Article Per Year (5 Year)
p-Index From 2020 - 2025
1.325
P-Index
This Author published in this journals
All Journal International Journal of Public Health Science (IJPHS) HAYATI Journal of Biosciences Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Indonesian Journal of Urology MEDISAINS The Indonesian Biomedical Journal Health Notions Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Oceana Biomedicina Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Journal of Global Pharma Technology
Karyono Mintaroem
Laboratorium Patologi Anatomi Fakultas Kedokteran Universitas Brawijaya-RSSA Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

Published : 20 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 20 Documents
Search

 1   2 
POTENSI EKSTRAK BAWANG DAYAK (Eleutherine sp) SEBAGAI OBAT HERBAL TERSTANDAR (OHT) PADA PENGOBATAN MEDIS Poerwosusanta, Hery; Ali, Mulyohadi; Noor, Zairin; Mintaroem, Karyono; Widjajanto, Edi
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 3, No 2 (2018)
Publisher : Akademi Farmasi ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (8.262 KB)

Abstract

Bawang Dayak (Eleutherine sp) merupakan salah satu tanaman yang tumbuh liar di hutan Kalimantan yang berpotensi dikembangkan menjadi Obat Herbal Terstandard. Berdasarkan studi etnofarmakologi, tanaman ini dimanfaatkan masyarakat suku Dayak sebagai obat diabetes, stroke, kanker payudara, antihipertensi, mempercepat penutupan luka, dan pengobatan jantung. Meski sudah digunakan turun temurun dan riset yang berkelanjutan, bawang Dayak belum dimanfaatkan dokter formal untuk pengobatan klinis. Hal ini disebabkan belum adanya uji y akurat dan terstandar yang dapat digunakan sebagai bukti ilmiah. Pada sisi lain, masyarakat berpendapat bahwa penggunaan bawang Dayak sebagai jamu dapat berbahaya karena komplikasi akibat bercampur dengan Bahan Kimia Obat (BKO). Dengan demikian, bawang Dayak perlu diupayakan dalam Program Saintifikasi Jamu untuk mewujudkan jamu, obat herbal terstandar, dan fitofarmaka yang berkualitas, bermutu serta aman. Oleh karena itu, pada artikel ini akan dibahas beberapa riset tentang bioaktifitas bawang Dayak mulai fitokimia hingga tahapan uji praklinik
Green Tea Extract Increases The Number of Granulosa Cells and E2 Serum Levels of Female Rats Exposed by Cypermethrin Laili, Fitria Jannatul; Winarsih, Sri; Mintaroem, Karyono
Health Notions Vol 2 No 6 (2018): June 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

processing
The Effect of Extra Virgin Olive Oil (EVOO) on Expression of Vascular Endhothelial Growth Factor (VEGF) and Arteriole Number on Endometrium of Female Rattus norvegicus of Wistar Strain Exposed to Rhodamin B Anisak, Siti; Sujuti, Hidayat; Sutrisno, Sutrisno; Mintaroem, Karyono; Nurseta, Tatit; Kalsum, Umi
Health Notions Vol 2 No 8 (2018): August 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (505.013 KB)

Abstract

.
Moringa oleifera Meningkatkan Fungsi Memori pada Tikus Model Kurang Energi Protein Illiandri, Oski; Widjajanto, Edi; Mintaroem, Karyono
Jurnal Kedokteran Brawijaya Vol 26, No 1 (2010)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (526.827 KB) | DOI: 10.21776/ub.jkb.2010.026.01.3

