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PENGARUH SEDUHAN RIMPANG KUNYIT KUNING (Curcuma longa Linn.) TERHADAP PEMAHAMAN BACAAN Nathaniel Nickander Pramuditha Pekasa; Fen Tih; Julia Windy Gunadi
JURNAL ILMU FAAL OLAHRAGA INDONESIA Vol 4, No 1 (2021)
Publisher : PAIFORI

Increasing globalization makes humans need the knowledge to compete globally. One way to increase knowledge is by reading. Reading comprehension is the process of interpreting a reading in order to gain a thorough knowledge of the passage. Therefore it is necessary to consume beverages to improve energy and cognitive function. In this study, the researcher used yellow turmeric rhizome steeping as an enhancer of cognitive function. The objective of this research was to determine the effect of consuming yellow turmeric rhizome steeping on the cognitive function which is reading comprehension. This study was quasi-experimental, comparative using pretest and post-test design, conducted on 30 men aged between 18-22 years. Participants were asked to do a reading comprehension test (pretest) than consume 200 cc of water mixed with 10 grams of yellow turmeric rhizome powder. Participants took rest for 90 minutes and asked to do a reading comprehension test (post-test). The measured data was the reading comprehension test score, in the form of a correct answer of 10 questions. Data were analyzed using Wilcoxon Signed Rank Test. The average score of correct answers increased very significantly, before consuming yellow turmeric steeping was 47,33 to 73,33 after consuming yellow turmeric rhizome steeping with p < 0,001. Therefore yellow turmeric rhizome steeping increases reading comprehension.

Effect of Methanolic Extract in Ointment and Powder of Kalanchoe Pinnata (Lamk) Leaf in Ointment towards Incision Wound Healing in Mice Adi K Suprapto; Fen Tih; Endang Evacuasiany
Journal of Medicine and Health Vol. 1 No. 1 (2015)
Publisher : Universitas Kristen Maranatha

Wound is a very common thing that can happen to all people around the world. The purpose of this study is to investigate the effect of methanolic extract and powder of Kalanchoe pinnata (Lamk) leaf in ointment. The methodology is laboratoric experimental design. Six groups of mice (n=30) were incised for 8 mm and treated with different treatment: methanolic extract of Kalanchoe pinnata (Lamk) leaves in ointment (SEMDSB) 10%, SEMDSB 20%, Kalanchoe pinnata (Lamk) leaves powder in ointment (SSDSB) 10%, SSDSB 20%, vaseline album (ointment) as negative control, andÂ povidone iodine ointment as positive control. Examination is carried out by measuring the width of wounds in mice every day until the wound interlocked. Data analysis used one way ANOVA continued by Tukey HSD with Î±=0,05. The result showed the average time for wound healing (in days) are: SEMDSB 10% (7.2), SEMDSB 20% (6.6), SSDSB 10% (8.8), SSDSB 20% (7.6), negative control (10.6), and positive control (7.8). SEMDSB 10%, SEMDSB 20%, and SSDSB 20% showed highly significant difference (p = 0,000) and SSDSB 10% showed significant difference (p=0,021) when compared to negative control. As conclusion, methanolic extractÂ and powder of Kalanchoe pinnata (Lamk) leaves in ointment can accelerate wound healing time.Â Keywords: ointment, Kalanchoe pinnata (Lamk), wound healing, mice

Black Chocolate Consumption Reduces Subjective Symptoms in 18-22 Years Old Females with Premenstrual Syndrome Eliza Nurazizah; Fen Tih; Winny Suwindere
Journal of Medicine and Health Vol. 1 No. 1 (2015)
Publisher : Universitas Kristen Maranatha

Menstruation is the release of the endometrium with bleeding every month, except during pregnancy. Before or during menstruation, a woman may experience stiffness or abdominal cramps, mood fluctuations and other physical and psychological disorders, which is termed as premenstrual syndrome (PMS). The aim of this research is to observe and value the effect of dark chocolate on clinical symptoms of PMS. This research is an experimental prospective, using experimental design with one group pre and post test. Subjects were 30 women aged 18-22 years. Every day for 2 weeks before menstruation period, subjects took 20 gram of dark chocolate, then were asked to answer questionaire. The data measured is the score as well as individual PMS symptoms before and after eating dark chocolate, was analyzed using a nonparametric Wilcoxon test, followed by McNemar chi square with Î±=0.05. A highly significant decrease was found in anxiety symptoms, whereas statistically significant reduction was found in fatigue or feeling tired, cramps abdominal, bloating, diarrhea, headache, back pain, change in appetite, muscle or joint pain, and problems in concentration. But the symptom of acne complaint was increased from 73.3% to 76.7%. Consumption of dark chocolate reduces premenstrual syndrome scores on women aged 18-22 years.Â Keywords: dark chocolate, premenstrual syndrome

