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All Journal e-Journal Pustaka Kesehatan Jurnal Ilmu Kesehatan Masyarakat STOMATOGNATIC- Jurnal Kedokteran Gigi Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva UNEJ e-Proceeding Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Journal of Dentomaxillofacial Science Warta Pengabdian Padjadjaran Journal of Dental Researchers and Students Journal of Community Service and Empowerment Odonto dental journal
Tantin Ermawati
Bagian Ilmu Kesehatan Gigi Masyarakat, Fakultas Kedokteran Gigi, Universitas Jember
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Public Health Social Sciences Other

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Journal : UNEJ e-Proceeding

 1 
EFFECTS OF ROBUSTA COFFEE BEAN EXTRACT (Coffea robusta) ON THE VIABILITY OF NEUTROPHILS EXPOSED BY Porphyromonas gingivalis Tantin Ermawati
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

The new paradigm evolving today in thetreatment of periodontal infection is the use a hostmodulator therapy i.e. therapy that aims to improvethe host immune response to bacterial infection.Good immune response is necessary in increasingthe phagocytic function that in this case is played byneutrophil cells, monocytes and macrophages, whichserved as the first line of defense against bacterialinfections. One of the bacteria causing periodontalinfection is P. gingivalis. It has the biggest role incausing periodontal disease, where in the proteolyticenzyme such as gingipain contributes to thebacterial pathogenicity.1, 2 During the initial invasionP. gingivalis will colonize the gingival sulcus andinvade into the gingival tissues and will induce aninflammatory response and continue to alveolarbone resorption.3The immune response that acts first againstinvading bacteria is neutrophils. The presence ofbacterial adhesion to neutrophils allows neutrophilssecrete microbicidal substance by destroying thebacterial membrane and fagocyting bacteria. Aneutrophil can phagocyte bacteria before becominginactive or cell lysis. Phagocytosis that occurs canaffect the lysis of neutrophils. This can emerge veryfatal impacts because if the neutrophils undergo lysisthen chemical components and enzymes may breakinto the tissue leading to degradation of variousorganic molecules of its adjacent tissue.4 NowdaysIndonesia has developed a lot of research onmedicinal plants, such as Robusta coffee beans.Robusta coffee beans naturally have substances suchas caffeine, phenolic compounds, trigonellin andchlorogenic acid which have antibacterial activity.Besides as antibacterial chlorogenic it also hasantioxidant properties.5 Based on the abovebackground, the researchers want to developRobusta coffee beans as host modulator therapy tomaintain the viability of neutrophils by observingneutrophil cell viability against P. gingivalis appliedby Robusta coffee bean extract which will be usefulfor preventing periodontal tissue infections of theoral cavity.
Co-Authors Achmad Gunadi Anisa Nur Hakima Dania Kartikasari Depi Praharani Desi Sandra Sari Dessy Rachmawati Dhilan Purna Aji Dwi Warna Aju Fatmawati Favinas Octa Nuri Tsalats Febriana Tria N Hakima, Anisa Nur Happy Harmono Ika Wahyu Purnamasari Jannata Hafidata Rabbani Kwartarini Murdiastuti M Melok M Melok, M Mei Syafriadi Nadie Fatimatuzzahro Nazilatur Rohmah Nazilaturrohmah Nulend, Jenneke Klein Nurul Iffah, Astrid Ganadya Peni Pujiastuti Pintan Qorina Destianingrum Pudji Astuti Rendra Chriestedy Prasetya Riezki Dwianggraini W Riezki Dwianggraini W, Riezki Ristya Widi Endah Yani Suhartini Suhartini Suhartini Suhartini Tecky Indriana Yuliana Mahdiyah Daat Arina Zahara Meilawati Zahara Meilawaty Zahreni Hamzah