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The Banana (Musa balbisiana Colla) Peels Flour Modulates HTR2B Receptor Expression in the Liver Diabetic Rats Andreanyta Meliala; Paramita Narwidina; Herlin Ajeng Nurrahma; Irwan Supriyanto
HAYATI Journal of Biosciences Vol. 29 No. 3 (2022): May 2022
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.29.3.279-287

Uncontrolled diabetes mellitus (DM) has been linked to depression and lipid metabolism impairment. Serotonin (5-HT) has been known to improve lipid metabolism and affect mood. The 5-Hydroxytryptophan (5-HTP) in banana peel flour (BPF) is a precursor to synthesize 5-HT in the body, which is linked to initiating liver regeneration via HTR2B receptors. The impact of 5-HTP in the diet on HTR2B receptor expression has yet to be thoroughly investigated. We aimed to elucidate the correlation between serum lipid profile and immobility time in Tail Suspension Test (TST) as depressive-like behavior and compare the expression of HTR2B receptor in healthy and diabetic rats. Male Wistar (Rattus norvegicus) rats were assigned to the control and treatment groups in a DM model with streptozotocin (60 mg/kg) injected intraperitoneally, then either fed standard diet or BPF 10% supplemented standard diet for 21 days. Immunohistochemical staining was used to examine the expression of 5-HT, HTR2B receptors. We determined that diabetic rats fed the standard diet supplemented 10% BPF group showed significantly lower concentrations of total cholesterol and triglycerides compared to diabetic rats fed a standard diet and it was positively correlated between total cholesterol and LDL with the duration of immobility time in TST. The average immunoreactivity score in diabetic rats fed 10% BPF was the highest among the other groups, indicating that the available BPF dose is sufficient for HTR2B activation, which will support the liver cell regeneration process, and should be investigated further.

The administration of long-term high-fat diet in ovariectomized wistar rat (Study on Daily Food Intake, Lee Index, Abdominal Fat Mass and Leptin Serum Levels) Dita Fitriani; Andreanyta Meliala; Denny Agustiningsih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 48, No 2 (2016)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

ABSTRACT Leptin and estrogen have an important role in energy homeostasis through anorexic effects on the central nervous system. These hormones can decrease food intake, increases energy expenditure and thermogenesis. Long-term high-fat diet can lead to impaired leptin function. Moreover, estrogen, deficiency is a risk factor of obesity in menopause. The aim of this study is to investigate the effect of long-term high-fat diet on leptin serum levels in ovariectomized rats. Twenty-eight female Wistar rats (Rattus norvegicus) aged 6-8 weeks with body weight 120-150 g were used in this study. Rats were divided into 4 groups i.e. OVXSC groups: rat were ovariectomized and given a standard diet; OVXH groups: rat were ovariectomized and given a high-fat diet; SHAMSC groups: rat were not ovariectomized and given a standard diet; SHAMHF groups : rat were not ovariectomized and given a high-fat diet. Pre-post test with control group design for measurement of serum leptin levels, food intake, and Lee index. While post-test only control group design for measurement of abdominal fat mass. Pearson test was used to analyze the correlation between leptin serum levels, food intake, Lee index and abdominal fat mass. Paired t-test was used to analyze the differences between values before and after being treated. The daily food intake dropped in rat fed a high-fat diet although it was not statistically significant (p>0.05). Ovariectomy significantly increase Lee index (p<0.05). Obesity occurs in ovariectomized group, both of high-fat diet and standard diet. Abdominal fat mass was significantly higher in high-fat compared to standard diet group (p<0.05). Increase in levels of serum leptin highest in OVX-HF group (16.45 ± 8.75 ng/mL), and the lowest in the SHAM-SC (2.98 ± 1.61 ng/mL). In conclusion, serum leptin levels positively correlated with Lee index and abdominal fat mass, but negatively correlated with daily food intake.

PENGARUH PEMBERIAN EKSTRAK KULIT PISANG KEPOK KUNING (Musa balbisiana) TERHADAP ASUPAN MAKAN DAN BERAT BADAN TIKUS WISTAR (Rattus norvegicus) JANTAN Wiwiek Fatchurohmah; Andreanyta Meliala
Scripta Biologica Vol 4, No 3 (2017)
Publisher : Fakultas Biologi | Universitas Jenderal Soedirman

