Rakesh Kumar Jha
Unknown Affiliation

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

Role of Omega 3 Fatty acids, Vitamin D, Vitamin B12, Vitamin B6 and Folate in Mental wellbeing- A Short review of Literature Lata Kanyal Butola; Deepika Kanyal; Ranjit Ambad; Rakesh Kumar Jha
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14323

Abstract

Neuropsychiatric conditions have been linked to around 14 percent of the global disease burden, mainlydue to the chronically debilitating nature of depression and other widespread mental disorders, alcohol anddrug use disorders, and psychosis. The science and lay press have confirmed that vitamin D is an importantfactor that can have major health benefits in the prevention and treatment of many chronic diseases. Mostpeople have inadequate vitamin D levels in this country. This is also relevant for people with depression andother mental illnesses as well. Inadequate food consumption, lifestyle or other factors are a major causes ofVitamin D deficiency. Successful diagnosis and treatment of insufficient levels of vitamin D in people withdepression and other mental illnesses could be a simple and cost-effective therapy that could enhance thelong-term health outcomes and quality of life of patients. It is now well known that omega-3 fatty acids areimportant for physical health, and there is growing evidence that omega-3 fatty acids may also be importantfor mental health. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the two major omega-3fatty acids in fish oil, have essential biological roles within the CNS. DHA is a major structural componentof neuronal membranes, and modifying the neuronal membrane fatty acid composition contributes tofunctional changes in the behaviour of phospholipid membrane-embedded receptors and other proteins.EPA has major physiological roles that can influence the behaviour of neurons. For innumerable aspectsof brain functioning, adequate nutrition is needed. A modifiable risk factor for depression may be the poorquality of diet. The goal was to evaluate and synthesize the existing understanding of the role of nutritionin mental well-being. The risk of depression is increased by low omega-3 fatty acid status. Both fish oil andfolic acid supplements have been successfully used to treat depression. The response to antidepressants isdecreased by folate deficiency. Deficiencies in folate, vitamin B12, Vitamin D, Omega 3 fatty acids, VitaminB6 tend to be more prevalent in depressed individuals than in nondepressed individuals. In this short reviewof Literature we have focused on role of Omega 3 Fatty acids, Vitamin D, Vitamin B12, Vitamin B6 andFolate in Mental wellbeing.
Study of LDH Isoenzymes in Myocardial Infraction at Vidharbha Region (Central India) Rakesh Kumar Jha; Pradip Jain; Ankita Khandolkar; Archana Dhok
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.15084

Abstract

Introduction: A significant cause of morbidity and mortality worldwide is myocardial infarction (MI).Within the first few hours of the beginning of MI, the greatest risk of death occurs. Thus, for the effectivetreatment of patients with MI, early detection of cardiac ischemia is essential. Inappropriate diagnosis ofpatients with chest pain sometimes leads to improper admission, and vice versa, of patients without MI.Physical examination, precise ECG results and evaluation of cardiac biomarkers play an important rolein the early diagnosis of acute ischemia, in addition to clinical history. In the present analysis, the cardiacbiomarker lactate dehydrogenase released during a MI event is discussed in depth.Aim: We conducted a cross sectional study to examine the different levels of LDH isoenzymes in myocardialinfarction patients those admitted in cardiac care unit in SMHRC Nagpur.Material and Methods: The present study included 100 subjects of age group 30-80 years. Patients admittedto the coronary care unit at SMHRC & AVBRH between January 2020 and June 2020 was consideredeligible for the study. These guidelines ensured that sufficient blood samples were available and the criteriafor diagnosis were consistent. Lactate dehydrogenase isoenzyme was fractionated by agarose gel electrophoresis as described by Cawley and Eberhard. The stained slides were scanned on Chromoscan at 520 mixand the percentages of the fractions were quantitated.Results: The results obtained in the present study indicate that serum lactate dehydrogenase enzyme activityincreases 4-5 folds in the first 24-72 hours after the onset of clinical infarction with a peak on the second day.It then declines gradually towards the normal within two weeks. Thus, determination of total serum LDHis valuable if patients present themselves for clinical check up even after a week from the day of infarct.Although the contribution of myocardium to total serum lactate dehydrogenase is large, its interpretationbecomes difficult if the diseases of other organs such as liver, kidney, etc.Conclusion: In conclusion, the present data strongly support the use of Lactate dehydrogenase for thediagnosis of MI. Such a strategy should boost both the precision and sensitivity for myocardial infarctiondiagnosis.
Effect of Cigarette Smoking on Vitamin C in Non Pregnant and Pregnant Women Ankita Khandolkar; Rakesh Kumar Jha; Pradip Jain; Archana Dhok
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.15090

Abstract

Introduction: It is perceived that smoking cigarettes during pregnancy is unfortunate and can promptexpanded unconstrained early abortion in the first trimester, premature abruption of the placenta, pretermdelivery, decreased birth weight and SIDS. All things considered, children destined to mothers who smokeduring pregnancy weigh 150-300 gram not exactly those destined to mothers who don’t smoke and thedanger of little for-gestational age among ladies who smoke is at any rate twice as high as among ladieswho don’t smoke. For more seasoned ladies, the effect of smoking during pregnancy on fetal developmentand preterm conveyance are more noteworthy. The danger of placental issues can be expanded by long haulsmoking.Aim: Effect of cigarette smoking in non-pregnant and pregnant women’s on the blood serum level of vitaminCMaterial and Methods: The present study included 150 subjects of age group 25-35 years. Out which75 werenon-smokers pregnant women as a control group and 75 were smoker pregnant women as a studygroup. During this stage of pregnancy, the vitamin C levels in the maternal serum were colorimetricallydetermined. The respondents also answered a questionnaire about their smoking habits during pregnancy.Vitamin C intake was measured during the third trimester by monitoring food consumption over a 5-dayperiod (including Sunday) and vitamin C registration with dietary supplements.Results: In the present study, we found significant decreased levels of serum vitamin C and in pregnantcigarette smokers as compared to pregnant non-smokers.Vitamin C was protective for placental abruption innonsmokers but not in smokers (P=0.01).Conclusion: If the production of antioxidants (vitamin C) in smokers is lower compared to pregnant womenwho are not smokers, this could aggravate their newborn’s peroxidation problems. Supplementation ofvitamin C tends to be connected with a decrease in placental abruption and preterm birth in pregnant smokers.