Zita Arieselia
Department Of Pharmacology And Pharmacy, School Of Medicine And Health Sciences, Atma Jaya Catholic University Of Indonesia, Jakarta

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PENGETAHUAN DAN PERSPEKTIF MAHASISWA TENTANG PENUAAN DAN KEADAAN TUA Patrick, -; Arieselia, Zita; Rukmini, Elisabeth
Majalah Kedokteran Bandung Vol 46, No 4 (2014)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Perspektif akan penuaan dan keadaan tua yang negatif akan memudar bila sejak muda ditanamkan pandangan positif. Penelitian ini bertujuan membandingkan pengetahuan dan mencari korelasi antara pengetahuan dan perspektif mahasiswa Fakultas Kedokteran (FK) dan Teknobiologi (FTb) mengenai penuaan dan keadaan tua. Penelitian ini merupakan studi analitik komparatif dan korelatif dengan metode potong lintang. Penelitian dilakukan di FTb dan FK Unika Atma Jaya periode Januari?Mei 2013. Pengetahuan mengenai penuaan dan keadaan tua diukur dengan Facts about Aging Quiz 1 (FAQ 1). Perspektif terhadap penuaan dan kondisi tua diukur dengan Anxiety about Aging  Scale (AAS) dan Aging Semantic Differential (ASD). Sampel sebanyak masing-masing 45 mahasiswa FK dan FTb. Data FAQ 1 memperlihatkan pengetahuan mahasiswa FK dan FTb mengenai penuaan dan keadaan tua kurang baik serta tidak ada perbedaan bermakna (p=0,199). Data AAS memperlihatkan kecenderungan responden tidak takut terhadap lansia, tidak khawatir dengan keadaan fisiologisnya, kurang memperhatikan penampilan fisik, dan tidak takut kehilangan. Data ASD menunjukkan kecenderungan responden merasa lansia akan lebih berguna, tidak bergantung pada orang lain, dan mampu menerima diri sendiri. Uji korelasi FAQ 1 dengan AAS dan ASD tidak menunjukkan hubungan sehingga dapat disimpulkan tidak ada hubungan pengetahuan dengan perspektif terhadap penuaan dan keadaan tua.Kata kunci: Keadaan tua, mahasiswa, penuaan Students? Knowledge and Perspectives on Aged and AgingAbstractThe negative perspectives on aged and aging will be diminished if positive perspectives on aged condition and aging have been introduced in young age. This study aimed to compare and test the relationship between knowledge and perspective toward aged condition and aging among medical and biotechnology students. This study was a comparative analytical and correlative study with a cross-sectional method in the period of January to May 2013 conducted at the School of Biotechnology and the School of Medicine Atma Jaya Catholic University of Indonesia. Knowledge towards aged condition and aging was measured using the Facts about Aging Quiz 1 (FAQ 1). Perspective towards aged condition and aging was measured using the Anxiety about Aging Scale (AAS) and the Aging Semantic Differential (ASD). There were 45 students from each school.. Knowledge about aged condition and aging of the medical and biotechnology students was quite low. There were no significant differences (p=0.199) between the two groups. The AAS data showed that respondents did not have any fear of old people.They were also not really concern about physiological and physical appearances and were not afraid of lost. The ASD data showed that they tended to have positive views: the elderly people are useful, independent, and able to accept their condition. The correlation tests between FAQ 1-AAS and FAQ 1-ASD showed no correlation. In conclusion, there is no relationship between knowledge and perspective towards aged condition and aging.Key words: Aged, aging, students DOI: 10.15395/mkb.v46n4.339
HUBUNGAN EDUKASI KESEHATAN TENTANG CEDERA ANKLE DAN TERAPI LATIHANNYA TERHADAP TINGKAT PENGETAHUAN MAHASISWA KEDOKTERAN PEMAIN FUTSAL Yohanes Jason; Zita Arieselia
Bahasa Indonesia Vol 19 No 1 (2020): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v19i1.1164