Abstract

ABSTRAKMalnutrisi mempunyai pengaruh negatif  terhadap pertumbuhan dan perkembangan  janin,  khususnya pertumbuhan otak. Gangguan pertumbuhan otak serta perkembangannya dapat menyebabkan disfungsi pada penyimpanan informasi dan proses recalling, sehingga konsekuensinya akan terjadi gangguan memori. Kerusakan oksidatif merupakan salah satu jalur penyebab yang baru dikemukakan sebagai hipotesis penyebab kerusakan otak akibat malnutrisi pada tikus. Asupan nutrisi  yang  rendah  dapat menurunkan  kadar  antioksidan  pada  tikus  otak,  kemudian  akan menyebabkan  gangguan memori  yang progresif. Moringa oleifera merupakan  sebuah  tanaman  yang populer akhir-akhir  ini untuk digunakan sebagai tambahan makanan yang mengandung antioksidan di beberapa negara miskin. Tujuan dari penelitian ini adalah untuk membuktikan pengaruh   bubuk ekstrak Moringa oleifera terhadap perbaikan fungsi memori pada tikus dengan kekurangan energi protein. Pada penelitian ini digunakan tikus wistar sebanyak 20 ekor, yang dibagi kedalam 5 kelompok yang terdiri dari kelompok kontrol diet malnutrisi, kelompok diet normal, kelompok diet malnutrisi yang mendapatkan tambahan  diet  bubuk  daun Moringa  oleifera  dengan  dosis  180 mg,  kelompok  diet  malnutrisi  yang  mendapatkan tambahan diet bubuk daun Moringa oleifera dengan dosis 360 mg, dan kelompok diet malnutrisi yang mendapatkan tambahan diet bubuk daun Moringa oleifera dengan dosis 720 mg. Uji Morris watermaze digunakan untuk mengukur perbaikan memori, sedangkan metode xanthin oxidase digunakan untuk mengukur kadar antioksidan otak. Potongan hipokampus diambil sepanjang 5 s.d. 6 mm pada rostral sulcus cerebrocerebelaris. Penelitian  ini dapat membuktikan bahwa bubuk ekstrak daun Moringa oleifera mampu meningkatkan kadar antioksidan SOD pada otak tikus dan mampu memperbaiki  fungsi memori pada kekurangan energi protein. Kata Kunci: Kelor, malnutrisi, M. Oleifera, morris watermaze  test, superoxide dismutase
Pengembangan Model Mencit Alergi dengan Paparan Kronik Ovalbumin Barlianto, Wisnu; Kusuma, Mohamad Slamet Chandra; Karyono, Setyawati; Mintaroem, Karyono
Jurnal Kedokteran Brawijaya Vol 25, No 1 (2009)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (743.47 KB) | DOI: 10.21776/ub.jkb.2009.025.01.1

Abstract

ABSTRACTHistology expression in asthma show inflammatory processes and airway structural changes. Treatmentdevelopment in asthma needs appropriate animal models but most animal models use short term allergenexposure. The aim of this research was to create develop allergic mouse model with allergic inflammationand structural changes histology expression. Eight female BALB/c mice, 6-12 weeks old, 80-100 gramswere divided into two groups. The first group were exposed to a normal saline solution where the secondgroup received ovalbumin. Mice were sensitized by intraperitoneal injection of ovalbumin on day 0 and 14and challenged by nebulization of 1% ovalbumin three times weekly for 6 weeks. Twenty four hours afterfinal exposure, the mice were sacrificed by lethal cardiac puncture. The level of total IgE in serum weremeasured by ELISA and IL-4 receptor expression were examinated by immunohistochemistry.Morphometric analysis was performed to count inflammatory cells, eosinophil, goblet cells, epithel andsmooth muscle thickness. Differences between the control and exposed mice were analyzed by Mann-Whitney test. There were a significant differences in total IgE serum and expression IL-4 receptor betweenthe two groups (P < 0,05). The morphometric analyzing also demonstrated significant differences betweenthese two groups (P < 0,05). Chronic ovalbumin exposure through inhalation produced allergicinflammation and airway structural changes.Keywords: allergic inflammation, mouse models, chronic exposure, ovalbumin
Pengaruh Sel Limfosit T Regulator CD4 CD25 Foxp3 dan Transforming Growth Factor (TGF) β terhadap Airway Remodelling Bronkiolus Paru pada Model Mencit Asma Faturrachman, Dicky; Barlianto, Wisnu; Mintaroem, Karyono
Jurnal Kedokteran Brawijaya Vol 27, No 2 (2012)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (850.772 KB) | DOI: 10.21776/ub.jkb.2012.027.02.4