Cytotoxic Activity of Red Fruit (Pandanus conoideus Lam.) Oil and Its Effect On Cyclooxygenase-2 Gene Expression in Raji Cells Fen Tih
Journal of Medicine and Health Vol. 1 No. 3 (2016)
Publisher : Universitas Kristen Maranatha

The number of cancer patient is increasing, while a really effective therapy has not yet been discovered. One concept of carcinogenesis is the relation between chronic inflammation and cancer. Cyclooxygenase-2 (COX-2) has a carcinogenic effect in inflamed and malignant tissues. Red Fruit contains carotenoid that can suppress COX-2 gene expression and tocopherol, which is a potent inhibitor ofÂ COX-2.Â The purpose of this study is to determine cytotoxic activity of Red Fruit oil and its effect on COX-2 gene expression. The experiment used 5 dosages of Red Fruit, 100, 200, 300, 400, and 500 Âµg/mL, exposed to Raji cells. However, unexposed Raji cells were used as control. Cytotoxic activities were evaluated by MTT Assay, while Lethal Concentration50 (LC50) was determined through regression-correlation analysis. Red Fruit oil effect on COX-2 gene expression was evaluated by Reversed Transcriptase Chain Reaction (RT-PCR) method and electrophoresis. Electrophoresis bands were analyzed by Scion Image for Windows. Optical Integrated Density (OID) of unexposed and exposed groups were statistically analyzed with one way Analysis of Variance (ANOVA), followed by Duncan test with Î±=0.05. The results showed that Red Fruit had a cytotoxic activity on Raji cells with LC50 of331.42 Âµg/mL. Red Fruit suppressed COX-2 gene expression with an effective dosage obtained at 500 Âµg/mL.Â Â Â Â Â Â Â Â Â Keywords: red fruit, cytotoxicity, cox-2 gene expression, raji cells

Antiinflammatory Effect of Andrographolide in Sambiloto Extract (Andrographis paniculata) on Ulcerative Colitis Selonan Susang Obeng; Daniel Welson; Fen Tih; Ardo Sanjaya; Diana Krisanti Jasaputra; Julia Windi Gunadi; Yusuf, Inez Felia
Keluwih: Jurnal Kesehatan dan Kedokteran Vol. 4 No. 2 (2023): Keluwih: Jurnal Kesehatan dan Kedokteran (June)
Publisher : Direktorat Penerbitan dan Publikasi Ilmiah, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/kesdok.V4i2.5909

Abstract—Ulcerative colitis (UC) is an idiopathic chronic inflammatory disease of the gastrointestinal tract which is one of the inflammatory bowel diseases (IBD). In Indonesia, epidemiological data obtained from hospital reports, generally show that the incidence of UC is higher than Crohn's Disease (CD). Mesalamine as a drug of choice for UC, is related to some side effects. Therefore, herbal plants such as sambiloto (Andrographis paniculata) could be used as a complementary therapy in UC. The purpose of this article is to provide information about the potential mechanisms of andrographolide (AG) as a bioactive compound in sambiloto (Andrographis paniculata) extract as an anti-inflammatory agent. The method used by authors in this article is a narrative review method, by collecting studies about the anti-inflammatory effect of AG on UC through a database search. The results showed that one of the ingredients of sambiloto, diterpenoid labdane compound in the active form of AG, is able to inhibit the expression of pro-inflammatory cytokines so that it has the potential to act as an anti-inflammatory similar to mesalamine in UC therapy. Additionally, sambiloto contains flavonoids and polyphenols which serve as antioxidants. In conclusion, AG has an anti-inflammatory property that might be utilized as a part of UC complementary therapy. Keywords: andrographolide, andrographis paniculata, inflammation, ulcerative colitis, sambiloto Abstrak—Kolitis ulseratif (KU) adalah penyakit inflamasi kronis idiopatik saluran pencernaan termasuk dalam salah satu inflammatory bowel disease (IBD). Di Indonesia, data epidemiologi diperoleh dari pelaporan rumah sakit, secara umum menunjukkan insidensi KU lebih tinggi daripada Crohn’s Disease (CD). Mesalamine sebagai pilihan terapi untuk KU, dapat menimbulkan beberapa efek samping. Oleh karena itu, tanaman herbal seperti sambiloto Andrographis paniculata dapat digunakan sebagai terapi komplementer pada KU. Tujuan artikel ini adalah memberikan informasi mengenai potensi dan mekanisme senyawa bioaktif andrographolide (AG) pada ekstrak sambiloto (Andrographis paniculata) sebagai agen antiinflamasi. Metode yang digunakan oleh penulis dalam artikel ini adalah metode narrative review, dengan mengumpulkan beberapa studi tentang efek antiinflamatori dari AG pada KU melalui pencarian database. Hasil dari analisis data menunjukkan bahwa salah satu kandungan sambiloto, senyawa labdane diterpenoid dalam bentuk aktif AG, mampu menghambat ekspresi sitokin proinflamasi sehingga berpotensi sebagai antiinflamasi serupa dengan mesalamin pada terapi KU. Selain itu, sambiloto memiliki kandungan flavonoid dan polifenol yang berfungsi sebagai antioksidan. Sebagai simpulan, AG memiliki properti antiinflammatori yang dapat digunakan sebagai bagian dari terapi komplementer pada KU. Kata kunci: andrographolide, andrographis paniculata, inflamasi, kolitis ulseratif, sambiloto

