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Aktivitas Gel Fraksi Etil Asetat dari Ekstrak Etanol Daun Ubi Jalar Untuk Pengobatan Luka Bakar Hanifah Fajar Rahmadani; Diah Pratimasari; Muhammad Saiful Amin
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 8 No. 2 (2021): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v8i22021.143-149

Pendahuluan: Luka bakar merupakan peristiwa hilangnya jaringan yang disebabkan kontak dengan sumber panas. Penggunaan bahan alam sebagai pengobatan luka bakar menggantikan penggunaan obat dengan bahan sintetis yang dapat memberikan efek samping. Bahan alam yang memiliki aktivitas sebagai pengobatan luka bakar salah satunya adalah daun ubi jalar (Ipomoea batatas L.). Tujuan: Penelitian ini berfokus pada penggunaan fraksi etil asetat dari ektrak etanol daun ubi jalar (Ipomoea batatas L.) sebagai alternatif dalam pengobatan luka bakar. Metode: Ekstraksi senyawa dalam daun ubi jalar menggunakan etanol 70% dan difraksinasi menggunakan pelarut etil asetat. Fraksi etil asetat daun ubi jalar (Ipomoea batatas L.) diidentifikasi untuk melihat senyawa metabolit sekunder. Fraksi etil asetat daun ubi jalar (Ipomoea batatas L.) diformulasi dalam bentuk gel dengan konsentrasi 1%, 2% dan 3%. Uji luka bakar menggunakan hewan uji tikus galur wistar jantan yang telah diberikan perlakuan luka bakar derajat 2. Pembuatan luka bakar menggunakan logam berdiameter 2 cm yang dipanaskan pada api bunsen. Pengamatan luka bakar dilakukan setiap 3 hari sekali dengan mengukur diameter luka bakar. Penurunan luka bakar diolah menggunakan Uji One Way Anova dan dibuat grafik penurunan luka bakar. Hasil: Hasil analisa statistik dengan menggunakan Uji One Way Anova menunjukkan nilai p > 0,05 yang berarti tidak ada perbedaan signifikan secara statistik. Namun, secara kualitatif menunjukkan trend penurunan luka bakar, grafik tertinggi diperoleh pada pemberian F2 dengan konsentrasi fraksi etil asetat daun ubi jalar (Ipomoea batatas L.) 2%. Kesimpulan: Fraksi etil asetat daun ubi jalar (Ipomoea batatas L.) memberikan aktivitas pengobatan luka bakar.

Peningkatan Kualitas Hidup Lansia dalam Penanganan Stroke bagi Kader PKK dan Kesehatan di Gilingan, Banjarsari, Surakarta Novena Yety Lindawati; Endah Kurniawati; Dian Puspitasari; Diah Pratimasari
Jurnal Surya Masyarakat Vol 1, No 2 (2019): Mei 2019
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jsm.1.2.2019.139-145

