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All Journal ODONTO Dental Journal Conservative Dentistry Journal Odonto dental journal
Christabel, Phebe Fedora
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Dentistry Health Professions Medicine & Pharmacology

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A review of sodium diclofenac as a potential medicament to eliminate Enterococcus faecalis in regenerative endodontic treatment Prasetyo, Eric Priyo; Yuanita, Tamara; Setyabudi; Bin Sharizal, Shafy Shariz; Sukandar, Wilson; Paidal, Nurfahira; Charles, William; Christabel, Phebe Fedora; Liong, Michelle; Prasetyaningtias, Silvia Arlita Hayu
Conservative Dentistry Journal Vol. 14 No. 2 (2024): July-December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v14i2.2024.71-74

Abstract

Background: Traumatic dental injuries often occur in the community reaching 85% of patients and in preschool children the proportion reaches 17%. Among the injuries are tooth fracture, tooth luxation, tooth avulsion and open apex which causes pulp death or necrosis, causing root growth to stop. Regenerative endodontic treatment (RET) with a biological approach to treat necrotic immature permanent teeth can promote pulpal growth, increase the thickness of the dentin wall and form apical foramens. Enterococcus faecalis bacteria can be resistant to some drugs and root canal irrigation substances and may persist in the root canal system. Recently, sodium diclofenac has been reported to retain a new potential to eliminate Enterococcus faecalis biofilm. This shows that sodium diclofenac is potential as an anti-biofilm material. Purpose: To evaluate the potential use of sodium diclofenac in RET. Review: This review was investigated in PubMed and Google Scholar containing keywords: Sodium Diclofenac, Enterococcus faecalis and Regenerative Endodontic Treatment. Sodium diclofenac is a potential medicament to eliminate Enterococcus faecalis biofilm therefore has a potency to be used in Regenerative Endodontic Treatment. Conclusion: The success rate of RET depends on the elimination of microorganisms in the root canal systems. The use of sodium diclofenac as a medicament to eliminate Enterococcus faecalis biofilm is potential to be used in RET. Further researches are encouraged to explore the benefits of sodium diclofenac as a medicament in RET.
ANTIBACTERIAL EFFECT OF NANNOCHLOROPSIS OCULATA AS ROOT CANAL STERILIZATION MATERIAL ON STREPTOCOCCUS MUTANS BIOFILM Soesilo, Diana; Puspita, Sinta; Christabel, Phebe Fedora
Odonto : Dental Journal Vol 8, No 2 (2021): December 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (287.325 KB) | DOI: 10.30659/odj.8.2.119-125

Abstract

ABSTRACTBackground: Streptococcus mutans in the most frequent microbiota that causes pulp necrosis because of caries. The microorganism that is colonized and embedded in the biofilm matrix is resistant to antimicrobials compared to planktonic cells. Root canal sterilization materials must have good biocompatibility with tissues. Nannochloropsis oculata is an algae that contains various compounds such as terpenoids, alkaloids, and flavonoids that have potential as antibacterial and antioxidant and can be used as alternative to root canal sterilization. Method: This research was true experimental laboratory research with post-test only control group design. The antibacterial potential of Nannochloropsis oculata was tested using the biofilm method, divided into 5 groups. The control group was: K- (aquadest), K+ (calcium hydroxide), and the treatment group was given Nannochloropsis oculata: P1 (0.625%), P2 (1.25%), and P3 (2.5 %). Congo Red method test was to determine the formation of biofilm that shows black strains on agar. While biofilm test with Microtiter Plate Assay to measure the value of biofilm that were inhibited in Optical Density (OD) value in the ELISA Reader. The lower the value, the more biofilm inhibited, with OD value, inhibition percentage could counted Result: The result of all treatment groups were increasing in percentage inhibition value shows inhibition in biofilm growth (p <0.05). Conclusion: Nannochloropsis oculata had an antibacterial effect on the biofilm of Streptococcus mutans
ANTIBACTERIAL EFFECT OF NANNOCHLOROPSIS OCULATA AS ROOT CANAL STERILIZATION MATERIAL ON STREPTOCOCCUS MUTANS BIOFILM Soesilo, Diana; Puspita, Sinta; Christabel, Phebe Fedora
Odonto : Dental Journal Vol 8, No 2 (2021): December 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.8.2.119-125

Abstract

ABSTRACTBackground: Streptococcus mutans in the most frequent microbiota that causes pulp necrosis because of caries. The microorganism that is colonized and embedded in the biofilm matrix is resistant to antimicrobials compared to planktonic cells. Root canal sterilization materials must have good biocompatibility with tissues. Nannochloropsis oculata is an algae that contains various compounds such as terpenoids, alkaloids, and flavonoids that have potential as antibacterial and antioxidant and can be used as alternative to root canal sterilization. Method: This research was true experimental laboratory research with post-test only control group design. The antibacterial potential of Nannochloropsis oculata was tested using the biofilm method, divided into 5 groups. The control group was: K- (aquadest), K+ (calcium hydroxide), and the treatment group was given Nannochloropsis oculata: P1 (0.625%), P2 (1.25%), and P3 (2.5 %). Congo Red method test was to determine the formation of biofilm that shows black strains on agar. While biofilm test with Microtiter Plate Assay to measure the value of biofilm that were inhibited in Optical Density (OD) value in the ELISA Reader. The lower the value, the more biofilm inhibited, with OD value, inhibition percentage could counted Result: The result of all treatment groups were increasing in percentage inhibition value shows inhibition in biofilm growth (p <0.05). Conclusion: Nannochloropsis oculata had an antibacterial effect on the biofilm of Streptococcus mutans
Co-Authors Bin Sharizal, Shafy Shariz Charles, William Diana Soesilo, Diana Eric Priyo Prasetyo Liong, Michelle Paidal, Nurfahira Prasetyaningtias, Silvia Arlita Hayu Puspita, Sinta Setyabudi Sukandar, Wilson Tamara Yuanita