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Hematological scoring system as an early diagnostic tool for neonatal sepsis Fathia Meirina; Bidasari Lubis; Tiangsa Sembiring; Nelly Rosdiana; Olga Siregar
Paediatrica Indonesiana Vol 55 No 6 (2015): November 2015
Publisher : Indonesian Pediatric Society

Background Sepsis was the leading cause of death in babies by 30%-50% in developing countries. Early diagnosis of neonatal sepsis is still a difficult problem because of clinical features are not specific. Blood culture is the gold standard, but it takes several days and is expensive. The hematological scoring system (HSS) consists of hematologic parameters (leucocyte count, polymorphonuclear (PMN) cells, degenerative changes, and platelet count) for early diagnosis of neonatal sepsis. Objective To measure HSS as an early diagnostic tool for neonatal sepsis. Methods A cross sectional study was conducted in March to June 2013. Samples were collected by consecutive sampling. Fourty neonates suspected sepsis in neonatology unit H. Adam Malik Hospital, Medan, North Sumatera, underwent routine blood count, blood culture, and peripheral blood smear. Each hematologic parameters were analysed using the HSS of Rodwell et al. The hematologic parameters were total leucocyte count, total PMN cells, total PMN immature, I:T PMN ratio, I:M PMN ratio, degenerative changes, and platelet count. The total value revealed HSS score. Diagnostic study parameters were calculated. Results Ten of fourty neonates had sepsis based on blood culture results. The HSS score >=4 had sensitivity 80%, specificity 90%, with positive predictive value (PPV) 73%, negative predictive value (NPV) 93%, ROC curve showed cut off point 0.902 (95% CI 0.803 to 1.0). Conclusion Score HSS >=4 could be used as an early diagnostic tool for neonatal sepsis.

Tuberculosis risk factors in children with smear-positive tuberculosis adult as household contact Nora Hajarsjah; Ridwan M. Daulay; Oke Rina Ramayani; Wisman Dalimunthe; Rini Savitri Daulay; Fathia Meirina
Paediatrica Indonesiana Vol 58 No 2 (2018): March 2018
Publisher : Indonesian Pediatric Society

Background Children in household contact of adults with smear-positive tuberculosis (TB) are at higher risk of TB infection. Screening of these children is a main strategy for eliminating childhood TB.Objective To determine risk factors of TB among children in household contact with smear-positive adult TB patients.Methods This case-control study was conducted in 5 public health centers at Batu Bara District, North Sumatera. We studied children from birth to 18 year-old living in the same house as adults with smear-positive TB. A tuberculosis scoring system was used to diagnosis TB in the children. Associations between risk factors and the incidence of TB were analyzed using Chi-square, Mann-Whitney U, and logistic regression tests.Results We enrolled 145 children who had household contact with smear-positive adult TB patients. Subjects were allocated to either the case group [TB score >6; 61 subjects (42.0%)] or the control group [TB score <6; 84 subjects (58.0%)]. Bivariate analysis revealed that nutritional status, immunization status, number of people in the house, sleeping in the same bed, and duration of household contact had significant associations with the incidence of TB. By multivariate logistic regression analysis, nutritional status and duration of household contact were significant risk factors for TB, with OR 5.89 and 8.91, respectively.Conclusion Malnutrition and duration of household contact with smear-positive adult TB patients of more than 6 hours per day were risk factors for TB among children.

Association of Vitamin D Intake in Pregnant Women and Birth Weight Cindy Rolexza; Fathia Meirina
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 13, No 1 (2024): March 2024
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v13i1.2712

Background: Insufficient maternal consumption of vitamin D can have adverse effects on fetal development and increase the likelihood of low birth weight. This research aimed to establish the correlation between the quantity of vitamin D consumed by expectant mothers and the weight of newborns. Methods: This study utilized an analytical observational design with a cross-sectional approach, collecting data from August to November 2022. Information on Vitamin D intake and birthweight was obtained via questionnaire interviews with 96 pregnant women delivering at the University of North Sumatera Hospital or Maharani Women’s and Children Hospital. Semi-Food Frequency Questionnaires (FFQs) served as the data collection instrument. Non-probability consecutive sampling was employed. Statistical techniques, including Chi-square and Fisher's Exact test, were used for data analysis. Findings indicated a prevalence of inadequate vitamin D intake among mothers (3.125%). The mean daily consumption of vitamin D among expectant women was 19.99 μg/day. Mother's education level did not significantly influence the outcome (p=0.589). Results: The results of this study suggest that there was no significant association between maternal age at pregnancy (p=0. 135), gestational age (p=0. 771), parity (p=0958), and baby's sex (p=0. 448) with birth weight. Conclusion: An observed association existed between the prenatal intake of vitamin D and neonatal birth weight in expectant mothers.

