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All Journal Jurnal Teknosains Biology, Medicine, & Natural Product Chemistry Majalah Obat Tradisional Jurnal Farmasi Sains dan Komunitas PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Pharmaceutical Sciences and Research (PSR)
Andhi FAHRURROJI
Universitas Tanjungpura
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Health Professions Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences

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Losio Antioksidan Buah Naga Merah (Hylocereus polyrhizusBritton and Rose) Sinaga, Amanda Angelina; Luliana, Sri; Fahrurroji, Andhi
Pharmaceutical Sciences and Research Vol. 2, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hylocereus polyrhizus Britton and Rose (Red dragon fruit) has been shown to have antioxidant activity which contains vitamin C, polyphenol, and flavonoid. This research was aimed to investigate antioxidant activity from H. polyrhizus in form of lotion. Lotion were made with 5 concentration from H. polyrhizus methanol extract were 0.04, 0.08, 0.16, 0.32 and 0.64%. Lotion antioxidant activity was measured using DPPH method. The result showed that H. polyrhizus methanol extract had antioxidant activity with inhibition concentration were 19.99±0.33; 25.01±0.08; 39.14±0.04; 66.69±0.12 and 83.37±0.05. The result showed significant differences on antioxidant activity. The physical stability observation of five formula with cycling test method showed unstability because of discolouration (oxidation). As well as the methods of mechanical test showed unstability of lotion because saponification process.
Kinetic optimization of angkak – red ginger extraction and its impact on antioxidant activity Missy, Felesia; Fahrurroji, Andhi; Nugraha, Fajar; Anastasia, Desy Siska
Jurnal Teknosains Vol 13, No 2 (2024): June
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/teknosains.86975

Abstract

A mixture of angkak and red ginger is a Chinese herbal concoction with potential as an antioxidant. This herbal combination can be extracted using the kinetic hot maceration method by optimizing the stirring speed to be more efficient. Previous studies have shown that using 400, 600, and 800 rpm stirring speeds provides the best IC50 and yield. Based on these problems, this research aims to determine the effect of increasing stirring speed on IC50 and % yield in the extraction of angkak and red ginger, as well as prove the benefits of this herbal combination through the IC50 value. The method used is extracting a mixture of angkak and red ginger at kinetic variations of 400, 600, and 800 rpm using a magnetic hotplate stirrer at a temperature of 60ºC for 2 hours; determination of % yield; determining the chromatogram profile using TLC; determination of antioxidant activity using DPPH; as well as data analysis of percentage yield and IC50 using SPSS. Analysis using SPSS shows that the stirring speed significantly affects the % yield, where increasing the moving speed above 400 rpm results in a decrease in the % yield. However, the moving speed does not affect the IC50. The TLC chromatogram profile shows the presence of 6-gingerol compounds in angkak and red and yellow pigment compounds in red ginger, which have potential as antioxidants. The optimization results in this study obtained optimal % yield and IC50 at 400 rpm with average values, respectively, namely 15.933 ± 3.4771% and 103.76 ± 10.032 ppm, and the combination of angkak and red ginger ingredients can work synergistically to increase yield and antioxidant.
Pelatihan Pembuatan Nano Liquid Aromaterapi bagi Kader PKK Desa Wajok Hilir di Kabupaten Mempawah: Training on Manufacturing Aromatherapy Nano liquid for PKK Cadres in Wajok Hilir Village in Mempawah District Pratiwi, Liza; Wijianto, Bambang; Fahrurroji, Andhi; Yuswar, Muhammad Akib
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 3 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i3.6251

Abstract

So far, essential oils have only been used as perfume and sold as raw material. On average, residents of Wajok Hilir village have yards covered with essential oil-producing plants such as lavender, lemongrass, and coconut. The aim of the PKM Program is training in utilizing community resources to make essential oils for aromatherapy in nano-liquid preparations. The development of this product must be oriented towards developing a practice that is easy to apply and environmentally friendly without ignoring environmental health. The solution to overcome existing problems is to provide knowledge to partners about the benefits of nano liquid preparations as aromatherapy and mosquito repellent and training on using essential oils as aromatherapy. Pharmacists provided training on making "nano liquid" products. This training activity will involve PKK cadres from Wajok Hilir village. The output target of this activity is to increase the level of quality empowerment of partners by driving sustainable activity programs from product results. This service activity showed that the 31 participants comprised the majority of women and homemakers, 77.4% with a high school education level. The results of measuring participants' knowledge and skills showed an increase in the pre-test and post-test scores, which were 55.5 and 78.33, respectively. In conclusion, the service activities that have been carried out have increased the knowledge and abilities of participants regarding the use of essential oils as aromatherapy in the form of nano-liquid preparations.
Antihyperlipidemic Effectivity of Sweet Orange Peel Extract (Citrus sinensis) on Triglyceride Levels in Male Mice (Mus musculus) Induced by High Cholesterol Lumbantoruan, Ellya Catharine Romanna Aprilya; Zakiah, Mistika; Fahrurroji, Andhi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005944

