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All Journal Jurnal Kedokteran Brawijaya Universa Medicina Indonesian Journal of Global Health research Narra J Cermin Dunia Kedokteran
Rita Evalina
Divisi Alergi-Imunologi, Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Indonesia / RSU Cipto Mangunkusumo Jakarta
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Additional probiotic therapy lowers SCORAD index in children with atopic dermatitis Ekaputri, Jessica; Evalina, Rita; Deliana, Melda
Universa Medicina Vol 35, No 2 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.68-74

Abstract

Background Atopic dermatitis (AD) is a common skin disease that is usually chronic, relapsing, causing pruritus and frequent in children. The pathogenesis of AD involves genetic, immunological and environmental factors causing skin barrier dysfunction and dysregulation of the immune system. Probiotic treatment has been claimed to offer several functional properties including stimulation of the immune system and plays an important role in AD. The objective of this study was to evaluate the effect of probiotic therapy on atopic dermatitis in children.Methods A randomized controlled trial was conducted on 62 children suffering from AD from December 2015 to January 2016. AD severity was assessed based on the scoring of atopic dermatitis (SCORAD) index. Subjects were divided into two groups consisting of 32 and 30 children, the probiotic (probiotic + emollient) and control (emollient) groups, respectively. SCORAD index was re-evaluated after 2 weeks of therapy. The data was analyzed using Mann Whitney test.Results After the intervention, the mean SCORAD index in the probiotic group was significantly much lower than the control group (18.09 ± 8.59 vs 23.21 ± 8.71; p=0.001). The mean decrease in SCORAD index in the probiotic group was 40.4 %, much higher than the control group 25.2%. The number needed to treat (NNT) score of probiotic treatment was 5.3.Conclusion The addition of probiotics to conventional therapy effectively lowers SCORAD index by 40.4% in atopic dermatitis. The impact of probiotics on SCORAD indices is thought to be attained by modification of the immunogenicity of potential allergens.
FAKTOR YANG DIDUGA MENJADI RESIKO PADA ANAK DENGAN RINITIS ALERGI DI RSU DR. CIPTO MANGUNKUSUMO JAKARTA Harsono, Ganung; Munasir, Zakiudin; Siregar, Sjawitri P; Suyoko, HEM Dadi; Kumiati, Mia; Evalina, Rita; Palupi, Ratih D
Jurnal Kedokteran Brawijaya Vol 23, No 3 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (114.548 KB) | DOI: 10.21776/ub.jkb.2007.023.03.2

Abstract

This researach was aimed to describe the risk factor profile of pediatric patients with allergic rhinitis. 1792 medical recordsof outpatients pediatric allergy immunology clinic in Cipto Mangunkusumo Hospital from 1997 to 2005. Fifty patients were diagnosed with allergic rhinitis and 22% of them  were having allergic rhinitis with bronchial asthma.Allergic rhinitis were identified higher in boys (62%) than girls (38%) and ranged from 5 months to 13 years and 8 months old. Atopic history were identified in 24 patients (48) while atopic history in patient family were identified in mother (42%), father (40%), and siblings (24%). Total IgE serum increased in 35 patients (88,57%) while total eosinophil serum increased in 28 patients (80%). The most common aeroallergen by skin prick test was house dust mite (36%) and the most common food allergen was shrimp (40%). There were several factors that contribute to the development of allergic rhinitis such as age, sex, family atopic history and increasing in total IgE serum and total eosinophil serum . House dust mite and shrimp were the most common allergen identified in allergic rhinitis. Keywords: allergic rhinitis, risk factors, pediatric
Sensitivitas dan Spesifisitas Kriteria American College of Rheumatology (ACR) dan Systemic Lupus International Collaborating Clinics (SLICC) untuk Diagnosis Lupus Eritematosus Sistemik Sembiring, Krisnarta; Irsa, Lily; Evalina, Rita; Lubis, Mahrani
Cermin Dunia Kedokteran Vol 46, No 1 (2019): Obstetri - Ginekologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (103.676 KB) | DOI: 10.55175/cdk.v46i1.543

Abstract

Lupus eritematosus sistemik (LES) merupakan penyakit autoimun yang sering dijumpai pada remaja. Manifestasi klinis yang bervariasi dengan perjalanan penyakit yang sulit diduga menyebabkan angka kecacatan dan kematian penyakit ini cukup tinggi. Terdapat dua kriteria penegakan diagnosis LES, yaitu: kriteria American College of Rheumatology (ACR) dan Systemic Lupus International Collaborating Clinics (SLICC). Kriteria SLICC lebih sensitif dibandingkan ACR sehingga lebih baik untuk menapis pasien dan mempercepat manajemen penyakit.Systemic lupus erythematosus (SLE) is a common autoimmune disease in adolescents. Various clinical manifestations and unpredictable clinical course reslut in high morbidity and mortality. Two diagnostic criteria are: American College of Rheumatology (ACR) and Systemic Lupus International Collaborating Clinics (SLICC) criteria. SLICC criteria is more sensitive; it is better to be used to screen patients and hasten the management of the disease.
A pediatric case and literature review of mucormycosis: Diagnostic and treatment challenges in a resource poor setting Lubis, Inke ND.; Farah, Sara; Pasaribu, Ayodhia P.; Evalina, Rita; Daulay, Rini S.; Wijaya, Hendri
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.426

