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All Journal Jurnal Kedokteran Brawijaya Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan
Muhamad Ayus Astoni
Bagian Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Gadjahmada Yogyakarta
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Jurnal Kedokteran Brawijaya

 1 
HIPERHOMOSISTEINEMIA SEBAGAI RISIKO PENYAKIT JANTUNG KORONER Astoni, Muhamad Ayus; Irawan, Bambang
Jurnal Kedokteran Brawijaya Vol 21, No 3 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (150.441 KB) | DOI: 10.21776/ub.jkb.2005.021.03.1

Abstract

The elevation of total plasma homocysteine is associated with increase of risk for cardiovascular disease, cerebrovascular disease, and atherothrombosis in peripheral arteries. Several prospective and retrospective studies had conformed the positive association between hyperhomocysteinemia and risk for cardiovascular disease. However, it whether hyperhomocysteinemia is an independent riskfactor for cardiovascular disease associated with  the others risk factors still become a question. The aim of this study was to identify the association between hyperhomocysteinemia and increased risk for cardiovascular disease. A matched case-control study based on 50 consecutive adult  patients aged more than 18 years old who admitted in Dr. SardjitoGeneral Hospital by first acute coronary syndrome.Fifty comparison control subjects were randomly selected age and gender group-matched patients admitted caused by conditions other than cardiovascular disease to the same hospital. Each case was enrolled, and comparison subject was randomly selected. Fasting blood samples for homocysteine were obtained from both groups. Chi square test, McNemar chi square test, and independent t test had been used in univariate analysis. Confounding factors had been analysed using
Co-Authors A.A. Ketut Agung Cahyawan W Fuad Bakry Gita Dwi Prasasty Mitayani Purwoko, Mitayani Muhammad Irsan Saleh Rasyid, Riana Sari Puspita Suprianto, Imam Syadra Bardiman Zuhdi, Kgs. Muhammad