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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Majalah Obat Tradisional IJCER (International Journal of Chemistry Education Research) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Pengabdian Magister Pendidikan IPA
Asih Triastuti
Department Of Pharmacy, Universitas Islam Indonesia, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Antiangiogenic Effect Of The Chloroform Extract Of Tinospora crispa (L.) Miers Stem In The Chick Embryo Chorioallantoic Membrane (CAM) Induced By bFGF Asih Triastuti
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 11, ISSUE 2, August 2010
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

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Abstract

Cancer is one of the most complex disease involving molecular process cause it is hard to be cured. There are many natural compounds which have been used empirically in the society in order to treat cancer. One of them is a kind of herbal medicine called ‘Brotowali’ (Tinospora crispa (L.) Miers). The objective of this research was  to know antiangiogenic effect of the chloroform extract of  brotowali stem using CAM method induced by bFGF. In this research, the inhibition test is done by the CAM at 9 day chick embryo divided  into  seven groups of treatment. Group I is  as the paper disc controller, group II as the bFGF controller, group III as  bFGF +  DMSO 0,8% solvent controller, group IV, V, VI and VII, as the group that conduct the angiogenesis inhibition test. The last four group were given 10 ng of bFGF each and the chloroform extract of brotowali stem with the doses of 15 μg/ml, 60 μg/ml, 240 μg/ml and 960 μg/ml. After having been incubated for 3 days (egg at 12 day), CAM were carefully observed  macroscopically and microscopically. The result showed that  the chloroform extract of brotowali stem can  inhibit the angiogenesis in CAM induced by bFGF. It show that the angiogenesis inhibition for the dose of the chloroform extract of  brotowali stem were successively rise  due to the dose increment, with angiogenic potency  31,87±9,01%,  43,12±8,01%, 53,44±2,70% and  62,81±4,74%.   Keywords : cancer, angiogenesis, Tinospora  crispa (L.) Miers, bFGF, CAM
Aktivitas Penghambatan Migrasi Leukosit Ekstrak Diklorometana Daun Sendok (Plantago major) pada Mencit yang Diinduksi Tioglikolat Asih Triastuti
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 19, ISSUE 2, August 2019
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/eksakta.vol19.iss2.art11

Abstract

Plantago major (daun sendok) telah dilaporkan memiliki beberapa aktivitas farmakologi seperti antibakteri, antidiabetes, antioksidan, dan membantu menyembuhkan luka. Tujuan penelitian ini untuk mengetahui aktivitas antiinflamasi ekstrak diklorometana P.major pada model peritonitis yang diinduksi tioglikolat. Ekstrak diklorometana P.major diuji aktivitasnya sebagai antiinflamasi melalui penghambatan migrasi leukosit. Mencit jantan Swiss dibagi menjadi 7 kelompok yaitu kelompok normal (tanpa perlakuan), kontrol negatif (pemberian tioglikolat), kontrol positif (pemberian indometasin), kontrol pelarut (dimetilsulfoksida/DMSO 10%), dan kelompok perlakuan ekstrak P.major dengan dosis 200, 400, dan 600 mg/kgBB. Jumlah leukosit dihitung dengan hemositometer dan dianalisis dengan Kruskal-Wallis dan Mann-Whitney. Hasil menunjukkan bahwa ekstrak dengan dosis 200, 400, dan 600 mg/kgBB mampu menghambat migrasi leukosit pada mencit yang telah diinduksi tioglikolat ditandai dengan penurunan jumlah leukosit secara signifikan (p<0,05) meskipun efektivitasnya lebih rendah dibandingkan dengan indometasin. Kemampuan ekstrak dalam menghambat migrasi leukosit semakin besar seiring dengan peningkatan dosis. Ekstrak diklorometana P. major mengandung asam ursolat yang sebelumnya telah dilaporkan aktif menghambat enzim siklooksigenase 2 (COX-2). Hal ini memperkuat dukungan P. major sebagai agen anti inflamasi dan sangat potential untuk dikembangkan sebagai sediaan farmasi.
PENGARUH TRAGAKAN SEBAGAI PENGIKAT TERHADAP SIFAT FISIK TABLET HISAP EKSTRAK JAHE (Zingiber officinalle Roxb.) Wintari Taurina; Yandi Syukri; Asih Triastuti
Majalah Obat Tradisional Vol 18, No 2 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (661.951 KB) | DOI: 10.22146/tradmedj.7982