Abstract

Peran CD4 CD25 Foxp3  dan TGF-β dalam remodeling saluran napas masih didapatkan kontroversi dan perlu diteliti lebih  lanjut. Tujuan dari penelitian  ini adalah membuktikan efek meningkatnya  jumlah  limfosit T Reg CD4 CD25 Foxp3 dan TGF-β terhadap penurunan remodeling saluran napas bronkial paru pada model mencit asma. Mencit Balb/c dibagi menjadi 2 kelompok,  yaitu  dengan  sensitisasi  ovalbumin  dan  tanpa  sensitisasi.  Sensitisasi  dilakukan  selama  9 minggu.  Jumlah limfosit T reg CD4 CD25 Foxp3  diperiksa dengan  flowcytometry dan TGF-β diperiksa dengan ELISA. Parameter remodeling saluran napas  (ketebalan epitel, ketebalan  fibrosis subepitel,  jumlah sel goblet, ketebalan otot polos) diukur dengan analisis  morfometri  dari  pemeriksaan  histopatologi.  Analisis  statistik  dengan  uji  T  berpasangan  dan  analisis  jalur hubungan  (analisis  jalur).  Hasil  menunjukkan  tidak  ada  perbedaan  yang  signifikan  dalam  jumlah  limfosit  T  reg CD4 CD25 Foxp3  (p=0,763) dan TGF-β (p=0,246) dalam 2 kelompok. Ditemukan perbedaan signifikan dalam parameter remodeling pada kedua kelompok (p=0,000). Tidak ada korelasi langsung yang signifikan antara T reg dan TGF-β dengan parameter  remodeling. Tren yang diperoleh dengan peningkatan  jumlah  limfosit  sel T  reg, menunjukkan penurunan parameter remodeling. Didapatkan adanya pengaruh limfosit T reg CD4 CD25 Foxp3  terhadap remodeling saluran napas yang ditunjukkan dengan ketebalan epitel baik secara langsung maupun tidak langsung melalui TGF-β, meskipun tidak signifikan secara statistik.Kata Kunci: Remodeling saluran napas, TGF-β, T  reg CD4 CD25 Foxp3
Efek Kombinasi Ekstrak Anamirta cocculus dan Artemisin terhadap Penurunan Jumlah Sel Apoptosis Jaringan Paru Mencit Malaria Fitri, Loeki Enggar; Syamsuri, Dara Dasawulansari; Simamora, Dorta; Soemarko, Soemarko; Mintaroem, Karyono
Majalah Kedokteran Bandung Vol 45, No 2 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1715.153 KB)

