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All Journal Medical Journal of Indonesia Damianus Journal of Medicine Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh
Ali Baziad
Endocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Description of bone mineral density in postmenopausal women at Immunoendocrinology Integrated Laboratory, Faculty of Medicine University of Indonesia Wibisono, D. S.; Baziad, Ali
Medical Journal of Indonesia Vol 13, No 1 (2004): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (253.478 KB) | DOI: 10.13181/mji.v13i1.127

Abstract

To identify the pattern of bone mineral density in postmenopausal women through retrospective study in 40 postmenopausal women using Dexa instrument in bones (L2 - L4). Results with 15% of survey formula accuracy were found: mean of menopausal age was 53.25 years, normal bone mineral density 30%, osteopenia 52.5%, and osteoporosis 17.5%. A very strong relationship (r=0.547) and a significant relationship (p=0.000) between body height and bone mineral density were found in this study, and there was a moderate (r=0.315) and significant (p= 0.047) relationship between body weight and bone mineral density, and likewise there was a moderate (r=-0.301) and significant (p=0.059) relationship between  duration of menopause and bone mineral density. By contrast, no relationship was found between age (r=0.119) and Body Mass Index (BMI) (r=0.086) and bone mineral density. (Med J Indones 2004; 13: 31-9)Keywords: Duration of menopause, menopause age, body height, body weight, body mass index, and bone mass density
Effect of Hormone Replacement Therapy (HRT) and low-dose combined oral pill on skin thickness, lipid profile and blood chemistry of menopausal women Baziad, Ali
Medical Journal of Indonesia Vol 12, No 4 (2003): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (161.085 KB) | DOI: 10.13181/mji.v12i4.113

Abstract

This study to evaluate the effect of hormone replacement therapy ( HRT ) and low-dose combinated oral pill on skin thickness , lipid profile and blood chemistry on menopausal woman.This study was carried out in one year randomized prospective study. 36 women were divided into 18 women receiving HRT and the other 18 receiving low-dose oral pill. The result of this study showed an increase in skin thickness (collagen) in both groups. But Those received low dose oral pill showed more . The increase of the skin thickness can prevent osteoporosis. The administration of HRT or low-dose oral pill could cause allteration in blood lipip profile and blood chemistry. But The changes were still within in normal limit. The administration of low-dose oral pill can be considered in postmeno-pausal women. (Med J Indones 2003; 12: 224-8)Keywords: Hormone replacement therapy, low-dose oral pill, menopausal women, skin thickness, lipid profile, blood chemistry.
The use of 17β Estradiol gel and progestogen tablet for hormone replacement therapy (HRT) in menopause Baziad, Ali
Medical Journal of Indonesia Vol 12, No 3 (2003): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (338.318 KB) | DOI: 10.13181/mji.v12i3.111

Abstract

The treatment and prevention of disease in menopausal women due to deficiency of estrogen hormone are done through the administration of estrogen hormone, known as hormone replacement therapy (HRT). The administration of HRT is commonly done through the administration of tablets. However, the administration of tablet will result in metabolism in the colon and liver. Tablets are usually used on a daily basis such that it may lead to boredom and results in gastrointestinal disorder. The administration of gel, on the other hand, is done by applying the gel to the body and therefore metabolism in the colon and liver can be prevented. In women with uterus, estrogen must be combined with progestogen. The type of progestogen recommended is the one with natural derivative and which possesses antimineralocorticoid properties, such that fluid retention can be avoided. One of the types of progestogen which does not result in fluid retention is nomogestrol acetate. Nomogestrol acetate will also inhibit 17β hydrosisteroiddehydrogency enzyme type 1, such that estradiol (E2) is prevented from being transformed into estron (E1). As a result, E2 level in the breast tissue is kept at minimum, thereby reducing the risk of breast cancer. (Med J Indones 2003; 12: 194-8) Keywords: 17β estradiol gel, hormone replacement therapy, progestogen, nomogestrol acetate, enzyme
The benefits of progesterone therapy in imminent abortion Abadi, A.; Baziad, Ali; Hestiantoro, Andon
Medical Journal of Indonesia Vol 14, No 4 (2005): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.027 KB) | DOI: 10.13181/mji.v14i4.205