Stroke merupakan penyebab kecacatan nomor satu dan penyebab kematian nomor tiga setelah penyakit jantung dan kanker baik dinegara maju maupun berkembang. Di Indonesia, stroke merupakan penyebab kematian pada semua kelompok umur, dengan proporsi tertinggi pada usia 55-64 tahun mencapai, 26,8% baik diperkotaan maupun dipedesaan. Kegiatan pengabdian masyarakat dalam bentuk promotif, preventif, kuratif, dan rehabilitatif dengan memberikan penyuluhan tentang penyakit stroke dan penanganannya secara alami, workshop pembuatan minuman pencegah stroke, serta pelatihan senam pencegah stroke. Evaluasi kegiatan dilakukan dengan metode pretest dan postest terhadap materi penyuluhan yang diberikan serta kuisioner tentang pelaksanaan kegiatan yang telah dilakukan. Kegiatan pengabdian masyarakat diikuti oleh 43 peserta yang terdiri dari kader PKK dan kesehatan serta perwakilan lansia dari tiap RW di Gilingan, Banjarsari, Surakarta. Hasil kegiatan ini menunjukkan adanya peningkatan persentase tingkat pengetahuan dan pemahaman peserta mengenai penyakit stroke setelah pemberian penyuluhan “Mengenal Penyakit Stroke” dari 35% menjadi 95%. Peningkatan jumlah peserta yang memahami cara penanganan penyakit stroke secara alami juga terlihat setelah pemberian penyuluhan “Pemanfaatan Obat Alam Indonesia untuk Terapi Penyakit Stroke” dari 42% menjadi 93%. Evaluasi terhadap pelaksanaan kegiatan pengabdian ini juga menunjukkan hasil yang sangat baik terhadap tema yang diambil sebanyak 86,05% peserta memilih sangat menarik dan 13,95% memilih menarik. Kegiatan pengabdian ini meningkatkan pengetahuan, pemahaman, dan wawasan mengenai penyakit stroke dan penanganannya secara alami bagi Kader PKK dan Kesehatan serta perwakilan para lansia di Gilingan, Banjarsari, Surakarta sehingga dapat mensosialisasikan ke seluruh masyarakat serta mengurangi angka kejadian stroke di daerah tersebut.Kata Kunci : stroke, pencegahan dan penanganan alami stroke, kader PKK dan kesehatanAbstractStroke is one of the cause of disability and death (its rank is after heart disease and cancer) worldwide. In Indonesia, stroke is the cause of death in all age groups, with the highest proportion is at the age of 55-64 years reaching 26.8% both in urban and rural areas. Community service activities in stroke promotive, preventive, curative, and rehabilitative forms was held by providing counseling about stroke and how to handle it naturally, workshops on making health drinks to prevent strokes, as well as stroke prevention exercises. Evaluation of activities was carried out with the pretest and posttest method of counseling material provided as well as questionnaires about the implementation of activities that had been carried out. Community service activities were attended by 43 participants consisting of PKK workers (kader), community health workers (kader), and elderly representatives from each RW in Gilingan, Banjarsari, Surakarta. The results of this activity indicate an increase in the percentage of the level of knowledge and understanding of participants regarding stroke after giving counseling "Recognizing Stroke" from 35% to 95%. An increase in the number of participants who understand how to deal with stroke naturally is also seen after giving counseling "Utilization of Indonesian Natural Herbs for Stroke Therapy" from 42% to 93%. The evaluation of the implementation of this service activity also showed very good results on the theme taken as many as 86.05% of the participants chose very interesting and 13.95% chose interesting. This service activity increases knowledge, understanding, and insight into stroke and its handling naturally for PKK kader, community health kader and representatives of the elderly in Gilingan, Banjarsari, Surakarta so that they can socialize to the whole community and reduce the incidence of stroke in the area.

Peningkatan Kualitas Hidup Lansia dalam Penanganan Stroke bagi Kader PKK dan Kesehatan di Gilingan, Banjarsari, Surakarta Novena Yety Lindawati; Endah Kurniawati; Dian Puspitasari; Diah Pratimasari
Jurnal Surya Masyarakat Vol 1, No 2 (2019): Mei 2019
Publisher : Universitas Muhammadiyah Semarang

Stroke merupakan penyebab kecacatan nomor satu dan penyebab kematian nomor tiga setelah penyakit jantung dan kanker baik dinegara maju maupun berkembang. Di Indonesia, stroke merupakan penyebab kematian pada semua kelompok umur, dengan proporsi tertinggi pada usia 55-64 tahun mencapai, 26,8% baik diperkotaan maupun dipedesaan. Kegiatan pengabdian masyarakat dalam bentuk promotif, preventif, kuratif, dan rehabilitatif dengan memberikan penyuluhan tentang penyakit stroke dan penanganannya secara alami, workshop pembuatan minuman pencegah stroke, serta pelatihan senam pencegah stroke. Evaluasi kegiatan dilakukan dengan metode pretest dan postest terhadap materi penyuluhan yang diberikan serta kuisioner tentang pelaksanaan kegiatan yang telah dilakukan. Kegiatan pengabdian masyarakat diikuti oleh 43 peserta yang terdiri dari kader PKK dan kesehatan serta perwakilan lansia dari tiap RW di Gilingan, Banjarsari, Surakarta. Hasil kegiatan ini menunjukkan adanya peningkatan persentase tingkat pengetahuan dan pemahaman peserta mengenai penyakit stroke setelah pemberian penyuluhan “Mengenal Penyakit Stroke” dari 35% menjadi 95%. Peningkatan jumlah peserta yang memahami cara penanganan penyakit stroke secara alami juga terlihat setelah pemberian penyuluhan “Pemanfaatan Obat Alam Indonesia untuk Terapi Penyakit Stroke” dari 42% menjadi 93%. Evaluasi terhadap pelaksanaan kegiatan pengabdian ini juga menunjukkan hasil yang sangat baik terhadap tema yang diambil sebanyak 86,05% peserta memilih sangat menarik dan 13,95% memilih menarik. Kegiatan pengabdian ini meningkatkan pengetahuan, pemahaman, dan wawasan mengenai penyakit stroke dan penanganannya secara alami bagi Kader PKK dan Kesehatan serta perwakilan para lansia di Gilingan, Banjarsari, Surakarta sehingga dapat mensosialisasikan ke seluruh masyarakat serta mengurangi angka kejadian stroke di daerah tersebut.Kata Kunci : stroke, pencegahan dan penanganan alami stroke, kader PKK dan kesehatanAbstractStroke is one of the cause of disability and death (its rank is after heart disease and cancer) worldwide. In Indonesia, stroke is the cause of death in all age groups, with the highest proportion is at the age of 55-64 years reaching 26.8% both in urban and rural areas. Community service activities in stroke promotive, preventive, curative, and rehabilitative forms was held by providing counseling about stroke and how to handle it naturally, workshops on making health drinks to prevent strokes, as well as stroke prevention exercises. Evaluation of activities was carried out with the pretest and posttest method of counseling material provided as well as questionnaires about the implementation of activities that had been carried out. Community service activities were attended by 43 participants consisting of PKK workers (kader), community health workers (kader), and elderly representatives from each RW in Gilingan, Banjarsari, Surakarta. The results of this activity indicate an increase in the percentage of the level of knowledge and understanding of participants regarding stroke after giving counseling "Recognizing Stroke" from 35% to 95%. An increase in the number of participants who understand how to deal with stroke naturally is also seen after giving counseling "Utilization of Indonesian Natural Herbs for Stroke Therapy" from 42% to 93%. The evaluation of the implementation of this service activity also showed very good results on the theme taken as many as 86.05% of the participants chose very interesting and 13.95% chose interesting. This service activity increases knowledge, understanding, and insight into stroke and its handling naturally for PKK kader, community health kader and representatives of the elderly in Gilingan, Banjarsari, Surakarta so that they can socialize to the whole community and reduce the incidence of stroke in the area.

