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Potensi Ekstrak Rumput Kebar (Biophytum petersianum Klotzsch) Dalam Mempertahankan Jumlah Sel Sertoli Mencit (Mus musculus) Model Diabetes Melitus Etik Yuliarini Widodo; Reny I’tishom; Bambang Purwanto
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 11, No 3 (2020): Juli 2020
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf11311

Abstract

Background: Hyperglycemia is a common effect of uncontrolled DM. The main impact of DM on male infertility is the result of hyperglycemia which causes an increasing in free radicals which cause oxidative stress in the testes, and then attacks Sertoli cells. Increasing of free radicals will cause disruption and damage to this cell, including apoptosis and atrophy and then caused decreasing in the number of Sertoli cells. Kebar grass contains antioxidants compounds, such as flavonoids and vitamin E. There are synergy effects between vitamin E and flavonoids which reinforce both in working to improve infertility as an antioxidant. Objective: To compared the number of Sertoli cells between groups which receiving extract kebar grass (Biophytum petersianum Klotzsch) and the control group in diabetes mellitus mice (Mus musculus) model. Methods: The research subjects used DM male mice which were divided into 5 groups: 2 control groups (K- and K+) and 3 treatment groups (P1, P2, P3). Day 1 to day 5, all groups were induced by STZ. The 11th day to the 45th day, the control group (K+) is given metformin 2 mg/head /day, the P1, P2 and P3 groups is given kebar grass with dose of 67,5; 135 and 270 mg/kg/day and metformin 2 mg/head/day. The 11th day to the 31th day, the control group (K-) is given CMC-Na 1% suspension. The 46th day is done surgery and sampling testicular tissue. Examination of the number of Sertoli cells is done through examination of the histological picture of testicular tissue that has been given Haematoxylin-Eosin (HE) staining. Results: Statistical tests showed that there was significant differences with a value of p = 0.000 (
Persepsi Risiko Keselamatan dan Kesehatan Menyelam pada Penyelam Tradisional dengan Kelumpuhan di Provinsi Maluku: Studi Kualitatif La Rakhmat Wabula; Kusnanto Kusnanto; Bambang Purwanto
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 10, No 3 (2019): Juli 2019
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf10305

Abstract

Background: One of the diverse communities was found in Maluku Province. Traditional diver diving expertise is obtained from generation to generation. Traditional divers have not received formal education and training related to diving. The safety and health aspects of the driving method and the tools used are not according to the standard. The risk of injury and illness due to non-standard diving has increased even higher, although to date the health aspects of traditional divers in Maluku Province have never been explored. Objective: This study aims to explore the perceptions of the risk of diving safety and health behavior in traditional divers who experience paralysis in Maluku Province. Method: The study used qualitative with a case study approach. The subjects of this study were traditional diver fishermen in Ambon City, West Seram District, and Buru Province District with ten participants. The research phase in the form of an interview will begin on January 15 - February 15, 2019. Data analysis uses thematic theory driven. Results: Identification found two main themes: 1) Vulnerability; and 2) Severity. Conclusion: Traditional diver's perceptions of safety and health while diving can form self-efficacy so as to reduce morbidity and mortality from diving. Keyword: perception; safety and health behavior; and traditional divers ABSTRAK Latar belakang: Salah satu komunitas penyelam ditemukan di Provinsi Maluku. Keahlian menyelam penyelam tradisional diperoleh secara turun temurun. Penyelam tradisional belum memperoleh pendidikan dan pelatihan formal terkait penyelaman. Aspek keselamatan dan kesehatan dari metode menyelam dan alat yang digunakan belum sesuai standar. Risiko cidera dan penyakit akibat penyelaman yang tidak standar meningkat lebih tinggi, meskipun sampai saat ini aspek kesehatan penyelam tradisional di Provinsi Maluku belum pernah di ekplorasi. Tujuan: Penelitian ini bertujuan untuk mengeksplorasi tentang persepsi risiko perilaku keselamatan dan kesehatan menyelam pada penyelam tradisional yang mengalami kelumpuhan di Provinsi Maluku. Metode: Penelitian menggunakan kualitatif dengan pendekatan studi kasus. Subjek dari penelitian ini adalah nelayan penyelam tradisional yang berada di Kota Ambon, Kabupaten Seram Bagian Barat, dan Kabupaten Buru Provinsi sejumlah sepuluh partisipan. Tahap penelitian berupa wawancara akan dimulai pada 15 Januari – 15 Februari 2019. Analisis data mengunakan tematik theory driven. Hasil: Identifikasi menemukan dua tema utama: 1) Kerentanan; dan 2) Keparahan. Kesimpulan: Persepsi penyelam tradisional tentang keselamatan dan kesehatan saat menyelam dapat membentuk efikasi diri sehingga dapat menurunkan angka kesakitan dan kematian akibat menyelam. Kata kunci: persepsi; perilaku keselamatan dan kesehatan; dan penyelam tradisional
Perbandingan Efektivitas Mindfulness Based Intervention Terhadap Diabetes Resilience Training pada Diabetes Burnout Syndrome dan Kontrol Glikemik Penderita Diabetes Melitus Tipe 2 Made Dian Kusumawati; Kusnanto Kusnanto; Bambang Purwanto
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 13, No 1 (2022): Januari 2022
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf.v13i1.1648

