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PERBEDAAN EFEKTIFITAS ANTIBAKTERI ANTARA EKSTRAK DAUN SIRIH MERAH (Piper crocatum) DAN EKSTRAK DAUN SIRIH HIJAU (Piper betle L.) TERHADAP Porphyromonas gingivalis Dwianggraini W, Riezki; Pujiastuti, Peni; Ermawati, Tantin
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 10, No 1 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Almost people in the world got periodontal disease. It is about 50 % of adult population. Porphyromonas gingivalis (P. gingivalis) is anaerobic negative gram bacteria and played role in periodontitis, especially chronic periodontitis. Periodontal disease can be prevented by decreasing of plaque accumulation with oral rinse. Oral rinse can use traditional herbal, such as green and red betel leaf. Aim of this study was to know difference of antibacterial effectivity of green (piper betle l) and red (piper crocatum) betel leaf extract toward P. gingivalis. This research used well diffusion methods. There used 24 samples and divided 3 groups. First group used red betel leaf extract, second group used green betel leaf extract and third group used sterile aquadest. The samples were incubated for 24 hours in room temperature 37Â°C. Then, they were measured by inhibition zone by calipers. The result showed diameters of inhibition zone of green betel leaf was larger than red betel leaf and sterile aquadest. One way Anova test showed there was significant difference between the groups. The conclusion showed green betel leaf extract had antibacterial activity more than red betel leaf extract toward P. gingivalis.

HUBUNGAN KADAR GLUKOSA DARAH DENGAN PERTUMBUHAN A. actinomycetemcomitans PADA TIKUS DIABETES MELITUS Ermawati, Tantin
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 9, No 1 (2012)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Diabetes mellitus is a systemic disease characterized by insulin deficiency. Common symptoms in people with diabetes is elevated blood glucose is called hyperglycemia. Manifestations in the oral cavity are inflammation of gingival tissue or periodontitis. The bacteria that play a role in the severity of periodontal disease is A. actinomycetemcomitans. The purpose of this study was to determine the relationship of blood glucose levels with the growth of A. actinomycetemcomitans in DM rats treated with insulin therapy. Methode 20 three month old male Wistar rats with weight of 170-200 grams were divided into two groups. First, periodontitis and DM were manipulated into all groups through aloksan injection with dose of 170 mg/kg. Those rats in group I were treated with insulin, those in group II were without treatment. In the third and seventh weeks, the blood glucose levels and the number of A. actinomycetemcomitans was measured. The data was tested by using Pearson test. The results showed that there is a strong relationship between blood glucose levels with the growth of A. actinomycetemcomitans. Conclusion: The increasing blood glucose levels are very strongly associated with an increase in the number of A. actinomycetemcomitans and otherwise in DM rats with insulin therapy.

STATUS KESEHATAN PERIODONTAL DAN TINGKAT KEBUTUHAN PERAWATAN PASIEN YANG DATANG KE KLINIK PERIODONSIA RSGM UNIVERSITAS JEMBER TAHUN 2011 Ermawati, Tantin; Sari, Desi Sandra; Melok, M
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 9, No 2 (2012)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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The CPITN is a screening procedure for identifying actual and potential problems posed by periodontal disease. The aim of this study was to know periodontal status and periodontal treatment needs from patient that come to RSGM department periodontia faculty of dentistry Jember University in the year 2011. The study population comprised 191 adolescences (10 â 59 years). An observational study was conducted at RSGM of Jember University. The results of the study showed that individuals with a health periodontium is 1.05 %, score (1) with bleeding on probing is 3.14 %. Periodontal pocket (4-5mm) was recorded 17.27 %. The highest periodontal score is scores 2 (calculus) 78.53% of the population need dental scaling. We conclude that prevalence periodontal disease in patients that come to periodontics department is very high and periodontal treatment need with scaling.

