta, capital city of Indonesia, had been extremely hit by the COVID-19 pandemic. Public consistence with control measures was important, which was greatly affected by knowledge, attitudes and practices towards COVID-19. This study aimed to investtigate knowledge, attitudes and practices of Jakarta residents for COVID-19.Subjects and Method: This was an analytic observational study with a cross-sectional design. Sample was gathered online from 221 Jakarta residents, range in age 10 to 60 years, which use self-reported questionnaires consisting of consent, questions about sociodemographics, knowledge, attitudes and practices relevant to COVID-19 and analyzed using t-test and ANOVA. A linear regression analysis was conducted to identify factors associated with knowledge, attitude and practice. Results: Participants showed moderate level of knowledge (mean= 71.20; SD= 8.37), positive attitudes (mean= 53.47; SD= 5.10) and moderate practice (mean= 78.63; SD= 12.73). Results demonstrated that women have better knowledge (mean= 72.1; SD= 9.0; p= 0.360), optimistic attitudes (mean= 55.1; SD = 6.2; p= 0.005) and great practices (mean= 80.1; SD= 11.6; p= 0.316) towards COVID-19 than men. Elderly have better knowledge (mean= 75.6; SD= 5.0; p= 0.001), optimistic attitude (mean= 56.3; SD= 3.8; p= 0.033) and good practices (mean= 82.4; SD= 14.3; p= 0.301) than younger individuals.Conclusion: Directed approaches in health promotion should be integrated for vulnerable populations, such as men, younger people, and low-income earners who would be at greater risk of COVID-19.Keywords: COVID-19, knowledge, attitude, practiceCorrespondence: Andree Kurniawan. Department of Internal Medicine, Faculty of Medicine Pelita Harapan University. Boulevard Jenderal Sudirman, Karawaci, Tangerang, Banten, Indonesia 15811. Email: andree.kurniawan@uph.edu. Mobile: +62-815-8891-655.Journal of Epidemiology and Public Health (2020), 05(04): 477-488https://doi.org/10.26911/jepublichealth.2020.05.04.10

Management of Autoimmune Hemolytic Anemia in the Midst of Coronavirus Disease 2019 Pandemic: A Case Report Kurniawan, Andree; Halim, Devina Adella
Medicinus Vol. 9 No. 2 (2020): February : 2020
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i7.2761

Introduction : The novel coronavirus disease 2019 (COVID-19) has become a pandemic involving all people and can be severe and life-threatening in a certain population such as those with comorbidity. Autoimmune hemolytic anemia (AIHA) is an autoimmune hematologic disease characterized with antibodies production that binds to red cell surface antigens. In this pandemic, several concerns have been raised by autoimmune disease clinicians and patients regarding the use of immunosuppressive drugs. In this case report, we illustrate the problems of autoimmune hemolytic anemia patient when she got active case.Case Illustration : A 28 years old lady was admitted to the hospital owing to fatigue and tiredness during exercise for two weeks. She had been diagnosed with autoimmune hemolytic anemia before and did not comply with the treatment. This patient has been reevaluated of having AIHA from the symptoms of fatigue, enlarged spleen, low hemoglobin, increased reticulocytes, signs of hemolytic in blood smear examination, increased indirect bilirubin, LDH and the Combs’ test result was given positive. She received methylprednisolone 2 mg/kg of body weight intravenously, washed packed red cells (PRC), calcium and proton pump inhibitor. She was discharged at the seventh day since admission and she was prescribed oral methylprednisolone equal to 1 mg/kg body weight.Conclusion : This is an educated case of non-compliance of AIHA that should be given high dose steroid and blood transfusion during hospitalization amid the COVID-19 pandemic. The recommendation of treatment for AIHA was still the same as before the pandemic occured.

A Systematic Review of Coronavirus Disease 2019 with Respiratory Distress Syndrome in Adult: Focus on Risk Factors, Mechanism, Diagnosis, and Treatment Jodhinata, Claudia; Kurniawan, Andree; Halim, Devina Adella
Medicinus Vol. 10 No. 1 (2020): October:2020
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v8i2.3442

Context: Coronavirus disease 2019 (COVID-19) is a newly discovered disease, caused by SARS-CoV-2 and currently has become a pandemic. Acute respiratory distress syndrome (ARDS) is the most common complication in COVID-19. There were numerous conflicting results among articles related to it. The aim of this study is to ascertain the most compelling evidence about ARDS in COVID-19.Evidence Acquisition: This systematic review was registered in PROSPERO (CRD42020180379). A systematic search was conducted in PubMed, PubMed central, and Google Scholar on April 16, 2020. Two reviewers independently searched and selected the articles. The risk of bias was evaluated using the Newcastle-Ottawa Quality assessment tool.Results: A total of 1,647 articles were screened, 9 articles were included. Patients were classified as having various degrees of ARDS, the diagnosis of COVID-19 was confirmed by PCR nasopharyngeal swab. Risk factors of ARDS in COVID-19 reported were older age, male gender, and pre-existing medical conditions. Cytokine storm was thought to play a role in the mechanism of ARDS. The main treatment for COVID-19 was supportive and symptomatic. To date, there is no antiviral treatment recommended for COVID-19 and the given treatment for ARDS in COVID-19 was similar to other pneumonia-induced ARDS. No additional therapy specific for ARDS in COVID-19 has been proposed.Conclusion: Our synthesis of the literature showed that there was no good evidence in the mechanism and treatment of ARDS. Further translation research in the mechanism of ARDS and continuing with clinical trials evaluating drug efficacy for ARDS in COVID-19 is needed.

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