A positive energy imbalance results in overweight and obesity. Overweight and obesity are the major risk factors for many diseases, including diabetes, cardiovascular diseases, and mental health. Animal studies suggested that serotonin involves in food intake control. The Banana peel is a potential natural source of serotonin precursor; furthermore, it may influence food intake. This study aimed to determine the effect of banana peel extract on food intake and body weight gain in male Wistar rats. Twenty-four male Wistar rats (8-10 weeks old), were divided into four groups for feeding treatment. All four group were; the control group (C), the banana peel extract dosage of 4 g/kg BW group (T1), the banana peel extract dosage of 8 g/kg BW (T2), and the banana peel extract dosage of 16 g/kg BW (T3). The food intakes were measured daily, while rats body weights were recorded at the beginning and the end of the three days experimental periods. The study found the rats in the T1 group (8.80 ± 2.63) showed no significant difference in food intake compared to C group (10.68 ± 1.89), T2 group (6.65 ± 3.12), and T3 group (5.42 ± 1.59). Rats in the T2 group (p = 0.038) and T3 group (p = 0.005) showed lower food intake significantly compared to control group. After three days of treatment, the T3 group showed a significant decrease in body weight compared to control group (p = 0.008). This study concluded, the administration of banana peel extract dosage of 8 g/kg BW and 16 g/kg BW suppressed food intake, while the dosage of 16 g/kg BW reduced the body weight in male Wistar rats.

Effects of Physical Exercise on Indicators of Inflammation Risk of the Gaster in a Male Wistar Rat Aging Model Created with D-galactose Induction Murwaningsih, Dian; Meliala, Andreanyta; Sofro, Zaenal M
Makara Journal of Health Research Vol. 22, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Physical exercise is a non-pharmacological treatment for various diseases. Aging is associated with deteriorating physiological function, and elderly individuals generally have inflammation or infection in the digestive tract. This study aimed to examine the effects of mild and moderate physical exercise intensities on the indicators of inflammation risk of the gaster in a male Wistar rat aging model created with D-galactose induction. Methods: This experimental research study had a post-test-only group design. The study included 24 3-month-old male Wistar rats weighing 200-300 g. The rats were equally divided into four groups (saline,+light-intensity physical exercise, and D-galactose+moderate-intensity physical exercise)D-galactose, D-galactose. D-galactose was continuously administered at 300 mg/ml/kg body weight. The study period was four weeks. The number of fibrocytes, mucosal thickness, and the number and size of mucosal glands were analyzed. Results: D-galactose induction triggered aging. Physical exercise had an effect on weight gain and decreased the number of fibrocytes. However, there were no effects on mucosal thickness and the number and size of mucosal glands. Conclusions: Physical exercise of mild/moderate intensity had an effect on the number of fibrocytes but did not have impact on the mucosal thickness or the number and size of mucosal glands.

The association between Hb levels in placenta previa patients with apgar scores Nurrahma, Herlin Ajeng; Nur Intan, Yulice Soraya; Meliala, Andreanita; Narwidina, Paramita
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 2 (2022): December 2022
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Hemoglobin (Hb) level is a biochemical indicator of the nutritional status of pregnant women, and a low Hb level reduces blood supply to the placenta, which influences the incidence of placenta previa. A placenta previa develops in the lower portion of the uterus, completely or partially expanding to cover the entire birth canal and the internal uterine ostium. The APGAR score is commonly used as a predictor of infant mortality and long-term disability and as an indicator of infant health at birth. The risk of maternal and infant mortality and morbidity increases in placenta previa patients with inadequate vascularization, which can be caused by low Hb levels. This study aimed to determine the relationship between Hb levels and APGAR scores in patients with placenta previa at Sultan Agung Islamic Hospital in Semarang. This analytic observation study is a cross-sectional analysis with purposive sampling method. From January 2017 to January 2018, all placenta previa patients hospitalized at Sultan Agung Hospital in Semarang were included in this study. In this study, we used subject data that met the criteria for inclusion. The p-value derived from the chi-square analysis is 0.041 (p< 0.05). A test of association was conducted. This test revealed that the OR was 11.5 (OR > 1). Low Hb levels (11 g/dl) could significantly increase the risk of a lower APGAR score at 5 min in patients with placenta previa who have a low Hb level.

