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All Journal Idea Nursing Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Cakrawala Pedagogik Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks JIKEM: Jurnal Ilmu Komputer, Ekonomi dan Manajemen Bioscientia Medicina : Journal of Biomedicine and Translational Research Maternity and Neonatal : Jurnal Kebidanan Jurnal Pengabdian Masyarakat dan Riset Pendidikan Prosiding Seminar Nasional Unimus
Mutia Sari
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Deciphering Activity in Early Facial Vitiligo: A Case Report Integrating Clinical, Wood's Lamp, and Dermoscopic Findings Rina Gustia; Mutia Sari; Afifah Alfyanita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1408

Abstract

Background: The management of non-segmental vitiligo hinges on accurately assessing disease activity to guide appropriate therapy. A clinical challenge arises in patients presenting with a low vitiligo area scoring index (VASI), suggesting limited disease, which may be discordant with underlying inflammatory activity, potentially leading to therapeutic inertia. Case presentation: A 34-year-old woman with Fitzpatrick skin type III presented with a two-month history of rapidly progressing facial vitiligo, preceded by an erythematous phase. Despite a low VASI score of 1, the patient-reported vitiligo disease activity (VIDA) score was +4. Dermoscopy was instrumental, revealing definitive in-vivo evidence of inflammation and instability, including a pinkish background, telangiectasias, and a reversed pigment network. Based on this discordance between disease extent and activity, a multi-modal therapeutic regimen was initiated. A six-month follow-up demonstrated disease stabilization and significant perifollicular repigmentation, with resolution of the inflammatory dermoscopic signs. Conclusion: This case report illustrates the critical importance of an integrated diagnostic approach that moves beyond area-based assessment. It highlights how dermoscopy, when used to resolve the clinical paradox of low-extent but high-activity disease, can serve as an objective biomarker to justify timely and robust immunomodulatory intervention. This approach is crucial for altering the disease trajectory and optimizing patient outcomes.
A Multidisciplinary Approach to Managing Multiple Tuberous Xanthomas in a Pediatric Patient with Familial Hypercholesterolemia Type II: A Rare Case Clarissa Maharani Putri; Rina Gustia; Ennesta Asri; Mutia Sari; Indah Indria Sari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 3 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i3.1214

Abstract

Background: Familial hypercholesterolemia (FH) is a rare inherited disorder characterized by high cholesterol levels, primarily high levels of low-density lipoprotein cholesterol (LDL-C). This condition can lead to premature cardiovascular disease. A less recognized but significant manifestation of FH is the development of multiple tuberous xanthomas, which are exogenous masses or fatty deposits on the skin. Case presentation: This report describes the case of a 4-year-old female child who presented to the Dermatology, Venereology, and Aesthetics Department of Dr. M. Djamil General Hospital Padang with multiple yellowish, painless, and non-itchy lumps on her body. These lumps were located on her knuckles, hands, elbows, buttocks, knees, back of knees, ankles, and feet. The lumps had been progressively increasing in size over the past month. Her medical history revealed that she first developed a yellowish lump on her right ankle two years prior, which gradually spread to other areas of her body. A dermoscopic examination showed a yellow-brown structureless area, and laboratory tests confirmed hypercholesterolemia with elevated LDL levels. Her triglycerides were normal, and both of her parents also had hypercholesterolemia. A histopathology examination confirmed the diagnosis of xanthoma. The patient was diagnosed with tuberous xanthomas and treated with simvastatin 1x10 mg, along with surgical excision of the xanthomas and flap reconstruction under general anesthesia. Conclusion: This case highlights the importance of a multidisciplinary approach in managing multiple tuberous xanthomas in a child with FH. While surgical excision can effectively remove the lesions, ongoing lipid-lowering therapy is crucial to prevent recurrence and reduce cardiovascular risks associated with FH. Collaboration among dermatologists, pediatric cardiologists, and pediatric nutritionists is vital to ensure comprehensive care and enhance the patient's overall quality of life.
Early-Onset Urticaria Pigmentosa in a 7-Month-Old Infant: A Case Report Nellia Fonna; Mutia Sari; Rina Gustia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 3 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i3.1218