Abstract

 Introduction: Diabetes burnout is a major challenge in the management of Diabetes mellitus. It can lead the patient to an uncontrolled blood sugar situation, which ends up in an increased mortality rate caused by Diabetes complications. The aim of this study was to compare the effectiveness of a mindfulness-based intervention to diabetes resilience training on diabetes burnout syndrome and glycemic control in type 2 diabetes mellitus patients. Methods: Eight databases were systematically searched namely Scopus, ProQuest, PubMed, Science Direct, EBSCO, SINTA, Springer Link, and Google Scholars, using a randomized controlled trial or quasi-experimental design, published between 2011-2021 with the combinations of 6 groups of keywords in English and Bahasa Indonesia limited articles. Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines and JBI’s checklist were followed during all stages of this review. The researcher independently assessed the eligibility of the studies by title, abstract, full-text, and the methodological quality of the studies. Data tabulation and narrative analysis of study findings were performed. Results and Analysis: A total of 25 studies were satisfied the inclusion criteria and have been included in this review. Of the studies reviewed, 3549 participants included were T2DM patients undergoing Diabetes treatments for more than 6 years. Of the 12 mindfulness-based studies, 7 studies showed a significant effect. Meanwhile, in diabetes resilience training, 8 out of 13 studies showed a significant effect on both outcomes. The significance of the results in both interventions as indicated by the p-value < 0 .05 Discussion: Mindfulness reducing depression by increasing the volume and density of the gray areas of the brain which previously decreased due to stress or depression. Meanwhile, diabetes resilience training works by increasing cognitive, social, and effective brain coping functions in the hippocampus and prefrontal cortex areas, so that respondents become more aware of their self-management and glycemic control. Conclusion: Both interventions are effective in reducing diabetes burnout/depression. But diabetes resilience training is more effective if given in early diabetes conditions because the knowledge gained will help respondents to be aware of their self-management and glycemic control earlier.Keywords: diabetes burnout syndrome; glycemic control; mindfulness; diabetes resilience trainingABSTRAK Pendahuluan: Diabetes burnout merupakan tantangan utama dalam pengelolaan Diabetes mellitus. Hal ini berdampak pada tidak terkontrolnya gula darah pasien, yang berakhir dengan peningkatan angka kematian disebabkan oleh komplikasi Diabetes. Tujuan dari penelitian ini adalah untuk membandingkan efektivitas intervensi berbasis mindfulness dengan diabetes resilience training terhadap diabetes burnout dan kontrol glikemik penderita DMT2. Metode: delapan database dicari secara sistematis meliputi: Scopus, ProQuest, PubMed, Science Direct, EBSCO, SINTA, Springer Link, dan Google Scholars, menggunakan Randomized Controlled Trial atau desain kuasi eksperimen, diterbitkan antara tahun 2011-2021 dengan kombinasi 6 kelompok kata kunci dalam bahasa Inggris dan bahasa Indonesia. The Joanna Briggs Institute Guideline digunakan untuk menilai kualitas studi, sedangkan PRISMA checklist digunakan sebagai panduan dalam membuat review. Peneliti secara independen menilai kelayakan penelitian berdasarkan judul, abstrak, teks lengkap, dan kualitas metodologi penelitian. Data diekstraksi, ditabulasi, dan analisis naratif dari temuan studi ditampilkan serta dirangkum secara singkat. Hasil dan analisis: sebanyak 25 studi memenuhi kriteria inklusi dan telah dimasukkan dalam tinjauan ini. Dari seluruh studi yang ditinjau, 3549 responden adalah pasien DMT2 yang menjalani perawatan diabetes selama lebih dari 6 tahun. Dari 12 studi berbasis mindfulness, 7 studi menunjukkan efek yang signifikan. Sementara itu, dalam studi diabetes resilience training, 8 dari 13 studi menunjukkan efek yang signifikan pada kedua outcomes. Signifikansi hasil pada kedua intervensi ditunjukkan dengan p-value < 0,05. Diskusi: mindfulness menurunkan depresi dengan meningkatkan volume dan kepadatan area abu-abu otak yang sebelumnya menurun karena stres atau depresi. Sementara itu, diabetes resilience training bekerja dengan meningkatkan fungsi kognitif, sosial, dan koping otak di area hipokampus dan korteks prefrontal, sehingga responden menjadi lebih sadar akan manajemen diri dan kontrol glikemik mereka. Kesimpulan: kedua intervensi efektif dalam menurunkan burnout/depresi diabetes. Namun, diabetes resilience training lebih efektif jika diberikan pada kondisi awal diabetes karena pengetahuan yang diperoleh akan membantu responden untuk menyadari manajemen diri dan kontrol glikemiknya lebih dini.Kata kunci: diabetes burnout syndrome; kontrol glikemik; mindfulness; diabetes resilience training
Pemberian Ekstrak Rumput Kebar (Biophytum petersianum Klotzsh) Dapat Meningkatkan Berat Testis Mencit Model Diabetes Mellitus Yohana Djurumana; Reny I’tishom; Bambang Purwanto
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 11, No 3 (2020): Juli 2020
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf11320

