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Correlation Between Akt and p53 Protein Expression and Chemoradiotherapy Response in Cervical Cancer Patients IIN KURNIA; BUDININGSIH SIREGAR; SETIAWAN SOETOPO; IRWAN RAMLI; TJAHYA KURJANA; . ANDRIONO; MARINGAN DIAPARI LUMBAN TOBING; BETHY SURYAWATHI; TEJA KISNANTO; DEVITA TETRIANA
HAYATI Journal of Biosciences Vol. 21 No. 4 (2014): December 2014
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1416.842 KB) | DOI: 10.4308/hjb.21.4.173

Abstract

Akt is a protein that is associated with cell proliferation and is expressed at high levels in cancer cells. Some research indicates it may play a role in increasing the resistance of cancer cells to chemotherapy treatment. P53 is a tumor suppressor protein that influences the cell cycle and apoptosis. The purpose of this study was to examine the relationship between the expression of Akt and p53 in cancerous tissue before chemoradiation treatment, and the clinical response to treatment of cervical cancer patients. Twenty microscopic tissue samples were taken from cervical cancer biopsies obtained from patients before cancer treatment. The tissue samples were stained with p53 and Akt antibodies via immunohistochemistry technique, to measure expression of both proteins. After completion of chemoradiotherapy, patients’ clinical response to treatment was determined using the pelvic control method. Our results revealed no correlation between expression of Akt and p53 index (P = 0.74) as well as between p53 Index and chemoradiotherapy clinical response (P=0.29). There was significant correlation between expression of Akt and cervical cancer chemoradiotherapy response (P = 0.03). There was no correlation found between p53 index and chemoradiotherapy clinical response (P = 0.29). High expression of Akt may related with high cell proliferation and resistance to chemoradiotherapy.
IMPLEMENTASI KURIKULUM MERDEKA TERHADAP PENGUATAN KARAKTER SISWA SEKOLAH DASAR DI KOTA SERANG Andriani Sariwardani; Suhendi; Arif Hidayat; Ema Nurmawaty; Iin Kurnia; Dwi Saktiawan; Setiyanto; Rusyani
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 11 No. 01 (2026): Volume 11 No. 01 Maret 2026 Published
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v11i01.42482

Abstract

This study aims to describe the implementation of the Merdeka Curriculum in strengthening the character of elementary school students in Serang City through the Project for Strengthening the Profile of Pancasila Students (P5). The research method employed is descriptive qualitative, with data collection techniques including observation, interviews, and documentation across several public elementary schools in Serang. The results indicate that the implementation of the Merdeka Curriculum provides flexibility for teachers to integrate character values—such as independence, mutual cooperation (gotong royong), and Banten’s local wisdom—into the learning process. The primary challenges faced include the adaptation of teaching modules and inconsistent character assessment methods. Overall, however, the Merdeka Curriculum is effective in enhancing students' ethical awareness and social behavior within the school environment.
PENGARUH PENGELOLAAN SAMPAH DIGITAL MELALUI APLIKASI WAMS (WASTE MANAGEMENT SISTEM) DALAM MENUMBUHKAN KARAKTER PEDULI LINGKUNGAN PADA DIRI SISWA SEKOLAH DASAR DI KOTA SERANG Suhendi; Tito Parta Wibowo; Arif Hidayat; Iin Kurnia; Dwi Saktiawan; Setiyanto
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 11 No. 02 (2026): Volume 11 Nomor 02, Juni 2026 Published
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v11i02.49738

Abstract

This study aims to determine the influence of digital waste management through the WAMS (Waste Management System) application in fostering environmental care character among elementary school students in Serang City. The increasing waste problem demands technology-based management innovations capable of building environmental awareness from an early age. The WAMS application is utilized as a digital waste management medium that facilitates students in sorting, recording, and monitoring waste management activities effectively and educationally. This research employed a quantitative approach using a survey method. The subjects of the study were elementary school students in Serang City who participated in the use of the WAMS application in school waste management activities. Data collection techniques included questionnaires, observations, and documentation. The data were analyzed using descriptive and inferential statistical analysis to determine the level of influence of the application on the development of students’ environmental care character. The results showed that digital waste management through the WAMS application had a positive and significant effect on the environmental care character of elementary school students. Students demonstrated increased awareness in maintaining environmental cleanliness, proper waste sorting habits, and responsibility toward the school environment. Therefore, the WAMS application can serve as an innovative alternative in supporting environmental character education in elementary schools.