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All Journal HAYATI Journal of Biosciences Pendas : Jurnah Ilmiah Pendidikan Dasar Jurnal Akuntansi, Ekonomi dan Manajemen Bisnis
IIN KURNIA
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Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences Economics, Econometrics & Finance Other

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Correlation Between Akt and p53 Protein Expression and Chemoradiotherapy Response in Cervical Cancer Patients IIN KURNIA; BUDININGSIH SIREGAR; SETIAWAN SOETOPO; IRWAN RAMLI; TJAHYA KURJANA; . ANDRIONO; MARINGAN DIAPARI LUMBAN TOBING; BETHY SURYAWATHI; TEJA KISNANTO; DEVITA TETRIANA
HAYATI Journal of Biosciences Vol. 21 No. 4 (2014): December 2014
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1416.842 KB) | DOI: 10.4308/hjb.21.4.173

Abstract

Akt is a protein that is associated with cell proliferation and is expressed at high levels in cancer cells. Some research indicates it may play a role in increasing the resistance of cancer cells to chemotherapy treatment. P53 is a tumor suppressor protein that influences the cell cycle and apoptosis. The purpose of this study was to examine the relationship between the expression of Akt and p53 in cancerous tissue before chemoradiation treatment, and the clinical response to treatment of cervical cancer patients. Twenty microscopic tissue samples were taken from cervical cancer biopsies obtained from patients before cancer treatment. The tissue samples were stained with p53 and Akt antibodies via immunohistochemistry technique, to measure expression of both proteins. After completion of chemoradiotherapy, patients’ clinical response to treatment was determined using the pelvic control method. Our results revealed no correlation between expression of Akt and p53 index (P = 0.74) as well as between p53 Index and chemoradiotherapy clinical response (P=0.29). There was significant correlation between expression of Akt and cervical cancer chemoradiotherapy response (P = 0.03). There was no correlation found between p53 index and chemoradiotherapy clinical response (P = 0.29). High expression of Akt may related with high cell proliferation and resistance to chemoradiotherapy.
IMPLEMENTASI KURIKULUM MERDEKA TERHADAP PENGUATAN KARAKTER SISWA SEKOLAH DASAR DI KOTA SERANG Andriani Sariwardani; Suhendi; Arif Hidayat; Ema Nurmawaty; Iin Kurnia; Dwi Saktiawan; Setiyanto; Rusyani
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 11 No. 01 (2026): Volume 11 No. 01 Maret 2026 Published
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v11i01.42482

Abstract

This study aims to describe the implementation of the Merdeka Curriculum in strengthening the character of elementary school students in Serang City through the Project for Strengthening the Profile of Pancasila Students (P5). The research method employed is descriptive qualitative, with data collection techniques including observation, interviews, and documentation across several public elementary schools in Serang. The results indicate that the implementation of the Merdeka Curriculum provides flexibility for teachers to integrate character values—such as independence, mutual cooperation (gotong royong), and Banten’s local wisdom—into the learning process. The primary challenges faced include the adaptation of teaching modules and inconsistent character assessment methods. Overall, however, the Merdeka Curriculum is effective in enhancing students' ethical awareness and social behavior within the school environment.
Strategi Pemasaran Digital Berbasis Influencer Lokal Dalam Menghadapi Perubahan Tren Konsumen Pada Bisnis Food & Beverage Di Bangka Belitung Iin Kurnia; Yusnita Yusnita
Jurnal Akuntansi, Ekonomi dan Manajemen Bisnis Vol. 6 No. 1 (2026): Maret : Jurnal Akuntansi, Ekonomi dan Manajemen Bisnis
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jaemb.v6i1.8513

Abstract

This study explores the effectiveness of digital marketing strategies that utilize local influencers in responding to emerging consumer trends within the Food and Beverage (F&B) sector in Bangka Belitung. The research focuses on how local influencers affect consumer purchase decisions and which digital approaches are most relevant for businesses. Guided by Terence A. Shimp’s influencer marketing theory, the study employs a mixed-methods design combining surveys, in-depth interviews, and Focus Group Discussions (FGD) with business actors and local influencers. The findings indicate that local-influencer-based digital marketing is highly effective in building trust, strengthening consumer engagement, and enhancing brand awareness, particularly among Millennial and Gen Z audiences. The success of this strategy depends largely on the alignment between the influencer’s character and the business concept, as well as the authenticity and credibility of the content. Overall, the study highlights the strategic potential of local influencers in supporting the growth and competitiveness of F&B businesses in Bangka Belitung.
Co-Authors . ANDRIONO Andriani Sariwardani ARIF HIDAYAT BETHY SURYAWATHI Budiningsih Siregar Devita Tetriana Dwi Saktiawan Ema Nurmawaty Ketut Tirtayasa MARINGAN DIAPARI LUMBAN TOBING Rusyani SETIAWAN SOETOPO Setiyanto Suhendi Teja Kisnanto TJAHYA KURJANA Yusnita Yusnita