Abstract

Ginger (Zingiber Officinale Roxb.) is a traditional plants usually used to relieve pain, rheumatism, and neutralize poison. The aim of this study was to get the optimum concentration of tragacanth as a binding agent in ginger lozenges formulation. The components from ginger were extracted using percolation with ethanol 70% and then evaporated using rotary evaporator. Lozenges were made in three formulas ; formula 1 (5%), 2 (7,5%), 3 (10%) of tragacanth using wet granulation method. Granules and tablets were tested for its physical properties, and analyzed using Pearson correlation. The result showed that, all of three formulas were good, comply with a regulation of physical properties and soluble time in the mouth. Variation of tragacanth concentration affected physical properties of tablets. It showed that the greater concentration of tragacanth, the larger the hardness and the longer the soluble time of tablets. The formula (tragacanth 10% b/v) gave an optimum physical properties and soluble time of tablets, with weight variety deviation 0,98%, hardness 10,18 kg, friability 0.11% and soluble time 11.50 minutes. The three formulas were received by respondens with prerequirement of improving sweetness, repairing form and the color of tablets.
FORMULASI TABLET HISAP EKSTRAK GAMBIR (Uncaria gambir (Hunter) Roxb.) DENGAN VARIASI BAHAN PENGIKAT GOM ARAB (Gummi Acaciae) Lutfi Chabib; Asih Triastuti; Rischi Dwi Irianti
Majalah Obat Tradisional Vol 15, No 2 (2010)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (168.367 KB) | DOI: 10.22146/tradmedj.8073

Abstract

Gambier is one of the medicinal plants commonly used for chewing, which has benefits for oral health and dental. Gambier has a property as a remedy lozenges, stomachache, toothache, and can be used to prevent the formation of dental plaque. This research aims to create a dosage of dried extract in the form of lozenges. In these lozenges we used variations gummi acaciae to obtain a binder concentration that can produce tablets that meet the requirements. Gambier extract was obtained by remaceration, with 80% ethanol. Tablets formulated with a binder concentration gom arabic 10%, 17.5% and 25% using direct compression method. The results showed that the concentration variation can minimize the variation of the gummi acaciae weight uniformity, increased hardness, lower % fragility, and increase the time dissolved lozenges. All of tablets have good physical tablets properties. The third formula is the most acceptable by the respondents in terms of color, taste, and time of dissolution. 
Peningkatan Asuhan Kemandirian Penggunaan Tanaman Obat Pada Kader PKK di Dusun Pucung Kranggan II Berbah Sleman Yogyakarta Arde Toga Nugraha; Asih Triastuti
Jurnal Pengabdian Magister Pendidikan IPA Vol 4 No 3 (2021)
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (264.072 KB) | DOI: 10.29303/jpmpi.v4i3.842

Abstract

This service activity aims to provide independent care for the use of medicinal plants and traditional medicines as a promotional and preventive effort, which is beneficial for the efficiency and effectiveness of families in maintaining the family health. Independent care is built in the form of a cadre of TAMAWA (Tanam-Manfaat-Waspada/Grow-Use-Alert) frameworks of medicinal plants and traditional medicines, the participants of which are PKK in the village of Pucung Kranggan II. The TAMAWA cadres were formed in each neighbourhood association /RT, with four members per RT. The TAMAWA framework was formed and guided by a community service team, in collaboration with the Center for Herbal Medicine Study (PSOH UII) of the Department of Pharmacy, Universitas Islam Indonesia through several activities, including training in traditional medicinal/medicinal plants, training in traditional medicinal recipes, and the built of a family medicinal plant garden (TOGA). The output of this service is the production of a smartbook for TAMAWA cadres containing the types, benefits, usage preparations, drug interactions and side effects of medicinal plants/traditional medicines and the built of  TOGA gardens in each RT in the village. Other outputs have also been produced, such as information media in the form of videos and brochures. It is hoped that this service program will increase public knowledge of medicinal plants/traditional medicines. Also, it is hoped that the community will be more independent and empowered to manage daily health
Phyllanthus niruri (Meniran) Sebagai Imunomodulator: Mekanisme aksi dan senyawa bioaktif Uzulul Hikmah; Asih Triastuti
Jurnal Ilmiah Farmasi Vol. 18 No. 2 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss2.art19