Abstract

Introduction: Indoor-soccer is among top ten sports that often causes injuries, with an incidence rate of 55.2 injuries per 10.000 hours of sports participation. Ankle injury is the most common and when this is not handled well, it may result in chronic ankle instability. The aim of this study was to explore the association between health education about ankle injury and exercise therapy on knowledge level among medical students who were member of indoor-soccer sport. Methods: This research was an experimental study with a cross-sectional approach, conducted at School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia with purposive sampling. Health education was provided using slideshow and the knowledge level was measured using questionnaires. Data was analyzed with a paired T-test test. Results: Total respondents were 36 students. The level of knowledge of students before being given health education about ankle injury and exercise therapy was 66.3+11.6 (mean, range 40.0 - 93.3) which was significantly increased to 78.5+6.3 (mean; range 63.3 - 96.7) after being given health education about ankle injury and exercise therapy (p value <0.05, paired T-Test test). Conclusion: There is an increased knowledge among soccer members after health education explaining about ankle injury and exercise therapy. Therefore, it is necessary to equip the players with health education before any sports begin to avoid sport injury.
Anticandidal Activity of Lactoferrin, Apolactoferrin, and Oligosaccharides on Mueller-Hinton and Sabouraud Dextrose Agar against Fluconazole Resistant-Candida Albicans Maureen Miracle Stella; Sem Samuel Surja; Zita Arieselia
Althea Medical Journal Vol 9, No 3 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v9n3.2408

Abstract

Background: The demand for novel, useful, potential, and safe antifungal drugs and rapid fungal susceptibility test methods due to antifungal resistance and high prevalence of Candida albicans infection are continuing. Therefore, this study aimed to assess and compare the antifungal activity of lactoferrin, apolactoferrin, and oligosaccharides isolated from human, bovine, goat, and formula milk against C. albicans on Mueller-Hinton agar supplemented with 2% glucose and 5 µg/mL methylene blue and sabouraud dextrose agar.Methods: Lactoferrin, apolactoferrin, and oligosaccharides were extracted from human, bovine, goat, and formula milk. Lactoferrin was identified using the Bradford test and Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis. Oligosaccharides were identified using Thin-Layer Chromatography. The antifungal activity of lactoferrin, apolactoferrin, and oligosaccharides against fluconazole-resistant Candida albicans ATCC 10231 was determined and compared using the disk diffusion method on Mueller-Hinton agar and sabouraud dextrose agar. The inhibition zone formed around the disk was observed after 24 hours of incubation.Results: Lactoferrin showed an inhibition zone on sabouraud dextrose agar against C. albicans, but not on Mueller-Hinton agar. Meanwhile, apolactoferrin and oligosaccharides showed no antifungal activity on both agar media.Conclusions: Different agar media in the diffusion disk test can give different results even though using the same test method and substance. These results could shed light and become the useful references on why some potential antifungals could yield a different results in in-vitro studies, in-vivo studies, or clinical trials.
Pharmacogenomic Role in Cytochrome P450 Enzymes-Mediated Metabolism for Drug Therapy Lonah; Zita Arieselia; Jonny Setiawan; Rita Dewi; Maria Dara Novi Handayani; Linawati Hananta
Journal of Urban Health Research Vol. 1 No. 3 (2023): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v1i3.4629

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The rapid development of genetic science in recent decades has provided opportunities for clinical implementation. In the field of pharmacology, this opens up hope for the use of more targeted drugs with fewer side effects.Genetic variation's influence on pharmacological response has been well-established in practice. Patients' responses to pharmacological therapies can be varied, ranging from positive effects to serious adverse drug reactions (ADRs). Numerous genetic variations have been found to have a major impact on how people react to routinely prescribed medications over time, according to experts. In order to use this genetic information to inform treatment choices, a pharmacogenomic (PGx) profile can be used. PGx works on identifying and validating genomic variations that affect drug response. The generic approach to healthcare has given way to a more individualized and precise treatment paradigm as it has developed. Keywords: Adverse Drug Reactions - Genetic Variants – Pharmacogenomics - Cytochrome P450
Prevalence of E-cigarette Users Students and Determinant Factors Affecting Their Use Behavior Zita Arieselia; Lonah Lonah; Linawati Hananta; Margareta Amelia; Fenny Mariska; Via Dolorosa Halilintar; Mariani Santosa; Meiliyana Wijaya; Rita Dewi; Jonny Setiawan; Monalisa Heryani
Bahasa Indonesia Vol 22 No 2 (2023): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v22i2.3820