EFFECT OF ORAL TRIPEPTIDE-COLLAGEN ON MICROCIRCULATION (NAIL FOLDS) AND SKIN WRINKLES Jasaputra, Diana Krisanti; Surjati, Hani; Fen Tih
Berkala Ilmiah Kedokteran Duta Wacana Vol. 9 No. 2 (2024): BERKALA ILMIAH KEDOKTERAN DUTA WACANA
Publisher : Faculty of Medicine Universitas Kristen Duta Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21460/bikdw.v9i2.927

Background: Accelerated aging is associated with increased exposure to reactive oxygen species (ROS), leading to lower collagen and elastin levels in the body. This reduction reduces microvascular activity, causing microcirculatory disorders and skin wrinkles. Administering collagen tripeptides can help improve the microcirculation system. Objective: This study aims to investigate the effects of collagen tripeptide on improving microcirculation, reducing skin wrinkles, and lowering excessive ROS toxicity. Method: The research method used is experimental with a pre-post study approach without using a control group and descriptive quantitative data analysis. We measured microcirculation using a microscope, quantified ROS levels with the QYM-DI microscope, and assessed nasolabial fold depth with an acupuncture needle. Results: The study results indicate that collagen tripeptide significantly improves microcirculation, reduces skin wrinkles, and decreases excessive ROS toxicity. The non-parametric Wilcoxon test results are as follows: (1) there is a significant difference before and after collagen tripeptide consumption in terms of microcirculation improvement (p = 0.000), reduction of skin wrinkles on the nasolabial folds (p = 0.008), and reduction of ROS (p = 0.000). This improves microcirculation, which in turn reduces skin wrinkles on the nasolabial folds. Conclusion: Consuming collagen tripeptide for three months can improve microcirculation, reduce skin wrinkles on the nasolabial folds, and reduces ROS.

Effect of Methanolic Extract in Ointment and Powder of Kalanchoe Pinnata (Lamk) Leaf in Ointment towards Incision Wound Healing in Mice Adi K Suprapto; Fen Tih; Endang Evacuasiany
Journal of Medicine and Health Vol 1 No 1 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i1.495

Wound is a very common thing that can happen to all people around the world. The purpose of this study is to investigate the effect of methanolic extract and powder of Kalanchoe pinnata (Lamk) leaf in ointment. The methodology is laboratoric experimental design. Six groups of mice (n=30) were incised for 8 mm and treated with different treatment: methanolic extract of Kalanchoe pinnata (Lamk) leaves in ointment (SEMDSB) 10%, SEMDSB 20%, Kalanchoe pinnata (Lamk) leaves powder in ointment (SSDSB) 10%, SSDSB 20%, vaseline album (ointment) as negative control, andÂ povidone iodine ointment as positive control. Examination is carried out by measuring the width of wounds in mice every day until the wound interlocked. Data analysis used one way ANOVA continued by Tukey HSD with Î±=0,05. The result showed the average time for wound healing (in days) are: SEMDSB 10% (7.2), SEMDSB 20% (6.6), SSDSB 10% (8.8), SSDSB 20% (7.6), negative control (10.6), and positive control (7.8). SEMDSB 10%, SEMDSB 20%, and SSDSB 20% showed highly significant difference (p = 0,000) and SSDSB 10% showed significant difference (p=0,021) when compared to negative control. As conclusion, methanolic extractÂ and powder of Kalanchoe pinnata (Lamk) leaves in ointment can accelerate wound healing time.Â Keywords: ointment, Kalanchoe pinnata (Lamk), wound healing, mice