Abstract

Background: In addition to the influence of diabetes on male reproduction lowers testosterone levels of FSH and LH, the second number of hormones is reduced will interfere with the process of spermatogenesis. If the spermatogenesis process is interrupted then the number of germ cells decreases, this will cause a decrease in the weight of the testes. Objective: To analyze the effect of extract grass administration to the weight of the testicles diabetes Mellitus mice between the treatment group and the control. Methods: The research used DM male mice which is divided into 5 groups each consisting of 6 mice. Day 1 till day 5 all STZ-induced groups. On the 11th day to the 45th day, the control group (K +) was given metformin 2mg/head/day. The control group (K-) was given CMC-Na 1%. Group P1, P2 and P3 was given Kebar grass with dose of 67, 5mg/day, 135mg/kg/day, and 270mg/kg/day and metformin 2mg/head/day. The 46th was done with the release and sampling of the right and left testicles. Testicular weighing used analytic scales 0.001gram. Results: Statistical tests showed that there was a discrepancy in the p-value = 0.000 (0.05) on testicular weight. Conclusion: Increased testicular weight model of diabetes mellitus that gets the grass extractions of Kebar. Keywords: Kebar grass extract; testicular weight; diabetes mellitus ABSTRAK Latar belakang: Pengaruh diabetes mellitus terhadap reproduksi pria menurunkan kadar testosterone yaitu FSH dan LH, jumlah ke dua hormone tersebut berkurang maka akan mengganggu roses spermatogenesis. Proses spermatogenesis terganggu maka jumlah sel germinal mengalami penurunan, hal ini akan menyababkan berat testis menurun. Tujuan: menganalisisi pengaruh pemberian ekstrak rumput kebar terhadap berat testis mencit model diabetes mellitus antara kelompok perlakuan dan kontrol. Metode: penelitian menggunakan mencit DM yang dibagi menjadi lima kelompok setiap kelompok terdiri dari 6 ekor mencit. Hari ke 1 sampai hari ke 5 semua kelompok diinduksi STZ. Hari ke 11 sampai hari ke 45 kelompok kontrol (K+) disonde metformin 2mg/ekor/hari. Kelompok kontrol (K-) disonde CMC Na 1%. Kelompok P1,P2 dan P3 disonde ekstrak rumput kebar dengan dosis, 67,5mg/kgBB/hari, 135mg/kgBB/hari, 270mg/kgBB/hari dan metformin 2mg/ekor/hari. Hari ke 46 dilakukan pembedahan dan pengambilan sampel testis kanan dan kiri dan Penimbangan berat testis mencit menggunakan timbangan analitik dengan skala 0,001 gram. Hasil: uji statistik menunjukkan terdapat perbedaan bermakna dengan nilai p= 0,000 (p
Efektivitas Ekstrak Rumput Kebar (Biophytum petersianum Klotzch) dalam Meningkatkan Tebal Epitel Tubulus Seminiferus Pada Mencit (Mus musculus) Jantan Model Diabetes Melitus Magfira Febrianty Lacindung; Bambang Purwanto; Reny I’tishom
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 11 (2020): Nomor Khusus Mei-Juni 2020
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf11nk310