Pengaruh Usia Ibu, Kadar Hemoglobin, Trombosit, dan Leukosit Darah pada Ibu Hamil Terhadap Kejadian Berat Badan Lahir Rendah (BBLR) (Studi Observasi Analitik di Rumah Sakit Islam Sultan Agung) : The Effect of Maternal Age, Hemoglobin, Platelet, and Blood Leukocyte Levels in Pregnant Women on the Incidence of Low Birth Weight (LBW) (Analytical Observational Study at Sultan Agung Islamic Hospital) Herlin Ajeng Nurrahma; Yulice Soraya Nur Intan; Andreanyta Meliala; Paramita Narwidina
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 6 No. 4: APRIL 2023 - Media Publikasi Promosi Kesehatan Indonesia (MPPKI)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v6i4.3009

Latar belakang: Kelahiran bayi dengan Berat Badan Lahir Rendah (BBLR) menjadi penyebab utama kematian prenatal dan terjadinya masalah pada masa tumbuh kembang. Banyak faktor yang menyebabkan kejadian BBLR meningkat, diantaranya usia Ibu saat melahirkan, kadar Hemoglobin (Hb), trombosit dan leukosit yang tidak berada dalam rentang normal. Tujuan: Untuk mengetahui hubungan antara usia saat melahirkan, kadar Hb, trombosit, dan leukosit Ibu hamil dengan kejadian BBLR di RS Islam Sultan Agung Semarang, periode Januari 2017-2018. Metode: Penelitian observasional dengan desain cross sectional menggunakan data rekam medis pasien. Data diambil dari 63 Ibu hamil yang dirawat selama periode Januari 2017-2018 di RS Islam Sultan Agung. Data penelitian dianalisis mengunakan uji Chi Square. Hasil: Ibu dengan usia beresiko berpotensi 0,912 kali melahirkan bayi dengan BBLR dibandingkan dengan Ibu berusia tidak beresiko, walaupun secara statistik tidak bermakna. Ibu dengan kadar leukosit ≤13.000/µL memiliki kecenderungan 0,260 lebih kecil secara signifikan (nilai P<0,05) untuk melahirkan bayi dengan BBLR , sedangkan untuk parameter Hb dan trombosit memiliki nilai OR sebesar 0,673 dan 1,326, hal ini berarti Ibu dengan kadar Hb<11 g/dL memiliki kecenderungan 0,673 kali memicu kejadian BBLR, sedangkan kelompok Ibu dengan kadar trombosit <150.000/µL memiliki resiko 1,3 kali lebih besar dibandingkan dengan Ibu dengan kadar trombosit ≥150.000/µL untuk mencetuskan kejadian BBLR. Kesimpulan: Hubungan antara usia Ibu hamil, kadar Hb, dan trombosit dengan kejadian BBLR tidak bermakna secara statistik, namun Ibu dengan kadar leukosit ≤13.000/µL memiliki kecenderungan 0,260 lebih kecil secara signifikan untuk melahirkan bayi dengan BBLR dibandingkan dengan Ibu dengan kadar leukosit >13.000/µL.

FLIPPED CLASSROOM IMPLEMENTATION ON MECHANISM OF NUTRIENT HANDLING TO FACILITATE MULTIPLE PERSPECTIVE APPROACH Meliala, Andreanyta; Sumiwi, Yustina Andwi Ari; Nuryana, Ch.Tri; Sunarti, Sunarti; Narwidina, Paramita
Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Vol 12, No 4 (2023): Desember
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpki.85078

Background: Due to the content of lectures for nutrient handling often delivered from one scientific discipline, students do not gain a comprehensive understanding. The flipped classroom learning approach helps improve students' overall comprehension by integrating multiple scientific disciplines such as physiology, anatomy, biochemistry, and histology.Aims: The purpose of this study is to assess the efficacy of the flipped classroom learning approach in nutrition management lectures that incorporate physiology, anatomy, biochemistry, and histology.Methods: A basic pre-post test design was employed in this research. The flipped classroom method was used by first asking students to learn the topic via instructional videos, lecture files, and a pre-test (58 questions) on the eLOK UGM platform. The panel discussion was then carried out by lectures from four departments, including physiology, anatomy, biochemistry, and histology, via the Zoom platform (virtual synchronous learning). Finally, students were required to do a post-test with the same content as the pre-test.Results: According to the findings of this study, the average pre-test score of college participants was less than 80, whereas the average post-test score was 84.22, with 73.20% of the participants scoring higher than 80. The integrated panel discussion affected male participants' N-Gain scores. Male participants scored 0.74 (high category) while female participants scored 0.69 (medium category). Conclusions: The flipped classroom method can support approaches from departments of anatomy, physiology, histology, and biochemistry - in a relatively time-efficient but more effective means of improving understanding of nutrient handling.

