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All Journal Althea Medical Journal Jurnal Online Mahasiswa (JOM) Bidang Keguruan dan Ilmu Pendidikan Indonesian Journal of Rheumatology Medica Hospitalia Al-Mubin: Islamic Scientific Journal JURNAL PENGABDIAN MASYARAKAT AKADEMISI
Syarief Hidayat
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Religion Humanities Dentistry Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Althea Medical Journal

 1 
Relation between Preinfarction Angina and Coronary Collateral Circulation in Patients with Acute Myocardial Infarction Achmad Shidiq; Syarief Hidayat; Januarsih Iwan Rachman
Althea Medical Journal Vol 3, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Coronary collateral circulation conduits an alternative blood flow to the ischemic myocardium in the setting of coronary artery occlusion which can prevent the infarction area to extend more widely. Well-developed coronary collaterals are closely related with the presence of preinfarction angina. However, the duration of preinfarction angina which can induce well-developed coronary collateralization is in controversy. The aim of this study was to evaluate the relation between duration of preinfarction angina and coronary collaterals circulation in patients with acute myocardial infarction.Methods: This cross-sectional study was conducted from May to November 2013 in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. Seventy three acute myocardial infarction (AMI) patients were included in the study. The patients were divided into Group 1 (<7 days) and Group 2 (≥7 days) based on their preinfarction angina history. The coronary collaterals were assesed and graded as good (Rentrop score 2−3) and poor (Rentrop score 0−1).Statistical analysis was performed using the chi-square test.Result: The presence of a well-developed coronary collateral was not significantly different in <7days than ≥7 days duration of preinfarction angina [50.8% v 75.0%, p=0.124].Conclusions: There is no relation between the duration of preinfarction angina and coronary collaterals circulation in patients with acute myocardial infarction. [AMJ.2016;3(1):28–33]DOI: 10.15850/amj.v3n1.709
Durian Consumption Effect on the Plasma Malondialdehyde Level as Biomarker of Stress Oxidative in Rats Anugrah Aulia Ulil Amri; Ani Melani Maskoen; Syarief Hidayat
Althea Medical Journal Vol 3, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Background: Excessive consumption of durian (Durio zibethinus Murray) in Indonesia is often connected with its effect on health. This study aims to understand the effect of durian consumption to malondialdehyde (MDA) in plasma as oxidative stress biomarker.Methods: The study used an experimental research design on animal models, in the Biochemistry and Molecular Biology Department, Faculty of Medicine, Universitas Indonesia, July–August 2012. Thirty two Sprague-Dawley rats were used, divided into four groups: control, treatment week 1, 2, and 3. Each treatment group was given 20 gram durian fruit diluted with water until 20 ml volume per oral, divided into two doses (10 ml each) with 4 hours interlude between doses for 1 week, 2 weeks, and 3 weeks. All groups got normal diet and water ad libitum. Plasma MDA level was measured by TBARS method, then analyzed using Kurskal-Wallis and Mann-Whitney tests.Results: Seventeen samples were successfully decapitated (5 for control; 6 for week 1; 3 for week 2; 3 for week 3). Average plasma MDA level for control treatment week 1, 2 and 3 groups were 0.707 nmol/ml, 0.432 nmol/ml, 0.312 nmol/ml, and 0.746 nmol/ml respectively. Data was significant (p<0.05) with p=0.02. Compared with control group, a significant increase occurred in week 1 and 2 groups with p=0.028 and p=0.025 respectively.Conclusions: Results of durian consumption show MDA level significantly decreases in week 1 and 2. However, MDA level dramatically increases exceeding control group level in week 3. [AMJ.2016;3(1):22–8] DOI: 10.15850/amj.v3n1.695
Coronary Risk Factors and Collateral Circulation in Acute Myocardial Infarction Sheila Sumargo; Julius B. Dewanto; Syarief Hidayat
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Coronary arterial stenosis, the major cause of acute myocardial infarction (AMI), induces shear stress to surrounding arteriolar endothelium. This stimulates changes in endothelial cells, smooth muscle cells and fibroblast to create collaterals that can provide alternative blood flow to the jeopardized myocardial area. However, coronary collateralization is various among AMI patients. The aim of this study was to analyze the correlation between coronary risk factors and collateral sirculation in AMI patients.Methods: A retrospective cross-sectional study was carried out to 148 medical records of hospitalized AMI patients in Dr. Hasan Sadikin General Hospital Bandung, Indonesia. All patients were assessed for coronary collateral circulation which were graded as good (Rentrop score 2–3) and poor (Rentrop score 0–1). Risk factors noted in this study were age group, sex, hypertension, diabetes mellitus and diagnosis (ST-segment Elevation Myocardial Infarction (STEMI) or Non STEMI (NSTEMI)) according to the medical record data. Results: Hypertension was found to be associated with the presence of good coronary collateral circulation (p=0.02, PR=1.410 [95% CI 1.030-1.930]). Sex, age group, diabetes mellitus and STEMI or NSTEMI diagnosis were not statistically significant.Conclusions: Hypertension was the only coronary risk factor associated to the presence of well-developed coronary collaterals. The increase of myocardial oxygen demand and flow of collateral feeding coronary artery in the setting of hypertension may contribute to the results.  DOI: 10.15850/amj.v2n4.688
Co-Authors Achmad Shidiq Andri Reza Rahmadi Ani Melani Maskoen Anisa Putri Maharani Anugrah Aulia Ulil Amri Daeng Ayub Iola Riris Simanjuntak Januarsih Iwan Rachman Julius B. Dewanto Laniyati Hamijoyo M. Arief Safi'i Paulus Anam Ong Putri Kurnia Sari Said Suhil Achmad Sheila Sumargo Solly Aryza