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All Journal ODONTO Dental Journal Interdental Jurnal Kedokteran Gigi (IJKG) Odonto dental journal
Boy Muchlis Bachtiar
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Public Health

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Journal : ODONTO Dental Journal

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The Role of IL-6 and IGF-1 in Periodontitis Bone Destruction Ikrima, Abidah; Gunawan, Erwin; Rohmah, Devi Kartika; Bachtiar, Boy Muchlis; Bachtiar, Endang Winiati
Odonto : Dental Journal Vol 12, No 1 (2025): April 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.1.127-135

Abstract

Periodontitis is an inflammatory condition affecting the tissues supporting the teeth, destroying the periodontal ligament and alveolar bone. This condition is initiated by periodontal pathogens, which trigger an immune response resulting in tissue damage. Pro-inflammatory cytokines, particularly IL-6, have an important role in this process. IL-6, produced by various cells, including immune and periodontal ligament cells, enhances osteoclastogenesis by enhancing RANKL expression, thereby promoting bone resorption. Conversely, IGF-1, a hormone like insulin, is critical in bone homeostasis and regeneration. IGF-1, synthesised in the liver and locally in tissues, aids in the proliferation and differentiation of osteoblasts and osteoclasts, facilitating bone remodelling. IGF-1 also interacts with IL-6 to modulate inflammatory responses and osteoclast activity. Understanding the interplay between IL-6 and IGF-1 offers insights into the mechanism of bone resorption in periodontitis and identifies potential therapeutic targets. This study aims to elucidate the roles of IL-6 and IGF-1 in periodontitis-induced bone resorption and explore their therapeutic implications for periodontal health. 
The Potency of miRNA 221-3p as a Molecular Biomarker Of Temporomandibular Disoder: Narrative Review Rintoko, Bimo; Tanti, Ira; Bachtiar, Endang Winiati; Bachtiar, Boy Muchlis; Prihastari, Lisa
Odonto : Dental Journal Vol 12, No 3 (2025): December 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.3.241-250

Abstract

United States. The trigeminal nerve might be the source of orof facial pain. Pain can be difficult to diagnose and treat due to the variability of pain complaints. miRNA 221-3p could be a potential biomarker for pain. Genetic polymorphisms and genetic mutations can lead to changes in the activity of inflammatory mediators, sex hormones, matrix-degrading enzymes, and the immune system, which affect bone remodeling homeostasis in the temporomandibular joint.Method: Scientific databases PubMed, Scopus, and Google Scholar were searched for articles published between 2013 and 2023 in order to conduct the study. 168 carefully selected publications providing information on possible biomarkers, particularly miRNA 221-3p, were included in the review of the literatureResult: Genetic polymorphisms and genetic mutations can lead to changes in the activity of inflammatory mediators, sex hormones, matrix-degrading enzymes, and the immune system, which affect bone remodeling homeostasis in the temporomandibular joint. In addition, activity changes were also observed in neurotransmitters and pain receptors, which resulted in relatively high pain sensitivity. Thus, this condition also increases susceptibility to TMD. Genetic analysis and biomarkers of temporomandibular disorders may improve sensitivity and specificity measures in diagnosing and treating patients with TMDConclusion: As a multifactorial disease, genetic factors are risk factors for TMD. Genetic polymorphisms and genetic mutations can lead to changes in the activity of inflammatory mediators, sex hormones, matrix-degrading enzymes, and the immune system, which affect bone remodeling homeostasis in the TMD
Co-Authors Endang Winiati Bachtiar Erwin Gunawan Ikrima, Abidah Ira Tanti Lisa Prihastari, Lisa Lukman Hakim Makmun Natalina , Ratna Ramadhani Refyan, Sarah Athiyyahmaulidya Rintoko, Bimo Robert Lesang Rohmah, Devi Kartika Wahyu Sulistiadi Yulianti Kemal