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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences E-Jurnal Medika Udayana Jurnal Kedokteran Brawijaya Jurnal Kesehatan Islam : Islamic Health Journal
Desy Andari
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Medicine & Pharmacology Public Health

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HUBUNGAN ANTARA OVERWEIGHT DENGAN NYERI PUNGGUNG BAWAH DI RSUD KANJURUHAN KEPANJEN PERIODE JANUARI-DESEMBER TAHUN 2013 Nurhiqmah Aisyiah Fitriyani; Febri EBS; Desy Andari
Saintika Medika Vol. 11 No. 1 (2015): Juni 2015
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.v11i1.4194

Abstract

HUBUNGAN ANTARA OVERWEIGHT DENGAN NYERI PUNGGUNG BAWAH DI RSUD KANJURUHAN KEPANJEN PERIODE JANUARI-DESEMBER TAHUN 2013. Latar Belakang: Nyeri punggung bawah merupakan suatu gangguan muskuloskeletal pada daerah punggung bawah yang banyak dikeluhkan penderita yang berkunjung ke dokter. Banyak faktor yang dapat memperberat resiko terjadinya nyeri punggung bawah, salah satunya adalahoverweight. Tujuan Penelitian: Mengetahui hubungan, kuatnya pengaruh dan besarnya factor resiko antara overweight dengan nyeri punggung bawah di RSUD Kanjuruhan Kepanjen periode Januari-Desember tahun 2013. Metode Penelitian: Penelitian observasional analitik dengan pendekatan cross sectional, dengan besar sampel sebanyak 82 orang yaitu 41 penderita nyeri punggung bawah dan 41 orang lainnya penderita non nyeri punggung bawah. Analisis data dengan menggunakan statistik uji chi-square dengan á=0.05 dan uji korelasi koefisien kontingensi. Hasil Penelitian: Menunjukkan bahwa penderita dengan diagnosis nyeri punggung bawah yang datang ke RSUD Kanjuruhan Kepanjen memiliki indeks massa tubuh kategori overweight (30.5%), sedangkan sampel yang overweight tapi non nyeri punggung bawah (13.4%). Kesimpulan: Terdapat hubungan yang signifikan antara overweight dengan nyeri punggung bawah di RSUD Kanjuruhan Kepanjen periode Januari-Desember tahun 2013 (p= 0.002). Overweight memberikan pengaruh yang tidak begitu kuat (lemah) terhadap nyeri punggung bawah (r= 0.325) dan seseorang yang overweight mempunyai resiko yang lebih besar untuk mengalami nyeri punggung bawah (OR= 4.261). Kata Kunci: Overweight, Nyeri punggung bawah
PENGARUH PEMBERIAN EKSTRAK DAUN KELOR (Moringa oleifera lam.) TERHADAP SEL KARDIOMIOSIT PADA TIKUS PUTIH (Rattus novergicus strain wistar) DENGAN DIET ATEROGENIK Cindy Alverina; Desy Andari; Gita Sekar Prihanti
Saintika Medika Vol. 12 No. 1 (2016): JUNI 2016
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.v12i1.5257

Abstract

ABSTRAK Hiperkolesterolemia akan menyebabkan aterosklerosis yang menjadi faktor resiko yang kuat terhadap penyakit kardiovaskular yang ditandai dengan kerusakan kardiomiosit. Penyakit kardiovaskular menjadi salah satu penyebab kematian terbesar pada usia produktif. Ekstrak daun kelor (Moringa oleifera lam.) dengan kandungan vitamin C dan beta karoten diduga mencegah nekrosis kardiomiosit sehingga menurunkan resiko penyakit kardiovaskular. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak daun kelor (Moringa oleifera Lam.) terhadap sel kardiomiosit jantung pada tikus putih (Rattus novergicus strain wistar) dengan diet aterogenik. Penelitian ini menggunakan metode post test only control group design  yang terbagi dalam 4 kelompok acak yaitu kelompok kontrol (diet aterogenik) dan 3 kelompok perlakuan (ekstrak daun kelor 200mg/KgBB, 400mg/KgBB dan 600mg/KgBB). Setiap kelompok terdiri 5 hewan coba dengan perlakuan selama 35 hari. Setiap kelompok dibuat preparat histologi jantung (pewarnaan HE) dan diamati dibawah mikroskop(400x) dengan bimbingan ahli patologi anatomi. Hasil uji one-way ANOVA menunjukkan terdapat perbedaan antar kelompok tikus (p<0,05). Hasil uji post hoc menunjukkan dosis 600mg/KgBB yang paling signifikan dalam mencegah nekrosis kardiomiosit. Ekstrak daun kelor (Moringa oleifera lam.) berpengaruh sebesar 78,5% terhadap jumlah nekrosis kardiomiosit, hal ini diduga disebabkan adanya kandungan vitamin C, beta karoten, beta sitosterol, flavonoid dan polyphenol.Kata Kunci : Ekstrak daun kelor, Diet Aterogenik, Nekrosis Kardiomiosit.
Pengaruh Ekstrak Buah Labu Siam (Sechium edule) terhadap Ketebalan Dinding Aorta Tikus Putih (Rattus norvegicus strain wistar) Model Aterosklerosis Desy Andari; Aulia Wiraldi Putra; Meddy Setiawan
Jurnal Kesehatan Islam : Islamic Health Journal Vol 11, No 1 (2022): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v11i1.16079