Abstract

Background: Phyllanthus niruri (meniran) is a medicinal plant with antimicrobial, antioxidant, anticancer, anti-inflammatory, antiplasmodial, antiviral, hepatoprotective diuretic, and immunomodulator properties. Objective: This review examined the activity, mode of action, and active compounds of P. niruri as an immunomodulator in various preclinical and clinical studies, along with the bioactive compounds and their mechanism. Results: Flavonoids, lignans, terpenoids, and alkaloids, among other phytochemicals found in P. niruri, play an essential part in the pharmacological activity of the plant. The immunomodulation activity of P. niruri has been extensively researched in preclinical (in silico, in vitro, and in vivo) and clinical trials. A study in silico revealed the potential of P. niruri as an immunomodulator in Covid-19 infection by inhibiting the COVID-19 target receptors spike glycoprotein (6LZG) and major protease (5R7Y and Mpro). In addition, P. niruri boosted macrophage phagocytic activity, increased antibody total, and reduced inflammation in vitro and in vivo experiments. P. niruri also showed immunomodulatory effects in both healthy subjects and patients.  Conclusion: P. niruri exhibits pharmacological potential as an immunomodulator in preclinical and clinical trials, according to the findings of various investigations. Keywords: Phyllanthus niruri, immunomodulator, immunostimulant Intisari  Latar belakang: Phyllanthus niruri merupakan tanaman obat yang memiliki beberapa aktivitas farmakologi seperti antimikroba, antioksidan, antikanker, antiinflamasi, antiplasmodium, antivirus, diuretik, hepatoprotektif, dan sebagai imunomodulator.  Tujuan: Melakukan tinjauan analisis mengenai aktivitas, mekanisme, dan senyawa aktif P. niruri sebagai imunomodulator pada uji preklinis maupun uji klinis. Hasil: Kandungan kimia P. niruri seperti flavonoid, lignan, terpenoid, dan alkaloid berperan penting pada aktivitas farmakologi P. niruri sebagai imunomodulator.  Uji in silico menunjukkan potensi P. niruri sebagai imunomodulator pada infeksi Covid-19 dengan berikatan pada protein spike dan protease yang bertanggungjawab pada replikasi dan pematangan virus. Uji in vitro dan in vivo menunjukkan bahwa P. niruri mampu meningkatkan aktivitas fagositosis dari makrofag, meningkatkan antibodi serum total, dan mengurangi inflamasi. Pengujian klinis membuktikan bahwa P. niruri memiliki aktivitas imunomodulator baik pada subjek uji sehat maupun pada pasien.  Kesimpulan: P. niruri memiliki aktivitas sebagai imunomodulator baik pada pengujian preklinis maupun klinis.  Kata kunci : P. niruri, imunomodulator, imunostimulan
Metabolomic and Cytotoxicity Profiles of Ethanol Extract of Peronema canescens Jack on Human Non-small Lung Cancer Cell A549 Anjayani, Nuri; Amalia, Senya Putri; Sukmarini, Linda; Tamhid, Hady Anshory; Primahana, Gian; Triastuti, Asih
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 1 (2025): J Sains Farm Klin 12(1), April 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.1.7-14.2025