STATUS KEBERSIHAN MULUT DAN KESEHATAN PERIODONTAL PASIEN YANG DATANG KE KLINIK PERIODONSIA RSGM UNIVERSITAS JEMBER PERIODE AGUSTUS 2009 â AGUSTUS 2010 Praharani, Depi; Ermawati, Tantin; Pujiastuti, Peni
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 8, No 3 (2011)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Level of oral hygiene have a close relationship with periodontal health status; where good oral hygiene will minimize the occurrence of periodontal disease. Aims of this study were to assess the oral hygiene status and periodontal health patients that come to Department of Periodontics of Jember University Dental Hospital at August 2009 until August 2010. This type of research is an observational study of clinical (cross sectional). A total of 155 sample (87 males and 66 females) were examined by using Oral Hygiene Index-Simplified (OHI-S) and Periodontal Index. Good oral hygiene was seen in 11% of total sample examined, 54,2% had fair oral hygiene and rest 34,8% showed poor oral hygiene. 0,6% of total sample examined had healthy periodontal, 18,1% had simple gingivitis, 41,3% had initial of periodontal disease destructive, 37,45 had periodontal disease destructive and 2,6% had terminal disease. Oral hygiene status and periodontal health examination revealed that majority of sample had fair oral hygiene and periodontal disease destructive.

PERIODONTITIS DAN DIABETES MELITUS Ermawati, Tantin
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 9, No 3 (2012)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Periodontitis is a chronic infection disease caused by periodontopathogen bacteria in the oral cavity. Severity of periodontitis can be affected by systemic diseases such as diabetes mellitus. Diabetes mellitus is occurred metabolic disruption that is characterized by hyperglycemia due to insulin deficiency. Increasing blood glucose levels can lead to manifestations in the oral cavity in the form of inflammation of the gingival tissue, attachment loss and alveolar bone destruction. Periodontitis is one of the sixth complications of diabetes mellitus. There are inter- related relationship between periodontitis and diabetes mellitus.

Daya Hambat Ekstrak Biji Kopi Robusta (Coffea robusta) terhadap Pertumbuhan Fusobacterium nucleatum Hakima, Anisa Nur; Ermawati, Tantin; Harmono, Happy
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 15 No 2 (2018)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v15i2.17932

Fusobacterium nucleatum is a bacteria found in normal flora of the oral cavity that plays a role in the occurrence of periodontal disease. The prevalence of periodontal disease in Indonesia reaches 70%. One treatment by using medicinal plants is robusta coffee beans. Robusta coffee beans contain volatile acids, chlorogenic acids, caffeine acids, phenols and caffeine suspected to be antibacterial. The objective of this study was to determine the inhibition of coffee robusta extract on growth of Fusobacterium nucleatum. This study used disc diffusion method with 4 samples in each study group. The study group consisted of 6 treatment groups (12,5%, 25%, 50% and 100% coffee robusta extract), positive control group (chlorhexidine gluconate 0,2%), and negative control group (sterile aquades). Data were analyzed using One Way Anova test and LSD (Least Significant Difference) test. Coffee robusta extract has the ability to inhibit the growth of Fusobacterium nucleatum. The concentration of coffe robusta extract 100%, 50%, 25%, 12,5% have same ability to inhibit the growth of Fusobacterium nucleatum.

Efek Gel Ekstrak Biji Kopi Robusta (Coffea canephora) terhadap Jumlah Sel Makrofag dan Limfosit Jaringan Gingiva Tikus Periodontitis Ermawati, Tantin; Prasetya, Rendra Chriestedy; Fatimatuzzahro, Nadie; Nurul Iffah, Astrid Ganadya
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva Vol 9, No 2 (2020)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/di.9217

Periodontitis adalah inflamasi kronis yang disebabkan infeksi bakteri salah satunya P. gingivalis. Produk bakteri berupa lipopolisakarida (LPS) mampu meningkatkan sekresi sitokin proinflamatori sehingga terjadi peningkatan jumlah sel makrofag dan limfosit. Hal ini menyebabkan kerusakan jaringan periodontal yang lebih lanjut. Biji kopi robusta memiliki kandungan polifenol, alkaloid dan saponin yang berfungsi sebagai antiinflamasi dan antioksidan. Penelitian ini bertujuan untuk mengetahui efek pemberian gel ekstrak biji kopi robusta terhadap jumlah sel makrofag dan limfosit pada gingiva model tikus periodontitis. Jenis penelitian yang digunakan adalah the post test only control group design. Dua puluh ekor tikus dibagi menjadi 5 kelompok yakni kelompok normal, periodontitis, periodontitis yang diterapi gel aloclair, kelompok periodontitis yang diterapi 0,025 g/mL gel ekstrak biji kopi robusta, dan kelompok periodontitis yang diterapi 0,05 g/mL gel ekstrak biji kopi robusta selama 7 hari perlakuan. Tikus didekapitasi dan dilakukan pengecatan HE untuk melihat jumlah sel makrofag dan limfosit. Hasil menunjukkan pemberian gel ekstrak kopi robusta dapat menurunkan jumlah sel makrofag dan limfosit sama dengan aloclair pada model tikus periodontitis yang diinduksi P. gingivalis. Gel ekstrak biji kopi 0,05 g/mL lebih efektif menurunkan limfosit dibandingkan 0,025 g/mL.