Abstract

Background: Atheroslerosis is a disease that formed due to cumulation of the fibrous tissues in vascular wall and gradually become thrombus. Chayote contains antioxidants such flavonoid, saponin, and ascorbic acid that could prevent the thickening of the vascular wall. Objective: To determine the effect of chayote extract on aortic vascular wall thickness in white rats with atherosclerosis model. Methods: True experimental with post-test only controlled group design. Sixteen white male rats divided into 4 groups: positive control group and 3 treatment groups that given chayote extract at different doses (20 mg/day, 40 mg/day, 80 mg/day). The H&E stained aortic preparate were observed with 400x magnification used optical microscope and vascular thickness were measured with optilab software. Data analized with one way ANOVA, post hoc, pearson and linear regression test. Result: There was significant effect of chayote extract to the aortic arch vascular wall thickness (ANOVA p=0,001) and the dose that started giving effect was 40 mg/day (Post Hoc test). There was very strong, significant, and reciprocally correlation between chayote extract and aortic wall thickness (R=-0,896). Chayote extract affected aortic wall thickness with the value of 80,4%. Conclusion: Chayote extract could prevent the thickening of aortic wall in atherosclerotic rats.
Excess Fibrin Deposits Decrease Fetal Weight of Pregnant Mice Infected by Plasmodium berghei Desy Andari; Zainabur Rahma; Yuliyanik yuliyanik; Sujarot Dwi Sasmito; Karyono Mintaroem; Loeki Enggar Fitri
Journal of Tropical Life Science Vol. 4 No. 2 (2014)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Low birth weight is commonly attributed to malaria in pregnancy, but the cellular and molecular mechanisms that underlie this poor birth outcome are incompletely understood. A universally described histopathological feature of placental malaria is excessive deposition of fibrin, the end-product of the coagulation cascade. This study was conducted to compare fibrin deposit in pregnant mice that infected by Plasmodium berghei (treatment group) to the normal pregnant mice (control group) and its association with fetal weight. This research is in vivo experimental laboratory study that used 18 pregnant Balb/c mice which divided to the control the group (8 mice) and treatment group (9 mice infected by P.berghei). Placentas were staining with Haematoxylin-Eosin (HE) for fibrin deposits examination whereas fetal weight was performed with Mettler analytical balance AE 50. Fetal weight of the treatment group was lower than those of the control group (t test, p=0,002). Fibrin deposits were increased in the treatment group (t test, p=0,005) and influenced weight of fetuses (Spearman r=-0,586, p=0,014). Weights of fetuses are interfered by fibrin deposits during malaria infection.
Pengaruh Asap Rokok Elektronik (E-Cigarettes) Dan Konvensional Terhadap Trakea Dan Jantung Tikus Putih Jantan andari, desy; Kharimah, Yusrotun; Harianja, Ade Friskilla; Pravitasari, Dwi Nurwulan
E-Jurnal Medika Udayana Vol 12 No 3 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i03.P07

Abstract

Electronic cigarettes (e-cigarette) smoker was increasing from 0.3% in 2011 to 2.5% in 2015. E-cigarettes claimed to be safe for smoker, but subsequent research has shown that e-cigarette smoke also contains harmful ingredients beside nicotine, like carbon monoxide (CO). These contents presumed to increase the goblet cells in the trachea and can cause myocardial ischemia in the left ventricle of the heart which leads to necrosis. This study was conducted to determine the effect of e-cigarette and conventional cigarette smoke on tracheal goblet cells and left ventricular necrosis of the heart of male white rats (Rattus norvegicus strain wistar). Experimental study with post-test control only group design. 16 rats were divided into 4 groups: normal group, conventional cigarette group (kretek) with 2.3 mg nicotine, 3 mg nicotine e-cigarette, and 0 mg nicotine e-cigarette. Trachea and heart of rats were prepared using HE-staining and observed with a light microscope with 400x magnification. All data were analyzed using One-way ANOVA, Kruskall Wallis and Post-Hoc tests. Cigarette smoke had a significant effect on tracheal goblet cell (ANOVA p=0.000) and left ventricular necrosis of the heart (Kruskal Wallis p=0.002). Post-Hoc test showed a significant difference in the number of goblet cells and left ventricular necrosis of the heart (p (-- removed HTML --) 0.005). This is due to the toxic materials such as carbon monoxide, propylene glycol, formaldehyde, nitrosamines, and other carcinogenic substances. E-cigarette and conventional cigarettes smoke could affect increasing of tracheal goblet cells and left ventricular necrosis of rat.
Co-Authors ., Nurmasari Agustini, SM Aisyiah Fitriyani, Nurhiqmah Alifaneta Yustisiani Alverina, Cindy Aulia Wiraldi Putra Cindy Alverina Dwi Nurwulan Pravitasari EBS, Febri Febri EBS Gita Sekar Prihanti Harianja, Ade Friskilla Isbandiyah . Isbandiyah ., Isbandiyah Karyono Mintaroem Karyono Mintaroem Kharimah, Yusrotun Loeki E Fitri, Loeki E Loeki Enggar Fitri Meddy Setiawan Nurhiqmah Aisyiah Fitriyani Nurmasari . Prasetyaning, Utari Rahma, Zainabur SM Agustini Sujarot Dwi Sasmito sujarot dwi sasmito, sujarot dwi Thontowi Djauhari Utari Prasetyaning Yuliyanik yuliyanik Yustisiani, Alifaneta Zainabur Rahma