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All Journal Damianus Journal of Medicine Medicinus : Jurnal Kedokteran Cermin Dunia Kedokteran
Arini Setiawati
Departemen Farmakologi dan Terapi, Fakultas Kedokteran Universitas Indonesia
Health Professions Medicine & Pharmacology Public Health

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Profil Respons Glukosa Darah dan Tingkat Rasa Kenyang setelah Pemberian Diabetasol® Dibandingkan Makanan Padat Gizi Terkontrol pada Pasien Diabetes Melitus tipe 2 Eliana, Fatimah; Handoko, Iwan Surjadi; Diah Ambarwati, Fransisca; Setiawati, Arini
Cermin Dunia Kedokteran Vol 45, No 7 (2018): Onkologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (637.545 KB) | DOI: 10.55175/cdk.v45i7.640

Abstract

Tujuan penelitian ini adalah untuk menentukan stabilitas kadar glukosa darah harian, tingkat kenyang, dan keamanan setelah menggunakan Diabetasol® dibandingkan dengan makanan padat dengan gizi terkontrol. Diabetasol® adalah makanan indeks glikemik rendah mengandung isomaltulosa, resisten dekstrin, dan inulin. Penelitian ini merupakan studi awal, prospektif, acak, terbuka, dan melibatkan 30 subjek DM tipe 2 pria dan wanita. Pengukuran glukosa darah dengan continuous glucose monitoring selama 48 jam di setiap kunjungan. Tingkat rasa kenyang diukur dengan kuesioner satiety quotient dengan visual analog scale (VAS) pada interval 0, 15, 30, 60, dan 120 menit. Evaluasi efek samping didasarkan pada terjadinya hipoglikemia dan masalah pencernaan selama masa pengobatan. Hasil penelitian menunjukkan respons glikemik Diabetasol® lebih rendah dibandingkan makanan padat gizi terkontrol kendati tidak bermakna, di lain pihak Diabetasol® memberikan rasa kenyang lebih lama tanpa efek samping serius.The purpose of this study was to determine the stability of daily blood glucose level, satiety level, and safety after using Diabetasol® in comparison with controlled nutrition solid food. Diabetasol® is low glycemic index foods contained of isomaltulose, resistant dextrin, and inulin. This study is a preliminary, prospective, randomized, open-ended study, and involving 30 male and female type 2 DM subjects. Blood glucose was measured with continuous glucose monitoring within 48 hours after every visit. The satiety level was measured with satiety quotient questionnaire with visual analog scale (VAS) at interval of 0, 15, 30, 60, and 120 minutes. The evaluation of side effects was based on the occurrence of hypoglycemia and digestive problems during the treatment period. Eventhough not stastistically significant, Diabetasol® leads to decreased glycemic response and longer satiety compared to controlled nutrition solid foods, with no serious side effects.
KADAR 2,3-DINOR-6-KETO-PROSTAGLANDIN-F1 DALAM URIN WANITA PASCAMENOPAUSE ALAMI DAN PRAMENOPAUSE YANG MINUM ASPIRIN 100 MG Arieselia, Zita; Setiawati, Arini; Setiabudy, Rianto; Baziad, Ali
Bahasa Indonesia Vol 10 No 2 (2011): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