Abstract

Plasmodium dalam eritrosit akan menginduksi respons imun, berupa produksi radikal bebas yang dapat menyebabkan kerusakan jaringan paru. Kombinasi ekstrak Anamirta cocculus dan artemisin diharapkan dapat mencegah komplikasi akibat radikal bebas yang dihasilkan oleh sel imun maupun artemisin. Studi eksperimental dengan metode post test control group design only dilakukan di Laboratorium Parasitologi dan Biomedik Fakultas Kedokteran Universitas Brawijaya periode Juni–Oktober 2010 untuk membuktikan efek pemberian kombinasi ekstrak A. cocculus dan artemisin terhadap jumlah sel apoptosis jaringan paru mencit galur Balb/C yang diinfeksi Plasmodium berghei. Mencit dibagi dalam 6 kelompok, kelompok 1 terdiri atas 9 ekor mencit normal, kelompok 2 mencit yang diinfeksi P. berghei tanpa terapi, kelompok 3 mencit yang diinfeksi P. berghei dan diterapi artemisin dosis 0,04 mg/gBB, serta 3 kelompok perlakuan mencit diinfeksi P. berghei dan diterapi kombinasi artemisin 0,04 mg/gBB dengan ekstrak A. cocculus 0,01 mg/gBB; 0,1 mg/gBB; dan 1 mg/gBB. Sel apoptosis dihitung dari ekspresi caspase-3 pada pewarnaan imunohistokimia. Pemberian ekstrak A. cocculus dosis 0,01 mg/gBB; 0,1 mg/gBB; dan 1 mg/gBB serta artemisin selama 3 hari menurunkan jumlah sel apoptosis secara signifikan dibandingkan dengan kelompok artemisin monoterapi (p=0,00; 0,026; 0,000). Hubungan lama terapi dengan ekspresi caspase-3 menunjukkan pada kelompok terapi kombinasi ekstrak A. cocculus 0,01 mg/gBB dan artemisin 0,04 mg/gBB memiliki korelasi positif yang signifikan (p=0,013). Simpulan, terapi jangka pendek kombinasi ekstrak A. cocculus dan artemisin mempunyai efek yang lebih baik dibandingkan dengan pemberian artemisin monoterapi dalam hal penurunan jumlah sel apoptosis jaringan paru. [MKB. 2013;45(2):69–77]Kata kunci: Anamirta cocculus, apoptosis sel paru, artemisin,caspase-3, malariaThe Effect of Anamirta cocculus Extract and Artemisin Combination in Decreasing Number of Apoptotic Lung Cells of Malaria Infected MiceThe presence of Plasmodium in erythrocytes will induce immune responses, including the production of free radicals which can lead to lung tissue cells damage. Combination therapy of Anamirta cocculus extract and artemisin is expected to prevent complications caused by free radicals produced by immune cells and artemisin. This experimental study which using post test control group design only was done in Laboratory of Parasitology and Biomedic Faculty of Medicine, Brawijaya University on June–October 2010 to prove the effect of combination therapy of A. cocculus extract and artemisin towards the number of apoptotic lung tissue cells of Balb/C mice infected by Plasmodium berghei. Mice were divided into 6 groups, the first normal Balb/C mice, the second mice infected by P. berghei without treatment, the third mice infected by P. berghei and treated with artemisin 0.04 mg/g BW, and 3 combination contains mice infected by P. berghei and treated with a combination of artemisin 0.04 mg/ gBW and A.cocculus extract 0.01 mg/gBW, 0.1 mg/gBW, 1 mg/ gBW respectively. The apoptotic cells of lung tissue were counted from the expression of caspase-3 in immunohistochemical staining. In day 3 combination A. cocculus extract dose 0.01 mg/gBW, 0.1 mg/gBW, 1 mg/ gBW and artemisin reduced the number of apoptotic cells significantly compared to the artemisin monotherapy (p=0.00, 0.026, 0.000). There was a positive corelation between the length of treatment and the expression of caspase-3 (p=0.013) on group that treated with combination of A. cocculus extract 0.01 mg/gBW and artemisin 0,04 mg/gBB. In conclusion, the short treatment of combination A. cocculus extract and artemisin has a better effect than artemisin monotherapy in decreasing number of apoptotic lung tissue cells. [MKB. 2013;45(2):69–77]Key words: Anamirta cocculus, artemisinin, caspase 3, lung apoptotic cell, malaria DOI: http://dx.doi.org/10.15395/mkb.v45n2.91
Haemozoin Deposits Influence Fetal Weight of Pregnant Mice Infected by Plasmodium berghei Andari, Desy; Fitri, Loeki E; Mintaroem, Karyono
Jurnal Kedokteran Brawijaya Vol 28, No 4 (2015)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (836.275 KB) | DOI: 10.21776/ub.jkb.2015.028.04.4

Abstract

Low birth weight is commonly attributed to malaria in pregnancy, but the cellular and molecular mechanisms that underlie this are incompletely understood. Many of hormones and cytokines are dysregulated in this case and it alters histological structure of placenta which known as placenta malaria. In the placenta malaria, there is an accumulation of infected erythrocytes, macrophages and malarial pigment (haemozoin). This study was conducted to compare the levels of plasma and placenta interferon-gamma (IFN-γ) and haemozoin deposit in pregnant mice that infected by Plasmodium berghei (treatment group) to the normal pregnant mice (control group) and its association with fetal weight. This in vivo experimental laboratory study used pregnant Balb/c mice which divided to control and treatment group. Placentas were staining with Haematoxylin-Eosin (HE) for haemozoin deposits examination. Plasma and placenta levels of IFN-γ examined with ELISA assay. Levels of IFN-γ were higher in plasma than placenta and slightly higher in treatment group than control group, but the differences were not significant (p>0,05). Fetal weight of treatment group was lower than those of control group (p=0,002) however there was no correlation between fetal weight and plasma as well as placenta levels of IFN-γ (p>0,05). Haemozoin deposit was found only in treatment group and influenced weight of fetuses (Spearman=-0,633, p=0,006). Weights of fetuses are more interfered by haemozoin deposit and seemly not by plasma and placenta levels of IFN-γ during malaria infection.Keywords: Fetal weight, gamma interferon, haemozoin, malaria, placenta
Excess Fibrin Deposits Decrease Fetal Weight of Pregnant Mice Infected by Plasmodium berghei Andari, Desy; Rahma, Zainabur; yuliyanik, Yuliyanik; Sasmito, Sujarot Dwi; Mintaroem, Karyono; Fitri, Loeki Enggar
Journal of Tropical Life Science Vol 4, No 2 (2014)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Low birth weight is commonly attributed to malaria in pregnancy, but the cellular and molecular mechanisms that underlie this poor birth outcome are incompletely understood. A universally described histopathological feature of placental malaria is excessive deposition of fibrin, the end-product of the coagulation cascade. This study was conducted to compare fibrin deposit in pregnant mice that infected by Plasmodium berghei (treatment group) to the normal pregnant mice (control group) and its association with fetal weight. This research is in vivo experimental laboratory study that used 18 pregnant Balb/c mice which divided to the control the group (8 mice) and treatment group (9 mice infected by P.berghei). Placentas were staining with Haematoxylin-Eosin (HE) for fibrin deposits examination whereas fetal weight was performed with Mettler analytical balance AE 50. Fetal weight of the treatment group was lower than those of the control group (t test, p=0,002). Fibrin deposits were increased in the treatment group (t test, p=0,005) and influenced weight of fetuses (Spearman r=-0,586, p=0,014). Weights of fetuses are interfered by fibrin deposits during malaria infection.
Preparedness of members of the Indonesian emergency and disaster nurses association Guruh Suprayitno; Ahsan Ahsan; Karyono Mintaroem
International Journal of Public Health Science (IJPHS) Vol 9, No 4: December 2020
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v9i4.20500