Abstract

Background: Administration of antioxidants has been proven to reduce the production of free radicals in the body. One of the natural ingredients that contain antioxidants are Kebar grass. Kebar grass (Biophytum petersianum Klotzch) contains three types of chemical compounds that could potentially impact spermatogenesis. Those are flavonoids, saponins and tannins so it needs to investigate the effect on the testicles with a model of diabetes mellitus (DM). Purpose: Analyzed the Effectivness of Biophytum petersianum Klotzch extract to the epithelium thickness of the seminiferous tubules of mice (Mus musculus) model of diabetes mellitus. Methods: This research was a post test only control group design using Balb / C 45 male tail number, divided 5 groups were randomly selected. K-: DM mice group was given CMC Na 1% for 21 days. K +: DM mice group was given CMC Na 1% + metformin 2 mg / gBW for 35 days. (P1, P2, P3): DM group of mice given doses of 67.5 kebar seaweed extract, 135, 270 mg / kg + metformin 2 mg / gBW 35 days. Valid to 45 surgery and sampling and examination of thickness of seminiferous tubule epithelium. Results: The observation of thick epithelium of the seminiferous tubules was significant difference (p = 0.005) with a mean negative control group (K) 65 235 ± 5012, positive control(K +) 71 216 ± 12 514, (P1) 76 756 ± 6144, (P2) 80 660 ± 4140, (P3) 81 418 ± 7319. Conclusion Extract grass kebar (Biophytum petersianum Klotzch) efectivness in improving a thick epithelium of the seminiferous tubules in male mice model of diabetes mellitus. Keywords: kebar grass; diabetes mellitus; thick epithelium of the seminiferous tubules ABSTRAK Latar belakang : Pemberian antioksidan terbukti dapat menurunkan produksi radikal bebas di tubuh. Salah satu bahan alami yang mengandung antioksidan adalah rumput kebar. Rumput kebar (Biophytum petersianum Klotzch) mengandung tiga jenis senyawa kimia yang berpotensi memberikan pengaruh terhadap proses spermatogenesis, yaitu flavonoid, saponin dan tannin sehingga perlu dijadikan penelitian untuk melihat potensi pada testis dengan model diabetes melitus. Tujuan : Menganalisis efektivitas pemberian ekstrak rumput kebar (Biophytum petersianum Klotzch) terhadap tebal epitel tubulus seminiferus pada mencit (Mus musculus) jantan model diabetes melitus. Metode : Penelitian ini merupakan penelitian eksperimental dengan post test only control group design menggunakan mencit Balb/C jantan sejumlah 45 ekor, dibagi 5 kelompok dipilih secara acak. K- : kelompok mencit DM diberikan CMC Na 1% selama 21 hari. K+ : kelompok mencit DM diberikan CMC Na 1% + metformin 2 mg/gBB selama 35 hari. (P1, P2, P3) : kelompok mencit DM diberikan ekstrak rumput kebar dosis 67,5, 135, 270 mg/kgBB + metformin 2 mg/gBB 35 hari. Hari ke 36 dilakukan pembedahan dan pengambilan sampel dan melakukan pemeriksaan tebal epitel tubulus seminiferus. Hasil : Hasil pengamatan tebal epitel tubulus seminiferus didapatkan ada perbedaan yang signifikan (p=0,005) dengan rerata kelompok kontrol negatif (K-) 65.235 ± 5.012, kontrol positif (K+) 71.216 ± 12.514, ( P1) 76.756 ± 6.144, (P2) 80.660 ± 4.140, (P3) 81.418 ± 7.319. Kesimpulan : Ekstrak rumput kebar (Biophytum petersianum Klotzch) efektif dalam meningkatkan tebal epitel tubulus seminiferus pada mencit jantan model diabetes melitus . Kata kunci: rumput kebar; diabetes melitus; tebal epitel tubulus seminiferus
Green Tea (EGCG) Decreases Malondialdehide in Oxidative Stress Exposure to Psychological Stress M. Dodi F Priaminda; Bambang Wirjatmadi; Bambang Purwanto; Merryana Adriani
Health Notions Vol 2, No 7 (2018): July
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn20707