Abstract

Cancer has a high prevalence and mortality in the world. Cancer treatment is still hampered by high levels of side effects, drug resistance and the lack of affordable prices for anticancer drugs. It is necessary to develop new anticancer drugs to help overcome this problem. One of the plants that has the potential to be developed as an anticancer drug is Sungkai (Peronema canescens Jack). This study aims to determine the cytotoxic activity of sungkai leaf and identify its metabolomic profile. The sungkai leaves were macerated for 24 hours with 96% ethanol. Metabolomic profiles were analyzed with Ultra High-Performance Liquid Chromatography-High Resolution Mass Spectrometry (UHPLC-HRMS). Chemical structure identification was performed by MS-DIAL and MS-FINDER platforms. The ethanol extract of sungkai leaves was analyzed for its cytotoxic activity using the MTT test on A549 lung cancer cells and its selectivity on normal HDFa fibroblast cells. The ethanol extract of sungkai showed IC50 105,21 µg/mL on A549 cells and no cytotoxic activity against normal HDFa cells. Based on the metabolomic analysis, 7 furano terpenoid compounds were detected in the ethanol extract, namely peronemin A2; A3; B1; B2; B3: C1; and D1 along with other compounds. In conclusion, the ethanol extract of P. canescens leaves has cytotoxic and selective activity against A549 lung cancer cells, and potential to be further developed as an anticancer drug candidate. Peronemins and other substances like flavonoids and polyphenols may be linked to the cytotoxic properties of sungkai leaves
EFEK ANTI PROLIFERATIF EKSTRAK ETANOL KULIT BATANG TANAMAN CANGKRING (Erythrina fusca Lour) TERHADAP SEL MYELOMA Meiyanto, Edy; Sismindari, Sismindari; Triastuti, Asih
Jurnal Ilmiah Farmasi Vol. 1 No. 1 (2004)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTErythrina fusca Lour has been traditionally used to cure hepatosis, malaria, hematuria, andcancer. The bark of this plant contains  carotene, polifenol, thiamin, saponin, and alkaloiderythralin and erythramin. The aim of this research was to know the underlying mechanism of itseffect as antiproliferative against Myeloma cells. The bark powder was extracted using ethanol(70%) and was used for the experiment after freezed drying. Citotoxicity test of this extractperformed LC50 of 0,367 mg/ml. The rate of proliferation was observed by doubling time effectagainst proliferating cells. The cells were exposed with ethanolic extract in RPMI 1640 mediumcontaining 1) 0,25 mg/ml 2) 6,25x10-2mg/ml, and 3) 1,56x10-2mg/ml and every 0, 6, 12, 24, 48,and 72 hours cell were counted. The result showed that extract treated cells delayed proliferation atall concentration with doubling time dose 2) of 161, 38 hours, and dose 3) of 93,91 hours, whereasdoubling time of control cells were 69,86 hours. Ethidium bromide staining of extract treated cellsshowed apoptosis like profile. These results indicated that ethanolic extract of the bark of Erythrinafusca Lour has an antiproliverative effect on Myeloma cell line. Several mechanisms might accountfor this effect, like inhibiting cell cycle progression, signal transduction, causing delayed andapoptosisKeywords: Erythrina fusca Lour, atiproliferative, Myeloma
Improving Students’ Knowledge and Engagement in Immunology Course Using Video-Based Learning and Concept Mapping in Modified E-tivities Triastuti, Asih; Pramundita Ramadani, Arba
IJCER (International Journal of Chemistry Education Research) VOLUME 8, ISSUE 1, APRIL 2024
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/ijcer.vol8.iss1.art3

Abstract

E-tivities were implemented in the online class of Immunology at the Department of Pharmacy UII using video-based learning (VBL) and concept mapping exercises to enhance student motivation and knowledge. The class measurement method was used by comparing the previous academic year's lecture evaluation and outcomes (the 2021 semester without video and concept mapping) and the 2022 semester (with E-tivities using VBL and concept mapping). According to the evaluation results, the combination of learning methods with learning video and concept mapping increased the student's interest and enthusiasm for learning. Furthermore, the student's mastery of the material increased from 8% to 41%, resulting in an increase in the student's final grade. The combination of video-based learning and concept mapping increased student motivation and knowledge
Co-Authors Amalia, Senya Putri Anjayani, Nuri Arde Toga Nugraha Edy Meiyanto Jong Won Choi LINDA SUKMARINI Lolyta Fournia Sari Lutfi Chabib, Lutfi Melinda Dewi M Pramundita Ramadani, Arba Primahana, Gian Rischi Dwi Irianti Rischi Dwi Irianti, Rischi Dwi Riyanto Sismindari . Sri harnanik Sri harnanik Sri Mulyaningsih Sri Mulyaningsih Suparmi Suparmi Tamhid, Hady Anshory Uzulul Hikmah Wintari Taurina Yandi Syukri Yon Haryanto