Black Chocolate Consumption Reduces Subjective Symptoms in 18-22 Years Old Females with Premenstrual Syndrome Eliza Nurazizah; Fen Tih; Winny Suwindere
Journal of Medicine and Health Vol 1 No 1 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i1.502

Menstruation is the release of the endometrium with bleeding every month, except during pregnancy. Before or during menstruation, a woman may experience stiffness or abdominal cramps, mood fluctuations and other physical and psychological disorders, which is termed as premenstrual syndrome (PMS). The aim of this research is to observe and value the effect of dark chocolate on clinical symptoms of PMS. This research is an experimental prospective, using experimental design with one group pre and post test. Subjects were 30 women aged 18-22 years. Every day for 2 weeks before menstruation period, subjects took 20 gram of dark chocolate, then were asked to answer questionaire. The data measured is the score as well as individual PMS symptoms before and after eating dark chocolate, was analyzed using a nonparametric Wilcoxon test, followed by McNemar chi square with Î±=0.05. A highly significant decrease was found in anxiety symptoms, whereas statistically significant reduction was found in fatigue or feeling tired, cramps abdominal, bloating, diarrhea, headache, back pain, change in appetite, muscle or joint pain, and problems in concentration. But the symptom of acne complaint was increased from 73.3% to 76.7%. Consumption of dark chocolate reduces premenstrual syndrome scores on women aged 18-22 years.Â Keywords: dark chocolate, premenstrual syndrome

Cytotoxic Activity of Red Fruit (Pandanus conoideus Lam.) Oil and Its Effect On Cyclooxygenase-2 Gene Expression in Raji Cells Fen Tih
Journal of Medicine and Health Vol 1 No 3 (2016)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i3.516

The number of cancer patient is increasing, while a really effective therapy has not yet been discovered. One concept of carcinogenesis is the relation between chronic inflammation and cancer. Cyclooxygenase-2 (COX-2) has a carcinogenic effect in inflamed and malignant tissues. Red Fruit contains carotenoid that can suppress COX-2 gene expression and tocopherol, which is a potent inhibitor ofÂ COX-2.Â The purpose of this study is to determine cytotoxic activity of Red Fruit oil and its effect on COX-2 gene expression. The experiment used 5 dosages of Red Fruit, 100, 200, 300, 400, and 500 Âµg/mL, exposed to Raji cells. However, unexposed Raji cells were used as control. Cytotoxic activities were evaluated by MTT Assay, while Lethal Concentration50 (LC50) was determined through regression-correlation analysis. Red Fruit oil effect on COX-2 gene expression was evaluated by Reversed Transcriptase Chain Reaction (RT-PCR) method and electrophoresis. Electrophoresis bands were analyzed by Scion Image for Windows. Optical Integrated Density (OID) of unexposed and exposed groups were statistically analyzed with one way Analysis of Variance (ANOVA), followed by Duncan test with Î±=0.05. The results showed that Red Fruit had a cytotoxic activity on Raji cells with LC50 of331.42 Âµg/mL. Red Fruit suppressed COX-2 gene expression with an effective dosage obtained at 500 Âµg/mL.Â Â Â Â Â Â Â Â Â Keywords: red fruit, cytotoxicity, cox-2 gene expression, raji cells

Effect of Chewing Xylitol Gum on Salivary Volume and Acidity Alfonsa Angwarmase; Fen Tih; Meilinah Hidayat
Journal of Medicine and Health Vol 1 No 5 (2017)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i5.542

Dental caries or tooth decay is a result of the production of acid from fermentation ofbacteria that destroy tooth tissue. It can be prevented by maintaining the stability of salivaryvolume and acidity. Chewing xylitol gum is beneficial for increasing salivary volume andacidity. The aim of the study is to determine the effect of chewing xylitol gum on salivary volumeand acidity. The study is a quasi experiment conducted to 30 males aged between 17-25 yearsold. Pre and post treatmentâ€™s salivary volume are measured with measuring cup. Pre and posttreatmentâ€™s salivary acidity are measured using a pHmeter with 0,1 accuracy. Data areanalyzed with paired â€œtâ€ test (a = 0,05). Average salivary volume after chewing xylitol gumincreased very significantly from 0,26 mL to 13,37mL (p=0,000). Average salivary acidity afterchewing xylitol gum increased very significantyly from 6,47 to 7,36(p=0,000). The researchconcludes that chewing xylitol gum increases salivary volume and acidity.Keywords : dental caries, xylitol, salivary volume, salivary acidity

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