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Exposure to psychological stress can cause oxidative stress. Provision of exogenous antioxidants is expected to reduce the occurrence of oxidative stress. Green tea with its active ingredient Epigalocatechin Galat is considered to reduce the occurrence of oxidative stress. The purpose of this study was to examine the administration of green tea (EGCG) on the effect decreasing MDA levels against Wistar Strain (Rattus norvegicus) white rats exposed to psychological stress; with Randomized Post Test design of only group design by grouping into 5 groups, with control group and treatment group. Administration of steeping green tea (EGCG) with a single dose. To find out the significant influence of the independent variable on a set of variable group tested Manova. Post hoc testing using LSD (Least Significance Different) was performed to see significant differences between groups. In this study, obtained MDA data with significant decrease at the 6th hours after consum EGCG. Keywords: oxidative stress; green tea, EGCG, malondialdehide
Robusta Coffee Decreased Malondialdehyde Levels in Wistar Mice Experiencing Oxidative Stress Rahmi Syarifatun Abidah; Bambang Wirjatmadi; Bambang Purwanto; Merryana Adriani
Health Notions Vol 1, No 4 (2017): October-December
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (607.78 KB) | DOI: 10.33846/hn.v1i4.68

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Coffee drinking is a habit that still doubtful for it’s benefits. Many active ingredients in robusta coffee (Coffea canephora) are very useful for health, especially the antioxidant content that can ward off free radicals that absorbed in the body. Free radicals can be caused by psychological stress exposure. Excessive amounts of radicals in the body cause oxidative stress. This study aimed to see the robusta coffee effect on decreasing levels of Malondialdehyde (MDA) with “randomized post test only control group” design with 25 samples of white male rat strain wistar (Rattus norvegicus). Samples were divided into 5 groups: control groups and randomized treatment groups. Treatment given in psychological stress and giving robusta coffee drink with single dose. This study used “one way anova” test and followed by “pos hoc tukey HSD” test for statistics. Robusta coffee had an effect in MDA levels changing. There was a MDA levels decreasing in 1 hour after robusta coffee drinking in experimental rats with oxidative stress conditions that were exposed by psychological stress. Keywords: Robusta coffee, Malondialdehyde, Oxidative stress
Cocoa liquor increases SOD activity in wistar rats experiencing oxidative stress Kartika Wahyu Dwi Putra; Bambang Wirjatmadi; Bambang Purwanto; Merryana Adriani
Health Notions Vol 2, No 1 (2018): January
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (252.472 KB) | DOI: 10.33846/hn.v2i1.98