Abstract

Mucormycosis is an emerging disease that primarily affects immunocompromised patients; however, it has also been reported in immunocompetent individuals. Studies in the pediatric population are limited and reported mostly in case studies or series. The aim of this case report is to present a pediatric mucormycosis originated from Sumatra Island, Indonesia. A 13-year-old boy was referred to a tertiary hospital with facial necrosis involving the nasal, oral, and left maxillary areas, as well as left periorbital edema. No known underlying conditions were documented. The diagnosis was confirmed by histopathological findings of broad, pauci-septate, ribbon-like hyphae branching at 90°. The patient was managed by a multidisciplinary team consisting of the ear, nose, and throat, infectious diseases, dermatology, surgery, microbiology, and pathology departments. Management of the patient included debridement of the necrotic lesion and antibiotics and anti-fungal (fluconazole). Due to unavailability, the patient was not treated with amphotericin B. The patient died after 30 days of admission. This case highlights the importance of maintaining a high suspicion of invasive mucormycosis, even in immunocompetent children, when symptoms and signs are present, especially in resource-limited settings.
Norwegian scabies in human immunodeficiency virus and tuberculosis-infected child: A case report Wijaya, Hendri; Kollins, Fini; Lubis, Inke ND.; Pasaribu, Ayodhia P.; Evalina, Rita; Nababan, Kristo A.; Paramita, Deryne A.
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.661

Abstract

Norwegian scabies is a rare scabies with the manifestation of thick crusts of the extremities of the skin that contain eggs and mites. Several conditions in which scabies infection is easily transmitted include immunocompromised, home nursing, and severe neurological disorder. The aim of this case report was to present a thorough analysis of a comprehensive resource for the management of Norwegian scabies patients, with a specific focus on individuals who also have HIV or other immunocompromising diseases.  A 1-year-and-7-month-old boy was presented to the hospital with a chief complaint of a thick crust that he had experienced for four months. It began as a red papule in the lower extremity, then crusted and spread to the whole body. The patient kept scratching due to itching, had a recurrent fever and diarrhea for three months, and cough for one month. The patient was diagnosed with human immunodeficiency virus (HIV) and pulmonary tuberculosis at three months, suspected to get the infection from the parents. Sarcoptes scabiei was found from microscopy examination of skin scraping. The patient received holistic treatment, including antiretroviral drugs, antituberculosis medication, scabies treatment, and malnutrition treatment. Appropriate scabies treatment aimed at peeling crusted skin, relieving itching, and increasing the patient ability to use the extremities. Comorbidity conditions caused by HIV and pulmonary tuberculosis should also be treated to optimize the outcome. The patient was discharged in good condition with sanitation education and regular follow-up at the outpatient clinic. This case highlights that Sarcoptes scabiei infestation may be a clue to an immunocompromised condition. Holistic therapy aiming to cure underlying infection, infestation and underlying nutrition and psychosocial problems must be addressed to fully cure this high-burden case.
Association Between Glycaemic Control and Cardiac Function in Children with Diabetes Mellitus Ridho, M; Lubis, Siska Mayasari; Amelia, Putri; Harahap, Juliandi; Evalina, Rita; Meirina, Fathia
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.7020

Abstract

The prevalence of Diabetes Mellitus (DM) among children and adolescents has been progressively increasing, with Type 1 DM constituting the majority of cases. Cardiovascular disease (CVD) is a major long-term complication, yet early cardiac involvement remains poorly understood in this population. This study aimed to assess the association between glycaemic control and cardiac function in paediatric patients with DM. A cross-sectional observational study was conducted involving 30 children with type 1 or type 2 DM at H. Adam Malik General Hospital, Medan. Glycaemic control was assessed using HbA1c levels. Cardiac function was evaluated using electrocardiography (ECG) and echocardiographic parameters, including ejection fraction (EF), fractional shortening (FS), tricuspid annular plane systolic excursion (TAPSE), and E/A ratio. Data were analysed using Chi-Square and Mann-Withney Test. Most subjects (90%) had poor glycaemic control (HbA1c ≥7%). Cardiac dysfunction (reduced EF <55%) was identified in 16.7% of patients. However, no statistically significant associations were found between cardiac function and HbA1c, duration of diagnosis, blood pressure, or body mass index (BMI) (p>0.05). There was no significant relationship was found between glycaemic control and cardiac function, highlighting the need for more sensitive diagnostic tools and long-term follow-up to detect subclinical cardiovascular complications.
Co-Authors Amelia, Putri Ayodhia P. Pasaribu, Ayodhia P. Daulay, Rini S. Farah, Sara Fathia Meirina, Fathia Ganung Harsono Harahap, Juliandi HEM Dadi Suyoko Hendri Wijaya, Hendri Jessica Ekaputri, Jessica Kollins, Fini Lily Irsa, Lily Lubis, Inke ND. Lubis, Mahrani Melda Deliana, Melda Mia Kumiati Nababan, Kristo A. Paramita, Deryne A. Ratih D Palupi Ridho, M Sembiring, Krisnarta Siska Mayasari Lubis, Siska Mayasari Sjawitri P Siregar Zakiudin Munasir