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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Riset Kesehatan Jurnal Farmasi Sains dan Komunitas

Damiana Sapta Candrasari

Faculty Of Pharmcy, Universitas Sanata Dharma,

Author-ID : 2386800

Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Articles

PREVENTION EFFECTS OF METHANOLIC EXTRACT OF Eurycoma longifolia ROOTS ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICY IN RATS Phebe Hendra; Eustachia Diajeng Wandansari; Elni Meilianti; Bella Anggelina; Damiana Sapta Candrasari; Fenty Fenty
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 1 (2019)
Publisher : Sanata Dharma University

The objective of this study was to investigate preventive effects of methanolic extract of Eurycoma longifolia roots (MEEL) against carbon tetrachloride-induced hepatotoxicity in rats. A total of 25 rats were randomly divided into five groups (n=5). Group I was treated with Sodium CMC 1% w/v (peroral, 6 days), and group II was treated with single dose of CCl4 in olive oil (1:1) 2 mL/kg (intraperitoneal injection). Groups III-V received 75, 150, and 300 mg/kg BW of MEEL (peroral, 6 days), respectively, and administration of CCl4 in olive oil (1:1) 2 mL/kg (intraperitoneal injection) on the seventh day. The hepatoprotective potential was estimated by measuring serum activity of biochemical parameters. Further, liver weight ratio and histopathological changes were determined. The serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) were significantly (p0.05) increased and albumin decreased significantly (p0.05) in the CCl4 treated group, but treatment with MEEL 75 mg/kg significantly (p0.05) prevented the elevation of ALT, AST, and LDH. Histopathological changes also indicated hepatic protection of the MEEL at 75 mg/kg. This finding suggested that methanolic extract of Eurycoma longifolia roots at 75 mg/kg was enough to give a protective effect against CCl4-induced hepatotoxicity

KAJIAN MOLEKULER RESISTENSI Candida albicans TERHADAP ANTIFUNGI Damiana Sapta Candrasari
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Abstract: Candida albicans is one of the species Candida which mostly cause infection inhuman. Antifungal agent azole, polyene, echinocandin, and flucytosine are commonly used forCandida albicans infection treatment. The increasing using antifungal agent will causeantifungal resistance. Most of this resistance happen through gene mutation. This mutationmay influence efflux pumps, interaction of the drug and the target enzyme, the component offungal structure biosynthesis, and conformation of compound in fungal cell.Keywords: Candida albicans, antifungal agent, resistance, gene mutation

THE EFFECT OF PASAK BUMI ROOTS TOWARDS BLOOD GLUCOSE LEVEL IN GLUCOSE-LOADED MICE Fransisca Fransisca; Gracia Easter Kalangi; Damiana Sapta Candrasari; Phebe Hendra
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 15, No 1 (2018)
Publisher : Sanata Dharma University

The aim of this research is to evaluate the effect of pasak bumi roots (Eurycoma longifolia Jack) towards the blood glucose level in glucose-loaded mice. The blood glucose-lowering effects were tested using Oral Glucose Tolerance Test (OGTT) method. The mice were given with infusion of pasak bumi roots at the doses of 0.83; 1.67; 3.33 g/kgBW and methanol extract of pasak bumi roots at the doses of 102; 210; 420 mg/kgBW. All treatments were conducted orally, 30 minutes before the administration of glucose (2 g/kgBW). The blood glucose levels were measured at 0 minute before the administration of glucose and at 15, 30, 60, 90, and 120 minutes after the administration of glucose. Blood samples were obtained through the mice tails vena lateralis using glucometer. The blood glucose levels result which were obtained at the 0 until 120 minutes were calculated to obtain AUC. AUV values of each treatment group were analyzed statistically. Based on the results of the research, it can be concluded that the methanol extract of pasak bumi roots has blood glucose-lowering effect at the doses of 210 and 420 mg/kgBW, but infusion of pasak bumi roots does not have effects on lowering the blood glucose level in the glucose-loaded mice.

PERCEPTIONS OF TRADITIONAL MEDICINES FOR SELF-MEDICATION AMONG PEOPLE IN DIENG PLATEAU CENTRAL JAVA PROVINCE, INDONESIA Aris Widayati; Damiana Sapta Candrasari; Lusia Jois Mariana; Veronica Veronica
Jurnal Riset Kesehatan Vol 10, No 2 (2021): NOVEMBER 2021
Publisher : Poltekkes Kemenkes Semarang

Traditional medicines are commonly used in the community. One type of traditional medicines that is popular among people is "jamu". "Jamu" can be made from plants, animals, minerals, or a mixture of them that has been used for generations based on empiric experience. This study aimed to describe perceptions of the use of traditional medicines for self-medication among people in Dieng Plateau, Kejajar, Wonosobo, Central Java Province. This is a descriptive study with a qualitative approach. Respondents were adults more than 18 years old who had experience in using traditional medicines and were selected with non-random accidental sampling. Thirty-one (31) respondents signed informed consent. Data were collected using an interview guideline and analyzed using enumerative approach. Most of the respondents used traditional medicines for self-medication one to five times a month. They expressed that traditional medicine is like "Jamu", primarily liquid, with limited or no side effects. Traditional medicine was mostly obtained from local groceries at affordable prices. Most of the respondents have a positive attitude towards the use of traditional medicines. They have the willingness to use traditional medicines to deal with their symptoms or minor illnesses. Their satisfaction experience in using traditional medicine will motivate them to do so in the future. Based on the results, it can be said that traditional medicines have an important role in the health care system particularly for self-medication.

The effect of a-terpineol on cell cycle, apoptosis and Bcl-2 family protein expression of breast cancer cell line MCF-7 Damiana Sapta Candrasari; Sofia Mubarika; Mae Sri Hartati Wahyuningsih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 47, No 2 (2015)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

ABSTRACT The cytotoxic activity of a-terpineol on T47D and HeLa cancer cell lines have been reported. This study was conducted to evaluate the effect of a-terpineol on cell cycle, apoptosis and Bcl-2 as well as Bax expression on MCF-7 cell line. The cytotoxic activity of a-terpineol was determined using MTT cell assay. Cell cycle and apoptosis were analysed using flowcytometry, whereas Bcl-2 and Bax expression were evaluated using immunohistochemistry. The results showed that a-terpineol had cytotoxic effect on the MCF-7 cell lines with an IC50 value of 33.0 ± 5.4 μg/mL. a-Terpineol induced cell accumulation in Sub-G1 lead to apoptosis of the MCF-7 cell. Moreover, a-terpineol inhibited Bcl-2 and induced Bax expressions. In conclusion, a-terpineol has potential anticancer activity against MCF-7 cancer cell line trough through cells cycle inhibition and apoptosis stimulation.

Co-Authors Bella Anggelina Elni Meilianti Fenty Fenty Fransisca Fransisca Gracia Easter Kalangi Lusia Jois Mariana Mae Sri Hartati Wahyuningsih Phebe Hendra Phebe Hendra Sofia Mubarika Haryana VERONICA VERONICA Wandansari, Eustachia Diajeng Widayati, Aris

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