Abstract

Background: Urticaria pigmentosa (UP) is the most common form of cutaneous mastocytosis in children, accounting for 70-90% of cases. UP typically presents in infancy or early childhood with characteristic skin lesions that vary in appearance. The hallmark of UP is the presence of reddish-brown macules or papules that urticate or blister upon rubbing, a phenomenon known as Darier's sign. Histopathological examination of a skin biopsy is confirmatory, demonstrating an increased number of mast cells in the dermis. Case presentation: We report a case of early-onset UP in a 7-month-old infant boy who presented with multiple hyperpigmented macules all over his body. The lesions were pruritic and had progressively increased in size and number over the past two weeks. Dermatological examination revealed multiple erythematous macules on the face, hyperpigmented macules on the chest, abdomen, and extremities, hyperpigmented plaques on the legs, and a nodule on the back. The lesions exhibited a positive Darier's sign, characterized by swelling and redness upon rubbing. Systemic examination was unremarkable, with no evidence of hepatomegaly, splenomegaly, or lymphadenopathy. Dermoscopy of the lesions revealed a central pigment network and a light brownish peripheral structure, suggestive of UP. Histopathological examination of a skin biopsy confirmed the diagnosis of UP, demonstrating an increased number of mast cells in the dermis. The patient was treated with oral antihistamines (cetirizine) and topical corticosteroids (hydrocortisone) for four weeks, resulting in significant regression of the lesions. Conclusion: This case highlights the importance of recognizing the clinical features of UP in infants. Early diagnosis and appropriate management can help alleviate symptoms and improve the quality of life for affected children.
EFFORTS TO IMPROVE CHILDREN'S EXPRESSIVE LANGUAGE DEVELOPMENT THROUGH ROLE-PLAY ACTIVITIES AT THE AGE OF 4-5 YEARS AT AL-FAUZAN PAUD, TENJOAYU VILLAGE, TANARA DISTRICT, SERANG REGENCY Fatimah, Endang; Novita Sari; Inten Risna; Amat Hidayat; Mutia Sari
Cakrawala Pedagogik Vol 9 No 3 (2025): Cakrawala Pedagogik
Publisher : Sekolah Tinggi Keguruan dan Pendidikan Syekh Manshur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51499/cp.v9i3.794

Abstract

This research is motivated by the limited expressive language skills of most children aged 4–5 years at the Al-Fauzan PAUD, Tenjoayu Village, Tanara, Serang Regency. The purpose of the research is to examine the implementation of role-playing activities in improving the expressive language development of early childhood. The method used is descriptive qualitative with primary and secondary data sources. Data collection techniques include in-depth interviews, observation, and documentation to obtain a comprehensive picture of the research focus. Data analysis of this research refers to the qualitative approach of Miles & Huberman which emphasizes the stages of data reduction, data presentation, and drawing conclusions so that the research results reflect the real social context. The results of the study indicate that role-playing activities make a significant contribution to improving children's expressive language skills. Theoretically, the results of this study are supported by Vygotsky's view of the Zone of Proximal Development (ZPD) which emphasizes the importance of social interaction and the role of teachers in helping children achieve higher language skills. The conclusion of the study shows that role-playing activities at the Al-Fauzan PAUD are implemented through planning, implementation, and evaluation stages with a thematic approach that is appropriate to the characteristics of children aged 4–5 years. This activity effectively improves vocabulary, the use of complete sentences, and children's confidence in speaking
Peran Akademik dalam Pengembangan PAUD: Pendampingan Holistik Integratif oleh Program Studi PIAUD IAIN Lhokseumawe: Pengabdian Fuadi, Noval; Jufri; Mutia Sari
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 4 No. 3 (2026): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 4 Nomor 3 (Januari 202
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v4i3.5312

Abstract

This mentoring program aims to increase the understanding and capacity of educators and early childhood education personnel in North Aceh Regency in implementing the Integrative Holistic Early Childhood Education model, as a form of implementation of the Tri Dharma of Higher Education. The method used is Participatory Action Research with a problem solving and participatory approach, which is carried out through the stages of problem identification, preparation, socialization, implementation, monitoring, and evaluation. The activity involved 15 Early Childhood Education units as samples. The results of the mentoring showed a significant increase in participants' understanding, from 45% to 85%. The implementation of Integrative Holistic services in the assistance unit was achieved with the following percentages: education services 50%, health, nutrition, and care 25%, parenting 15%, protection 5%, and welfare 5%. Participants assessed that mentoring is very useful for optimizing services for children. It is concluded that academic mentoring based on Participatory Action Research is effective in building the ability to practice Early Childhood Education based on Integrative Holistic in the field.
Co-Authors Afifah Alfyanita Amat Hidayat Anum, Qaira Budi Satria Clarissa Maharani Putri Deasy Archika Alvares Ennesta Asri Fatimah, Endang Fitri Novianti Gardenia Akhyar Indah Indria Sari Inten Risna Irdawati Izrul Irma Fitria Jannaton Naim Jufri Maryani Nellia Fonna Noval Fuadi Novita Sari Nurul hayati Rauzatunnur Rina Gustia Rizkia Chairani Asri Satya Wydya Yenny Shelvi Fadillah Harahap Siti Aisyah Tutty Ariani Yola Fadilla Yosse Rizal