Hubungan Status Gizi Dengan Lama Rawat Inap Pasien Pneumonia Balita Rizone, Alifya Shifwah; Meirina, Fathia; Hamdi, Tasrif; Aldy, Fithria
Jurnal Kesehatan Mahardika Vol. 12 No. 1 (2025): Jurnal Kesehatan Mahardika
Publisher : LPPM ITEKES Mahardika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54867/jkm.v12i1.239

Introduction: Pneumonia is known as a primary contributor to hospital admissions among toddlers globally. Numerous factors influence the duration of hospitalization in toddlers with pneumonia, one of them is nutritional status. This study aims to ascertain the correlation between nutritional status and the duration of hospitalization in pediatric pneumonia patients. Methods: This was an analytic observational study with a cross-sectional design. The study samples were children aged 2-59 months with pneumonia who were hospitalized in the period January 2022-January 2024 selected through the consecutive method. After calculating using the Slovin formula, a minimum sample size of 67 people was required. Data were analyzed through univariate analysis and bivariate analysis through chi-square through SPSS software version 27. Results: Of the 77 patients, the majority were aged 12-59 months (61%), male (55.8%), well-nourished (62.3%), and length of stay ≤5 days (55.8%). The bivariate analysis found no relationship between nutritional status and the length of stay of pneumonia patients under five with a p-value = 0.422 (p-value > 0.05). Conclusion: There is no relationship between nutritional status and the length of stay of pneumonia patients under five.

Factors Influencing Tuberculosis Infection in Children with Close Contact of Adult Pulmonary Tuberculosis Patients Mayasri, Fadhliani; Dalimunthe, Wisman; Sianturi, Pertin; Amelia, Rina; Daulay, Rini Savitri; Meirina, Fathia
Jurnal Keperawatan Priority Vol. 8 No. 2 (2025)
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jukep.v8i2.6647

This research aims to determine the factors that influence tuberculosis infection in children with close contact with adult pulmonary tuberculosis sufferers. This research is an analytical observational study with a consecutive sampling method at the Glugur Darat Health Center in November 2024 until January 2025. Bivariate analysis using chi-square to determine whether there is a relationship between the independent and dependent variables. The type of test used is the Fisher Exact and Kruskal Wallis Test. There is no multivariate test because there are no significant variables in the bivariate test. In total, in 42 samples there were 10 children with positive Mantoux tests. Of the 23 female children there were 7 (30.4%) with positive results and of the 19 male children there were 3 (15.8%) positive results. Of the 39 children with a history of BCG immunization, there were 10 (25.6%) with tuberculosis infection. Of the 37 children with parents whose income was <UMR, 10 children (27%) had tuberculosis infection. 37 children whose parents had junior high school education, 9 people (24.3%) had tuberculosis infection. 10 children aged 1-5 years and 6-10 years, there were 2 (20%) each with tuberculosis infection. 26 children aged 11-18 years, there were 6 people (27.3%) with tuberculosis infection. There was no significant relationship between age, gender, immunization status, nutritional status, parental income and parental education level in this research.

Association Between Glycaemic Control and Cardiac Function in Children with Diabetes Mellitus Ridho, M; Lubis, Siska Mayasari; Amelia, Putri; Harahap, Juliandi; Evalina, Rita; Meirina, Fathia
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.7020

The prevalence of Diabetes Mellitus (DM) among children and adolescents has been progressively increasing, with Type 1 DM constituting the majority of cases. Cardiovascular disease (CVD) is a major long-term complication, yet early cardiac involvement remains poorly understood in this population. This study aimed to assess the association between glycaemic control and cardiac function in paediatric patients with DM. A cross-sectional observational study was conducted involving 30 children with type 1 or type 2 DM at H. Adam Malik General Hospital, Medan. Glycaemic control was assessed using HbA1c levels. Cardiac function was evaluated using electrocardiography (ECG) and echocardiographic parameters, including ejection fraction (EF), fractional shortening (FS), tricuspid annular plane systolic excursion (TAPSE), and E/A ratio. Data were analysed using Chi-Square and Mann-Withney Test. Most subjects (90%) had poor glycaemic control (HbA1c ≥7%). Cardiac dysfunction (reduced EF <55%) was identified in 16.7% of patients. However, no statistically significant associations were found between cardiac function and HbA1c, duration of diagnosis, blood pressure, or body mass index (BMI) (p>0.05). There was no significant relationship was found between glycaemic control and cardiac function, highlighting the need for more sensitive diagnostic tools and long-term follow-up to detect subclinical cardiovascular complications.

