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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Sainteks INDONESIAN JOURNAL OF PHARMACY JSFK (Jurnal Sains Farmasi & Klinis) Refleksi Pembelajaran Inovatif Medical Sains : Jurnal Ilmiah Kefarmasian Khazanah: Jurnal Mahasiswa Medical Sains : Jurnal Ilmiah Kefarmasian
Bambang Hernawan Nugroho
Department Of Pharmacy, Universitas Islam Indonesia
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences

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Journal : EKSAKTA: Journal of Sciences and Data Analysis

 1 
Pemanfaatan Ekstrak Daun Tin (Ficus carica L.) Berbasis Nanoteknologi Liposom Sebagai Pengobatan Antihiperglikemia Bambang Hernawan Nugroho; Aldia Dwi Karina Ningrum; Denox Asih Pertiwi; Tasya Salsabila; Yandi Syukri
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 19, ISSUE 2, August 2019
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/eksakta.vol19.iss2.art12

Abstract

Kandungan flavonoid dalam ekstrak daun tin (Ficus carica L.) memiliki aktiftas anti diabetes. Namun, ekstrak daun tin memiliki kelarutan dan absorpsi yang rendah. Penelitian ini bertujuan untuk mengetahui efektivitas liposom ekstrak daun tin sebagai antihiperglikemia terhadap kadar glukosa darah puasa ikan zebra. Ekstrak daun tin distandarisasi berdasarkan parameter nonspesifik kemudian diformulasikan ke dalam liposom. Selanjutnya dilakukan karakterisasi melalui pengamatan terbentuknya liposom secara visual, pembacaan ukuran partikel dengan Particle Size Analyzer (PSA), uji stabilitas, dan Transmission Electron Myroscope (TEM). Uji antihiperglikemia terdiri dari tiga kelompok dan dipilih secara acak.  Kelompok kontrol negatif, positif, dan perlakuan diberi Aloksan pada hari pertama dan glukosa 1%. Pada hari ke-7, kelompok kontrol positif diberi Metformin, sedangkan kelompok perlakuan diberi liposom. Ikan zebra diperiksa kadar gula darah puasa dengan glucometer. Formula ke-5 dengan waktu ultrasonikasi selama 8 menit telah memenuhi kriteria sediaan liposom yang baik dengan karakteristik warna putih susu, ukuran partikel 116,17 ± 4,40nm; PI 0,439 ± 0,01Ð; zeta potensial -18,53 ± 0,41mV; stabil selama 24 jam; dengan morfologi bentuk bulat, memanjang, dan tidak beraturan. Liposom ekstrak daun tin terbukti mampu menurunkan kadar glukosa darah puasa ikan zebra sebesar 62,09%. Dapat disimpulkan bahwa liposom ekstrak daun tin berpotensi sebagai alternatif pengobatan antihiperglikemia. 
Composite of Polylactic Acid/Chitosan/Ag-Hydroxyapatite Synthesized Using Turmeric Leaves Extract-Mediated Silver Nanoparticle and Snail Shell as Antibacterial Material Rahmania Audita; Khoirunisa khoirunisa; Hasna' Azizah Azzahra'; Bambang Hernawan Nugroho; Habibi Hidayat; Is Fatimah
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 2, ISSUE 2, August 2021
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol2.iss2.art5

Abstract

The development of an antibacterial composite of polylactic acid/chitosan/silver nanoparticle-doped hydroxyapatite has been synthesized. The composite was prepared using the silver nanoparticles (AgNPs) green synthesized by using turmeric (Curcuma longa Linn) leaves extract-mediated AgNPs and snail shell as biogenic calcium for hydroxyapatite synthesis. The precipitation method of hydroxyapatite by the doping of AgNPs was the first step, followed by composting with polylactic acid and chitosan as the polymer binder. Physicochemical characterization of the material was studied by using XRD, SEM, and FTIR analyses, and the antibacterial catalytic performance was examined against Escherichia coli (E. coli). The results showed that the synthesized AgNPs are within the <100 nm range in size and not significantly influence the crystallinity of the Ag/HAp. The composite materials maintained the antibacterial activity against E. coli.
Co-Authors Agung Giri Samudra Aldia Dwi Karina Ningrum Aldia Dwi Karina Ningrum Anik Ariyani Apriza Hongko Putra Citrariana, Shesanthi Denox Asih Pertiwi dia Purnika Dimas Adhi Pradana Galuh Annaba Maharani Habibi Hidayat Hannie Fitriani Hasna' Azizah Azzahra' Herianto Pandapotan Illah Rahmawat Is Fatimah Istanti Istanti Ita Nurma Sari Khoirunisa khoirunisa Lailiana Garna Nurhidayati M Munawwarah Multi Tri Wardhani Nilam Permata Sari Nurfijrin Ramadhani, Nurfijrin Oktavia Indrati, Oktavia Prima Aulia Putra Rahmania Audita Reny Nadya Oktari Reza Pertiwi Rika Artikawati Sani K, Fathnur Septiani Eka Cahyani Shinta Dewi Sirikit Wangi Sarindang Sirikit Wangi Sarindang Suparmi Suparmi Suparmi Suparmi Tasya Salsabila Tendy Kurniawan Tri Senja Aprilia Tri Senja Aprilia Yandi Syukri Yoga Febriana