Abstract

Hyperlipidemia is a significant risk factor for atherosclerosis in arteries and cardiovascular disease, especially coronary heart disease (CHD), the leading cause of global mortality. Treatment of hyperlipidemia can be done through chemical treatment. However, statins have potentially dangerous side effects such as myopathy and rhabdomyolysis, so a therapeutic solution with minimal toxicity is needed. One of the potential treatments is Citrus sinensis orange peel, which contains antihyperlipidemic bioactive compounds, namely hesperidin, and naringenin. The aim of this research is to determine the effectivity of sweet orange peel extract (Citrus sinensis) on high cholesterol-induced male mice (Mus musculus) triglyceride levels. Citrus sinensis orange peel was extracted by maceration method using 50% ethanol as solvent. Lipid profile measurements were performed three times using the GPO-PAP method. The concentration of orange peel extract in the treatment group (P1, P2, P3) was 10%, 5%, and 1%. The positive control received 40 mg atorvastatin treatment, the negative control received 1% CMC Na, and the control received abnormal treatment. Antihyperlipidemic therapy with Citrus sinensis sweet orange peel extract has a strong relationship/influence on triglyceride levels in mice. Sweet orange peel extract (Citrus sinensis) has antihyperlipidemic effectiveness in reducing blood triglyceride levels in mice (Mus musculus) induced by high cholesterol. The effective dose is 1% dose.
Red Ginger Effect on Yield Percentage and Antioxidant Activity in Red Ginger–Angkak Combination Nugraha, Fajar; Fahrurroji, Andhi; Anastasia, Desy Siska; Meilvina, Meilvina
Majalah Obat Tradisional Vol 30, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.89432

Abstract

Red ginger and angkak are often combined in Chinese cuisine to maintain health. Both of these ingredients are known to have potent antioxidant activity respectively, but the combination of red ginger and angkak has never been studied. The purpose of this research is to see the effect of the amount of red ginger on the percentage of yield and antioxidant activity in the combination of red ginger and angkak. Red ginger and angkak extracts are combined, each ingredient is extracted singly. The amount of red ginger was varied, namely 10, 20, 30, and 40 g. In comparison, the number of angkak remains at 55 g. Both materials were extracted by kinetic heat at a temperature of 600C and a stirring speed of 800 rpm for 120 minutes. The yield percentage of the viscous extract obtained was calculated, and its antioxidant activity was analyzed using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. In addition, the chromatogram profile test of red ginger and angkak was also carried out. Increasing the amount of red ginger in the red ginger - angkak extract did not have a significant effect (p>0.05) on the yield percentage but had a significant effect (p<0.05) by increasing the antioxidant activity of the red ginger - angkak extract. The combined extracts' antioxidant activity was less than the red ginger extract. The ginger chromatogram profile shows ten different spots, while angkak has three different spots.
The Effect of Angkak Addition Towards DPPH Antioxidant Activity and Yields in Mixed Angkak-Red Ginger Extracts Christy, Clarissa; Nugraha, Fajar; Fahrurroji, Andhi; Anastasia, Desy Siska
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.73-82

Abstract

Angkak and red ginger, which represents West Borneo’s Chinese ethnic group’s herbal cooking, were studied to produce antioxidant activity through shogaol along with monacolin K and respond to DPPH (2, 2-diphenyl-1-picrylhydrazyl) test. This research aims to combine the two ingredients into extracts and observe how they affect the yields and IC50 value. Methods were started with the extraction of both materials in a variety of simplicia powder weights using 800 rpm stirring speed at 60°C for 120 minutes. The extracts were then tested for percentage yield (%), Thin Layer Chromatography (TLC), and half-maximal inhibitory concentration (IC50) value. IBM SPSS Statistics 25 analysis was also carried out at the end for yields and IC50 values data. Results showed that the angkak addition affected the IC50 value without giving any significant impact on each yield amount (p-value>0,05). Increased angkak in the variations led to the IC50 values decrease, ranging from 122.996 ppm (Mix 1) to 225.399 ppm (Mix 3). Angkak’s pigments and red ginger’s polyphenol compounds which provide antioxidant ability were found to occupy Mix extracts based on the TLC profile. In conclusion, angkak decreased the DPPH antioxidant activity of its extract combination with red ginger, but did not affect the yield percentage.
Co-Authors Amanda Angelina Sinaga, Amanda Angelina Anastasia, Desy Siska Bambang WIJIANTO Christy, Clarissa Emilia - Fajar Nugraha Liza Pratiwi Luliana, Sri Lumbantoruan, Ellya Catharine Romanna Aprilya Meilvina, Meilvina Missy, Felesia Mistika Zakiah Wintari Taurina Yuswar, Muhammad Akib