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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Mutiara Medika: Jurnal Kedokteran dan Kesehatan Biomedika The Indonesian Biomedical Journal Medical Laboratory Technology Journal Jurnal Gizi Klinik Indonesia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of Community Empowerment for Health Journal of Informatics, Information System, Software Engineering and Applications (INISTA) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Tri Ratnaningsih
Clinical Pathology Departement, Medicine Public Health And Nursing Faculty, Universitas Gadjah Mada
Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Journal of Community Empowerment for Health

 1 
Pengkayaan ilmu petugas puskesmas sebagai langkah penurunan angka anemia di Kabupaten Sleman Emy Huriyati; Tri Ratnaningsih; Abdul Wahab; Arta Farmawati; Nur Imma Fatimah Harahap; Ainun Nisa
Journal of Community Empowerment for Health Vol 1, No 1 (2018)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (405.688 KB) | DOI: 10.22146/jcoemph.38560

Abstract

ABSTRAK Fokus Dinas Kesehatan Kabupaten Sleman untuk penanggulangan anemia dewasa ini bukan hanya pada ibu hamil saja, melainkan sudah dimulai dari remaja puteri, jauh sebelum mereka hamil. Langkah pemerintah dalam menanggulangi anemia dengan adanya suplementasi besi dikhawatirkan tidak tepat sasaran. Sejauh ini deteksi anemia oleh petugas puskesmas hanya sebatas pemeriksaan haemoglobin saja dan kejadian anemia yang terdeteksi masih bersifat general, tidak spesifik anemia defisiensi besi. Subjek dalam kegiatan ini adalah petugas puskesmas meliputi dokter, ahli gizi dan ahli teknologi laboratorium medis yang diambil secara purposive sampling. Metode yang diterapkan dalam kegiatan ini adalah pelatihan dengan rangkaian kegiatan yaitu penyuluhan dengan pre-test dan post-test, tutorial kasus, dan praktikum. Analisis data hasil kegiatan menggunakan uji paired t-test antara nilai pre-test dan post-test. Uji statistik dikatakan signifikan bila p-value kurang dari 0,05. Total peserta yang mengikuti kegiatan adalah 71 orang dari target awal 75 orang (persentase kedatangan= 94,67%). Pelatihan terkait anemia defisiensi besi untuk petugas puskesmas dapat meningkatkan tingkat pemahaman sebesar 32,82 poin (p<0,0001), yang merupakan delta kenaikan nilai pre-test dan post-test. Pemilihan metode untuk kegiatan pelatihan dirasa sudah tepat dengan pertimbangan hasil evaluasi kegiatan menunjukkan sebagian besar peserta kegiatan menilai metode pelatihan efektif atau sangat efektif (74,7%). Program pelatihan dapat meningkatkan pemahaman petugas puskesmas di Kabupaten Sleman terkait anemia defisiensi besi.KATA KUNCI pelatihan; puskesmas; pengetahuan; anemia defisiensi besi ABSTRACT The focus of the Sleman District Health Office in the prevention of anemia is not only on pregnant women anymore as it currently involves young women, long before they become pregnant. The government's step in overcoming anemia with iron supplementation is argued to fail to hit the target. So far the detection of anemia by health center officials is only limited to hemoglobin examination, indicating that the detection of anemia is still general and not specific to iron deficiency anemia. The subjects of this study were community health center staffs including doctors, nutritionists and medical laboratory technology experts who were picked by purposive sampling. The methods used were training with a series of activities: education with pre-test and post-test, case tutorials, and practicum. Paired t-test was performed to compare the difference of value between pre-test and post-test. P-value of less than 0.05 was considered statistically significant. The total participants who took part in the activity were 71 people from the initial target of 75 people (percentage of arrivals = 94.67%). Training related to iron deficiency anemia for health center officers can increase the level of understanding by 32.82 points (p <0,0001). The methods chosen for training activities were considered appropriate with around three-quarters (74,7%) of the participants rated the training method effective or very effective. The training program can improve the understanding of health center staff in Sleman Regency regarding iron deficiency anemia.KEYWORDS training; community health center; knowledge; iron deficiency anemia 
Evaluasi HbA1c, hs-CRP, dan indeks massa tubuh pada populasi sehat: Sebuah studi komunitas Arum Tri Wahyuningsih; Fuad Anshori; Elizabeth Henny Herningtyas; Tri Ratnaningsih
Journal of Community Empowerment for Health Vol 2, No 2 (2019)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.52 KB) | DOI: 10.22146/jcoemph.44003

Abstract

Insulin resistance as a cause of type 2 diabetes mellitus is associated with subclinical inflammatory processes. Insulin resistance with obesity, hypertension, and dyslipidemia contribute to metabolic syndrome that increased risk of cardiovascular disease. High sensitivity C-reactive protein (hs-CRP) is an inflammatory marker that is thought to be associated with both type 2 diabetes mellitus and cardiovascular disease. This study evaluated hs-CRP, HbA1c, and body mass index in a healthy community. This cross-sectional study is an observational analytic study evaluating the association between hs-CRP, HbA1c, and body mass index. The research subjects were all healthy on a community gathering in community service programs, and if there were any signs or symptoms of infection or inflammation, they would be excluded. Measurements of hs-CRP and HbA1c were carried out using the HPLC and ELISA methods, respectively. The measurement results were analyzed to evaluate the characteristics of the subject and assess the relationship between the parameters studied with different mean and correlation tests. In 25 subjects involved, it was found that 96% had an HbA1c value of <6.5% with a normal body mass index of 15 subjects (60%), and the rest were in the category of overweight. The median hs-CRP level was 2.99 mg / L (0.81-13.74 mg / L), with a low heart risk category of only 4% of all study subjects. There was no correlation between hs-CRP with HbA1c (r = 0.35; p = 0.868) and body mass index (r = 0.37; p = 0.069). Only one subject was included in the diabetes diagnostic criteria, but 96% of the study population had hs-CRP, which was included in the medium-risk and high-risk category for heart disease. There was no association between hs-CRP and HbA1c and body mass index in healthy populations in this community.
Genetic polymorphism of ALDH2 linkage to kidney function status of East Nusa Tenggara alcohol drinkers and cigarette smokers Busyra Busyra; Yudha Nurhantari; Suhartini Suhartini; Maria Agnes Etty Dedy; Tri Ratnaningsih
Journal of Community Empowerment for Health Vol 4, No 2 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.61559

