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All Journal Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Cancer
Harsono, Ali Budi
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Performance of Pre-Operative IOTA Three-Step Algorithm in Detecting Ovarian Carcinoma in a Referral Center in Indonesia Kurniadi, Andi; Permadi, Wiryawan; Kusuma, Aria Yusti; Kireina, Jessica; Andarini, Mia Yasmina; Winarno, Gatot Nyarumenteng Adhipurnawan; Harsono, Ali Budi
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.1044

Abstract

Background: To assess the diagnostic performance of a three-step algorithm using the International Ovarian Tumor Analysis (IOTA) Group ‘simple rules’, ‘simple descriptors’, and Assessment of Different NEoplasias in the adneXa (ADNEX) model for discriminating benign and malignant adnexal masses. Methods:  This was a retrospective observational study, performed at a tertiary-care university hospital, on women diagnosed with adnexal mass on ultrasonography from January 2021 and February 2022. The examiner first classified the mass using ‘simple descriptors’ (first step) and, if not possible, using ‘simple rules’ (second step). For inconclusive masses, an assessment using the ADNEX model was done as the third step. All masses were managed surgically. Histopathology results were used as the reference standard.Results: One hundred and forty-one women were included (median age of 48 years). Histopathology results showed 104 (73.76%) mass to be malignant, and 37 (26.24%) mass to be benign. Twelve (8.51%) of 141 masses could be classified using simple descriptors, 89 (63.12%) masses were classified using simple rules, and 40 (28.37%) masses were classified using the ADNEX model. Overall accuracy, sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio of the three-step algorithm were 89.36%, 94.23%, 75.68%, 91.59%, 82.35%, 3.87, and 0.08 respectively.Conclusions: The IOTA three-step algorithm, based on the sequential use of simple descriptors, simple rules, and ADNEX model, performs well for classifying adnexal masses as benign or malignant
Effect of Methotrexate on Anti-Mullerian Hormone Levels, β-hCG and Tumor Size in Women with Low-Risk Gestational Trophoblast Disease Madjid, Tita Husnitawati; Masitoh, Imas; Harsono, Ali Budi; Purwara, Benny Hasan; Rinaldi, Andi; Mose, Johannes Cornelius; Sunardi, Sunardi
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 1 Maret 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i1.610

Abstract

Introduction: This study aimed to evaluate the effect of methotrexate (MTX) chemotherapy on anti-mullerian hormone (AMH) levels, human chorionic gonadotropin (HCG) levels, and tumor size in women with gestational trophoblastic disease (GTD). Method: This study was conducted at Hasan Sadikin General Hospital, Bandung, West Java, from April to October 2020. The AMH level, beta human chorionic gonadotropin (ß-hCG) and tumor size in women with a low risk of GTD prior to and after MTX chemotherapy treatment were measured and compared.Results: Our study found a reduction in mean AMH level to 0.82 ng/ml after the MTX chemotherapy. The mean AMH level after chemotherapy in women with low-risk GTD decreased to 0.82 ng / ml. In addition, ß-hCG level decreased after chemotherapy with MTX. There was a negative relationship between ß-hCG level and tumor size before and after chemotherapy. Higher ß-hCG levels and tumor size before chemotherapy resulted in a further increase in AMH after chemotherapy.Discussion: There was a decrease in AMH and ß-hCG levels after three cycles of MTX chemotherapy in women with low-risk GTD. Tumor size and ß-hCG correlated with post-chemotherapy AMH results.Pengaruh Metotreksat terhadap Kadar Hormon Anti Mullerian, β-hCG dan Ukuran Tumor pada Wanita dengan Penyakit Trofoblas Gestasional Risiko RendahAbstrakPendahuluan: Penelitian ini mengevaluasi efek kemoterapi metotreksat (MTX) terhadap kadar hormon anti-mullerian (AMH), kadar human chorionic gonadotropin (HCG), dan ukuran tumor pada wanita yang didiagnosis penyakit trofoblas gestasional (GTD) risiko rendah.Metode: Penelitian ini dilakukan di Rumah Sakit Umum Pusat Hasan Sadikin, Bandung, Jawa Barat, dari bulan April hingga Oktober 2020. Kadar AMH, beta human chorionic gonadotropin (ß-hCG), dan ukuran tumor pada wanita dengan GTD risiko rendah sebelum dan sesudah pengobatan kemoterapi MTX diukur dan dibandingkan.Hasil: Pada penelitian kami menemukan penurunan kadar AMH rata-rata menjadi 0,82 ng/ml setelah kemoterapi MTX. Rata-rata kadar AMH setelah kemoterapi pada wanita dengan GTD risiko rendah menurun menjadi 0,82 ng/ml. Selain itu, kadar ß-hCG juga menurun setelah kemoterapi dengan MTX. Terdapat hubungan negatif antara kadar ß-hCG dan ukuran tumor sebelum kemoterapi dan AMH setelah kemoterapi. Kadar ß-hCG yang lebih tinggi dan ukuran tumor sebelum kemoterapi menunjukkan peningkatan lebih tinggi pada AMH setelah kemoterapi.Kesimpulan: Terjadi penurunan kadar AMH dan ß-hCG setelah tiga siklus kemoterapi MTX pada wanita dengan GTD risiko rendah. Ukuran tumor dan kadar ß-hCG berkorelasi dengan hasil kadar AMH setelah kemoterapi.Kata kunci: Kemoterapi, Metotreksat, Hormon anti-mullerian, ß-hCG, Tumor trofoblas gestasional
Karakteristik Tumor Trofoblas Gestasional Risiko Tinggi di RSUP Dr. Hasan Sadikin Bandung Tahun 2019 – 2021 Hidayat, Yudi Mulyana; Megantari, Salsa Bila; Harsono, Ali Budi; Suardi, Dodi; Mantilidewi, Kemala Isnainiasih
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.493

