Paidal, Nurfahira
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A review of tissue engineering in regenerative endodontic treatment Prasetyo, Eric Priyo; Wahjuningrum, Dian Agustin; Sampoerno, Galih; Sukandar, Wilson; Shariz Bin Sharizal, Shafy; Paidal, Nurfahira; Fadiyan Amriel, Menza; Gunawan, Nathania Elita; Suardita, Ketut; Tjendronegoro, Evelyn
Conservative Dentistry Journal Vol. 14 No. 1 (2024): January-June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v14i1.2024.1-5

Abstract

Background: Regenerative endodontic treatments are classified based on approach in the procedures and principles. One is cell-free approach that involves a revitalization procedure to achieve continued root growth while the other is cell-based approach which involves pulp/dentin regeneration through isolation and ex vivo expansion of stem cells seeded in the scaffold and then transplanted into the canal space. Technically, the cell-free approach is simpler than cell-based approach because the former does not concern about external stem cell isolation and culture. Currently, the gold standard and the one that has been clinically performed is cell-free approach. Cell-based approach is still not a standard because currently the cell-based approach is still in the clinical trial stage. Purpose: to evaluate the biological basis and clinical protocols recently used in regenerative endodontic treatment and discuss potentially future treatment approaches. Review: The literature review was searched in PUBMED with the keywords: immature permanent teeth, pulp revascularization, stem cells and regenerative endodontics. The regenerative endodontic treatments with various procedures and techniques result in a significant increase in root length and dentinal wall thickness. Stimulation of stem cells in apical root canal system is required to induce tissue formation and continued root maturation. Conclusion: The success of regenerative endodontic therapy relies on the development of a technique that enables clinicians to create functional pulp tissue within cleaned and shaped root canal systems. It is hoped that further research studies are required to define advantages and limitations of cell-free and cell-based approach.
A review of sodium diclofenac as a potential medicament to eliminate Enterococcus faecalis in regenerative endodontic treatment Prasetyo, Eric Priyo; Yuanita, Tamara; Setyabudi; Bin Sharizal, Shafy Shariz; Sukandar, Wilson; Paidal, Nurfahira; Charles, William; Christabel, Phebe Fedora; Liong, Michelle; Prasetyaningtias, Silvia Arlita Hayu
Conservative Dentistry Journal Vol. 14 No. 2 (2024): July-December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v14i2.2024.71-74

Abstract

Background: Traumatic dental injuries often occur in the community reaching 85% of patients and in preschool children the proportion reaches 17%. Among the injuries are tooth fracture, tooth luxation, tooth avulsion and open apex which causes pulp death or necrosis, causing root growth to stop. Regenerative endodontic treatment (RET) with a biological approach to treat necrotic immature permanent teeth can promote pulpal growth, increase the thickness of the dentin wall and form apical foramens. Enterococcus faecalis bacteria can be resistant to some drugs and root canal irrigation substances and may persist in the root canal system. Recently, sodium diclofenac has been reported to retain a new potential to eliminate Enterococcus faecalis biofilm. This shows that sodium diclofenac is potential as an anti-biofilm material. Purpose: To evaluate the potential use of sodium diclofenac in RET. Review: This review was investigated in PubMed and Google Scholar containing keywords: Sodium Diclofenac, Enterococcus faecalis and Regenerative Endodontic Treatment. Sodium diclofenac is a potential medicament to eliminate Enterococcus faecalis biofilm therefore has a potency to be used in Regenerative Endodontic Treatment. Conclusion: The success rate of RET depends on the elimination of microorganisms in the root canal systems. The use of sodium diclofenac as a medicament to eliminate Enterococcus faecalis biofilm is potential to be used in RET. Further researches are encouraged to explore the benefits of sodium diclofenac as a medicament in RET.