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Case Report: COVID-19 and Ischemic Stroke in A 16-Years-Old Patient Cynthia; Kumalawati, July
Magna Neurologica Vol. 2 No. 2 (2024): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v2i2.1140

Background: Recent reports show an increasing trend of ischemic stroke at a young age. Diseases associated with ischemic stroke at a young age, namely hereditary hypercoagulable conditions. Case: In this case a 16-year-old boy with clinical complaints of sudden weakness of the right hand and leg, numbness, loss of appetite, nausea and vomiting. Laboratory tests showed results of increased levels of hemoglobin, hematocrit, erythrocyte count, platelet count, leukocyte count and NLR. The neutrophil-to-lymphocyte ratio (NLR), calculated as a simple ratio between the neutrophil and lymphocyte counts measured in peripheral blood. CT scan examination showed acute infarction in the medial left temporal lobe and old infarction in the left frontal lobe (medial gyrus). Thoracic CT Scan examination showed the results of bilateral pneumonia suggestive of viral. The patient encountered COVID-19. The patient experienced cough and shortness of breath and showed abnormal ABG results, namely respiratory alkalosis, decreased oxygen saturation, fever, increased procalcitonin and increased cardiac markers. Discussion: This case report prompts discussions on various aspects of ischemic stroke in young patients, including the role of COVID-19, hypercoagulable states, hematological abnormalities, and diagnostic challenges, with implications for patient management and future research directions. Conclusion: SARS CoV-2 can affect the nervous system through several mechanisms that cause persistent infection, resulting in neurological diseases, including stroke. Young ischemic stroke is usually hypercoagulable and the most common cause is APS. In this patient, polycythemia was occured,that causes blood flow slows and oxygen supply to the brain is reduced. This can cause ischemic stroke.

Pengembangan Model Pendidikan Islam Berbasis Literasi Digital Untuk Generasi Alpha Di Indonesia Sudirman, Sudirman; Leli Hasanah Lubis; Ali Sadikin Ritonga; Khoirun Nisak; Cynthia
Tarbiyah bil Qalam : Jurnal Pendidikan Agama dan Sains Vol. 9 No. 2 (2025): Volume IX Edisi II ( Juli-Desember In-Press)
Publisher : Sekolah Tinggi Ilmu Tarbiyah Al-Bukhary Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar

Generasi Alpha, yang lahir sejak tahun 2010 ke atas, tumbuh dalam era digital dengan kemampuan teknologi yang tinggi dan gaya belajar visual-interaktif. Mereka memiliki kecepatan dalam mengakses informasi, namun juga menghadapi tantangan seperti rentang perhatian yang pendek dan risiko paparan konten digital tanpa bimbingan moral. Literasi Islam pada generasi ini menjadi perhatian utama karena mudah terpapar konten yang tidak sesuai dengan nilai-nilai Islam, sementara media pembelajaran Islam berbasis teknologi masih sangat terbatas. Kurangnya pendampingan dari orang tua dan keterbatasan kompetensi guru dalam penggunaan teknologi semakin memperburuk kondisi ini. Penelitian ini bertujuan untuk memahami fenomena rendahnya literasi Islam di kalangan Generasi Alpha serta merancang model pendidikan Islam berbasis teknologi yang efektif dan relevan dengan karakteristik mereka. Metode kualitatif deskriptif digunakan dengan teknik pengumpulan data berupa wawancara mendalam, observasi, dan studi dokumentasi pada guru Pendidikan Agama Islam, orang tua, dan siswa di tingkat Sekolah Dasar dan Madrasah Ibtidaiyah. Hasil penelitian menunjukkan perlunya pengembangan media pembelajaran digital interaktif, peningkatan kompetensi guru dalam teknologi, serta sinergi antara sekolah, orang tua, dan lingkungan sosial digital untuk meningkatkan literasi Islam secara efektif dan berkelanjutan.