Abstract

Tujuan: Penelitian ini bertujuan mengidentifikasi karakteristik demografi dan klinis pasien TTG risiko tinggi di RSUP Dr. Hasan Sadikin Bandung pada tahun 2019 – 2021.Metode: Penelitian ini menggunakan analisis secara deskriptif yang didapatkan melalui rekam medis pasien TTG risiko tinggi di RSUP Dr. Hasan Sadikin Bandung pada tahun 2019 – 2021 dengan metode total sampling. Hasil: Terdapat 69 rekam medis pasien yang memenuhi kriteria inklusi dan eksklusi. Hasil tersebut menunjukkan banyaknya pasien yang memiliki pendidikan terakhir pada jenjang SMA (49%), tidak memiliki pekerjaan (84%) yang didominasi oleh ibu rumah tangga, beretnis Sunda (93%), berasal dari daerah wilayah IV Priangan (54%), berusia lebih dari 40 tahun (57%), multipara (61%), memiliki riwayat mola (71%), interval dengan kehamilan sebelumnya 7 hingga 12 bulan (54%), kadar β-hCG yang diukur sebelum terapi sebanyak 10.000 - <100.000 mIU/mL (42%), tidak terjadi metastasis (68%)  diikuti hasil terjadinya metastasis pada paru-paru (26%), tidak memiliki hasil pemeriksaan tipe histopatologi (61%) diikuti hasil tipe histopatologi koriokarsinoma (33%), dan memiliki stadium I  (59%).Kesimpulan: Kasus TTG risiko tinggi di RSUP Dr. Hasan Sadikin Bandung pada tahun 2019 – 2021 lebih umum terjadi pada pasien yang memiliki pendidikan terakhir pada jenjang SMA, tidak memiliki pekerjaan yang didominasi oleh ibu rumah tangga, beretnis Sunda, berasal dari daerah wilayah IV Priangan, berusia lebih dari 40 tahun, riwayat multipara, riwayat mola, interval dengan kehamilan sebelumnya 7 hingga 12 bulan, kadar β-hCG yang diukur sebelum terapi sebanyak 10.000 - < 100.000 mIU/mL, tidak terjadi metastasis, dan memiliki stadium I.Characteristics of High Risk Gestational Trophoblast Neoplasia at Dr. Hasan Sadikin General Hospital Bandung in 2019 – 2021AbstractObjective: This research aims to identify the demographic and clinical characteristics of patients with high-risk GTN at Dr. Hasan Sadikin Bandung in 2019–2021.Method: This research used descriptive analysis, which was obtained from the medical records of patients with high-risk GTN at Dr. Hasan Sadikin General Hospital Bandung in 2019–2021 using the total sampling method.Results: 69 patient medical records met the inclusion and exclusion criteria. These results show that the number of patients who have had their last education at the high school level (49%), do not have a job (84%), are dominated by housewives, are of Sundanese ethnicity (93%), and come from region IV Priangan (54%), aged over 40 years (57%), multiparous (61%), had a history of molar (71%), an interval with a previous pregnancy of 7 to 12 months (54%), β-hCG level measured before therapy of 10,000– 100,000 mIU/mL (42%), no metastases (68%) followed by lung metastases (26%), no histopathological type (61%) followed by choriocarcinoma histopathological type (33%), and staging I (59%).Conclusion: High-risk GTN cases at Dr. Hasan Sadikin Bandung in 2019 – 2021 are more common in patients who have the last education at the high school level, do not have a job dominated by housewives, are of Sundanese ethnicity, come from the IV Priangan region, are over 40 years old, have a history of multiparas, a history of moles, an interval with a previous pregnancy of 7 to 12 months, β-hCG level measured before therapy was 10,000– 100,000 mIU/mL, no metastases occurred, and had stage I.Key words: Characteristics, Demographic, Gestational Trophoblastic Neoplasia, High Risk
Peran Magnetic Resonance Imaging pada Diagnosis Kanker Serviks yang Menyerupai Kanker Endometrium – Laporan Kasus Erfiandi, Febia; Harsono, Ali Budi; Soekersi, Hari; Dewayani, Birgitta Maria; Kireina, Jessica
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 1 Maret 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i1.444

