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All Journal Majalah Kedokteran Bandung Althea Medical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Nina Susana Dewi
Departemen Patologi Klinik Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Dr. Hasan Sadikin Bandung
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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Journal : althea medical journal

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Anonna muricata Linn Leaf Effect in Inhibiting SGPT Elevation Tanaya, Galih; Kuswinarti, Kuswinarti; Dewi, R. Nina Susana
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (727.699 KB)

Abstract

  Background: Hepatitis is an infection or inflammation disease of the liver which is caused by virus, toxic substance, and immunological abnormalities. Soursop plant as a medicinal plants is known to have an antioxidant effect and nowadays is used as an alternative drug for hepatitis. One of the methods to assess liver function is to measure the serum Glutamate Piruvate Transaminase (SGPT) level. The purpose of this study was to find the effect of Soursop Leaf  in inhibiting the SGPT elevation .Methods: An experimental study was conducted on 25 white male rats of wistar strain in the pharmacology laboratory of Faculty of Medicine, Universitas Padjadjaran during the period of September to October 2012. The rats were divided into 5 groups (group 1 and 2 as control; group 3, 4, and 5 as treatment groups treated by 200, 400, 600 mg/kgbw soursop extract, respectively). The soursop extract was administered to the treatment groups for 8 days. On the 8th day, group 2, 3, 4, and 5 received 1.6 ml CCl410% intraperitoneally. After 18 hours, the mean SGPT levels from all groups were measured. ANOVA test was used to analyze the result.Results : The mean SGPT levels were lower in the 3rd, 4th, and 5th group compared to group 2. There was a significant difference among treatment groups. Group 3 had the most significant result.Conclusion: Soursop leaf inhibits the elevation of SGPT level. Keywords: Hepatitis, SGPT, soursop leaf (Annona muricata) DOI: 10.15850/amj.v2n1.438 
Hand hygiene, health care workers, methicillin-resistant Staphylococcus aureus, nosocomial infection, Staphylococcus aureus Gunadi, Julius; Sastramihardja, Herri S.; Dewi, Nina Susana
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (489.362 KB)

Abstract

Background: Hypercholesterolemia is a major risk factor for coronary heart disease. Ear fungus (Auricularia auricula) contains soluble fiber (beta glucan) which is believed to have an effect of reducing cholesterol level. The aim of this study was to determine the effect of fungus infusion in reducing blood cholesterol.Methods: This study used the laboratory experimental method conducted in the pharmacology laboratory of Dr. Hasan Sadikin General Hospital Bandung. The subjects were 25 male Wistar rats which were randomly divided into 5 groups. The first group was given only distilled water as a negative control, the remaining groups were induced to be dyslipidemic and received fungus infusion with different doses of 18%, 36%, 72% and one group received no treatment.Results: The comparison of different doses showed all had the effect of reducing cholesterol levels compared to the positive control group (p<0.05). Each dose showed slight differences in their effectiveness, 18% (p=0.007; p<0.05), 36% (p=0.002; p<0.05), and 72% (p=0.014; p<0.05).Conclusions: ear fungus infusion had the effect of reducing cholesterol with the most effective concentration was 36%. [AMJ.2015;2(1):153–61]
Hand hygiene, health care workers, methicillin-resistant Staphylococcus aureus, nosocomial infection, Staphylococcus aureus Julius Gunadi; Herri S. Sastramihardja; Nina Susana Dewi
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (489.362 KB)

Abstract

Background: Hypercholesterolemia is a major risk factor for coronary heart disease. Ear fungus (Auricularia auricula) contains soluble fiber (beta glucan) which is believed to have an effect of reducing cholesterol level. The aim of this study was to determine the effect of fungus infusion in reducing blood cholesterol.Methods: This study used the laboratory experimental method conducted in the pharmacology laboratory of Dr. Hasan Sadikin General Hospital Bandung. The subjects were 25 male Wistar rats which were randomly divided into 5 groups. The first group was given only distilled water as a negative control, the remaining groups were induced to be dyslipidemic and received fungus infusion with different doses of 18%, 36%, 72% and one group received no treatment.Results: The comparison of different doses showed all had the effect of reducing cholesterol levels compared to the positive control group (p<0.05). Each dose showed slight differences in their effectiveness, 18% (p=0.007; p<0.05), 36% (p=0.002; p<0.05), and 72% (p=0.014; p<0.05).Conclusions: ear fungus infusion had the effect of reducing cholesterol with the most effective concentration was 36%. [AMJ.2015;2(1):153–61]
Anonna muricata Linn Leaf Effect in Inhibiting SGPT Elevation Galih Tanaya; Kuswinarti Kuswinarti; R. Nina Susana Dewi
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (727.699 KB)

Abstract

  Background: Hepatitis is an infection or inflammation disease of the liver which is caused by virus, toxic substance, and immunological abnormalities. Soursop plant as a medicinal plants is known to have an antioxidant effect and nowadays is used as an alternative drug for hepatitis. One of the methods to assess liver function is to measure the serum Glutamate Piruvate Transaminase (SGPT) level. The purpose of this study was to find the effect of Soursop Leaf  in inhibiting the SGPT elevation .Methods: An experimental study was conducted on 25 white male rats of wistar strain in the pharmacology laboratory of Faculty of Medicine, Universitas Padjadjaran during the period of September to October 2012. The rats were divided into 5 groups (group 1 and 2 as control; group 3, 4, and 5 as treatment groups treated by 200, 400, 600 mg/kgbw soursop extract, respectively). The soursop extract was administered to the treatment groups for 8 days. On the 8th day, group 2, 3, 4, and 5 received 1.6 ml CCl410% intraperitoneally. After 18 hours, the mean SGPT levels from all groups were measured. ANOVA test was used to analyze the result.Results : The mean SGPT levels were lower in the 3rd, 4th, and 5th group compared to group 2. There was a significant difference among treatment groups. Group 3 had the most significant result.Conclusion: Soursop leaf inhibits the elevation of SGPT level. Keywords: Hepatitis, SGPT, soursop leaf (Annona muricata) DOI: 10.15850/amj.v2n1.438 
Co-Authors Emmy Pranggono Fenny, - Galih Tanaya Galih Tanaya, Galih Herri S. Sastramihardja Hidayat . Ida Parwati Julius Gunadi Julius Gunadi, Julius Kuswinarti Kuswinarti Kuswinarti Kuswinarti, Kuswinarti Nadjwa Zamalek Dalimoenthe Nida Suraya Noormartany Nurlina Sirait Ratri Dwitiya Nestiti, Ratri Dwitiya Sylvia Rachmayati Victor Immanuel