Article Per Year (5 Year)
p-Index From 2020 - 2025
0.947
P-Index
This Author published in this journals
All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical Science and Technology IDJP (Indonesian Journal of Pharmaceutics) Jurnal Ilmiah Farmako Bahari
Firmansya, Ardianes
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

Published : 5 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 5 Documents
Search

 1 
UJI EVALUASI FISIK DAN AKTIVITAS ANTI JAMUR SEDIAAN OVULA EKSTRAK BAWANG PUTIH TERHADAP CANDIDA ALBICANS Nurdianti, Lusi; Adhani, Ai Gita Aisah; Hidayat, Taufik; Setiawan, Fajar; Aprillia, Ade Yeni; Tuslinah, Lilis; Firmansya, Ardianes
Jurnal Ilmiah Farmako Bahari Vol 15, No 1 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i1.2671

Abstract

Kandidiasis vulvovagina merupakan penyakit umum di kalangan wanita yang membutuhkan penanganan cepat. Kandidiasis vagina dapat diakibatkan oleh infeksi jamur, terutama Candida albicans menyebabkan gejala seperti gatal-gatal, keputihan, kemerahan vagina, dan ketidaknyamanan saat berhubungan seksual serta buang air kecil. Bawang putih (Allium sativum L.), khususnya senyawa allicin memiliki potensi sebagai antibakteri dan antijamur. Selain itu, bawang putih juga mengandung saponin dan flavonoid. Penelitian ini bertujuan untuk mengevaluasi potensi ekstrak etanol Allium sativum L sebagai antijamur terhadap Candida albicans dan untuk mengembangkan sediaan ovula berbasis gelatin dengan konsentrasi ekstrak 20%, 25%, dan 30%. Pengujian daya hambat ovula ekstrak Allium sativum L dilakukan dengan metode sumuran menggunakan Cylinder cup. Hasil penelitian menunjukkan bahwa ovula ekstrak Allium sativum L dengan konsentrasi 20%, 25%, dan 30% memiliki daya hambat rata-rata masing-masing 6,1±0,290 mm, 8,06±0,750 mm dan 11,33±0,460 mm. Analisis ANOVA dilanjutkan dengan uji Least Significant Difference (LSD) menunjukkan perbedaan signifikan dalam kemampuan ovula menghambat pertumbuhan Candida albicans. Oleh karena itu, disimpulkan bahwa ovula ekstrak Allium sativum L memiliki potensi sebagai antijamur yang efektif.
Antibacterial activity of guava leaf ethanolic extract (Psidium guajava L.) nanosuspension against Escherichia coli bacteria Nurdianti, Lusi; Yuliana, Anna; Raras, Euis; Setiawan, Fajar; Wulandari, Winda Trisna; Firmansya, Ardianes
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.26359

Abstract

Diarrhea is a condition where a person has bowel movements three or more times a day, with consistent stools. One of the common bacteria that causes diarrhea is Escherichia coli. Empirical and preclinical studies have demonstrated the effectiveness of guava leaves (Psidium guajava L.) in treating diarrhea due to their tannin content. Nanosuspension formulations can be created to simplify the use of guava leaves for medicinal purposes. This study aims to investigate the efficacy of guava leaf extract, both in its natural form and as a nanosuspension preparation, against Escherichia coli. Additionally, the study aims to characterize the guava leaf extract nanosuspension used in the experiment. The technique used to make nanosuspension involves ionic gelation methods by using chitosan as a polymer, and subsequent characterization of the resulting product includes organoleptic testing, specific weight, pH, sedimentation volume, and viscosity. After the characterization of the guava leaf nanosuspension, it was found that the optimal formula had a particle size of 245.7 nm at a concentration of 0.01%, a polydispersion index of 0.406, and a zeta potential of +26.9 mV. Guava leaf ethanol extract 1% has a diameter of the inhibitory zone of 4.05±0.45 mm. However, the nanosuspension form of P. guajava L at a concentration of 0.01% has an inhibitory zone diameter of 11.45±0.64 mm. The nanosuspension formulation using P. guajava L has met the evaluation requirements and has antibacterial activity against E. coli bacteria.
Pharmacokinetic Profile of Astaxanthin Nanoemulsion Using HPLC (High-Performance Liquid Chromatography) With Oral Routes Nurdianti, Lusi; Setiawan, Fajar; Rusdiana, Taofik; Sofyan, Iyan; Lisnawati, Elis; Firmansya, Ardianes
Indonesian Journal of Pharmaceutics Vol 5, Issue 2, May - August 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i2.52645