Abstract

Disaster is a global issue all around the world, and Indonesia has shifted its disaster mitigation strategies from emergency response to disaster management preparedness. This research analysed factors influencing the preparedness of members of the Indonesian emergency and disaster association (IEDNA) in the face of natural disasters in Indonesia. This research is analytical-observational with a cross-sectional approach. Sampling was performed on a population of 510 member nurses of the IEDNA by the probability sampling technique. Out of the 510 member nurses of the IEDNA, 107 were enrolled in this research. The Fisher’s exact test results show that knowledge had p= 0.001 (p< 0.05), while facilities and infrastructures availability p= 0.000 (p< 0.05), in their effects on nurse preparedness. The multivariate analysis yielded Exp(B) of 0.022 for knowledge and Exp(B) of 0.003 for facilities and infrastructures availability, while the Nagelkerke’s R-squared obtained was 66%. The variable preparedness was largely good, and there were significant relationships of knowledge and facilities and infrastructures availability to the preparedness of members of the IEDNA. The strongest factor was knowledge.
Co-Authors A.A. Ketut Agung Cahyawan W Adinda Chika Anindita Ahsan Ahsan Aina Angelina Anggie Sasmita Kharisma Putri Anisak, Siti Candra Rini Hasanah Putri Dara Dasawulansari Syamsuri Desy Andari Dian Nugrahenny Dicky Faizal Irnandi Dicky Faturrachman Djoko Wahono Soeatmadji Dorta Simamora Edi Widjajanto Edi Widjajanto Edwin Widodo Eviana Norahmawati Fadli, Muhammad Luqman Fardizia Putri Alia Ferry Sandra Fitria Jannatul Laili Ghifary, Faathir Baihaqi Guruh Suprayitno Harun Al Rasyid Hidayat Sujuti Indriati Dwi Rahayu Kalsumy, Umi Lavina Sofia Ardani Loeki E Fitri, Loeki E Loeki Enggar Fitri Mayangsari, Elly Melati Puspita Sari Mohamad Slamet Chandra Kusuma Mulyohadi Ali Mulyohadi Ali Nathania Bella Claresta Niarti Ulan Sari Siarnu Nur Permatasari Nura Fattah Cantika Yoga Oski Illiandri Poerwosusanta, Hery Pudji Rahajoe Rahma, Zainabur Retnani, Diah Prabawati Retty Ratnawati Selvi Marcellia Setyawati Karyono Setyawati Soeharto Setyawati Soeharto Soemarko Soemarko Sri Winarsih sujarot dwi sasmito, sujarot dwi Sutiman Bambang Sumitro Sutrisno Sutrisno Tatit Nurseta Tatit Nurseta Tika Ardhini Wardoyo Tony Suharsono, Tony Tri Yudani Mardining Raras Winarko Luminturahardjo Wisnu Barlianto Wulandari, Angernani Trias Yuliyanik yuliyanik Zairin Noor Zairin Noor