Pharmacological and Non-Pharmacological Strategies for Sedation and Analgesia in Critically Ill Children: A Systematic Review and Narrative Synthesis Andreas Eric; Cynthia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 9 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i9.1383

Background: The management of pain and agitation in the Pediatric Intensive Care Unit (PICU) is critical for patient comfort and preventing adverse outcomes. A wide array of sedation and analgesia strategies exists, but a synthesized appraisal of contemporary evidence is needed to guide clinical practice. This systematic review evaluates the efficacy and safety of various pharmacological and non-pharmacological interventions for sedation and analgesia in critically ill children. Methods: A systematic search was conducted in PubMed, Embase, Cochrane CENTRAL, and CINAHL for studies published between January 2020 and December 2024. Following the PRISMA 2020 guidelines, two independent reviewers screened studies, extracted data, and assessed the risk of bias using the Cochrane RoB 2 tool for Randomized Controlled Trials (RCTs) and the Newcastle-Ottawa Scale (NOS) for observational studies. Results: From 4,366 identified records, five studies (two RCTs, three observational) involving 875 patients met the inclusion criteria. Study 1, an RCT (n=120), found that adjunctive ketamine significantly reduced mechanical ventilation duration by a mean of 2.1 days (95% CI: 1.2-3.0, p=0.001) compared to standard care. Study 3, a prospective cohort study (n=350), linked continuous sedation to longer PICU stays (median 9 vs. 6 days, p<0.001) and a higher incidence of iatrogenic withdrawal syndrome (45% vs. 18%, p<0.001) compared to intermittent sedation. Study 4, an RCT on music therapy (n=85), demonstrated a significant reduction in postoperative pain scores. Observational studies supported the opioid-sparing effects of multimodal analgesia (Study 5) and noted differences in recovery profiles between midazolam and propofol (Study 2). Conclusion: This review highlights the benefits of a multimodal, goal-directed approach to pediatric sedation and analgesia. Adjunctive ketamine and non-pharmacological interventions show promise in reducing opioid reliance and improving clinical outcomes. Protocols favoring intermittent sedation may reduce length of stay and withdrawal incidence. These findings support a paradigm shift away from deep, continuous sedation towards more nuanced, patient-centered strategies.

Pharmacological and Non-Pharmacological Strategies for Sedation and Analgesia in Critically Ill Children: A Systematic Review and Narrative Synthesis Andreas Eric; Cynthia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 9 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i9.1383

Background: The management of pain and agitation in the Pediatric Intensive Care Unit (PICU) is critical for patient comfort and preventing adverse outcomes. A wide array of sedation and analgesia strategies exists, but a synthesized appraisal of contemporary evidence is needed to guide clinical practice. This systematic review evaluates the efficacy and safety of various pharmacological and non-pharmacological interventions for sedation and analgesia in critically ill children. Methods: A systematic search was conducted in PubMed, Embase, Cochrane CENTRAL, and CINAHL for studies published between January 2020 and December 2024. Following the PRISMA 2020 guidelines, two independent reviewers screened studies, extracted data, and assessed the risk of bias using the Cochrane RoB 2 tool for Randomized Controlled Trials (RCTs) and the Newcastle-Ottawa Scale (NOS) for observational studies. Results: From 4,366 identified records, five studies (two RCTs, three observational) involving 875 patients met the inclusion criteria. Study 1, an RCT (n=120), found that adjunctive ketamine significantly reduced mechanical ventilation duration by a mean of 2.1 days (95% CI: 1.2-3.0, p=0.001) compared to standard care. Study 3, a prospective cohort study (n=350), linked continuous sedation to longer PICU stays (median 9 vs. 6 days, p<0.001) and a higher incidence of iatrogenic withdrawal syndrome (45% vs. 18%, p<0.001) compared to intermittent sedation. Study 4, an RCT on music therapy (n=85), demonstrated a significant reduction in postoperative pain scores. Observational studies supported the opioid-sparing effects of multimodal analgesia (Study 5) and noted differences in recovery profiles between midazolam and propofol (Study 2). Conclusion: This review highlights the benefits of a multimodal, goal-directed approach to pediatric sedation and analgesia. Adjunctive ketamine and non-pharmacological interventions show promise in reducing opioid reliance and improving clinical outcomes. Protocols favoring intermittent sedation may reduce length of stay and withdrawal incidence. These findings support a paradigm shift away from deep, continuous sedation towards more nuanced, patient-centered strategies.