Abstract

Pendahuluan: Magnetic resonance imaging (MRI) merupakan modalitas penting dalam diagnosis kanker ginekologi, terutama serviks dan endometrium. Laporan kasus ini bertujuan melihat peranan MRI dalam menentukan asal tumor, keterlibatan parametrium, dan metastasis kelenjar getah bening retroperitoneal.Presentasi Kasus: Pada laporan kasus ini pasien didiagnosis kanker serviks stadium IB3 dengan diagnosis banding kanker endometrium stadium II karena keluhan perdarahan pasca-menopause, massa di serviks bersifat endofitik, dan ukuran uterus membesar. Hasil histopatologi kuretase yaitu endometrioid endometrial carcinoma moderately differentiated Dd/adenocarcinoma cervix. Magnetic resonance imaging (MRI) dilakukan untuk melihat asal tumor dan menetukan stadium. Skor MRI menganalisis tujuh perbedaan fitur: lokasi dan perfusi tumor, penyengatan perifer, massa atau distensi rongga endometrium, invasi miometrium, dan infiltrasi jaringan sekitar; skor 10 didapatkan pada kasus dengan menggunakan sekuens T2WI sagital, DWI-ADC, dan DCE yang menyimpulkan bahwa tumor berasal dari serviks dan telah menginfiltrasi parametrium.Kesimpulan: Skor MRI bisa dijadikan pertimbangan untuk melihat asal tumor (serviks atau endometrium) selain melihat keterlibatan parametrium dan kelenjar getah bening pelvis sehingga diagnosis dan manajemen lebih baik.The Role of Magnetic Resonance Imaging in the Diagnosis of Cervical Cancer Resembling Endometrial Cancer – A Case ReportAbstractObjective: Magnetic resonance imaging (MRI) is an important modality in the diagnosis of gynecological cancer, especially cervical and endometrial cancer. This case report aims to examine the role of MRI in determining tumor origin, parametrial involvement, and retroperitoneal lymph node metastases.Case presentation: In this case report, the patient was diagnosed with stage IB3 cervical cancer Dd/ stage II endometrial cancer due to complaints of postmenopausal bleeding, endophytic cervical mass, and uterine enlargement. The histopathological results of curettage were moderately differentiated endometrioid endometrial carcinoma Dd/adenocarcinoma of the cervix. Magnetic resonance imaging (MRI) is performed to determine the origin of the tumor and its stage. MRI score was analyzed for seven distinct features: tumor location and perfusion, peripheral rim, endometrial cavity mass or distension, invasion of the myometrium, and surrounding organs infiltration; score of 10 was obtained in these cases using sagittal T2WI, DWI-ADC, and DCE sequence which concluded that the tumor was cervical origin and had infiltrated the parametrium.Conclusion: MRI score can be considered to see the origin of the tumor (cervical or endometrial) in addition look for involvement of the parametrium and pelvic lymph nodes so that diagnosis and management will be better.Key words: Magnetic Resonance Imaging, Cervical Cancer, Endometrial Cancer, Gynecological Cancer, Parametrial Infiltration
Comparison of Chondroitin Sulfate-E Expression in Benign and Malignant Epithelial Type Ovarian Tumors Mantilidewi, Kemala Isnainiasih; A.W., Gatot Nyarumenteng; Kurniadi, Andi; Suardi, Dodi; Harsono, Ali Budi; Salima, Siti; A, Aditiyono; Hapsari, Kartika; Yantisetiasti, Anglita
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 2 July 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i2.861