Abstract

The causes of imminent abortion are multi-factorial. The biggest causal factor is the low level of serum progesterone level. The lowest critical level of serum progesterone for survivability of pregnancy is 10 ng/ml. Eighty percent of patients experiencing abortion showed that their progesterone level was < 10 ng/ml. Patients who realized that their pregnancy would experience hemorrhage generally would suffer from depression. Stress was one of the factors responsible for the occurence of abortion. Administration of natural progesterone substitution (not  progestogen) accelerates the disappearance of uterine contractions, and speeds up the stoppage of bleeding. In addition, progesterone has the effect of anti-anxiety. Adminstration of oral progesterone would result in metabolism in the intestine and liver, such that physiological level of serum progesterone could not be reached, while administration of suppositoria progesterone would result in physiological level of serum, such that it was effective to prevent imminent abortion. (Med J Indones 2005; 14:258-62)Keywords: progesterone, imminent abortion
Drospirinone: new generation of progestogen Baziad, Ali
Medical Journal of Indonesia Vol 14, No 3 (2005): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (226.778 KB) | DOI: 10.13181/mji.v14i3.187

Abstract

Drospirinone is a new generation of progestogen that possesses antimineralocorticoid effect. Progestogen of this type has been used as a component in combined contraceptives. The combined contraceptives of old generation contained progestogen component of testosterone derivative. Progestogen of this type does not have antimineralcorticoid effect, such that it could cause fluid retention. As a result, women who used combined pills of this type often complained of headache, breast pain, calf pain, increased body weight and blood pressure. Owing to its androgenic effect, combined contraception pills that contained testosterone-derived progestogen may cause acne and oily face. Combined contraception that contains drospirinone does not cause headache, breast pain, calf pain, increased body weight and blood pressure. Drospirinone has such a strong anti-androgenic nature that it does not result in acne and oily face. In addition, combination of ethinylestradiol and drospirinone can be used for treating pre-menstrual syndrome and menstrual pain. Drospirinone does not affect lipid and carbohydrate metabolism. (Med J Indones 2005; 14: 190-3)Keywords: drospirinone, oral contraceptive
Skin abnormality and hairloss: the reproductive endocrinological viewpoint Baziad, Ali
Medical Journal of Indonesia Vol 13, No 4 (2004): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (127.224 KB) | DOI: 10.13181/mji.v13i4.162

Abstract

Excessive androgen production may cause changes in female skin, such as hirsutism and acne. The administration of antiadrogenic hormone such as cyproteron acetate, may eliminate the hyperandrogenic effect on the skin. Hairloss may also caused either by hyper-androgenemia or by low estrogen level. The administration of either antiandrogen or estrogen may reduce hairloss. Virilization, which includes excessive growth of hair and clitoris enlargement, deepened voice, muscle hypertrophy and mammary hypoplasia are also associated with hyperandrogenemia. Antiandrogen treatment could eliminate these impacts of virilization. In contrast, cellulite was supected to be due to androgen deficiency, and the use of topical testosterone could eliminate it. It is concluded that skin and/or hairloss are associated with hormonal changes in women. The treatment with antiandrogenic hormones may reduce or cure these abnormalities. (Med J Indones 2004; 13: 258-63)Keywords: Hirsutism, virilization, acne, cellulite, hairloss, androgen, estrogen
Menopause and hormone replacement therapy Baziad, Ali
Medical Journal of Indonesia Vol 10, No 4 (2001): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1192.833 KB) | DOI: 10.13181/mji.v10i4.42