Abstract

Pendahuluan: Prevalensi pengguna rokok tembakau pada remaja di Indonesia terus meningkat dari 7,2% pada tahun 2013 menjadi 9,1% pada tahun 2018, tingkat penggunaannya dianggap dapat dikurangi dengan menggunakan rokok elektrik. Namun sebenarnya rokok elektrik belum dapat disebut sebagai terapi berhenti merokok konvensional karena belum terdapat bukti yang cukup kuat dan dampak penggunaannya pada kesehatan yang tidak dapat dikesampingkan. Sementara itu, beberapa studi menunjukkan bahwa penggunaan rokok elektrik juga berdampak buruk bagi kesehatan. Tujuan penelitian ini adalah untuk mengetahui prevalensi pengguna dan faktor determinan yang memengaruhi perilaku penggunaan rokok elektrik pada mahasiswa. Metode: Studi ini merupakan penelitian kuantitatif dengan desain studi potong lintang atau cross sectional. Sampel yang digunakan sebanyak 410 orang dengan kriteria inklusi berupa mahasiswa aktif Unika Atma Jaya serta orang yang telah setuju untuk menjadi responden penelitian setelah membaca informed consent, dan kriteria eksklusi yaitu responden yang mengisi kuesioner dengan tidak lengkap. Perhitungan sampel dilakukan dengan metode proportional stratified random sampling. Pengambilan data responden menggunakan kuesioner secara daring melalui Google Forms. Analisis data menggunakan uji Chi Square dan Mann-Whitney.   Hasil: Prevalensi pengguna rokok elektrik pada mahasiswa sebesar 21,7%. Pada penelitian ini faktor yang berpengaruh pada keputusan penggunaan rokok elektrik adalah jenis kelamin (p<0,001), persepsi (p<0,001), tersedianya suplai (p<0,001), dukungan keluarga (p=0,002), dan dukungan teman (p<0,001). Simpulan: Tingginya tingkat penggunaan rokok elektrik pada mahasiswa menunjukkan perlunya informasi dan edukasi serta promosi kesehatan mengenai dampak merugikan dari penggunaan rokok elektrik.
Pengaruh Variasi Ukuran Partikel pada Ekstraksi Biji Alpukat (Persea americana Mill.) Terhadap Penurunan Kadar Trigliserida Pada Tikus Hiperlipidemia Manalu, Jojor Lamsihar; Sukendar, Billy; Arieselia, Zita; Dewi, Rita; Narwati, Yulia Tanti
Bahasa Indonesia Vol 22 No 3 (2023): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v22i3.4333

Abstract

Pendahuluan:  Biji buah alpukat memiliki zat aktif yang dapat menurunkan kadar trigliserida.  Pemanfaatan biji buah alpukat sebagai obat penurun kadar trigliserida masih memiliki potensial yang perlu dikembangkan untuk menjadi salah obat herbal yang alternatif. Metode: Penelitian eksperimental dilakukan terhadap tikus Sprague Dawley, tikus diberikan sediaan propylthiouracil (PTU) selama 14 hari untuk mencapai kondisi hiperlipidemia yang dibagi ke dalam 2 kelompok intervensi. Kelompok pertama diberikan ekstrak biji alpukat yang diekstraksi dengan metode remaserasi dari biji alpukat yang digerus selama 15 menit dan kelompok kedua digerus selama 30 menit. Ukuran partikel didapatkan dari rata-rata diameter 10 partikel biji alpukat secara acak dari setiap variasi waktu penggerusan. Kadar trigliserida dalam darah tikus diukur setelah 14 hari pemberian PTU dan diukur lagi setelah 7 hari, dan 14 hari pemberian ekstrak biji alpukat. Analisis data menggunakan uji paired t-test dan unpaired t-test. Hasil: Rata-rata ukuran partikel biji alpukat pada kelompok 1 sebesar 27,03 µm dan kelompok 2 sebesar 13,50 µm Pemberian ekstrak biji alpukat mampu menurunkan kadar trigliserida secara signifikan dari hari 0-7, hari 0-14, dan hari 7-14 pada kelompok 1 (p<0,05). Hal yang sama ditemukan pada kelompok 2 (p<0,05) selain dari hari 7-14 (p>0,05). Tidak ditemukan perbedaan yang signifikan dalam penurunan trigliserida pada kelompok pertama dan kedua (p>0,05). Simpulan: Pemberian ekstrak biji alpukat dapat menurunkan kadar trigliserida pada tikus. Perbedaan waktu penggerusan dan ukuran biji alpukat yang diekstraksi tidak memengaruhi efektivitas dalam penurunan kadar trigliserida.  
Penurunan Kadar Malondialdehid (MDA) pada Tikus Putih Jantan Hiperlipidemia oleh Pemberian Ekstrak Etanol Bajakah Tampala Joneri, Richie; Manalu, Jojor Lamsihar; Dewi, Rita; Arieselia, Zita
Bahasa Indonesia Vol 23 No 1 (2024): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v23i1.4562

