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All Journal Herb-Medicine Journal Indian Journal of Forensic Medicine & Toxicology
Riyana Noor Oktaviyanti
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The efficacy of fractional erbium:YAG laser (2940 nm) compared to Microneedling of topical amniotic membrane stem cell conditioned medium (AMSC-CM) for photoaging Cita Rosita Sigit Prakoeswa; Riyana Noor Oktaviyanti; Wisnu Triadi Nugroho; Febrina D Pratiwi; Luh Mas Rusyati; I G A A Praharsini; I G A A Elis Indira
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14694

Abstract

Background: Photoaging is a complex biologic process that affects various layers of the skin. Amnioticmembrane stem cell conditioned medium (AMSC-CM) that contain growth factors and have capability toimprove clinical picture of photoaged skin. Microneedling and laser devices are transdermal drug deliverymethods which shows promising results to improve photoaging .Objective: To investigate the efficacy of topical AMSC-CM after YAG erbium fractional laser compare tomicroneedling in photoaging.Method :A clinical study, 60 adult women with photoaging. Randomized into two groups A 30 womenreceived AMSC-CM after fractional erbium:YAG laser (2940nm) and group B 30 woman received AMSCCM after microneedling. Both groups received the treatment 3 times with 2 weeks interval. The improvementof pore, wrinkle, and UV spot as was evaluate before, after and post treatment using computer-stimulatedphotograph skin analyzer.Result: The evaluation of pore and UV spot showed greater improvement in the group of AMSC-CM withfractional erbium:YAG laser compare to AMSC-CM with microneedling group (pore p:0,00 and UV spotp:0,00). There was no significant different (p 0.43) of wrinkle improvement between both groups.Conclusion: The combination of AMSC-CM and fractional erbium:YAG laser have better efficacy in theimprovement in photoaged skins.
The Effect of Amniotic Membrane Stem Cell Metabolite Product (AMSP-MP) Combine with Vitamin E after Microneedling in Photoaging Progress Cita Rosita Sigit Prakoeswa; Agatha Anindhita Ayu Ardhaninggar; Riyana Noor Oktaviyanti; Irmadita Citrashanty; Maylita Sari; Menul Ayu Umborowati; Dwi Murtiastutik
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14695

Abstract

Introduction: The photoaging is a cumulative process. Amniotic Membrane Stem Cell Metabolite Products(AMSC-MP) that contain cytokines and growth factors that have a role in the skin’s rejuvenation process.Vitamin E is an antioxidant that has a photoprotective effect. Topical combination of AMSC-MP and VitaminE are expected to have an effect on clinical photoaging improvement.Objective: To evaluate the effect of topical combination of AMSC-MP with vitamin E after microneedlingcompared with AMSC metabolite products after microneedling.Methods: A total 60 photoaging women were included in this experimental analytic, controlled, matchingresearch. Each participant’s face was allocated to topical combination of AMSC-MP and vitamin E inintervention group and AMSC-MP only in control group. Microneedling modality was use to enhanceepidermal penetration. Three treatment sessions were repeated at two weeks’ interval.Results: From the comparison of the two groups showed there were significant different of mean value inwrinkle, skin tone and UV spots with p-value < 0,005 in the intervention grup. While pore and polarized spotdo not show significant differences between two groups.Conclusion: The administration of a topical combination of MP-AMSC and vitamin E after microneedlingprovides clinical improvement in photoaging.
Giant Condyloma Accuminata in Pregnancy, Use of Trichloroacetic Acid combined with electrocauterization and excision Procedure: A Case Report Putri Cinthya Ismihari; Riyana Noor Oktaviyanti
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 4, No 3 (2021): Herb-Medicine Journal Juli 2021
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v4i3.10252

Abstract

Condyloma acuminata is a sexually transmitted disease caused by the Human Papilloma Virus (HPV). During pregnancy, condyloma acuminata can proliferate rapidly due to changes in immunity and increased blood supply. One of the safest therapeutic modalities is trichloroacetic acid (TCA). Electrocautery is another modality in pregnant patients.  A 16-year-old woman, 6-months pregnant, complained of a wart-like lump in the pubic area getting more prominent since the last two weeks and covering the vagina surface. The lump is not itchy and painless. From history-taking it was found that patient often changes partners. On physical examination, the lesions were multiple papules with a verrucous surface. The results of the work-up showed a positive acetowhite test. Patients are then treated with a TCA of 80-90% during pregnancy and followed by electrocautery and excision during cesarean section. The results of 80-90% TCA treatment followed by electrocautery and excision were satisfactory, and there were no recurrences when the patient went for a follow-up. TCA is a substance that is caustic and can erode skin and mucous membranes. TCA works by coagulation of proteins which causes dryness of cells and tissues. TCA is safe for pregnant women. Combination of TCA 80-90% with electrocautery and excision, in this case, proved to be effective with no sign of recurrence. The combination of TCA therapy with electrocautery and excision has proven effective and safe for pregnant patients.
Co-Authors Agatha Anindhita Ayu Ardhaninggar Cita Rosita Sigit Prakoeswa Dwi Murtiastutik Febrina D Pratiwi I Gusti Ayu Agung Elis Indira I Gusti Ayu Agung Praharsini Irmadita Citrashanty Luh Made Mas Rusyati Maylita Sari Menul Ayu Umborowati Putri Cinthya Ismihari Wisnu Triadi Nugroho