Abstract

The global population in the 21st century has reached 6.2 billion people, by the year 2025 it is to be around 8.3-8.5 billion, and will increase further. Elderly people are expected to grow rapidly than other groups. The fastest increase in the elderly population will take place in Asia. Life expectancy is increasing steadily throughout developed and developing countries. For many  menopausal women, increased life expectancy will accompanied by many health problems. The consequences of estrogen deficiency are the menopausal symptoms. The treatment of menopause related complaints and diseases became an  important socioeconomic and medical issue. Long term symptoms, such as the increase in osteoporosis fractures, cardio and cerebrovascular disesses and dementia, created a large financial burden on individuals and society. All these health problems can be lreated or prevented by hormone replacement therapy (HRT). Natural HRT is usually prefened. Synthetic  estrogen in oral contraceptives (oc) are not recommended for HRT. Many contra-indications for oc, but now it is widely usedfor HRT. The main reasons for discontinuing HRT are unwanted bleeding, fear of cancer, and negative side effects. Until now there are sill debates about the rebrtonship between HRT and the incidence of breast cancer. Many data showed that there were no clear relationship between the use of HRT and breast cancer. ThereÎore, nwny experts advocate the use of HRTfrom the first sign of climacteric complaints until death. (Med J Indones 2001;10: 242-51)Keywords: estrogen deficiency, climacteric phases, tibolone.
Effects of continuous Hormone Replacement Therapy (HRT) on FSH, lipid profiles, blood chemistry, and skin thickness in menopausal women Baziad, Ali
Medical Journal of Indonesia Vol 11, No 2 (2002): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (711.773 KB) | DOI: 10.13181/mji.v11i2.56

Abstract

This study was aimed to observe the effect of hormone replacement therapy (HRT) of estradiol 2 mg + 1 mg acetate noretisterone administered continuously on FSH hormone, lipid profile, blood chemistry, and skin thickness in menopausal women. The duration of HRT administration was 6 months. The subjects of the study were 35 menopausal women. The study was conducted from January 2001 to June 2001. After HRT administration of 6 months, a significant decrease of FSH was observed. No effect of HRT was found in bilirubin level; however, there was a slight increase of alkali phosphatase enzyme, and a signifcant increase in SGOT and SGPT. HRT caused a decrease of total cholesterol level and triglyceride level. In addition, a slight increase of LDL level and significant decrease of HDL level were observed. HRT administration with progesterone synthetic noretisterone showed an increase of skin collagen synthesis, which was indicated by the significant increase of skin thickness. (Med J Indones 2002; 11: 97-103)Keywords: HRT, FSH, menopause, lipid profile, blood chemistry, skin thickness
Impact of Hormone Replacement Therapy on stroke, and dementia due to Alzheimer’s disease on menopausal women Baziad, Ali
Medical Journal of Indonesia Vol 11, No 4 (2002): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.296 KB) | DOI: 10.13181/mji.v11i4.80

Abstract

As a result of estrogen deficiency in menopausal women various health problems occur. Disorders of central nervous system such as stroke and dementia due to Alzheimer’s disease are frequently encountered in menopausal women. Estrogen plays an important role in the maintenance of the dense network of neural fibres connecting one nerve cell to another, and in the synaptic activity facilitating cognitive thought and memory. Hormone replacement therapy (HRT) reduced the risk of stroke by 30 % and a reduction of 60 % in risk of stroke mortality. The HRT influence cognitive functioning in menopausal women and may reduce the risk of developing dementia. Women who received HRT performed better on several tests of memory and logical reasoning than women taking placebo. Vaginal bleeding episodes constitute the major cause of women’s dissatisfaction with combined HRT. (Med J Indones 2002; 11: 246-9). Keywords: HRT, menopause, memory, cognitive function, vaginal bleeding
Selective estrogen receptor modulators (SERM): A new choice for postmenopausal women and physicians who worry on cancer Baziad, Ali
Medical Journal of Indonesia Vol 10, No 3 (2001): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (449.261 KB) | DOI: 10.13181/mji.v10i3.29

Abstract

The postmenopausal state is characterized by the cessation of menstruation, loss of ovarian function, and a dramatic decrease in the level of circulating estrogen. This state of estrogen deficiency contributes to the acceleration of several age-related health problems in women, including cardiovascular disease, osteoporosis, and dementia. Estrogen replacement is clearly effective in the short-term and long-term treatment and prevention of postmenopausal symptoms. However, until now, the amount of HRT user is still very low. Fear of breast cancer and endometrial cancer are the most common concern in using hormone replacement therapy (HRT), although the relationship between long-term HRT and breast cancer remains controversial. For physicians or patients, who worry on cancer, the ideal drug is now available i.e. the selective estrogen receptor modulators (SERM), with the generic name raloxifine. (Med J Indones 2001; 10: 187-90)Keywords: HRT, raloxifine, osteoporosis, CVD, tamoxifen
Co-Authors A. Abadi Andon Hestiantoro Arini Setiawati D. S. Wibisono Rajuddin Rajuddin Rianto Setiabudy Zita Arieselia