Improving oral and dental health through counseling to elementary school students in Jember Ermawati, Tantin; Yani , Ristya Widi Endah; Syafriadi, Mei
Journal of Community Service and Empowerment Vol. 2 No. 1 (2021): April
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/jcse.v2i1.16034

Measures to prevent dental and oral diseases in children can be done by providing information about parts of the teeth, dental caries and the process of dental caries, as well as plaque control as an effort to prevent the occurrence of dental and oral diseases. This activity was carried out aimed at increasing understanding and knowledge of the importance of maintaining oral health in children, especially elementary school students. The knowledge that has been given is expected to be able to change the behavior of students of SDN Kranjingan III Jember, East Java-Indonesia to be able to maintain the health of their teeth and mouth properly. This can be seen through the debris index. In addition to counseling activities, other methods provided were demonstrations of how to brush teeth, demonstration of pictures and posters carried out by the service team from the Faculty of Dentistry, University of Jember. The service activities carried out can increase knowledge and improve the degree of dental and oral health of SDN Kranjingan III Jember students.

Efek Gel Ekstrak Biji Kopi Robusta (Coffea canephora) terhadap Jumlah Sel Makrofag dan Limfosit Jaringan Gingiva Tikus Periodontitis Ermawati, Tantin; Prasetya, Rendra Chriestedy; Fatimatuzzahro, Nadie; Nurul Iffah, Astrid Ganadya
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva Vol 9, No 2 (2020): November
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/di.9217

Periodontitis adalah inflamasi kronis yang disebabkan infeksi bakteri salah satunya P. gingivalis. Produk bakteri berupa lipopolisakarida (LPS) mampu meningkatkan sekresi sitokin proinflamatori sehingga terjadi peningkatan jumlah sel makrofag dan limfosit. Hal ini menyebabkan kerusakan jaringan periodontal yang lebih lanjut. Biji kopi robusta memiliki kandungan polifenol, alkaloid dan saponin yang berfungsi sebagai antiinflamasi dan antioksidan. Penelitian ini bertujuan untuk mengetahui efek pemberian gel ekstrak biji kopi robusta terhadap jumlah sel makrofag dan limfosit pada gingiva model tikus periodontitis. Jenis penelitian yang digunakan adalah the post test only control group design. Dua puluh ekor tikus dibagi menjadi 5 kelompok yakni kelompok normal, periodontitis, periodontitis yang diterapi gel aloclair, kelompok periodontitis yang diterapi 0,025 g/mL gel ekstrak biji kopi robusta, dan kelompok periodontitis yang diterapi 0,05 g/mL gel ekstrak biji kopi robusta selama 7 hari perlakuan. Tikus didekapitasi dan dilakukan pengecatan HE untuk melihat jumlah sel makrofag dan limfosit. Hasil menunjukkan pemberian gel ekstrak kopi robusta dapat menurunkan jumlah sel makrofag dan limfosit sama dengan aloclair pada model tikus periodontitis yang diinduksi P. gingivalis. Gel ekstrak biji kopi 0,05 g/mL lebih efektif menurunkan limfosit dibandingkan 0,025 g/mL.

Efek pemberian gel ekstrak biji kopi robusta (Coffea canephora) terhadap jumlah osteoblas dan osteoklas pada tulang alveolar tikus periodontitisThe effect of robusta coffee bean (Coffea canephora) extract gel on the number of osteoblasts and osteoclasts in the alveolar bone of periodontitis rats Nadie Fatimatuzzahro; Tantin Ermawati; Rendra Chriestedy Prasetya; Pintan Qorina Destianingrum
Padjadjaran Journal of Dental Researchers and Students Vol 4, No 2 (2020): Oktober 2020
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v4i2.28383