The Correlation of Anthocyanin Levels, Vitamin C Levels, and Antioxidant Activity of Purple Cabbage (Brassica Oleracea L.) Juice at Different Temperatures and Storage Periods Crescentiana Emy Dhurhania; Diah Pratimasari; Maliny Kurnia Salwa; Shinta Pasmawati; Muhammad Yusril Ihza Ramadhan
Indonesian Journal of Global Health Research Vol 4 No 4 (2022): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Purple cabbage (Brassica oleracea L. var. capitata f. rubra) is a plant from the Brassicaceae or Cruciferae family that can be grown in both highlands and lowlands. The amount of purple cabbage production is relatively high, but utilization by consumers is still low. The choice of how to use purple cabbage is to make juice, because it is easy to make and only takes a short time, and the freshness can still be enjoyed. The way of consuming juice is seen as more relevant and enjoyable for the general public than having to eat large amounts of purple cabbage. Anthocyanins and vitamin C are water-soluble compounds that have a major role in providing antioxidant activity of purple cabbage juice. Both anthocyanins and vitamin C are compounds that are easily oxidized by O2 in the air so that the length of contact with air during storage will affect their stability. Likewise, storage temperature is a factor that affects the stability of anthocyanins and vitamin C which will have an impact on their antioxidant activity. Therefore, this study was conducted to determine the correlation of anthocyanin levels, vitamin C levels, and antioxidant activity of purple cabbage juice at different temperatures and storage periods. Determination of anthocyanin levels, vitamin C levels, and antioxidant activity was carried out by UV-Vis spectrophotometry. On the 7th day of storage, the anthocyanin content decreased by 3.7% at cold temperature and 22.5% at room temperature; vitamin C content decreased by 59.1% at cold temperature and 75.7 at room temperature; antioxidant activity decreased with an increase of 9.8% IC50 at cold temperature and 24.9% at room temperature. Purple cabbage juice decreased its antioxidant activity after the crop was stored for 4 days and 7 days, both stored at cold and room temperature. This was caused by a decrease in the content of the main antioxidant compounds in purple cabbage, namely anthocyanins and vitamin C, during the storage process.

Identification of Flavonoid Compounds from Purified Extract of Beetroot Leaf (Beta Vulgaris L) Diah Pratimasari; Dian Puspitasari
Indonesian Journal of Global Health Research Vol 4 No 4 (2022): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Flavonoids are one of the secondary metabolites that have good pharmacological activity. One of the plants that contain flavonoid compounds is beetroot leaves. Beetroot leaves are waste or crop residues from beetroots that are rarely used. The use of extracts from plant leaves in the pharmaceutical world needs to consider the presence of ballast substances that can affect the activity of the extract. However, the purification process using organic solvents has the potential to lose the content of compounds contained in the extract, one of which is flavonoids. Therefore, this study aims to examine the profile of flavonoid compounds contained in purified extracts of beetroot leaves compared to the extract content. The study began with the manufacture of beetroot leaf extract, followed by the purification process of the extract using n-hexane and ethyl acetate as solvents. Extracts and purified extracts of beetroot leaves were then analyzed using Thin Layer Chromatography (TLC), UV-Vis Spectrophotometer and Infra Red (IR) Spectrophotometer. The results showed that the profile of flavonoid compounds contained in purified extract of beetroot leaves had similarities with the profile of flavonoid compounds found in beetroot leaf extract.

