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All Journal Indonesian Journal of Human Nutrition Medicosphere
Mahroos, Rifda El
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Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences

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Role of Ficus carica in Alleviating Chronic Hypoxia Impact in Rat’s Lungs Anggraini, Dini; Meliala, Andreanyta; Siswanto; Fitria, Laksmindra; Narwidina, Paramita; Mahroos, Rifda El; Sudesty, Shellya Puti
Indonesian Journal of Human Nutrition Vol. 11 No. 2 (2024)
Publisher : Department of Nutrition, Faculty of Health Sciences, Universitas Brawijaya Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.ijhn.2024.011.02.3

Abstract

Chronic Intermittent Hypoxia (CIH) can initiate oxidative stress and inflammation. Ficus carica is known to contain antioxidant compounds capable of suppressing oxidative stress. This study aims to investigate the protective role of Ficus carica puree (FCP) on the levels of Malondialdehyde (MDA), Superoxide Dismutase (SOD), SOD/MDA ratio, Platelet Lymphocyte Ratio (PLR), and Tumor Necrosis Factor-α (TNF-α) in the lungs of rats induced by CIH. Rats were treated with FCP at doses of 1.25 ml/200g (CIH-F1), 2.5 ml/200g (CIH-F2), and 5 ml/200g (CIH-F3). All rats, except for the neutral control group, were subjected to chronic intermittent hypoxia (CIH) for 4 hours/day for 30 days. The CIH-F2 and CIH-F3 groups demonstrated significantly lower levels of lung MDA compared to the CIH group. The CIH-F3 group showed a considerably lower level of lung SOD compared to the CIH group. However, the SOD/MDA exhibited a considerably greater value in the CIH-F3 induction group compared to the other groups. The TNF-α in lungs and PLR levels were significantly lower in the CIH-F3 group than in the CIH group. These findings suggest that FCP may serve as a functional food to mitigate the negative impact of hypoxic circumstances on lung health.
The Role Of Motility And Gastric Acid Secretion in The Pathophysiology of Gastroesophageal Reflux Disease (GERD): A Literature Review el mahroos, rifda
Journal of Diverse Medical Research : Medicosphere Vol. 2 No. 9 (2025): J Divers Med Res 2025
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v2i9.215

Abstract

Introduction: Gastroesophageal reflux disease (GERD) is a chronic disorder of the upper gastrointestinal tract that involves a complex interaction between physiologic and pathologic factors. The two main components that play a role in this dynamic are gastric motility and acid secretion. Methods: This review used a narrative literature review approach by searching the current scientific literature from various databases between 2015-2024. Discussion: Normal gastric motility maintains gastric emptying efficiency and lowers the risk of reflux, while disorders such as delayed gastric emptying increase intragastric pressure and trigger reflux. Excessive secretion of gastric acid, especially HCl and pepsin, amplifies the aggressive nature of gastric contents and exacerbates damage to the esophageal mucosa. These two aspects interact to create an imbalance between protective and aggressive factors in GERD. Conclusion: The interplay between gastric motility and acid secretion plays a key role in the transition from physiologic to pathologic mechanisms in GERD, so a thorough understanding of both is important in diagnosis and treatment strategies.
Co-Authors Dini Anggraini, Dini Laksmindra Fitria Meliala, Andreanyta Narwidina, Paramita Siswanto Sudesty, Shellya Puti