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Chocolate is a healthy food. The active ingredient in chocolate (Theobroma cacao L.), especially antioxidants, can counteract the free radicals present in the body. This study aimed to determine the effect of cocoa liquor on increased activity of Superoxyde Dismutase (SOD). The study design was randomized post test only control group with 20 samples of male white rats wistar (Rattus norvegicus). The sample was divided into 4 groups: 2 control groups and 2 treatment groups. The treatments provided were instantaneous physical activity and cocoa liquor preparation with a single dose. This study used one way anova and continued with post hoc tukey HSD test for statistic. The results showed that cocoa liquor had an effect on SOD activity. SOD activity increased in treatment group with cocoa liquor either 2 hours or 24 hours before the momentary physical activity. Keywords: Cocoa liquor, Superoxide dismutase, Oxidative stress
Intake of Folic Acid During Pregnancy Correlates to Preeclampsia Incidents in Health Center of Surabaya Putri Ulin Nuha; Bambang Purwanto; Rizki Pranadyan; Dwi Purwanti
Health Notions Vol 2, No 5 (2018): May
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (179.061 KB) | DOI: 10.33846/hn.v2i5.195

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Maternal Mortality Rate (MMR) in Indonesia based on 2015’s Health Profile of Indonesia has reached 305 per 100,000 live births. Preeclampsia is known being one of the most related factors of MMR Studies suggest that the use of folic acid may lower the risk of hypertensive disorders in pregnancy. It has been suggested that folic acid and Folic acid containing multivitamins may reduce the risk of preeclampsia by lowering plasma homocysteine concentrations in pregnant women. This cross sectional study aimed to analyze the correlation between intake of Folic acid with preeclampsia. Data was taken using Food Frequency Questionaire (FFQ) with semi quantitative approach by interviewing subjects. Sampling was obtained by simple random sampling with total 80 subjects. Data was analyzed using Chi square test. There were 15% of subjects diagnosed with preeclampsia and 83.3% of women with preeclampsia were deficient of Folic acid. Data analysis showed there is correlation between intake of Folic acid during pregnancy with preeclampsia in Sidotopo Wetan Health Care Centre (p= 0.028), while OR value was 0.158 (95% CI 0.032 to 0.776). It can be concluded that insufficient intake of Folic acid during pregnancy correlate to preeclampsia incidents. Keywords: Folic Acid, Preeclampsia, Incidents, Pregnancy
Both Acute and Chronic Exercise Decrease Total Cholesterol Level in Human Blood Bambang Purwanto; Wahyu N. Pratiwi; Abdurachman Abdurachman
Health Notions Vol 2, No 9 (2018): September
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (107.872 KB) | DOI: 10.33846/hn.v2i9.319

Abstract

Exercise such as Diabetes dance of Persadia 1 is the evolvement of prior diabetes dance series with aerobic principle with more eccentric movement. Diabetes dance of Persadia 1 has been inspected effective for lowering fasting blood glucose, but its still unknown about its effect on blood level of total cholesterol. The aim of this research was to analyze the effect of exercise on total cholesterol level. This research was experimental study, with 16 subject of healthy housewifes and divided on 2 groups, that were exercise and control group. Exercise group was given with diabetes dance of Persadia 1 while control group have the unstructured activity. Blood level of total cholesterol (TC) has been measured after 24 hours post single bout exercise (acute-AE) and repeated exercise (chronic exercise-CE). Paired t-test analysis on both acute (AC) (p=0.005) and chronic (CC) (p=0.006) shows TC decrease significantly on control group, as well as on AE (p=0.001) and CE (p=0.001). However, TC tend to increase on CC though not significantly increase (p=0.916), while on CE tend to decrease significantly (p=0.041). This study showed that both acute and cronic exercise decrease total cholesterol level in human blood. Keywords: Interleukin-6, Total cholesterol level, Exercise