Causes of Microbleeding in Alzheimer's: Role of Cerebral Amyloid Angiopathy and Factor Xa Inhibitors Cynthia; Nugraha, Jusak; Hamdan, Muhammad; Lumempouw, Silvia; Dharma, Rahajuningsih
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2388

This case report aims to analyze factors that may contribute to the pathophysiological mechanisms underlying microbleeding in Alzheimer’s disease (AD) patients with Deep Vein Thrombosis (DVT), thereby paving the way for appropriate therapeutic interventions and improved patient outcomes. An 80-year-old Indonesian woman, diagnosed with AD and DVT, was admitted to the neurobehavioral clinic on May 16, 2023. Microbleeding was detected in the right cerebellum, right occipital lobe, left caudate nucleus, and left-right frontal cortex based on the Brain MRI. The patient had been treated with factor Xa inhibitors once a day since April 17, 2018, due to DVT. The diagnosis of mild cognitive impairment with bilateral knee osteoarthritis was made on June 13, 2017. Laboratory findings on November 21, 2023, revealed an e-GFR of 36 mL/min/1.73m2, indicating a moderate to severe decline in kidney function. Alzheimer's dementia can cause Cerebral Amyloid Angiopathy (CAA), which can result in clot formation in the brain tissue and around cerebral arteries. This process deteriorates blood flow and impairs the clearance of amyloid beta-peptide (Aβ), leading to Aβ accumulation, microglia activation, synaptic dysfunction, and neuronal death. Decreased cerebral blood flow leads to hypoperfusion, cerebral microvascular infarctions, and microhemorrhages (also known as microbleeds). In elderly patients with Alzheimer's dementia, immobilization often leads to DVT, which is treated with factor Xa inhibitors. However, drug accumulation can occur due to decreased kidney function, potentially causing further microbleeds in the brain. Microbleeding found in this patient might be a consequence of Alzheimer’s pathology and or adverse effects of factor Xa inhibitors.

Penentuan Kondisi Optimum Waktu Aging Pada Sintesis Silika Xerogel Dari Limbah Abu Terbang Cynthia; Edi Nasra
Gudang Jurnal Multidisiplin Ilmu Vol. 2 No. 2 (2024): GJMI - FEBRUARI
Publisher : PT. Gudang Pustaka Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59435/gjmi.v2i2.282

Silika xerogel merupakan silika gel yang dihilangkan kandungan airnya dengan menaikkan suhu dan tekanan. Silika xerogel terdiri dari senyawa silika (SiO2) yang dapat diekstraksi dari abu terbang yang memiliki kandungan silika tinggi. Silika xerogel dapat disintesis dengan metode sol-gel. Proses ini terdiri dari empat tahap yaitu pembentukan sol, gelasi, aging, dan pengeringan. Tahapan aging sangat penting pada metode sol-gel, karena aging dapat mempengaruhi karakteristik dari silika xerogel yang dihasilkan, seperti luas permukaan, morfologi, volume dan ukuran pori, dan densitas silika xerogel. Berdasarkan hasil penelitian, waktu aging optimum pada waktu aging 18 jam dengan luas permukaan 23,005 m2/g dan hasil karakteristik dengan FTIR menunjukkan silika xerogel yang disintesis mengandung gugus silanol pada bilangan gelombang 3435,88 cm-1 dan siloksan pada bilangan gelombang 1039,74 cm-1

Social Media as a Tool for Improving Writing Skills and Vocabulary: A Case Study on 8th Graders at SMP WR Supratman 1 Medan Cynthia; Merry Kristian Ndruru
EduInovasi: Journal of Basic Educational Studies Vol. 5 No. 1 (2025): EduInovasi: Journal of Basic Educational Studies
Publisher : Intitut Agama Islam Nasional Laa Roiba Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/edu.v5i1.7286

Referring to connectivism theory, it is understood that knowledge is distributed across a network where connections facilitate the dissemination of information. In this context, students are seen as actively engaged in creating their own networks, leading to the development of new, beneficial understanding. The study examines the unique contributions of each social media platform in improving students' writing and vocabulary skills. This research adopts a qualitative approach with interview and observation. The findings show that the use of social media such as Instagram, YouTube, and TikTok can improve writing skills and English vocabulary mastery among 8th grade students of SMP WR Supratman 1 Medan. Through the various types of content they access, students can practice writing in English in informal and formal contexts, which allows them to develop better writing skills. Although there are variations in how students use social media, all students showed improvements in their writing skills, especially in terms of sentence structure and the use of more varied vocabulary.

