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All Journal Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam
N. Balatif
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Mathematics

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SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG 3’, 4’-DIMETOKSI KALKON Novianti, S.; Balatif, N.; Zamri, A.
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 1 (2014): Wisuda Februari 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Chalcones belong to important class of flavonoid compounds. They have also beenreported to have anticancer, antimicrobial, antifungal, antioxidant, and cytotoxicactivities. In this research, an analogous chalcone of (E)-3-(4-clorophenyl)-1-(3’,4’-dimetoxyphenyl) prop- 2-en-1-on was synthesized using microwave iradiation andnatrium hidroxide as catalyst. The compound showed a good yield, and then wascharacterized by UV spectroscopy, IR, 1 H-NMR, and Mass Spectroscopy. Its toxicityhas been identified using Brine Shrimp Lethality Test (BSLT) method on Artemiasalina Leach. The result showed that it had a good toxicity activity withLC 50 = 2.24 μg/ mL and potential as anticancer.
SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA KURKUMIN (3E,5E)-3,5-BIS(2’-HIDROKSIBENZILIDIN) -1-METILPIPERIDIN-4-ON Hasanah, U.; Zamri, A.; Balatif, N.; Eryanti, Y.
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 1 (2014): Wisuda Februari 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

The derivatives of curcumin are secondary metabolites belonging to the phenolicgroup. Some of them were reported to have biological activities such as anti-inflammatory, anticancer and antioxidant activities. In this study, a curcumin of(3E,5E)-3,5-bis(2’-hidroxybenzilidin)-1-metilpiperidin-4-onefrom1-methyl-4-piperidinone with 2-hydroxy benzaldehide has been successfully synthesized usingmicrowave irradiation method with NaOH (20%) as catalyst. Reaction was carried outfor 1 minute at 180 watt. The compound resulted was in the form of yellow crystalwith a yield of 72%. The compound was characterized by measuring its melting point,identifying by TLC, and elucidated by UV-Vis, FT-IR, MS, 1 H NMR, and 13 C NMR.Our result showed that the compound had the targeted molecule structure. Antibacterialtest was carried out using the agar diffusion method against Staphylococcus aureus,Escherichia coli, Bacillus subtilis, and Salmonella enteritidis. Overall, inhibition zoneranged from 6.5 to 10 mm and showed a very weak activity.
SINTESIS (E)-3-(3-BROMOFENIL)-1-(NAFTALEN-2-IL)PROP-2-EN-2-ON DARI 2-ASETILNAFTALEN DAN 3-BROMOBENZALDEHID I. Muttakin; N. Balatif; Jasril '
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 1 (2014): Wisuda Februari 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Chalcone of (E)-3-(3-bromophenil)-1-(naphtalen-2-yl)prop-2-en-2-one has beensynthesized from 2- acethylnapthalene and 3- bromobenzaldehyd by aldol condensationusing the stirring method with base catalyst (NaOH). The yield obtained for thiscompound was 61.21 %. The purity of product has been evaluated using TLC, meltingpoint test, and HPLC analysis. The structure of the synthesized compound wasconfirmed by UV UV, FTIR, NMR, and MS analysis. Data characterization showed thatthe compound obtained was the targeted compound.
Co-Authors A. Zamri I. Muttakin Jasril ' S. Novianti U. Hasanah Y. Eryanti