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Journal : METAMORFOSA Journal of Biological Sciences

Efek Ekstrak Daun Seledri (Apium graveolens L.) Terhadap Struktur Histologi Ginjal Tikus (Rattus norvegi Nana Zaimatul Husna; Mahriani Mahriani; Hidayat Teguh Wiyono
Metamorfosa: Journal of Biological Sciences Vol 8 No 1 (2021)
Publisher : Prodi Magister Ilmu Biologi, Fakultas MIPA, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/metamorfosa.2021.v08.i01.p10

Abstract

The kidneys are an important excretory organ for removing the rest of the body's metabolism. Kidney stones can affect kidney function. Celery contains flavonoid compounds that can improve the histological structure of the kidneys. This study aims to determine the effect of celery extract on the histological structure of the kidneys, namely the diameter of the glomerulus and tubule with protein deposits. This research is experimental with completely randomized design (CRD). The treatment group was divided into 4 groups, namely, negative control (K-), rats were only given food and drink; positive control (K+), rats induced Ethylene glycol (EG) 0.75% + Ammonium Chloride (AK) 2%, dose 1 (D1), rats induced EG 0.75% + AK 2% and celery extract 100 mg / kg, dose 2 (D2), rats induced EG 0.75% + AK 2% and celery extract 200 mg / kgBB. Celery extract was given for 14 days by gavage. Celery extract at doses of 100 and 200 mg / kgBB were able to improve the histological structure of the rats' kidneys induced by EG 0.75% and AK 2%. Keywords: celery, glomerular diameter, protein deposits
Prevalensi Kemampuan Mengecap Phenylthiocarbamide (PTC) Pada Penduduk Pulau Gili Ketapang Kabupaten Probolinggo Rike Oktarianti; Siti Agustina Wulandari; Hidayat Teguh Wiyono; Mahriani Mahriani
Metamorfosa: Journal of Biological Sciences Vol 10 No 1 (2023)
Publisher : Prodi Magister Ilmu Biologi, Fakultas MIPA, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/metamorfosa.2023.v10.i01.p07

Abstract

The taste of sensitivity of Phenylthiocarbamide (PTC), is autosomal dominant trait inherited. The taster controled by dominant allele while the non-taster determinated by recessive allele. The purpose of this study was to determine the prevalence and frequency of taster and non-taster alleles for PTC, as well as non-taster inheritance patterns at the population of Gili Ketapang island, Probolinggo district. Determination of the sample or respondents was carried out by randomly, total sample were 384 people, aged from 15-30 years. Detection of the taste sensitivity PTC was ask to respondents to taste the PTC solution. The PTC solution used was from the lowest concentration of 0.32mg/L (P13) to the highest concentration of 1300 mg/L (P1). The results showed that the prevalence of taster and non-taster were 96.88% and 3.12%, respectively. The frequency of taster (T) and non-taster alleles was 0.83 and non-taster was 0.17. The pedigree analysis of non-taster showed that non-taster individuals were born from heterozygous taster pairs (Tt) or from marriages between heterozygous taster individual (Tt) with non-tasters (tt). Keyword: Phenylthiocarbamide (PTC), taster, non taster