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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Phenomenon : Jurnal Pendidikan MIPA
Arif Widiatmoko
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Chemistry Education Health Professions Mathematics Medicine & Pharmacology Physics Public Health

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Epidermolysis Bullosa Acquisita Occuring In A Patient With Systemic Lupus Erythematosus Lita setyowatie; Yustian Devika Rahmawati; Arif Widiatmoko; Diah Prabawati Retnani
Saintika Medika Vol. 15 No. 2 (2019): December 2019
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol15.SMUMM2.9884

Abstract

Epidermolysis Bullosa Acquisita (EBA) is a rare, chronic autoimmune subepidermal bullous disease and has been noted to be associated with systemic lupus erythematosus (SLE). The incidence of EBA and SLE in one patient within the period of 1980-1990 found only 7 published case reports. A 23 years old woman with exfoliate skin since 12 years ago. Initially itchy on her buttock then appeared small blister. Blister spread almost the entire body and rupture. This complaint got worsening in a year accompanied with hair loss, weight loss, and oral ulcer. Dermatological examination showed patch eritematosa, hyperpigmentation, hypopigmentation, erotion with erythematous base, yellow brownish crust. Also obtained sclerodactyli toes and nail fingers. Laboratory examination anemia gravis, hypoalbuminemia, Coombs test +2, ANA Test negatif, dsDNA IgG 32,80. Histopathology examination showed blister subepidermal, no vacuolar degeneration, no superficial and deep infiltrat, and minimal lymphocyte. Patient had diagnosed SLE from Internal Department based on MEX-SLEDAI score. The patient was treated with metylprednisolone intravenous pulse dose 500 mg on 3 days then tappering off and wound care. Epidermolysis Bullosa Acquisita immunogenetically related with MHC class II haplotype in particular  HLA-DR2. This factor suggest playing role in the development of  EBA to express more aggresive SLE. 
Implementation of a Differentiated Project-Based Learning Model to Improve Students' Scientific Process Skills and Scientific Attitudes Nadila Qothrun Nada Nada; Ani Rusilowati; Budi Astuti; Arif Widiatmoko; Suharto Linuwih
Phenomenon : Jurnal Pendidikan MIPA Vol. 15 No. 1 (2025): Phenomenon: Jurnal Pendidikan MIPA
Publisher : Faculty of Science and Technology, Universitas Islam Negeri Walisongo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/phen.2025.15.1.28032

Abstract

This study aims to implement a differentiated Project-Based Learning (PjBL) model to improve students' science process skills and scientific attitudes in the topic of renewable energy. A quasi-experimental method with a pretest-posttest control group design was applied. The experimental class was taught using the differentiated PjBL model, while the control class used conventional PjBL. Instruments included open-ended tests to assess science process skills and Likert-scale questionnaires to evaluate scientific attitudes. The results showed a significant improvement in all science process skill indicators and scientific attitudes in the experimental class compared to the control group. Skills such as observing, questioning and predicting, conducting investigations, processing and analyzing data and information, evaluating and reflecting, as well as communicating results improved evenly across the board. Regression analysis indicated that science process skills positively influenced scientific attitudes, contributing 11.8% of the variance. These findings highlight the effectiveness of differentiated PjBL in offering more personalized and contextual learning experiences that develop both cognitive and affective student outcomes. Physics teachers are encouraged to integrate this model into classroom practice and to enhance their competence in designing student-centered project learning. Future studies may explore its application across different subjects and education levels to broaden its impact.
Co-Authors Ani Rusilowati Budi Astuti Lita setyowatie Nadila Qothrun Nada Nada Retnani, Diah Prabawati Suharto Linuwih Yustian Devika Rahmawati