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Abstract

Background: The prevalence of cardiovascular diseases in women increases sharply after menopause. In postmenopausal women, thromboxane production increases while prostacyclin production decreases. Low dose aspirin (75- 150 mg) has long been known as an antiplatelet aggregator. Aspirin reduces the production of both thromboxane (potent thrombocyte aggregator and vasoconstrictor) and prostacyclin (anti thrombocyte aggregator and potent vasodilator).Methods: The present study was an open-label clinical trial with 2 parallel groups. One group consisted of 15 premenopausal women (age > 40 years) while the other group 15 postmenopausal women (for 3 - 5 years). Twenty-four hours urine was collected from each subject before and after aspirin 100 mg daily for 7 days. The concentration of prostacyclin was measured as its metabolite (2,3-dinor-6-keto-prostaglandin-F1) in urine using EIA (Enzyme Immunoassay). Thromboxane as its urinary metabolites (11-dehidrotromboksan-B2) was also measured in these same urine samples in the previous study.Results: Previous study showed that aspirin significantly reduced thromboxane in both groups, with significantly larger percentage reduction in postmenopausal women compared to premenopausal women. Results of the present study showed that aspirin reduced prostacyclin significantly in both premenopausal women (mean difference = 78.44 ng/g creatinine; p = 0.001) and postmenopausal women (mean difference = 35.71 ng/g creatinine; p <0.001), but the percentage reduction between the groups was not significantly different (46,26% vs. 40,94%; p = 0,574). The decrease in thromboxane and prostacyclin should be compared (as the decrease in the ratio of 11-dehidrotromboksan-B2 / 2,3-dinor-6-keto-prostaglandin-F1) to assess aspirin efficacy as an antithrombotic. Calculation of the ratio of 11-dehidro-tromboksanB2 / 2,3-dinor-6-keto-prostaglandin-F1 before aspirin consumption was much higher in postmenopausal women compared to that in premenopausal women (4.09 vs. 1.13; p = 0.001). The decrease in 11-dehidro-tromboksan-B2 / 2,3- dinor-6-keto-prostaglandin-F1? ratio by aspirin was found much larger in postmenopausal women compared to that in premenopausal women (1.91 vs.0.17; p = 0.022).Conclusions: It was concluded that aspirin reduced prostacyclin significantly in each group with nonsignificant percentage reduction between groups, but reduced the 11-dehidro-tromboksan-B2/2,3-dinor-6-keto-prostaglandin-F1? ratio much larger in post-menopausal women compared to that in premenopausal women.
Randomized Trial Comparing Adjuvant Intravitreal Triamcinolone Acetonide 2mg and Bevacizumab 12,5mg for Diabetic Macular Edema Larasati, maria; Setiawati, Arini; Djatikusumo, Ari
Medicinus Vol. 7 No. 2 (2018): February 2018 - May 2018
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i2.1792

Abstract

ObjectivesTo evaluate the efficacy and safety of Intravitreal Triamcinolone Acetonide (IVTA) 2 mg and Bevacizumab (IVB) 12,5 mg for adjuvant therapy of Diabetic Macular Edema (DME)DesignThis was a prospective, randomized clinical trial. Each participants with DME was randomized to received single intravitreal injection of IVTA or IVB  and then being followed until fourth week after injection. The efficacy parameters were the improvement in Best Corrected Visual Acuity (BCVA) in logMAR and Standardized Central Macular Thickness (SCMT) by Optical Coherence Tomography. The safety parameters were the Intra Ocular Pressure (IOP) and Posterior Capsular cataract progression using LOCSIII criteria.ResultsTwenty five eyes of 20 participants were randomly assigned to receive IVTA 2 mg (n=12) and IVB (n=13). At 4 weeks, mean BCVA was better in IVTA group than in IVB group -0,39 logMAR (p<0,05). CMT reduction were significant in all visits of both groups. The SCMT showed 78,37%  at final follow-up for IVTA group. There were no statistic significant difference in the mean IOP and posterior capsular cataract changes among two groups. (p>0,05)ConclusionAdjuvant IVTA injections were more effective than IVB injections in patients with DME. However, it was associated with higher increment in IOP, despite not reaching statistical significance.
Co-Authors Ali Baziad Andhika Rachman Arif Abdillah Diah Ambarwati, Fransisca Dian Saraswati Djatikusumo, Ari Dwi R. Parwati Elise Kasakeyan Errol U. Hutagalung Faiz Faiz Fatimah Eliana, Fatimah Fitriyadi Kusuma Franciscus D. Suyatna Frans D. Suyatna Hadiarto Mangunnegoro Handoko, Iwan Surjadi Harmani Kalim HENI RACHMAWATI Ifran Saleh Ikhwan Rinaldi Iwan Darmansjah Iwin Sumarman Jan Susilo Jessie S. Pamudji Juan T. Sion Junita Indarti Karmel L Tambunan, Karmel L Karmel L. Tambunan Kris Pranarka Lugyanti Sukrisman Lukman H. Makmun Maria Marietta Bali Larasati Marina Hamadian Melva Louisa Metta S.S. Wiria Mulyarjo Mulyarjo Nafrialdi Nafrialdi Nina Irawati Nur A. Aroeman Rianto Setiabudy Robby Zulkarnain Roestiniadi D. Soemantri S. B. Gunawan Samsirun Halim Shufrie Effendi, Shufrie Sidartawan Soegondo Sofyanuddin Sofyanuddin Sri W.A. Jusman T. Djumhana Atmakusuma, T. Djumhana Tety H. Rahim Theresia G Kurniawan, Theresia G Wiguno Prodjosudjadi Yeyet C. Sumirtapura Zita Arieselia Zulkifli Alkaf