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The association between Hb levels in placenta previa patients with apgar scores Nurrahma, Herlin Ajeng; Nur Intan, Yulice Soraya; Meliala, Andreanita; Narwidina, Paramita
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 2 (2022): December 2022
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Hemoglobin (Hb) level is a biochemical indicator of the nutritional status of pregnant women, and a low Hb level reduces blood supply to the placenta, which influences the incidence of placenta previa. A placenta previa develops in the lower portion of the uterus, completely or partially expanding to cover the entire birth canal and the internal uterine ostium. The APGAR score is commonly used as a predictor of infant mortality and long-term disability and as an indicator of infant health at birth. The risk of maternal and infant mortality and morbidity increases in placenta previa patients with inadequate vascularization, which can be caused by low Hb levels. This study aimed to determine the relationship between Hb levels and APGAR scores in patients with placenta previa at Sultan Agung Islamic Hospital in Semarang. This analytic observation study is a cross-sectional analysis with purposive sampling method. From January 2017 to January 2018, all placenta previa patients hospitalized at Sultan Agung Hospital in Semarang were included in this study. In this study, we used subject data that met the criteria for inclusion. The p-value derived from the chi-square analysis is 0.041 (p< 0.05). A test of association was conducted. This test revealed that the OR was 11.5 (OR > 1). Low Hb levels (11 g/dl) could significantly increase the risk of a lower APGAR score at 5 min in patients with placenta previa who have a low Hb level.

FLIPPED CLASSROOM IMPLEMENTATION ON MECHANISM OF NUTRIENT HANDLING TO FACILITATE MULTIPLE PERSPECTIVE APPROACH Meliala, Andreanyta; Sumiwi, Yustina Andwi Ari; Nuryana, Ch.Tri; Sunarti, Sunarti; Narwidina, Paramita
Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Vol 12, No 4 (2023): Desember
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpki.85078

Background: Due to the content of lectures for nutrient handling often delivered from one scientific discipline, students do not gain a comprehensive understanding. The flipped classroom learning approach helps improve students' overall comprehension by integrating multiple scientific disciplines such as physiology, anatomy, biochemistry, and histology.Aims: The purpose of this study is to assess the efficacy of the flipped classroom learning approach in nutrition management lectures that incorporate physiology, anatomy, biochemistry, and histology.Methods: A basic pre-post test design was employed in this research. The flipped classroom method was used by first asking students to learn the topic via instructional videos, lecture files, and a pre-test (58 questions) on the eLOK UGM platform. The panel discussion was then carried out by lectures from four departments, including physiology, anatomy, biochemistry, and histology, via the Zoom platform (virtual synchronous learning). Finally, students were required to do a post-test with the same content as the pre-test.Results: According to the findings of this study, the average pre-test score of college participants was less than 80, whereas the average post-test score was 84.22, with 73.20% of the participants scoring higher than 80. The integrated panel discussion affected male participants' N-Gain scores. Male participants scored 0.74 (high category) while female participants scored 0.69 (medium category). Conclusions: The flipped classroom method can support approaches from departments of anatomy, physiology, histology, and biochemistry - in a relatively time-efficient but more effective means of improving understanding of nutrient handling.

Role of Ficus carica in Alleviating Chronic Hypoxia Impact in Rat’s Lungs Anggraini, Dini; Meliala, Andreanyta; Siswanto; Fitria, Laksmindra; Narwidina, Paramita; Mahroos, Rifda El; Sudesty, Shellya Puti
Indonesian Journal of Human Nutrition Vol. 11 No. 2 (2024)
Publisher : Department of Nutrition, Faculty of Health Sciences, Universitas Brawijaya Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.ijhn.2024.011.02.3