Abstract

Pendahuluan: Penyebab kematian tertinggi di Indonesia adalah stroke dan penyakit jantung koroner. Salah satu faktor risiko adalah hiperlipidemia. Hiperlipidemia berisiko menyebabkan aterosklerosis. Stres oksidatif telah terbukti berperan pada hiperlipidemia dan aterosklerosis. Salah satu biomarker untuk menentukan stres oksidatif adalah malondialdehid (MDA). Penggunaan antioksidan dapat mengurangi kerusakan yang diakibatkan oleh radikal bebas. Bajakah tampala adalah tanaman yang mengandung berbagai metabolit sekunder yaitu flavonoid, fenol, tanin, dan saponin. Metabolit sekunder tersebut berperan sebagai antioksidan dan memiliki efek hipolipidemik. Penelitian ini bertujuan untuk mengetahui efektivitas dari ekstrak bajakah tampala dalam pengobatan penyakit hiperlipidemia. Metode: Penelitian ini adalah studi eksperimental in vivo terhadap tikus dengan metode pre-test dan post-test. Sampel penelitian adalah 12 ekor tikus putih jantan Sprague-Dawley yang sehat dan tidak cacat berusia 8 minggu dengan berat badan ±200 gram. Tikus diinduksi hiperlipidemia selama 21 hari. Setelah itu, kelompok pertama diberikan ekstrak bajakah tampala dan kelompok kedua diberikan simvastatin selama 21 hari. Nilai absorbansi sampel campuran serum dengan reagen MDA assay kit pada panjang gelombang 450 nm, 532 nm, dan 600 nm diukur menggunakan metode spektrofotometri. Kadar MDA dihitung dengan rumus menggunakan nilai absorbansi tersebut. Data dianalisis dengan menggunakan uji T berpasangan dan uji T tidak berpasangan. Hasil: Hasil menunjukkan penurunan yang signifikan pada rerata kadar MDA tikus putih jantan hiperlipidemia yang diberikan ekstrak bajakah tampala (p<0,05). Tidak terdapat perbedaan rerata penurunan kadar MDA yang signifikan antara yang diberikan ekstrak bajakah tampala dengan simvastatin (p>0,05). Simpulan: Pemberian ekstrak bajakah tampala terbukti efektif dalam menurunkan kadar MDA pada tikus putih jantan hiperlipidemia.
PENGARUH KURANGNYA JUMLAH JAM TIDUR TERHADAP PERUBAHAN KADAR GULA DARAH PADA MAHASISWA PREKLINIK FAKULTAS KEDOKTERAN UNIKA ATMA JAYA Arieselia, Zita; Tasia, Yenna; Sasmita, Poppy Kristina
Bahasa Indonesia Vol 13 No 2 (2014): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

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Abstract

Pendahuluan: Kurangnya jumlah jam tidur adalah suatu hal yang wajar bagi masyarakat zaman sekarang dikarenakan mereka ingin memaksimalkan waktu mereka untuk dapat melakukan semua aktivitasnya. Sementara itu tidur diperlukan untuk mengembalikan proses biokimia atau fisiologis yang menurun ke keadaan semula. Terdapat beberapa penelitian yang menunjukkan bahwa kekurangan tidur kronis dapat meningkatkan risiko obesitas, penyakit kardiovaskular, dan peningkatan kadar gula darah, yang dapat berlanjut menjadi diabetes mellitus tipe 2. Tujuan: Penelitian ini merupakan studi pendahuluan untuk mengetahui efek berkurangnya jam tidur terhadap perubahan kadar gula darah. Metode: Mengukur kadar gula darah puasa dan kadar gula darah 2 jam setelah oral glucose tolerance test (OGTT) pada 18 mahasiswa preklinik Fakultas Kedokteran Unika Atma Jaya dalam keadaan cukup tidur (7 jam atau lebih) dan kurang tidur (kurang dari 7 jam) selama 2 malam. Data dianalisis menggunakan uji T berpasangan untuk melihat apakah kekurangan tidur selama 2 malam menyebabkan perubahan pada kadar gula darah puasa dan kadar gula darah 2 jam setelah OGTT. Hasil: Kadar gula darah puasa dan kadar gula darah 2 jam setelah OGTT meningkat setelah kekurangan tidur (kurang dari 7 jam) selama 2 malam. Kesimpulan: Kekurangan tidur parsial selama 2 malam menyebabkan peningkatan kadar gula darah puasa dan kadar gula darah 2 jam setelah OGTT.
KADAR 2,3-DINOR-6-KETO-PROSTAGLANDIN-F1 DALAM URIN WANITA PASCAMENOPAUSE ALAMI DAN PRAMENOPAUSE YANG MINUM ASPIRIN 100 MG Arieselia, Zita; Setiawati, Arini; Setiabudy, Rianto; Baziad, Ali
Bahasa Indonesia Vol 10 No 2 (2011): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

