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PENGARUH KONSENTRASI XANTHAN GUM TERHADAP STABILITAS FISIK KRIM VIRGIN COCONUT OIL (VCO) Beti Pudyastuti; Marchaban Marchaban; Rina Kuswahyuning
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 12, No 1 (2015)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (441.245 KB) | DOI: 10.24071/jpsc.00108

Abstract

Abstract: Virgin Coconut Oil (VCO) is a pure oils that is extracted from fresh coconut meat at low temperatures. The formulation of VCO in cream dosage form could retain skin moisture and improve the acceptability. Xanthan gum is one of the emulsifier that used to form oil in water (O/W) cream. The purpose of this research were to determine the effect of xanthan gum concentration to the physical stability of VCO cream. VCO creams were prepared by emulsifying the oil phase and the water phase with the variation of xanthan gum concentration (2.5; 2.7; 2.9; 3.1; 3.3% w/w). Observation of the physical stability of the cream includes organoleptic, emulsion type, droplets size, viscosity, spreadability, adhesion, and ratio of separation volume was conducted until 7th week, and also the freeze-thaw test for three cycles. The results showed that each formulation could produces homogeneous light brown cream with oil in water type. Increasing of xanthan gum concentration would increases viscosity of the cream so that spreadability decreases and adhesion increases during stability study. Ratio of separation volume increased after three cycles of freeze-thaw test. Cream with 3.3% w/w xanthan gum had the optimum physical stability.Keywords : VCO, O/W cream, xanthan gum, physical stability
FORMULASI MATRIKS TRANSDERMAL PENTAGAMAVUNON-0 DENGAN KOMBINASI POLIMER PVP K30 DAN HIDROKSIPROPIL METILSELULOSA Beti Pudyastuti; Akhmad Kharis Nugroho; Sudibyo Martono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (315.292 KB) | DOI: 10.24071/jpsc.0099

Abstract

Abstract: Transdermal delivery system is one of the delivery system for Pentagamavunon-0 (PGV-0) toavoid the high intensity of first pass metabolism of PGV-0 in peroral route. The purpose of this researchwas to optimize the formula of PGV-0 transdermal matrix with a combination of PVP K30 and HPMCpolymers.The simplex lattice optimization approach of the transdermal matrix formulas was performed byusing Design Expert 7.1.5 software. The visual appearance, weight, thickness, moisture content, moistureuptake, folding endurance, drug content, and dissolution efficiency of the release profil of PGV-0 from thematrix for 6 hours were evaluated as responses to determine optimum formula of matrix. The resultshowed that a combination of PVP K30 and HPMC polymers had a significant influence on the visualappearance, moisture content, and dissolution efficiency of PGV-0. Combination of 1.98% of PVP K30and 4.52% of HPMC as the optimum formula could produce homogeneous and flexible matrix withmoisture content of 3.21%. The dissolution efficiency was 9.11%, indicating that 101.93 g of PGV-0 wasreleased from the optimum formula during 6 hours.Keywords : Pentagamavunon-0, Transdermal matrix, PVP K30, HPMC
Deteksi Dini Hipertensi dengan Pemeriksaan Tekanan Darah pada Masyarakat Desa X, Kabupaten Banyumas: Early Detection of Hypertension by Checking Blood Pressure in The Community Of Village X, Banyumas Regency Parmasari, Damairia Hayu; Suryanto; Beti Pudyastuti; Dewi Latifatul Ilma
Jurnal Pengabdian Kepada Masyarakat: Kesehatan Vol. 4 No. 3 (2024): September
Publisher : Sekolah Tinggi Ilmu Kesehatan Notokusumo Yogyakarta

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Abstract

Abstrak: Kesehatan merupakan faktor penting untuk meningkatkan derajat kualitas hidup masyarakat. Jumlah penderita penyakit tidak menular tertinggi di Banyumas yaitu hipertensi sebanyak 173.434 orang. Faktor risiko hipertensi adalah stres, aktivitas fisik yang kurang, konsumsi makanan tidak sehat, obesitas, serta umur yang ditandai gejala klinis yaitu tekanan darah yang tidak normal (>120/80 mmHg). Deteksi dini melalui pengukuran tekanan darah secara rutin menjadi upaya preventif pengelolaan risiko hipertensi. Masyarakat Desa X, Kabupaten Banyumas memiliki kasus yang sama, dimana tahun 2022 hipertensi merupakan penyakit dengan prevalensi tertinggi. Hal ini berbahaya jika tidak ditangani karena akan banyak yang menderita hipertensi sehingga tidak produktif bekerja. Tujuan: Mencegah hipertensi dan meminimalisasi tingkat keparahan hipertensi pada Masyarakat Desa X, Kabupaten Banyumas. Metode: Deteksi dini hipertensi melalui pemeriksaan tekanan darah dengan spigmomanometer. Hasil: Berdasarkan hasil pengukuran tekanan darah pada Masyarakat Desa X, Kabupaten Banyumas kepada 25 orang diperoleh hasil rata-rata tekanan sistole dan diastole masing-masing adalah 146 mmHg dan 83,2 mmHg.Ini menunjukkan bahwa tekanan darah di Masyarakat Desa X masih di atas normal (hipertensi). Kesimpulan: Deteksi dini hipertensi melalui pengukuran tekanan darah dan edukasi faktor risiko hipertensi pada Masyarakat Desa X merupakan langkah preventif untuk mencegah hipertensi dan meminimalisasi tingkat keparahan hipertensi Masyarakat Desa X, Kabupaten Banyumas.   Abstract: Health is an important factor in improving people's quality of life. The highest number of non-communicable disease sufferers in Banyumas, namely hypertension, was 173,434 people. Risk factors for hypertension are stress, lack of physical activity, consumption of unhealthy food, obesity, and age which is characterized by clinical symptoms, namely abnormal blood pressure (>120/80 mmHg). Early detection through routine blood pressure measurement is a preventive measure for managing the risk of hypertension. The people of Village X, Banyumas Regency have the same case, where in 2022 hypertension will be the disease with the highest prevalence. This is dangerous if not treated because many people will suffer from hypertension and will not be productive at work. Objective: Prevent hypertension and minimize the severity of hypertension in the Village X Community, Banyumas Regency. Method: Early detection of hypertension through checking blood pressure with a sphygmomanometer. Results: Based on the results of measuring blood pressure in Village Community normal (hypertension). Conclusion: Early detection of hypertension through measuring blood pressure and education on hypertension risk factors in Village X Community is a preventive measure to prevent hypertension and minimize the severity of hypertension in Village X Community, Banyumas Regency.