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All Journal Majalah Kedokteran Bandung Jurnal MedScientiae
Anna Maria Dewajanti
Universitas Kristen Krida Wacana
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Hubungan Kebiasaan Mengonsumsi Kopi Susu dan Kopi Hitam dengan Tekanan Darah Dewajanti, Anna Maria; Pratiwi, Indah; Susilowati, Rina Priastini; Rumiati, Flora
Jurnal MedScientiae Vol. 3 No. 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.2879

Abstract

The habit of people who consume coffee will have an impact on increasing blood pressure, where if you drink 4 or more cups of coffee in one day, the systolic pressure will increase by approximately 10 mmHg and around 8 mmHg in diastolic blood pressure. The purpose of this study was to see the relationship between the habit of consuming milk coffee and black coffee with blood pressure in students of the Faculty of Medicine at Krida Wacana Christian University. This research used a cross-sectional approach with a population of 2020 Ukrida Faculty of Medicine students. The sample in this study was 102 people with a simple random sampling technique. It was found that the average 2020 Ukrida Faculty of Medicine student consumed coffee 1-2 times a day at a rate of 1-2 cups per day, but there were also some who consumed 3-4 cups of coffee a day. Data analysis used the Person Chi-Square and obtained the p-value for milk coffee: 0.126 and the p-value for black coffee: 0.656. So this shows that both milk coffee and black coffee have no significant relationship with an increase in blood pressure.
The Effectiveness of Pure Honey as Antioxidant and Gastroprotective in Sprague Dawley Rats (Rattus novergicus) Tanny, Sesilia Bella; Sumbayak, Erma Mexcorry; Dewajanti, Anna Maria; Rumiati, Flora
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3481

Abstract

Gastritis is a condition where inflammation occurs in the surface lining of the stomach which can be caused by several factors, one of which is non-steroidal anti-inflammatory drugs or NSAIDs. The most commonly used NSAIDs are aspirin, aspirin at a dose of 600 mg/kg can cause acute damage to the stomach. Honey with 30 ml/day or the equivalent of 2 tablespoons provides a gastroprotective effect or protection and healing for stomach damage because it contains antioxidants which reduce the level of damage to the stomach. The purpose of this study was to determine the antioxidant and gastroprotective effectiveness of pure honey in Rattus norvegicus Sprague Dawley rats induced by oral aspirin. This study used a laboratory experimental method which examined the effectiveness of pure honey as an antioxidant and gastroprotective for 11 days. The subjects used were 25 Rattus norvegicus. The results showed that based on histopathological scores, administration of 0.5 mL/kgBB honey for 4 days in experimental animals could significantly reduce gastric damage induced by aspirin 600 mg/kgBB. However, when viewed from the results of the data on GSH levels, there was no significant effect of giving honey on GSH levels in experimental animals.  
Potential of Binahong Leaf Extract (Anredera cordifolia) for Anemia Treatment in Anemic Rat Model Dewajanti, Anna Maria; Stephanus, Chealsea A.; Mano, Ivanna G; Purnamawati, Purnamawati; Rumiati, Flora; Sumbayak, Erma Mexcorry; Limanto, Agus
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3873

Abstract

Anemia, characterized by low hemoglobin (Hb) and erythrocyte counts, can be induced by reactive oxygen species (ROS) or known as hemolytic anemia. Binahong (Anredera cordifolia) has been explored for its potential in managing anemia; yet, its efficacy against ROS-induced anemia remains under investigated. This study, conducted from January to May 2023, aimed to evaluate the potential of Binahong leaf extract (BLE) in treating anemia caused by oxidative stress. Anemia was induced by administering NaNO2 to 24 rats (Rattus norvegicus), followed by the administration of BLE at doses of 50,100, and 200 mg/kgBW for seven days. Hemoglobin levels were measured using Sahli method and erythrocytes count were determined using a Hemocytometer at three stages: pre anemia (HA), before-treatment (H0), and after-treatment (H7). Results showed that BLE significantly increased the Hb level by 1.3g/dL (p=0.000), 3.87g/dL (p=0.034), and 4.53g/dL (p=0.016) at 50 mg/kgBW, 100mg/kgBW, and 200 mg/kgBW, respectively, after treatment. Additionally, a dose of 200 mg/kgBW significally increased the erythrocyte count by 3.84 x 106 L/mm3 (p=0.033). These findings suggested that BLE has the potential to improve Hb levels and erythrocyte counts in ROS-induced anemia, indicating a promising natural approach to managing anemia.
In-silico study of the Effectiveness of Allium sativum L. extract as an Angiotensin-Converting Enzyme (ACE) Inhibitor in Hypertension Limanto, Agus; Husain, Elma Eka Fitra; Dewajanti, Anna Maria
Majalah Kedokteran Bandung Vol 55, No 3 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n3.3287

Abstract

Over the last decade, the global prevalence of hypertension rate has increased by 5.2% and, in Indonesia, the prevalence rate has increased significantly from 25.8% in 2013 to 34.1% in 2018. Hypertension treatments using blood pressure-lowering drugs, such as angiotensin-converting enzyme (ACE) inhibitors, often cause unpleasant side effects. These side effects increase the interest in using potentially effective natural remedies, such as garlic. This study aimed to determine which organosulfur compounds in garlic can act as an ACE inhibitor to reduce blood pressure in hypertension using a cheminformatics approach. Eighteen organosulfur compounds of Allium sativum L. were screened based on Lipinski’s rules and ADMET evaluation. Seven compounds passed the screening and were subjected to QSAR analysis, molecular docking analysis, and molecular dynamics simulations to assess the stability of the protein. The seven compounds then underwent molecular docking and QSAR analysis. Ajoene (4,5,9-trithiadodeca-1,6,11-triene-9-oxide) and S-allylmercaptocysteine (SAMC) were two compounds with better docking values compared to the positive control compound. The QSAR analysis also showed that SAMC had an activity as an ACE inhibitor. The ADMET evaluation showed that Ajoene and SAMC had good absorption and could not penetrate the blood-brain barrier. Molecular dynamics simulation of ACE complexes Ajoene, SAMC, and Captopril ranged from 0.05 to 5.61 Å but exhibited a pattern of synonymous fluctuations for most residues. Based on the simulation data, the organosulfur compounds from garlic, Ajoene, and SAMC are proven to have a mechanism of action as ACE inhibitors to reduce blood pressure in hypertension.
Co-Authors Agus Limanto Erma Mexcorry Sumbayak Flora Rumiati Husain, Elma Eka Fitra Indah Pratiwi Limanto, Agus Mano, Ivanna G Purnamawati Purnamawati Stephanus, Chealsea A. Susilowati, Rina Priastini Tanny, Sesilia Bella