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Journal : Medula

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Pengaruh Bawang Putih Tunggal (Allium Sativum L) pada Aterosklerosis Angie Carolyn; agustyas tjiptaningrum; anggraini janar wulan
Medula Vol 11 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i4.301

Abstract

Atherosclerosis is characterized by changes in the size of arteries caused by the formation of atherosclerosis plaques consisting of necrosis cells, calcified areas, modified lipid accumulation, smooth muscle cells, endothelial cells, leukocytes, and foam cells. Coronary Artery Disease and stroke are the main clinical manifestations of atherosclerosis. One of the causes of aeroskelrosis is consuming too much food that contains high fat. The interaction between oxidized LDL and the walls of blood vessels, can cause endothelium dysfunction. In addition, oxidized LDL stimulates the formation of lipid peroxide free radicals, makes mononuclear cells (monocytes) differentiate into macrophages, then begins inflammation by removing pro-inflammatory cytokines. Single Clove Garlic (SGC) is a tropical plant found in Indonesia and is often used as an herbal remedy. Single Clove Garlic is a variation of garlic that is formed accidentally, due to extreme conditions. This type of onion contains Alliin (411.4 mg/mL), Allicin (268.2 mg/mL) and ajoene which makes it have a higher antioxidant capacity than regular garlic.  The use of SGC as quoted is considered to be beneficial for the cardiovascular system.
PERBEDAAN KADAR ASAM URAT TIKUS PUTIH (Rattus norvegicus) SETELAH PEMBERIAN KACANG TANAH (Arachis hypogaea L.) Nabila Nuranjumi; agustyas tjiptaningrum; sofyan musyabiq; hanna mutiara
Medula Vol 12 No 2 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i2.412

Abstract

The excessive uric acid levels in the body can increase the risk of hyperuricemia. The formation of uric acid starts from the synthesis of purines which produce inosine, adenine and guanine monophospate that will be degraded into uric acid. Peanuts contain purines so if it is consumed in excess, it can increase blood uric acid levels. To know the difference in the average blood uric acid levels of rats given peanuts at a dose of 1gr/200grBB, 2gr/200grBB, 4gr/200grBB and not given peanuts. This research used experimental research with post test control group design approach. The sample in this research used 28 rats that divided into 4 groups; K1 were only given standard feed, P1 were given 1gr / 200grBB peanuts, P2 were given 2gr/200grBB peanuts and P3 were given 4gr/200grBB peanuts in everyday for 28 days. Then measuring the blood uric acid levels of rats. The average blood uric acid level of rats before intervention (K1) is 3,28mg/dl, and after intervention is 3,87mg/dl (P1), 4,20mg/dl (P2) and 5,03mg/dl (P3). There is a significant difference between P2 and K1 (p=0,005 ), P3 and K1 (p=0,000 ). There is no a significant difference between P1 and K1 (p=0,130 ). There is a significant difference in the average blood uric acid level of rats given peanuts at a dose of 2gr/200grBB, 4gr/200grBB and not given peanuts. There is no significant difference in the average blood uric acid level of rats given peanuts at a dose of 1gr/200grBB and not given peanuts.
Gambaran Profil Lipid Pasien Infark Miokardium Akut di RSUD DR. H. Abdul Moeloek Lampung tahun 2021 Kevin Jeremia Purba; agustyas tjiptaningrum; syazili mustofa
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.573

Abstract

Acute myocardial infarction (AMI) is a condition in which the myocardium or heart muscle necrotizes as a result of a sudden lack of oxygen in the heart caused by atherosclerosis as the result of embolism or total thrombus. The risk factor of the disease is Dyslipidemia, characterized by disturbed lipid profiles such as decreasing of high density lipoprotein (HDL), increasing of low density lipoprotein (LDL), total cholesterol, and triglycerides. This study is usefull for understanding and describing the lipid profile in AMI patients at RSUD DR. H. Abdul Moeloek Lampung Province in 2021. This descriptive study used a cross-sectional research design and was conducted in the Medical Records section of RSUD DR. H. Abdul Moeloek Lampung Province. The results of this study showed that the dominant sex group was male with a total of 50 (79.4%) people. The dominant age group is the 56-65 year age group with a total of 27 (42.9%) people. The largest group of occupation were farmers with 11 (17.5%) people. The group with the most HDL cholesterol level was in the low limit (<40 mg/dl) as many as 31 (49.2%) people. The group with the highest LDL cholesterol level was in the optimal category (<100 mg/dl) of 24 (38.1%) people. The group with the highest triglyceride level was in the optimal category (<150 mg/dl) with a total of 38 (60.3%) people. The group with the highest total cholesterol level was in the optimal category (<200 mg/dl) with 41 people (65.1%). The group with the highest LDL/HDL cholesterol ratio was in the low category (<44) with 56 people.
Distribusi dan Situasi Vaksinasi COVID-19 Letifa Rahmadani; rasmi zakiah oktarlina; agustyas tjiptaningrum
Medula Vol 13 No 2 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i2.618

Abstract

Developing a safe and effective COVID-19 vaccine and getting it into people's hands is a global priority that can bring hope for ending the COVID-19 pandemic. However, the application of this vaccine can differ between countries. This study takes a close look at vaccination policies, vaccination plans, and their implementation in Indonesia which may be relevant to other developing countries. Supply constraints are one of the problems faced by developing countries, including Indonesia, especially at the beginning of the vaccination period due to relatively low coverage of vaccination plans. Limited supply from producers is one of the biggest challenges in the initial vaccination period. The plan to procure early vaccinations in Indonesia will allow Indonesia to obtain more vaccine supplies over time to cover sufficient populations to acquire immunity. Apart from the importance of vaccination distribution, the willingness of individuals to receive the COVID-19 vaccine is a major challenge in many countries. However, the demand for a COVID-19 vaccine is relatively high among the world's general population. However, skepticism is a major obstacle to efforts to control the current pandemic. To promote the equitable distribution of vaccines, it is necessary to ensure that levels of price, access and acceptance are independent of available resources among individuals and countries. This can be achieved by raising awareness about the health-protective impact of vaccines among all citizens. The issue of vaccine distribution has become critical and a significant challenge in dealing with COVID-19, a global epidemic that has turned into a national disaster. Therefore, this must be addressed immediately because it can directly increase cases of COVID-19. This literature review discusses the distribution of vaccines and the problems encountered during the process.
Co-Authors anggraini janar wulan Angie Carolyn Dian Isti Angraini hanna mutiara Intanri Kurniati Kevin Jeremia Purba Letifa Rahmadani Letifa Rahmadani Nabila Nuranjumi Novita Carolia Rasmi Zakiah Oktarlina Sofyan Musyabiq Wijaya Sri Hasnawati Syazili Mustofa