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Abstract

Background: The prevalence of cardiovascular diseases in women increases sharply after menopause. In postmenopausal women, thromboxane production increases while prostacyclin production decreases. Low dose aspirin (75- 150 mg) has long been known as an antiplatelet aggregator. Aspirin reduces the production of both thromboxane (potent thrombocyte aggregator and vasoconstrictor) and prostacyclin (anti thrombocyte aggregator and potent vasodilator).Methods: The present study was an open-label clinical trial with 2 parallel groups. One group consisted of 15 premenopausal women (age > 40 years) while the other group 15 postmenopausal women (for 3 - 5 years). Twenty-four hours urine was collected from each subject before and after aspirin 100 mg daily for 7 days. The concentration of prostacyclin was measured as its metabolite (2,3-dinor-6-keto-prostaglandin-F1) in urine using EIA (Enzyme Immunoassay). Thromboxane as its urinary metabolites (11-dehidrotromboksan-B2) was also measured in these same urine samples in the previous study.Results: Previous study showed that aspirin significantly reduced thromboxane in both groups, with significantly larger percentage reduction in postmenopausal women compared to premenopausal women. Results of the present study showed that aspirin reduced prostacyclin significantly in both premenopausal women (mean difference = 78.44 ng/g creatinine; p = 0.001) and postmenopausal women (mean difference = 35.71 ng/g creatinine; p <0.001), but the percentage reduction between the groups was not significantly different (46,26% vs. 40,94%; p = 0,574). The decrease in thromboxane and prostacyclin should be compared (as the decrease in the ratio of 11-dehidrotromboksan-B2 / 2,3-dinor-6-keto-prostaglandin-F1) to assess aspirin efficacy as an antithrombotic. Calculation of the ratio of 11-dehidro-tromboksanB2 / 2,3-dinor-6-keto-prostaglandin-F1 before aspirin consumption was much higher in postmenopausal women compared to that in premenopausal women (4.09 vs. 1.13; p = 0.001). The decrease in 11-dehidro-tromboksan-B2 / 2,3- dinor-6-keto-prostaglandin-F1? ratio by aspirin was found much larger in postmenopausal women compared to that in premenopausal women (1.91 vs.0.17; p = 0.022).Conclusions: It was concluded that aspirin reduced prostacyclin significantly in each group with nonsignificant percentage reduction between groups, but reduced the 11-dehidro-tromboksan-B2/2,3-dinor-6-keto-prostaglandin-F1? ratio much larger in post-menopausal women compared to that in premenopausal women.
Assessing the Correlation between Spicy Food Consumption and Dyspepsia Symptoms in Medical and Health Students at Atma Jaya Catholic University of Indonesia Lonah; Divara Ariesta Sekar Suryadi, Made; Arieselia, Zita; Vitria Kurniawan, Sandy; Hananta, Linawati; Setiawan, Jonny; Surjono, Edward; Santosa, Mariani; Ulina Margareta Situmorang, Evi; Fan, Tan Fei; Yuliana; Budiyanti, Ecie
Journal of Urban Health Research Vol. 2 No. 3 (2024): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v2i3.5463

Abstract

Introduction: The capsaicin (8-methyl-N-vanillyl-6-nonenamide) content in spicy foods can trigger irritation and increase gastric acid production, which potentially damages the stomach mucous layer by increasing chloric acid levels (HCl). It is known that dyspepsia has a variety of causes and one of them can be triggered by the consumption of irritating foods, such as spicy foods. Therefore, the research was conducted to determine whether there was a significant relationship between the consumption of spicy foods and the incidence of dyspepsia in students of the Faculty of Medicine and Health Sciences at the Atma Jaya Catholic University of Indonesia. Methods: This research method is an analytical observational study using cross-sectional methods. The main variables in this study were dyspepsia, measured using the Rome III questionnaire, and the frequency of spicy food consumption measured using the Food Frequency Questionnaire (FFQ). The sample consisted of 107 people randomly selected. The data was analyzed statistically using the Fischer Exact test. Results: This study showed that 56.1% of respondents frequently eat spicy foods, while the majority, as much as 95.3%, also have dyspepsia. There was a significant correlation between spicy eating habits and dyspepsia, with a p-value of 0.014 (p<0.05). Conclusion: The results showed a statistically significant relationship between spicy eating habits and dyspepsia, so it is recommended for students to reduce spicy food consumption as it can affect the onset of dyspepsia. Keywords: dyspepsia - spicy foods - stomach - Rome III questionnaire - food frequency questionnaire