Abstract

Objective: Ovarian cancer is the fifth leading cause of cancer-related death in women, due to late diagnosis and limited screening methods. Chondroitin Sulfate-E (CS-E) has shown potential as biomarkers. This study aims to evaluate CS-E expression in epithelial-type benign and malignant ovarian tumors and its potential as a biomarker using QuPath software.Methods: This observational analytic study used a cross-sectional design. Samples were selected based on histopathology of patients with epithelial-type benign and malignant ovarian tumors from surgeries in 2023. Immunohistochemistry using the GD3G7 antibody was performed to detect CS-E expression in tumor tissues preserved in paraffin blocks at Dr. Hasan Sadikin General Hospital Bandung. Expression was quantified using QuPath software. Statistical analysis used the Mann-Whitney and t-test. Result: No significant difference in CS-E expression was found between malignant and benign tumors (p = 0.492). Demographic factors (age, BMI, menopausal status, and parity) showed no significant differences between groups. Conclusion: CS-E expression has not yet demonstrated potential as a biomarker to distinguish between benign and malignant ovarian tumors.Perbandingan Ekspresi Chondroitin Sulfate-E pada Tumor Ovarium Jinak dan Ganas Tipe Epitel Abstrak Tujuan: Kanker ovarium merupakan penyebab kematian kelima terbanyak terkait kanker pada wanita yang disebabkan oleh keterlambatan diagnosis dan keterbatasan metode skrining. Chondroitin Sulfate-E (CS-E) menunjukkan potensi sebagai biomarker. Penelitian ini bertujuan mengevaluasi ekspresi CS-E pada tumor ovarium jinak dan ganas tipe epitelial serta menilai potensinya sebagai biomarker menggunakan perangkat lunak QuPath. Metode: Penelitian analitik observasional ini menggunakan desain potong lintang. Sampel dipilih berdasarkan hasil histopatologi pasien dengan tumor ovarium jinak dan ganas tipe epitelial dari operasi tahun 2023. Pemeriksaan imunohistokimia dengan antibodi GD3G7 dilakukan untuk mendeteksi ekspresi CS-E pada jaringan tumor yang diawetkan dalam blok parafin di RSUP Dr. Hasan Sadikin Bandung. Ekspresi dianalisis secara kuantitatif menggunakan perangkat lunak QuPath. Uji statistik yang digunakan adalah Mann-Whitney dan uji t. Hasil: Tidak ditemukan perbedaan bermakna dalam ekspresi CS-E antara tumor ganas dan jinak (p = 0,492). Faktor demografis (usia, indeks massa tubuh, status menopause, dan paritas) juga tidak menunjukkan perbedaan bermakna antar kelompok.Kesimpulan: Ekspresi CS-E belum menunjukkan potensi sebagai biomarker untuk membedakan antara tumor ovarium jinak dan ganas. Kata kunci: Biomarker, GD3G7, Glikosaminoglikan, Kanker Ovarium, Kondroitin sulfat 
Co-Authors A, Aditiyono A.W., Gatot Nyarumenteng Andi Kurniadi, Andi Andi Rinaldi Anglita Yantisetiasti Benny Hasan Purwara Dewayani, Birgitta Maria Dodi Suardi Erfiandi, Febia Gatot Nyarumenteng Adhipurnawan Winarno Hari Soekersi Kartika Hapsari Kemala Isnainiasih Mantilidewi Kireina, Jessica Kusuma, Aria Yusti Madjid, Tita Husnitawati Masitoh, Imas Megantari, Salsa Bila Mose, Johannes Cornelius Salima, Siti Sunardi Sunardi Wiryawan Permadi Yudi Mulyana Hidayat