Pengaruh Corporate Social Responsibility, Kepemilikan Manajerial, Green Banking, Likuiditas, Rentabilitas, dan Aktivitas Perusahaan Pada Perusahaan Sektor Perbankan yang Terdaftar di BEI Goh, Thomas Sumarsan; Elidawati; Syawaluddin; Cynthia
Owner : Riset dan Jurnal Akuntansi Vol. 8 No. 4 (2024): Artikel Research Oktober 2024
Publisher : Politeknik Ganesha Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33395/owner.v8i4.2339

Recently, issues related to sustainable development have become an important discussion in the academic, business, and government. As an intermediary, the banking sector has an important role in supporting the economy in Indonesia, so the company must be able to balance the company's interests with stakeholders' interests in improving financial performance to achieve sustainable development that has been determined until 2030. This research aims to examine and analyze corporate social responsibility, managerial ownership, green banking, liquidity, rentability, and company activities on the financial performance of banking sector companies listed on the IDX. The population in this research is 47 banking companies listed on the IDX for 2018-2022. The research sample was 42 banking companies listed on the IDX over five years. The data analysis model in this research is multiple linear regression analysis. The results show that corporate social responsibility, managerial ownership, and green banking partially have no impact on financial performance, but liquidity, rentability, and company activities partially have a significant effect on financial performance in banking sector companies listed on the IDX. Simultaneously, corporate social responsibility, managerial ownership, green banking, liquidity, rentability, and company activities significantly affect the financial performance of banking sector companies listed on the IDX.

Valuation of the Fair Market Value of the Shares of PT Link Net Tbk in Connection with the Acquisition of Shares by PT XL Axiata Tbk in 2022 Using the Discounted Cash Flow (DCF) and Abnormal Income Method Cynthia; Lumbantobing, Rudolf; Purnama, Eka Desy
International Journal of Science and Society Vol 6 No 1 (2024): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v6i1.1103

Corporate takeover actions (acquisitions) carried out by companies are always in the spotlight of the capital market public, because corporate acquisition actions are classified as material transactions that require very large financing, and it is not uncommon for there to be conflicts of interest in their implementation. However, sometimes there can be cases where a company acquires another company in the hope of gaining synergies but instead incurs losses, which may be due to an unreasonable acquisition price that can harm many parties including the public and shareholders. This can of course be prevented by assessing the performance of the company to be acquired previously and assessing the company's fair market (valuation). This research was conducted to analyze the fair market value of 20% of the shares of PT Link Net Tbk in connection with the planned acquisition by PT XL Axiata Tbk using the Discounted Cash Flow and Abnormal Income methods and to analyze the price offered by PT XL Axiata Tbk to acquire 20% of the shares of PT Link Net Tbk is classified as fair or not. The research results show that in the valuation using the Discounted Cash Flow (DCF) method, based on the results of calculating the fair market value of 20% of PT Link Net Tbk amounting to IDR 2,795,896 million or IDR 4,882 per share, while in the valuation using the Abnormal Income method, it is based on the results of calculating the value fair market 20% PT Link Net Tbk amounting to IDR 2,602,704 million or IDR 4,545 per share. If we compare the transaction value of the purchase of PT Link Net Tbk shares by PT XL Axiata Tbk which is IDR 4,800 per share, the transaction value is considered fair in both methods, both the Discounted Cash Flow (DCF) and Abnormal Income methods.

Implementasi Strategi CRM dan Penggunaan Digital Marketing pada UMKM di Credit Union Madani Kotabumi Tangerang Cynthia; Anisya, Cindy; Widya, Devania; Silaswara, Diana; Lenggo Ginny, Puti; Susanti, Metta; Winata, Suryadi; Limajatini
Abdi Dharma Vol. 2 No. 2 (2022): Jurnal Abdi Dharma (Jurnal Pengabdian Masyarakat)
Publisher : LP3kM Universitas Buddhi Dharma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31253/ad.v2i2.1732

This student creativity development activity was carried out based on the collaboration between the Faculty of Business, Buddhi Dharma University and KSP Madani which was held at KSP Madani Credit Union Kotabumi, Tangerang City. Banten Province. The training participants are UMKM members of cooperatives, and the activities are carried out within a period of three months, with training activities planned in the form of focus group discussions, material presentations and interactive question-and-answer between the giver of materials and training and mentoring participants. The material provided was in accordance with the needs requested by KSP Madani at the beginning of the meeting, namely knowledge and implementation of Customer Relationship Management (CRM) for UMKM actors under the guidance of KSP Credit Union Madani. Participants from the training are members of the Madani cooperative, which are UMKM business actors in the Culinary and Services sector The output plan of this student creativity development activity is in the form of improving the performance of cooperative management.

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