Bagaswoto Poedjomartono Bagaswoto Poedjomartono
Department Of Radiology, Radionuclear Services, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia; Dr. Sardjito General Hospital, Jalan Kesehatan No. 1, Yogyakarta 55281, Indonesia

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Overview of Boron Neutron Capture Therapy: a Medical Aspect Alan Anderson Bangun; Bagaswoto Poedjomartono
ASEAN Journal on Science and Technology for Development Vol. 35 No. 3 (2018): Developments in Nuclear Techniques in the Treatment of Cancer
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1010.558 KB) | DOI: 10.29037/ajstd.512

Abstract

Cancer is an abnormal growth of a cell due to the cell’s inability to control and maintain its proliferation, differentiation and apoptosis cycle. There are several methods to treat cancer; one of which is boron neutron capture therapy (BNCT). BNCT is a radiation modality by which a high radiation dose is delivered to tumor cells with lower damage to surrounding normal tissue. This modality has been used widely as a treatment for several cancer cases, such as head and neck cancer, breast cancer, and liver cancer. BNCT uses sodium borocaptate (BSH) or boronophenylalanine (BPA) as the delivery agent. Then, the tumor cell is irradiated by thermal radiation. This technique has excellent potential to become a main method of cancer therapy in the future, since it is noninvasive and has fewer side effects than other methods. Further studies on BNCT are needed to improve its performance as a cancer treatment modality.
Transcatheter Arterial Chemo Infusion/TACI for Breast Cancer Treatment: A Case Series Bagaswoto Poedjomartono; Alan Anderson Bangun; Rifki Bachtiar
Indonesian Journal of Cancer Vol 16, No 2 (2022): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (958.568 KB) | DOI: 10.33371/ijoc.v16i2.874

Abstract

Introduction:  Locally advanced breast cancer (LABC) is a large breast tumor with infiltration to surrounding muscle, skin, and lymph nodes, and sometimes followed by inflammatory breast cancer, a rapidly growing cancer that shows a swollen red lump on the skin. Transcatheter intraarterial chemo infusion (TACI) is considered a palliative therapy for inoperable cancer. This case report shows the qualitative results of TACI on LABC in three patients. Case Presentation: Three female patients with LABC were diagnosed and treated at Dr. Sardjito General Hospital Yogyakarta over three years (2014–2016). The age ranged from 48 to 62 years, with a mean age of 56 years. Clinical features include lumps in breasts, soft tissue swelling, ulcers, dimpling of breast skin, nipple discharge, and pain sensation in the breast area. The three patients underwent the TACI procedure. Therapeutic response was evaluated by observing the clinical morphology of the lesions. Conclusions: TACI showed potency as an efficient and effective alternative palliative therapy in the three LABC cases presented. However, further study is needed to inspect TACI’s efficacy and adverse effects in breast cancer cases to be used as evidence-based medicine.
Kemoembolisasi Transarterial (TACE) pada Karsinoma Hepatoselular (KHS) Bagaswoto Poedjomartono; Sudarmanto -
Indonesian Journal of Cancer Vol 3, No 3 (2009): Jul - Sep 2009
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (296.438 KB) | DOI: 10.33371/ijoc.v3i3.125

Abstract

Karsinoma hepatoselular (KHS) merupakan 5,6% dari seluruh kanker pada manusia. KHS menempati urutan ke-5 pada laki-laki dan ke-9 pada wanita. KHS juga menempati urutan ke-3 dari kanker sistem gastrointestinal setelah kanker kolorektal dan kanker lambung. Tingkat kematiannya sangat tinggi, menempati urutan ke-2 setelah kanker pankreas. Insiden karsinoma hepatoselular (KHS) di Asia Tenggara relatif tinggi pada laki-laki (18,35) dan wanita 5,70 per 100.000 penduduk. KHS mempunyai hubungan kuat dengan infeksi kronik virus hepatitis B (HBV), baik secara epidemiologis, klinis, maupun eksperimental. Karsinoma hepatoselular (KHS) juga mempunyai hubungan dengan virus hepatitis C (HCV), sirosis hati, aflatoxin, obesitas, diabetes melitus, dan alkohol.Diagnosis karsinoma hepatoselular (KHS) dapat ditegakkan dengan pemeriksaan biopsi sitohistologis, laboratorium, dan radiologi. Pemeriksaan laboratoris AFP yang sama atau lebih dari 400 ng/mL dan imajing USG sudah dapat digunakan sebagai parameter diagnosis karsinoma hepatoselular (KHS). Sedang pemeriksaan dengan CT atau MRI dapat mengidentifikasi adanya nodul hipervaskular arteri pada penyakit hati yang kronis.Pada KHS stadium dini, sebelum timbul vaskular yang dominan, bedah merupakan terapi pilihan. Tetapi, jika sudah timbul vaskularisasi yang dominan maka terapi kombinasi di antara bedah, ablasi, dan chemo dapat merupakan pilihan. Sedangkan pada tahap yang sudah menengah lanjut, terapi TACE merupakan pilihan.Keywords: KHS, KHS stadium menengah lanjut, TACE
Transcatheter Arterial Chemo Infusion (TACI) for Squamous Cell Carcinoma of the Tongue: A Case Report Poedjomartono, Bagaswoto; Bangun, Alan Anderson; Frinces, Freshilla Sonia; Indrarto, Erwin Yudhistira Yasanusaraharja; Faiz, Ahmad
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1043

Abstract

Introduction: Cancers of the lip and oral cavity, with the tongue being the most common site, accounted for more than 377,700 cases and more than 177,700 deaths worldwide in 2020. Ninety percent of these oral neoplasms are squamous cell carcinomas (SCC). The main treatments for oral cancers are surgery, radiotherapy, and chemotherapy, either combined or as stand-alone therapies. Transcatheter Arterial Chemo Infusion (TACI) is considered the definitive treatment for locoregionally advanced squamous cell carcinoma of the oral cavity, aiming to preserve function after surgery while maintaining or improving locoregional control and survival rates. This case report presents the qualitative result of TACI on SCC of the tongue. The aim of this case report is to demonstrate the potency of TACI as an alternative palliative therapy for SCC of the tongue. Case Presentation: A 37-year-old man with SCC of the tongue was diagnosed and treated at Dr. Sardjito General Hospital, Yogyakarta in 2021. The patient underwent TACI procedure and subsequent radiotherapy sessions subsequently. The therapeutic response was evaluated by observing the clinical morphology of the lesions. Conclusions: TACI is a minimally invasive technique used in the management of SCC. TACI has shown its potency as an efficient and effective alternative palliative therapy.