Pendahuluan: Periodontitis adalah peradangan jaringan pendukung gigi yang disebabkan oleh mikroorganisme, salah satunya Porphyromonas gingivalis, yang dapat menginduksi makrofag dan limfosit serta menstimulasi osteoblas untuk meningkatkan receptor activator of nuclear factor kβ-ligand (RANKL) dan menurunkan osteoprotegerin (OPG). Kondisi inflamasi yang berlanjut mengakibatkan OPG sedikit mengikat RANKL, sehingga RANKL berikatan dengan receptor activator of nuclear factor kβ (RANK) pada prekusor osteoklas. Hal ini akan mengaktifkan osteoklas dan menyebabkan kerusakan tulang. Osteoblas dan osteoklas berperan dalam keseimbangan resorpsi dan aposisi tulang. Biji kopi robusta mengandung senyawa aktif polifenol, alkaloid, dan saponin, yang bersifat antiinflamasi. Penelitian ini bertujuan untuk menganalisis efek gel ekstrak biji kopi robusta (C. canephora) terhadap jumlah osteoblas dan osteoklas pada tulang alveolar tikus periodontitis. Metode: Jenis penelitian eksperimental laboratoris, menggunakan teknik random sampling untuk penelitian in-vivo, diperoleh minimal sampel sebanyak 4 ekor tikus tiap kelompok; kelompok normal (KN); kelompok kontrol negatif gel plasebo K(-)7 dan K(-)14; kelompok kontrol positif gel aloclair K(+)7 dan K(+)14; dan kelompok gel ekstrak biji kopi 50% (KP7 dan KP14). Hewan coba didekapitasi pada hari ke-7 dan 14 setelah pemberian terapi gel, kemudian dilakukan pemrosesan jaringan dan pewarnaan HE. Penghitungan osteoblas dan osteoklas pada area sekitar tulang alveolar bukal M1 kiri bawah. Hasil: Terdapat perbedaan yang signifikan (p=0,001) antara rerata jumlah osteoblas kelompok gel ekstrak kopi (33,83±1,37) dibanding kontrol positif (23,24±2,31) dan kontrol negatif (18,91±2,07). Rerata jumlah osteoklas berbeda signifikan (p=0,001) pada kelompok gel ekstrak kopi (0,66±0,54) dibanding kontrol positif (3,08±1,10) dan kontrol negatif (4,00±2,07) (p=0,010). Simpulan: Pemberian gel ekstrak biji kopi robusta (C. canephora) dapat meningkatkan jumlah osteoblas dan menurunkan osteoklas pada tulang alveolar tikus periodontitis.Kata kunci: Gel ekstrak biji kopi robusta, osteoblas, osteoklas, periodontitis. ABSTRACTIntroduction: Periodontitis is an inflammatory disease affecting the teeth supporting tissues caused by specific microorganisms; one of them is Porphyromonas gingivalis, which can induce the macrophages and lymphocytes, then stimulate the osteoblasts to increase the receptor activator of nuclear factor kβ-ligand (RANKL) and decrease osteoprotegerin (OPG). Continued inflammatory conditions cause OPG to bind slightly to the RANKL; thus the RANKL will be able to binds to the receptor activator of nuclear factor kβ (RANK) in osteoclast precursors, which will activate the osteoclasts and cause bone damage. Osteoblasts and osteoclasts play a vital role in the balance of bone resorption and apposition. Robusta coffee beans contain active compounds such as polyphenols, alkaloids, and saponins, which act as anti-inflammatory agents. This research was aimed to analyse the effect of robusta coffee bean (C. canephora) extract gel on the number of osteoblasts and osteoclasts in the alveolar bone of periodontitis rats. Methods: Experimental laboratory research with simple random sampling technique for in-vivo study obtained the minimal sample number of 4 rats in each group; normal group (KN); negative control group placebo gel K(-)7 and K(-)14; positive control group of aloclair gel K(+)7 and K(+)14; and robusta coffee bean 50% extract gel group (KP7 and KP14). The rats were decapitated in the 7th and 14th days after treatment, and then the tissue processing and hematoxylin-eosin staining was carried out. Osteoblasts and osteoclasts were counted in the area around the buccal alveolar bone of the lower-left M1. Results: The results showed a significant difference (p = 0.001) between the mean number of osteoblasts in the coffee extract gel group (33.83 ± 1.37) compared to the positive control group (23.24 ± 2.31) and the negative control group (18.91± 2.07). The mean number of osteoclasts was also had a significant difference (p = 0.001) in the coffee extract gel group (0.66 ± 0.54) compared to the positive control group (3.08 ± 1.10) and (p = 0.010) with the negative control group (4.00 ± 2.07). Conclusion: Robusta coffee bean (C. canephora) extract gel can increase the number of osteoblasts and decrease the number of osteoclasts in the alveolar bone of periodontitis rats.Keywords: Robusta coffee bean extract gel, osteoblasts, osteoclasts, periodontitis.

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