Role of Ficus carica in Alleviating Chronic Hypoxia Impact in Rat’s Lungs Anggraini, Dini; Meliala, Andreanyta; Siswanto; Fitria, Laksmindra; Narwidina, Paramita; Mahroos, Rifda El; Sudesty, Shellya Puti
Indonesian Journal of Human Nutrition Vol. 11 No. 2 (2024)
Publisher : Department of Nutrition, Faculty of Health Sciences, Universitas Brawijaya Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.ijhn.2024.011.02.3

Chronic Intermittent Hypoxia (CIH) can initiate oxidative stress and inflammation. Ficus carica is known to contain antioxidant compounds capable of suppressing oxidative stress. This study aims to investigate the protective role of Ficus carica puree (FCP) on the levels of Malondialdehyde (MDA), Superoxide Dismutase (SOD), SOD/MDA ratio, Platelet Lymphocyte Ratio (PLR), and Tumor Necrosis Factor-α (TNF-α) in the lungs of rats induced by CIH. Rats were treated with FCP at doses of 1.25 ml/200g (CIH-F1), 2.5 ml/200g (CIH-F2), and 5 ml/200g (CIH-F3). All rats, except for the neutral control group, were subjected to chronic intermittent hypoxia (CIH) for 4 hours/day for 30 days. The CIH-F2 and CIH-F3 groups demonstrated significantly lower levels of lung MDA compared to the CIH group. The CIH-F3 group showed a considerably lower level of lung SOD compared to the CIH group. However, the SOD/MDA exhibited a considerably greater value in the CIH-F3 induction group compared to the other groups. The TNF-α in lungs and PLR levels were significantly lower in the CIH-F3 group than in the CIH group. These findings suggest that FCP may serve as a functional food to mitigate the negative impact of hypoxic circumstances on lung health.

Figs Fruit Act as Adequate Anti-Inflammatory Agents against Injured Intestines and Memory Impairment of Acute Hypoxia-Induced Rats Naurasarah, Zhafira; Meliala, Andreanyta; Supriyanto, Irwan; Onky Silvana Wijaya, Yogik; Narwidina, Paramita; Emmanuela Selamat, Claire; Kaila Priandika, Rangga
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.20650

Acute hypoxia (AH) may induce inflammation, increase reactive oxygen species (ROS) production, and play an important role in disrupting mucosal integrity and memory impairment through the gut-brain axis. As such, this study aimed to investigate the protective effects of Ficus carica puree (FCP) in rats with AH (10% O2, 90% N2, 4h) - induced intestinal injury. Thirty male Sprague-Dawley rats were divided into 6 groups: NC (negative control, untreated), PC (positive control), VC (vehicle, treated with corn oil), and FC1, FC2, and FC3 (FC1, 2, and 4 mL of FCP/200g). Histopathological analysis of the ileum, the levels of nitric oxide (NO), and tumor necrosis factor-α (TNF-α) were measured in plasma, and the novel object recognition (NORT) was used as a behavior test. The ileal tissues of FC1, FC2, and FC3 groups showed fewer inflammatory cells and less tissue damage than the NC group. The FCP exhibited non-dose-dependent anti-inflammation activity in TNF-α, NO, IL-6 levels, and histopathological analysis. Rats receiving all doses of FCP spent more time exploring the new object in NORT, suggesting the benefits of the phenolic compounds in Ficus carica as a functional food in alleviating the inflammatory and oxidative impacts of AH-induced intestinal injury.

Figs Fruit Act as Adequate Anti-Inflammatory Agents against Injured Intestines and Memory Impairment of Acute Hypoxia-Induced Rats Naurasarah, Zhafira; Meliala, Andreanyta; Supriyanto, Irwan; Onky Silvana Wijaya, Yogik; Narwidina, Paramita; Emmanuela Selamat, Claire; Kaila Priandika, Rangga
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.20650

Acute hypoxia (AH) may induce inflammation, increase reactive oxygen species (ROS) production, and play an important role in disrupting mucosal integrity and memory impairment through the gut-brain axis. As such, this study aimed to investigate the protective effects of Ficus carica puree (FCP) in rats with AH (10% O2, 90% N2, 4h) - induced intestinal injury. Thirty male Sprague-Dawley rats were divided into 6 groups: NC (negative control, untreated), PC (positive control), VC (vehicle, treated with corn oil), and FC1, FC2, and FC3 (FC1, 2, and 4 mL of FCP/200g). Histopathological analysis of the ileum, the levels of nitric oxide (NO), and tumor necrosis factor-α (TNF-α) were measured in plasma, and the novel object recognition (NORT) was used as a behavior test. The ileal tissues of FC1, FC2, and FC3 groups showed fewer inflammatory cells and less tissue damage than the NC group. The FCP exhibited non-dose-dependent anti-inflammation activity in TNF-α, NO, IL-6 levels, and histopathological analysis. Rats receiving all doses of FCP spent more time exploring the new object in NORT, suggesting the benefits of the phenolic compounds in Ficus carica as a functional food in alleviating the inflammatory and oxidative impacts of AH-induced intestinal injury.

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