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All Journal Indonesian Journal of Cancer Jurnal Penyakit Dalam Indonesia
Zubairi Djoerban
Divisi Hematologi-Onkologi Medik, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN dr. Cipto Mangunkusumo, Jakarta, Indonesia
Health Professions Medicine & Pharmacology

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Efficacy and Safety of In-Asia-Manufactured rhG-CSF 300 mcg As Primary Prophylaxis for Prevention of CHOP Chemotherapy-induced Severe Neutropenia in Elderly Patients with Lymphoma Non-Hodgkin Reksodiputro, Harryanto; Djoerban, Zubairi; Tambunan, Karmel L.; Sudoyo, Aru W.; Widjanarko, Abidin; Atmakusuma, Djumhana; Syafei, Syafrizal; Prayogo, Nugroho; Hukom, Ronald; Ranuhardy, Dody; Jack, Zakifman; Harsal, Asrul; -, Noorwati S; Karsono, Bambang; Effendi, Shufrie; Tadjoedin, Hilman
Indonesian Journal of Cancer Vol 3, No 1 (2009): Jan - Mar 2009
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Penelitian open-label, non-komparatif ini dilakukan untuk mengevaluasi efektivitas dan keamanan recombinant human G-CSF produksi Asia sebagai profilaksis primer dalam pencegahan neutropenia derajat berat pada pasien usia lanjut (>60 tahun) dengan limfoma non-Hodgkin (LNH) derajat sedang dan lanjut (stadium II,III,IV) yang mendapat terapi CHOP (siklofosfamid, doksorubisin, vinkristin). Profilaksis primer recombinant human G-CSF (rhG-CSF) produksi Asia dapat mengurangi median durasi neutropenia derajat 4 pada siklus sitostatistika ke-1 dan ke-2 menjadi tiga hari, sementara median durasi neutropenia derajat 3 pada siklus sitostistika ke-1 menjadi dua hari dan pada siklus sitostatistika ke-2 menjadi dua setengah hari, dari median durasi neutropenia grade 4 dan grade 3 tanpa G-CSF, yaitu empat dan lima hari berurutan. Febrile neutropenia ditemukan pada 7 pasien yang mendapat rhG-CSF produksi Asia (24.1%), lebih rendah jika dibandingkan studi tanpa rhG-CFS (31.3-34% FN). Tiga pasien mendapat rhG-CSF produksi Asia (10,3%) dirawat inap akibat febrile neutropenia, lebih rendah jika dibandingkan rawat inap pada studi tanpa rhG-CSF (24-28%). Kejadian yang tidak diinginkan terbanyak adalah mual dan muntah yang terjadi pada 9 (31%) pasien. Sebagai kesimpulan, penggunaan rhG-CSF produksi Asia untuk profilaksis primer pada pasien LNH usia lanjut yang mendapat regimen CHOP dapat mengurangi durasi neutropenia, mengurangi kejadian febrile neutropenia, dan angka rawat inap akibat febrile neutropenia.Kata kunci : Efektivitas, keamanan, G-CSF, LNH pada usia lanjut
Validity and Reability Test of Indonesian Version of World HealthOrganization Quality of Life-HIV BREF Questionnaire to MeasureThe Quality of Life Patients with HIV/AIDS Muhammad, Nanda N.; Shatri, Hamzah; Djoerban, Zubairi
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 3
Publisher : UI Scholars Hub

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Introduction. Health-related quality of life among HIV patients can be used as one of several indicators of successful therapy. WHOQOL-HIV BREF questionnaire is one of the instruments used to assess the patients’ quality of life that has been used in many countries, but never been tested for its validity and reliability in Indonesia. This study aims to determine the validity and reliability of the questionnaire WHOQOL-HIV BREF in bahasa Indonesia as a tool for measuring the quality of life of HIV patients. Methods. A cross-sectional study was conducted in HIV Integrated Service Unit Cipto Mangunkusumo General Hospital (RSCM) Jakarta in November 2016 with consecutive sampling method. The study was conducted in two phases: first phase for the language and cultural adaptation process and second phase to test the validity and reliability of the questionnaire. Results. Fifty six respondents filled the questionnaire, 69.6% of them were male. Using a multi-trait scaling analysis, correlation coefficient value had a high correlation with the total score domain. This meant that it had a good validation. Correlation between questionnaire domain WHOQOL-HIV BREF and SF-36 questionnaire domain obtained 6 significant domains that shown strong correlation coefficient (r = 0.60 to 0.79; p <0.005). Reliability of the questionnaire was assessed by intraclass correlation coefficient of each domain, which was range from 0.401 to 0.484 with Cronbach Alpha 0.513 to 0.798 . Conclusions. The questionnaire WHOQOL-HIV BREF in the Indonesian language is valid and reliable.
Co-Authors Abidin Widjanarko Anna M Lubis, Anna M Aru W. Sudoyo Arwin A.P. Akip, Arwin A.P. Asrul Harsal, Asrul Bambang Karsono Budi Utomo Daldiyono Daldiyono Djumhana Atmakusuma, Djumhana Dody Ranuhardy, Dody E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Erni J Nelwan, Erni J Evert D.C. Poetiray Evy Yunihastuti H.M. Sjaifoellah Noer Harryanto Reksodiputro, Harryanto HILMAN TADJOEDIN, HILMAN Irwanto Irwanto Iwan Iwan Julius R Samban Karmel L. Tambunan Ken Ayu Mastini, Ken Ayu Laurentius A Pramono, Laurentius A Murdani Abdullah Nanda N. Muhammad, Nanda N. Noorwati S -, Noorwati S Nugroho Prayogo Nuryati C. Siregar R Irawati Ismail, R Irawati Rafiq S. Nugroho Ratnawati Soediro Rino A Gani Ronald Hukom Sabarinah Sabarinah, Sabarinah Shufrie Effendi, Shufrie Soehartati Gondhowiardjo Surilena Hasan Syafrizal Syafei, Syafrizal Unggul Budihusodo Zakifman Jack, Zakifman