Chronic Intermittent Hypoxia (CIH) can initiate oxidative stress and inflammation. Ficus carica is known to contain antioxidant compounds capable of suppressing oxidative stress. This study aims to investigate the protective role of Ficus carica puree (FCP) on the levels of Malondialdehyde (MDA), Superoxide Dismutase (SOD), SOD/MDA ratio, Platelet Lymphocyte Ratio (PLR), and Tumor Necrosis Factor-α (TNF-α) in the lungs of rats induced by CIH. Rats were treated with FCP at doses of 1.25 ml/200g (CIH-F1), 2.5 ml/200g (CIH-F2), and 5 ml/200g (CIH-F3). All rats, except for the neutral control group, were subjected to chronic intermittent hypoxia (CIH) for 4 hours/day for 30 days. The CIH-F2 and CIH-F3 groups demonstrated significantly lower levels of lung MDA compared to the CIH group. The CIH-F3 group showed a considerably lower level of lung SOD compared to the CIH group. However, the SOD/MDA exhibited a considerably greater value in the CIH-F3 induction group compared to the other groups. The TNF-α in lungs and PLR levels were significantly lower in the CIH-F3 group than in the CIH group. These findings suggest that FCP may serve as a functional food to mitigate the negative impact of hypoxic circumstances on lung health.

Figs Fruit Act as Adequate Anti-Inflammatory Agents against Injured Intestines and Memory Impairment of Acute Hypoxia-Induced Rats Naurasarah, Zhafira; Meliala, Andreanyta; Supriyanto, Irwan; Onky Silvana Wijaya, Yogik; Narwidina, Paramita; Emmanuela Selamat, Claire; Kaila Priandika, Rangga
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.20650

Acute hypoxia (AH) may induce inflammation, increase reactive oxygen species (ROS) production, and play an important role in disrupting mucosal integrity and memory impairment through the gut-brain axis. As such, this study aimed to investigate the protective effects of Ficus carica puree (FCP) in rats with AH (10% O2, 90% N2, 4h) - induced intestinal injury. Thirty male Sprague-Dawley rats were divided into 6 groups: NC (negative control, untreated), PC (positive control), VC (vehicle, treated with corn oil), and FC1, FC2, and FC3 (FC1, 2, and 4 mL of FCP/200g). Histopathological analysis of the ileum, the levels of nitric oxide (NO), and tumor necrosis factor-α (TNF-α) were measured in plasma, and the novel object recognition (NORT) was used as a behavior test. The ileal tissues of FC1, FC2, and FC3 groups showed fewer inflammatory cells and less tissue damage than the NC group. The FCP exhibited non-dose-dependent anti-inflammation activity in TNF-α, NO, IL-6 levels, and histopathological analysis. Rats receiving all doses of FCP spent more time exploring the new object in NORT, suggesting the benefits of the phenolic compounds in Ficus carica as a functional food in alleviating the inflammatory and oxidative impacts of AH-induced intestinal injury.

Figs Fruit Act as Adequate Anti-Inflammatory Agents against Injured Intestines and Memory Impairment of Acute Hypoxia-Induced Rats Naurasarah, Zhafira; Meliala, Andreanyta; Supriyanto, Irwan; Onky Silvana Wijaya, Yogik; Narwidina, Paramita; Emmanuela Selamat, Claire; Kaila Priandika, Rangga
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.20650

Acute hypoxia (AH) may induce inflammation, increase reactive oxygen species (ROS) production, and play an important role in disrupting mucosal integrity and memory impairment through the gut-brain axis. As such, this study aimed to investigate the protective effects of Ficus carica puree (FCP) in rats with AH (10% O2, 90% N2, 4h) - induced intestinal injury. Thirty male Sprague-Dawley rats were divided into 6 groups: NC (negative control, untreated), PC (positive control), VC (vehicle, treated with corn oil), and FC1, FC2, and FC3 (FC1, 2, and 4 mL of FCP/200g). Histopathological analysis of the ileum, the levels of nitric oxide (NO), and tumor necrosis factor-α (TNF-α) were measured in plasma, and the novel object recognition (NORT) was used as a behavior test. The ileal tissues of FC1, FC2, and FC3 groups showed fewer inflammatory cells and less tissue damage than the NC group. The FCP exhibited non-dose-dependent anti-inflammation activity in TNF-α, NO, IL-6 levels, and histopathological analysis. Rats receiving all doses of FCP spent more time exploring the new object in NORT, suggesting the benefits of the phenolic compounds in Ficus carica as a functional food in alleviating the inflammatory and oxidative impacts of AH-induced intestinal injury.

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