Karakterisasi dan Penetapan Kadar Flavonoid Total Ekstrak dan Fraksi Bunga Pepaya Jantan (Carica papaya L.) dengan Spektrofotometri UV-Vis Dilla Nur Pratiwi; Nastiti Utami; Diah Pratimasari
Jurnal Ilmiah Farmasi Vol. 18 No. 2 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss2.art20

Background: The potential of pepaya jantan flowers (Carica papaya L.) as functional herbal ingredients, such as antioxidants, is influenced by the activity of secondary metabolites, one of which is flavonoids. Objective: This study aims to determine the total flavonoid content and characterization of flavonoids in the ethanol extract and flower fraction of papaya jantan (Carica papaya L.). Method: Pepaya jantan flower was extracted by maceration using ethanol 70% then fractionated using multilevel fractionation. The identification of flavonoids was tested using Taubeck, Wilstater, and TLC. Extract and fractions were determined of flavonoid content using the colorimetric method and identification of flavonoids based on the wavelength of cinnamoyl and benzoyl in the spectrum UV-Vis. Results: The results of the determination of flavonoid content showed that ethanol extract was the highest at 0.6805 ± 0.0045 %QE and n-hexane fractions were the lowest at 0.4178 ± 0.0058 %QE. Identification of flavonoids using the UV-Vis spectroscopy method showed the absorption of substituted 3-OH flavonol and free 3-OH flavonol. Conclusion: The highest flavonoid content was found in the ethanol extract of papaya jantan flower. The types of flavonoids in the extract and fractions of male papaya flower indicated the type of flavonol based on the wavelength of cinnamoyl and benzoyl.

Efektivitas Penurunan Kadar Glukosa Ekstrak Kasar dan Terpurifikasi Daun Umbi Bit (Beta Vulgaris L.) secara In Vitro Yohana Tri Wahyuningsih; Diah Pratimasari; Novena Yety Lindawati
Jurnal Farmasetis Vol 11 No 2 (2022): Jurnal Farmasetis: Agustus 2022
Publisher : LPPM Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (157.302 KB)

Diabetes melitus merupakan penyakit yang disebabkan gangguan metabolik yang mengakibatkan kadar glukosa melebihi batas normal. Salah satu faktor yang dapat menyebabkan terjadinya peningkatan kadar glukosa yaitu adanya peningkatan radikal bebas dalam tubuh. Kandungan polifenol dari tanaman diduga berhubungan dengan aktivitas antioksidan dan aktivitas antidiabetes. Semakin tinggi kandungan polifenol maka semakin kuat aktivitas antioksidan dan antidiabetesnya. Salah satu tanaman yang mempunyai kandungan polifenol adalah tanaman umbi bit (Beta vulgaris L.) pada bagian daun. Daun umbi bit dimaserasi dengan pelarut etanol 70%. Maserat yang telah diuapkan disebut Ekstrak Kasar Daun Umbi Bit (EKDUB). Ekstrak kasar difraksinasi dengan pelarut n-heksana dan etil asetat diperoleh Ekstrak Terpurifikasi Daun Umbi Bit (ETDUB). Uji kadar fenolik total dengan metode Folin-Ciocalteu. Uji efektivitas penurunan kadar glukosa dengan metode Nelson Somogyi. Kadar fenolik total ETDUB 58,815 mg GAE/g sampel sedangkan EKDUB 49,908 mg GAE/g sampel. Nilai EC50 EKDUB sebesar 22,73 ppm sedangkan ETDUB 18,34 ppm. Semakin tinggi kadar fenolik total semakin tinggi kemampuan ekstrak menurunkan kadar glukosa.