Abstract

Astaxanthin is a very strong antioxidant of the xanthophyll carotenoid group with very lipophilic properties, so in oral administration, its bioavailability is very low. This study aimed to examine the differences in the pharmacokinetic profile of astaxanthin and astaxanthin nanoemulsion via the oral route using the HPLC method. Research methods include validation methods using HPLC and continued determining pharmacokinetic profiles to determine whether astaxanthin in plasma is validated. The plasma was deproteinized with ethanol: tetrahydrofuran (1: 9), mobile phase Methanol: water milliQ: ethyl acetate (82:8:10 (v/v)), the flow rate is 1.2 mL/min, wavelength 474 nm and the sample measured isocratic. Calibration curves 0.25-10 mg/L,% Recovery 102.92, 103.11 and 102.25,% RSD 1.33, 1.65 and 2. The HPLC method is fast, simple, and can be used for routine analysis of astaxanthin. The results showed that in the astaxanthin nanoemulsion, there was an increasing in Cmax and AUC0-∞ which affected increasing the bioavailability value. Therefore, it was concluded that the study showed the presence of astaxanthin in nanoemulsions has greater absorption power than pure astaxanthin. Keywords: Pharmacokinetic profile, Astaxanthin, Validation of the HPLC method, Oral route
Formulation of a Spray Gel Containing Asiaticoside and Niacinamide Combination for Anti-acne Nurdianti, Lusi; Gustaman, Firman; Kurniady, Fabillah; Setiawan, Fajar; Firmansya, Ardianes
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.50520

Abstract

Asiaticoside is one of the compounds of the triterpenoid group that functions as an antibacterial by forming a complex with cell membranes that pass through hydrogen bonds, then destroying the permeability of bacterial cell walls. Spray gel is considered a more practical and safer form of gel preparations due to its use, which can minimize microorganism contamination. This study aims to determine the effect of variations in the concentration of asiaticoside combined with niacinamide on its physical properties and antibacterial activity. This research method was carried out experimentally to manufacture spray gel preparations with variations in asiaticoside concentrations of 0%, 1%, 2%, 3%, and 4%. Spray gel preparations were tested for physical properties, stability, and antibacterial activity using the good diffusion method by producing preparations that meet the requirements of physical properties testing, did not cause irritating effects on the skin, good stability and results of antibacterial activity of spray gels produce different inhibitory zone diameters of 1.73 mm ± 2.00 (F0); 5.21 mm ± 1.25 (F1); 6.38 mm ± 1.01 (F2); 12.57 mm ± 4.73 (F3) and 16.20 mm ± 5.04 (F4). The five formulas exhibit good physical properties, stability, and antibacterial activity against Propionibacterium acnes. 
Formulation And Evaluation of Preparations Edible Film Combination Gingerol And Curcumin As An Antibacterial Streptococcus pyogenes Causes Of Inflammation Of The Throat Nurdianti, Lusi; Lestari, Tresna; Nurmalasari, Anisa; Wulandari, Winda Trisna; Cahyati, Keni Ida; Setiawan, Fajar; Firmansya, Ardianes
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 1: March 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i1.27616

Abstract

Jahe (Zingiber officinale) dan kunyit (Curcuma longa L) merupakan tanaman herbal yang terkenal karena manfaat terapeutiknya. Tumbuhan ini mengandung unsur bioaktif yang masing-masing disebut sebagai gingerol dan kurkumin, yang menunjukkan kualitas potensi antibakteri. Tujuan utama dari penelitian ini adalah untuk menguji atribut dan sifat antibakteri dari zat-zat tersebut. potensi Edible Film yang terdiri dari 5% ekstrak jahe gingerol dan kombinasi kurkumin terhadap bakteri Streptococcus pyogenes. Penelitian ini menggunakan metode pengecoran pelarut, evaluasi film yang dapat dimakan melalui analisis sensori, pengukuran ketebalan, penilaian keseragaman berat, penentuan pH, pengujian kerapuhan, pengukuran ketahanan lipat, analisis waktu hancur dan disolusi, penentuan kadar air, penilaian elongasi dan kekuatan tarik, stabilitas pemeriksaan, uji hedonik, evaluasi aktivitas antibakteri terhadap bakteri Streptococcus pyogenes, dan analisis gugus fungsi. Hasil penelitian menunjukkan bahwa Edible Film mempunyai karakteristik berbentuk persegi panjang berukuran 2x3 cm dengan warna berbeda tiap formula, bau yang khas, rasa manis dan pedas, ketebalan 0,11 mm - 0,12 mm, keseragaman berat 60,3 mg-68,87 mg, kerapuhan. 1,14%-2,95%, ketahanan lipat >500x, waktu hancur <30 detik, waktu larut <60 detik, kadar udara 8,58%-12,05%, kuat tarik 2,42 MPa – 16,18 MPa yang sesuai dengan Standar Industri Jepang (JIS) dan teori yang ada, tetapi penambahan persen memberikan hasil yang buruk. Sediaan Edible film baik formula tunggal maupun kombinasi mampu menghambat bakteri dengan diameter zona hambat F2, F3, dan F4 masing-masing 6,56 mm, 6,36 mm, dan 6,92 mm terhadap bakteri Streptococcus pyogenes dengan masing-masing kategori sedang.
Co-Authors Adhani, Ai Gita Aisah Anna Yuliana, Anna Aprillia, Ade Yeni Cahyati, Keni Ida Elis Lisnawati FAJAR SETIAWAN Gustaman, Firman Iyan Sofyan, Iyan Kurniady, Fabillah Lilis Tuslinah, Lilis Lusi Nurdianti, Lusi Nurmalasari, Anisa Raras, Euis Taofik Rusdiana Taufik Hidayat Tresna Lestari, Tresna Winda Trisna Wulandari, Winda Trisna