Factors Influencing Tuberculosis Infection in Children with Close Contact of Adult Pulmonary Tuberculosis Patients Mayasri, Fadhliani Putri; Dalimunthe, Wisman; Sianturi, Pertin; Amelia, Rina; Daulay, Rini Savitri; Meirina, Fathia
Jurnal Keperawatan Priority Vol. 8 No. 2 (2025)
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jukep.v8i2.6647

This research aims to determine the factors that influence tuberculosis infection in children with close contact with adult pulmonary tuberculosis sufferers. This research is an analytical observational study with a consecutive sampling method at the Glugur Darat Health Center in November 2024 until January 2025. Bivariate analysis using chi-square to determine whether there is a relationship between the independent and dependent variables. The type of test used is the Fisher Exact and Kruskal Wallis Test. There is no multivariate test because there are no significant variables in the bivariate test. In total, in 42 samples there were 10 children with positive Mantoux tests. Of the 23 female children there were 7 (30.4%) with positive results and of the 19 male children there were 3 (15.8%) positive results. Of the 39 children with a history of BCG immunization, there were 10 (25.6%) with tuberculosis infection. Of the 37 children with parents whose income was <UMR, 10 children (27%) had tuberculosis infection. 37 children whose parents had junior high school education, 9 people (24.3%) had tuberculosis infection. 10 children aged 1-5 years and 6-10 years, there were 2 (20%) each with tuberculosis infection. 26 children aged 11-18 years, there were 6 people (27.3%) with tuberculosis infection. There was no significant relationship between age, gender, immunization status, nutritional status, parental income and parental education level in this research.

Pengaruh Terapi Antituberkulosis Fase Intensif Terhadap Status Gizi Penderita Tuberkulosis Anak di RSUP Haji Adam Malik Medan Tahun 2018 Fadila, Yuriza; Meirina, Fathia
SCRIPTA SCORE Scientific Medical Journal Vol. 2 No. 2 (2021): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v2i2.3374

Background: Tuberculosis (TB) is one of the 10 main causes of death from infectious diseases. Indonesia is among the 3 countries with the highest TB incidence in the world. The proportion of pediatric TB patients in North Sumatra Province is 2%. Antituberculosis therapy is a treatment used in TB patients. Successful diagnosis and treatment can prevent millions of deaths each year. Low endurance and malnutrition are factors that influence the possibility of someone becoming a TB patient. This situation can disrupt growth in children. Child growth can be monitored through nutritional status assessments. Objectives: This study aims to determine the effect of intensive phase antituberculosis therapy on the nutritional status of children with tuberculosis in Haji Adam Malik General Hospital Medan in 2018. Methods: This study uses an observational analytic method using a retrospective cohort design, using secondary data derived from medical records at Haji Adam Malik General Hospital Medan in 2018. Data obtained will then be processed and analyzed by the Wilcoxon test using a data processing program. The Wilcoxon test had a significant result (p = 0.001). Results: The mean increase in nutritional status after being given antituberculosis therapy in the age group of children 0-1 years and >1-5 years is a good nutritional status. The mean weight gain after being given antituberculosis therapy in the age group of children 0-1 years was 7.81 kg and >1-5 years was 15.32 kg. The pattern of a child's weight gain after reaching antituberculosis during the intensive phase has increased. Conclusion: In this study, it was found that antituberculosis therapy affected the nutritional status of children with tuberculosis during the intensive phase. Keywords: antituberculosis therapy, child growth, childhood TB, infectious disease Â Latar Belakang: Tuberkulosis (TB) merupakan salah satu dari 10 penyebab utama kematian dari golongan penyakit infeksi. Indonesia termasuk 3 negara dengan angka kejadian TB tertinggi di dunia. Proporsi pasien TB anak di Provinsi Sumatera Utara sebesar 2%. Terapi OAT merupakan tatalaksana yang digunakan pada pasien TB. Diagnosis dan pengobatan yang berhasil dapat mencegah jutaan kematian setiap tahunnya. Daya tahan tubuh yang rendah dan malnutrisi merupakan faktor yang mempengaruhi kemungkinan seseorang menjadi pasien TB. Keadaan ini dapat menyebabkan terganggunya pertumbuhan pada anak. Pertumbuhan anak dapat dipantau melalui penilaian status gizi. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh terapi antituberkulosis fase intensif terhadap status gizi penderita tuberkulosis anak di RSUP Haji Adam Malik Medan tahun 2018. Metode: Penelitian ini menggunakan metode analitik observasional dengan menggunakan desain kohort retrospektif, menggunakan data sekunder yang berasal dari rekam medik di RSUP Haji Adam Malik Medan tahun 2018. Data yang diperoleh selanjutnya akan diolah dan dianalisis dengan uji Wilcoxon menggunakan program pengolahan data. Uji Wilcoxon memiliki hasil yang signifikan (p = 0,001). Hasil: Rerata peningkatan status gizi setelah diberikan terapi antituberkulosis pada kelompok usia anak 0-1 tahun dan > 1-5 tahun adalah berstatus gizi baik. Rerata peningkatan berat badan setelah diberikan terapi antituberkulosis pada kelompok usia anak 0-1 tahun adalah 7,81 kg dan > 1-5 tahun adalah 15,32 kg. Pola kenaikan berat badan anak setelah terapi antituberkulosis selama fase intensif mengalami peningkatan. Kesimpulan: Pada penelitian ini didapatkan bahwa terapi antituberkulosis berpengaruh terhadap status gizi anak penderita tuberkulosis selama fase intensif. Kata Kunci: penyakit infeksi, pertumbuhan anak, TB anak, terapi OAT

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