The Correlation of Anthocyanin Levels, Vitamin C Levels, and Antioxidant Activity of Purple Cabbage (Brassica Oleracea L.) Juice at Different Temperatures and Storage Periods Crescentiana Emy Dhurhania; Diah Pratimasari; Maliny Kurnia Salwa; Shinta Pasmawati; Muhammad Yusril Ihza Ramadhan
Indonesian Journal of Global Health Research Vol 4 No 4 (2022): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Purple cabbage (Brassica oleracea L. var. capitata f. rubra) is a plant from the Brassicaceae or Cruciferae family that can be grown in both highlands and lowlands. The amount of purple cabbage production is relatively high, but utilization by consumers is still low. The choice of how to use purple cabbage is to make juice, because it is easy to make and only takes a short time, and the freshness can still be enjoyed. The way of consuming juice is seen as more relevant and enjoyable for the general public than having to eat large amounts of purple cabbage. Anthocyanins and vitamin C are water-soluble compounds that have a major role in providing antioxidant activity of purple cabbage juice. Both anthocyanins and vitamin C are compounds that are easily oxidized by O2 in the air so that the length of contact with air during storage will affect their stability. Likewise, storage temperature is a factor that affects the stability of anthocyanins and vitamin C which will have an impact on their antioxidant activity. Therefore, this study was conducted to determine the correlation of anthocyanin levels, vitamin C levels, and antioxidant activity of purple cabbage juice at different temperatures and storage periods. Determination of anthocyanin levels, vitamin C levels, and antioxidant activity was carried out by UV-Vis spectrophotometry. On the 7th day of storage, the anthocyanin content decreased by 3.7% at cold temperature and 22.5% at room temperature; vitamin C content decreased by 59.1% at cold temperature and 75.7 at room temperature; antioxidant activity decreased with an increase of 9.8% IC50 at cold temperature and 24.9% at room temperature. Purple cabbage juice decreased its antioxidant activity after the crop was stored for 4 days and 7 days, both stored at cold and room temperature. This was caused by a decrease in the content of the main antioxidant compounds in purple cabbage, namely anthocyanins and vitamin C, during the storage process.

Identification of Flavonoid Compounds from Purified Extract of Beetroot Leaf (Beta Vulgaris L) Diah Pratimasari; Dian Puspitasari
Indonesian Journal of Global Health Research Vol 4 No 4 (2022): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Flavonoids are one of the secondary metabolites that have good pharmacological activity. One of the plants that contain flavonoid compounds is beetroot leaves. Beetroot leaves are waste or crop residues from beetroots that are rarely used. The use of extracts from plant leaves in the pharmaceutical world needs to consider the presence of ballast substances that can affect the activity of the extract. However, the purification process using organic solvents has the potential to lose the content of compounds contained in the extract, one of which is flavonoids. Therefore, this study aims to examine the profile of flavonoid compounds contained in purified extracts of beetroot leaves compared to the extract content. The study began with the manufacture of beetroot leaf extract, followed by the purification process of the extract using n-hexane and ethyl acetate as solvents. Extracts and purified extracts of beetroot leaves were then analyzed using Thin Layer Chromatography (TLC), UV-Vis Spectrophotometer and Infra Red (IR) Spectrophotometer. The results showed that the profile of flavonoid compounds contained in purified extract of beetroot leaves had similarities with the profile of flavonoid compounds found in beetroot leaf extract.

Anti-Inflammatory Test of Topical Cream Preparations from Ethyl Acetate Fraction of Johar Leaves (Cassia siamea L.) in White Mice Audri Nandia Apriyanti; Diah Pratimasari; Eka Wisnu Kusuma
Jurnal Farmasi (Journal of Pharmacy) Vol 12, No 1 (2023)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v12i1.223

Johar leaves contain chemical compounds, there are alkaloids, saponins, tannins, flavonoids, barracol, sitosterol. This study aims to determine the anti-inflammatory effect of the johar leaf ethyl acetate fraction topically, to determine the optimum concentration of johar leaf ethyl acetate fraction in cream preparations, and to determine the physical properties of the johar cream and cream stability. The leaves of johar (Cassia siamea L.) were extracted using the maceration method with 70% ethanol. The ethanol extract of johar leaves was fractionated with water, n-hexane and ethyl acetate as solvents. The ethyl acetate fraction of johar leaves was made cream with a concentration of 2.5%, 5% and 10%. The basis and the three formulas were tested for the physical quality of the cream including the organoleptic test, homogeneity, viscosity, spreadability, adhesion, cream type, pH and cream stability. The anti-inflammatory effect was determined by measuring the thickness of the back skin of the mice. The data obtained were analyzed statistically One Way Anova with a confidence level of 95% to determine that there were significant differences between treatment groups. The results showed that the leaf ethyl acetate fraction cream could provide topical anti-inflammatory effects on carrageenan-induced white mice with an effective concentration of 5% with (% PI) of 36.67%. The ethyl acetate fraction of johar leaves with a concentration of 2.5% and 5% fulfilled the requirements for the physical properties of the cream, but the cream with a concentration of 10% did not meet the requirements in the pH test. And the ethyl acetate fraction cream of johar leaves was stable in 1 month storage

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