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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Indonesian Journal of Chemistry Jurnal Pengabdian Kesehatan Jurnal Farmasi dan Sains Indonesia (JFSI) Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat
Rini Dwiastuti
Faculty Of Pharmacy, Universitas Sanata Dharma
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Optimization and Physical Characterization of Kojic Acid Nanoemulsion Formula As A Whitening Agent Yovi Guanse; Rini Dwiastuti; Brigita Tuelvin Jenita Gandi; Lutfi Chabib
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009968

Abstract

Kojic acid (KA) as a topical formulation prevents hyperpigmentation through the inhibition of tyrosinase activity. However, KA has higher solubility in nonpolar solvents. Nanoparticle technology can be a novel innovation to enhance KA absorption into the skin. This study aims to improve the delivery of topically applied KA by enhancing absorption into the stratum corneum by optimizing the concentration of surfactant Tween 80 and co-surfactant Span 80. The nanoemulsion uses KA as an active ingredient and virgin coconut oil as the oil phase. The optimum area was analyzed using Design-Expert® 13 software, with a pure experimental design based on a 2x2 factorial design. The results indicate that all formulas are within the optimal region. Therefore, the determination of the optimal point can be grounded on the smallest composition within the optimal region with the objective of maximizing material efficiency, which is a formula with a concentration of Tween 80 and Span 80 of 10 grams and 3 grams, respectively. The particles are a spherical smooth shape and demonstrate an efficacy of 94.117% in inhibiting tyrosinase activity.
Antimicrobial Activity Test of Silver Nanoparticle Gel from Green Synthesis using Kelor Leaf (Moringa oleifera) as a Bioreductant Against Cutibacterium acne Afrianse Pabuang; Rini Dwiastuti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008272

Abstract

Moringa oleifera leaves contain flavonoid compounds that have the potential to act as bioreducers in the synthesis of silver nanoparticles. The antibacterial activity of silver nanoparticles can reduce topical antibiotic resistance, especially against acne-causing bacteria. This study aims to determine the antimicrobial activity of silver nanoparticles formulated in a gel form at concentrations F1 10%, F2 20%, and F3 30%, using Medi-Klin Gel® as a positive control. Testing was conducted on Nutrient Agar medium using the paper disk method with Cutibacterium acne bacteria, incubated for 24 hours at 37°C. Additionally, physical evaluations of the gel, including organoleptic properties, spreading ability, and pH, were performed. The results of the physical properties of the gel were analyzed using one-way ANOVA. Organoleptic evaluation results indicated that F1 had a more transparent gel color, while F2 and F3 had darker gel colors, and all three gels had a characteristic extract aroma. Physical evaluation results for spreading ability (5.5±0.25; 5.7±0.12; 6.27±0.08) and pH values (4.42±0.17; 5.35±0.15; 5.27±0.17) were obtained. Antimicrobial research results showed inhibition zones for F1 10% (7.53±0.20), F2 20% (9.43±0.32), F3 30% (11.16±0.12), and the positive control Medi-Klin Gel® (25.15±0.26). Based on this study, concentration differences influenced the physical evaluation results of the gel formulation. Our finding suggests that the formula with the highest concentration (30%) has physical properties reaching the requirements and exhibited the highest inhibitory effect and potential as an antibacterial agent for acne.
PENGARUH KUALITAS PELAYANAN TERHADAP LOYALITAS PASIEN RAWAT JALAN RUMAH SAKIT LUDIRA HUSADA TAMA YOGYAKARTA: - Y.B. Arya Primantana; Rini Dwiastuti
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p92-99

Abstract

This study analyzes the effect of service quality on outpatient loyalty through patient satisfaction at RS Ludira Husada Tama Yogyakarta. Using purposive sampling, 150 outpatients completed SERVQUAL-based questionnaires analyzed with SEM-PLS. Results showed that tangible (p=0.017) and assurance (p=0.002) dimensions significantly influenced patient satisfaction, while reliability (p=0.554), responsiveness (p=0.646), and empathy (p=0.902) did not. Patient satisfaction significantly influenced loyalty (p=0.001). The findings indicate that physical facilities and service assurance are critical factors in building patient loyalty through satisfaction in outpatient settings.. Keywords: service quality, patient satisfaction, patient loyalty, outpatient, SERVQUAL
Pendampingan Penurunan Stunting Area Puskesmas II Wonosari Gunung Kidul Dina Christin Ayuning Putri; Rini Dwiastuti; Florentinus Dika Octa Riswanto; Valentina Putri Embun Kinanti; Carolina Tiara; Hana Padmadiayu; Angelina Meissy; Resita Widya Bintari; Rimatul Jihan
Jurnal Pengabdian Kesehatan Vol 8, No 2 (2025): Jurnal Pengabdian Kesehatan
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM) STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/jpk.v8i2.463

Abstract

Angka stunting di Kabupaten Gunungkidul adalah yang tertinggi di wilayah Daerah Istimewa Yogyakarta. Banyak faktor mempengaruhi kejadian stunting, salah satunya adalah tingkat pengetahuan orang tua dan juga anak-anak. Dalam upaya penurunan angka stunting di Gunungkidul, diperlukan edukasi bagi orang tua dan anak-anak tentang stunting dan bagaimana cara mengatasinya. Kegiatan ini bertujuan untuk meningkatkan pengetahuan orang tua tentang stunting dan cara mengatasinya, serta mengenalkan makanan sehat bagi anak-anak. Kegiatan dilakukan dengan edukasi dalam bentuk penyuluhan-evaluasi-refleksi bagi orang tua. Materi bagi orang tua meliputi tinjauan medis stunting dan tatalaksana stunting. Edukasi makanan sehat bergizi bagi anak-anak disampaikan melalui video dan permainan. Evaluasi kegiatan dilakukan dengan proses refleksi yang menunjukkan bahwa orangtua yang mengikuti kegiatan ini memiliki peningkatan pengetahuan. Hal ini diperkuat dengan nilai postest peserta dengan rerata 88,75. Edukasi pada anak-anak juga berjalan baik, ditunjukkan dengan ketepatan anak-anak dalam menjawab dan menyebutkan makanan-makanan sehat tinggi gizi dalam aktivitas yang dilakukan.
Co-Authors Afrianse Pabuang Agatha Budi Susiana Lestari Akhmad Kharis Nugroho Angelina Meissy Bianca Levie Tania Brigita Tuelvin Jenita Gandi Carolina Tiara Christofori Maria Ratna Rini Nastiti Desi Amroni Kasanah Dewi Setyaningsih Dina Christin Ayuning Putri Dina Christin Ayuning Putri Elsa Irnandari Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Felicia Satya Christania Florentinus Dika Octa Riswanto Hana Padmadiayu Ignasius Adi Kurniawan Lutfi Chabib, Lutfi Marchaban Marchaban Marchaban Marchaban Marchaban Marchaban Marchaban Marchaban Maywan Hariono Michael Raharja Gani Muhammad Radifar Resita Widya Bintari Rimatul Jihan Sri Hartati Yuliani Sri Noegrohati Sri Noegrohati Valentina Putri Embun Kinanti Y.B. Arya Primantana Yovi Guanse