Abstract

Chronic kidney disease is a preventable high-burden disease. Several risk factors for impaired kidney function have been identified, including lifestyles, such as alcohol drinking and cigarette smoking. However, the evidence remains inconsistent. East Nusa Tenggara has the largest proportion of heavy alcohol drinking among all provinces in Indonesia. Genetic polymorphism of aldehyde dehydrogenase 2 (ALDH2) is related to alcohol drinking behavior through the inactivity of the ALDH2 enzyme, which leads to toxic acetaldehyde accumulation. This study aims to recognize the linkage of ALDH2 genotypes to kidney function among alcohol drinkers and cigarette smokers in East Nusa Tenggara. This study was a cross-sectional study of East Nusa Tenggara ethnicity, aged 18-60 years old. Demographic and lifestyle data were obtained via a questionnaire. DNA analysis was conducted with the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Creatinine and BUN levels were measured with a chemistry analyzer. Afterward, the estimated glomerular filtration rate (eGFR) was calculated from creatinine value using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. The association between kidney function status and alcohol drinking and cigarette smoking habits were analyzed using the chi-square test, then stratified based on genotype groups. Fifty-one subjects were included in this study, while the mean age was 26.33±1.33 years and the median age was 22 years. There were 37 (72.5%) alcohol drinkers and 14 (27.5%) non-drinkers; 28 (54,9%) cigarette smokers and 23 (45.1%) non-smokers. This study revealed no significant association between kidney function status and alcohol drinking habits. Cigarette smoking habits were inversely associated with eGFR decline and creatinine elevation in wild-type ALDH2 groups.
Alcohol dehydrogenase 1C (ADH1C) polymorphism is significantly associated with kidney function status in Nusa Tenggara Timur ethnicity: A cross-sectional study Budiatri Retno Noormaningrum; Yudha Nurhantari; Suhartini Suhartini; Tri Ratnaningsih; Maria Agnes Etty Dedy
Journal of Community Empowerment for Health Vol 4, No 3 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.61561

Abstract

Excessive alcohol consumption is harmful to many human organs, but the association with kidney function is still controversial. The disagreement in findings might be caused by ADH1C polymorphism's influence on alcohol metabolism rate. This study aims to determine the correlation between ADH1C polymorphism and kidney function status in Nusa Tenggara Timur (NTT) ethnicity, a population with highly prevalent alcohol consumption in Indonesia. We conducted a cross-sectional study of 76 subjects, who are natives of NTT, Indonesia. The genotyping of extracted DNA for ADH1C was done by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using restriction endonuclease SspI. Kidney function status was defined by serum urea level and estimated glomerular filtration rate (eGFR) that had been categorized according to percentiles. The correlation with the ADH1C allele was analyzed using chi-square tests. The genotype of ADH1C in NTT ethnicity was ADH1C*1/*2 (51.3%), ADH1C*2/*2 (47.4%), and ADH1C*1/*1 (1.3%). The results showed that the population had the ADH1C*2 (73.03%) and the ADH1C*1 (26.97%) allele. There was a significant association between ADH1C polymorphism and eGFR among NTT ethnicity (p=0.005) when eGFR was analyzed at the 25th percentile (74.75 mL/minute/1.73m2). However, we found no associations when eGFR was analyzed at 50th (p=0.571) and 75th (p=0.335) percentiles. The odds ratio shows that having the ADH1C*1/*2 genotype escalates the probability of declining eGFR 6.620 times compared to ADH1C*2/*2 (95% CI: 1.539-28.478), after adjusted for smoking behavior. We found no association between ADH1C polymorphism and serum urea level (p=0.123, 0.421, and 0.335). The majority of NTT ethnicity have the ADH1C*1/*2 genotype. Populations with ADH1C*1/*2 have higher odds ratio for eGFR below 74.75 mL/minute/1.73m2 than those with ADH1C*2/*2 genotype. There was no association between ADH1C polymorphism and serum urea levels.
Co-Authors . Suhartini Abdul Wahab Adika Zhulhi Arjana Ainun Nisa Aji Bagus Widyantara Arta Farmawati Arum Tri Wahyuningsih Bambang Sasangka Budi Mulyono Budiatri Retno Noormaningrum Busyra Busyra Dea Noviana Pramantik Desin Pambudi Sejahtera Dyah Aruming Tyas Elizabeth Henny Herningtyas Emy Huriyati Fuad Anshori Indarwati Setyaningsih Ismail Setyopranoto Maria Agnes Etty Dedy Maria Agnes Etty Dedy marsa, mardhatillah Nasution, Annio Indah Lestari Nur Imma Fatimah Harahap Purbosari Purbosari Rahmat Dani Satria Setyawati Setyawati Sri Sutarni Suhartini Suhartini Suhartini Suhartini Teguh Triyono Teguh Triyono Usi Sukorini Wirimena Hurimah Yudha Nurhantari