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In vitro penetration of alpha arbutin niosome span 60 system in gel preparation Desnita, Rise; Luliana, Sri; Anggraini, Silvana
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Alpha arbutin is a hydrophilic compound which is difficult to pass trough the stratum corneum. One of the effort to increase the penetration of the drug through the stratum corneum is by making in niosome system. This study aims to determine the optimum concentration of span 60 to improve the entrapment efficiency of niosome and investigate the increasing penetration of alpha arbutin using the niosome system in the preparation of the gel in vitro. Niosome consist a mixture of span 60 and cholesterol it made by thin layer hydration method. Concentration of span 60 was varied into three formulas were 100, 150 and 200 ÂµmoL. The formulation of gel was made in two formulas including formulation of niosome alpha arbutin and alpha arbutin in gel. The determination of enterapment efficiency showed that formula 100Âµmol has an optimum enterapment efficiency by 99.09%Â±0.1. The in vitro penetration tests with shed snake skin membrane showed that usage span 60 as a niosome composer could increase penetration of alpha arbutin in gel formulation with cumulative numbers of diffusion in 8 hours was 91.62%Â±2.32 compared to alpha arbutin in gel without niosome system about 73.00%Â±0.94.7.

Improving the in vitro penetration of niacinamide using span 60-based niosomal system in gel formulation Desnita, Rise; Luliana, Sri; kasim, zainab
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Niacinamide is one of the components of cosmeceutical products that reported to have skin benefits for the treatment of skin pigmentation, acne and wrinkles. However, the dermal penetration of niacinamide is poor. The carrier system which can be selected to carry the compound through the stratum corneum layer is the niosome system using span 60. This study was aimed to determine the concentration of span 60 that can trap niacinamide optimally and the ability of niosome system span 60 to increase in vitro penetration of niacinamide in gel formulation. The different formulations of nicotinamide niosome were formulated with variance concentrations of Span 60, that is, formula A 100 Î¼mol, formula B 150 Î¼mol, and formula C 200 Î¼mol. The entrapment efficiency testing was conducted using dialysis membrane. The gel formulation was prepared in two formulas, niacinamide niosome gel and niacinamide gel (without niosomes) and tested diffusion using Franz diffusion cell flow-through type. The result show that Formula A provides the most optimum entrapment efficiency of 99.03Â±0.026%. The results of the in vitro skin penetration studies for 8 hours indicate that the niosomal formulation using Span 60 could increase skin penetration with the percent cumulative amount of niacinamide niosomes was 82.87Â±1.6932% compared to niacinamide in gel without noisome system about 70.27Â±5,3212%.

Pengaruh Metode Pengeringan terhadap Aktivitas Antioksidan Ekstrak Etanol Daun Physalis angulata L. Luliana, Sri; Riza, Hafrizal; Iswahyudi, Ilham
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 5 No 1 (2018)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Proses pengeringan diperlukan untuk mempertahankan mutu suatu simplisia. Penelitian ini bertujuan untuk mengetahui pengaruh metode pengeringan terhadap aktivitas antioksidan daun ciplukan (Physalis angulata L.). Pengujian aktivitas antioksidan dilakukan terhadap metode pengeringan dengan menggunakan angin, matahari tidak langsung dan oven, serta sampel segar tanpa pengeringan. Aktivitas antioksidan diuji menggunakan metode 2,2-difenil-1-pikrilhidrazil (DPPH). Nilai IC50 sampel pengeringan angin, matahari tidak langsung, oven dan segar berturut-turut adalah 46,42 ± 3,37; 34,33 ± 2,24; 77,91 ± 3,44 and 57,63 ± 4,33 ?g/ml. Berdasarkan data hasil penelitian, kami menyimpulkan bahwa terdapat perbedaan signifikan (p<0,05) pada nilai aktivitas antioksidan tiap sampel yang dikeringkan dengan metode yang berbeda.

Formulasi Sediaan Gummy Candies Ekstrak Herba Pegagan (Centella asiatica) menggunakan pektin dari Daun Cincau Hijau (Cyclea barbata Miers) Amaria, Egita Feby; Luliana, Sri; Isnindar, Isnindar
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 5, No 1 (2021): Jurnal Farmasi Kalbar
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

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Gummy candies merupakan sediaan permen kenyal yang teksturnya dicapai dengan menggunakan gelling agent seperti gelatin dan pektin. Tujuan penelitian ini untuk mengetahui pengaruh variasi konsentrasi gelatin dan air daun cincau hijau terhadap sifat fisik gummy candies ekstrak herba pegagan (Centella asiatica). Metode : Gummy candies ekstrak herba pegagan dibuat dalam 4 formula dengan perbandingan konsentrasi gelatin dan pektin dari air daun cincau hijau yang berbeda (F1=15%:35% F2=20%:30% F3=25%:25% F4=30%:20%). Hasil : penelitian menunjukkan bahwa formula 4 merupakan formula dengan nilai kekerasan dan kekenyalan yang paling mendekati produk kontrol. Kesimpulan : dari penelitian ini menunjukkan bahwa perbedaan konsentrasi gelatin dan air daun cincau hijau tidak berpengaruh terhadap kekerasan tetapi berpengaruh terhadap kekenyalan gummy candies. Kata Kunci : Herba pegagan (Centella asiatica), gummy candies, gelatin, pektin, analisis tekstur, sifat fisik

UJI MIKROSKOPIK EKSTRAK ETANOL 96% HERBA CIPLUKAN (Physalis angulata L.) Istiqomah, Rifqi; Pratiwi, Liza; Luliana, Sri
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 4, No 1 (2019): Jurnal Farmasi Kalbar
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

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Physalis angulata L. is a plant whose extract or infusion has been used by many countries as a popular medicine for the treatment of diseases such as malaria, asthma, hepatitis, dermatitis and rheumatism. The ethanol extract of ciplukan herb has been studied to show non-toxic activity with an LC50 value of more than 1000 ?g / mL so that it is potential to be developed into a dosage form. This study aims to determine the correctness of a sample by identifying its distinctive fragments through microscopic testing. The research method begins with determining the sample to ensure that the plants to be used are appropriate. Then performed microscopic tests and extraction. The results showed that the typical fragments found in the ciplukan herbal simplicia were the transport files, while the yield value of 96% ethanol extract of ciplukan herbs obtained in this study was 2.04%. Keywords: Physalis angulata L., microscopic testing, extraction

IDENTIFIKASI SENYAWA FLAVONOID EKSTRAK DAUN SENGGANI (Melastoma malabathricum L.) MENGGUNAKAN METODE KROMATOGRAFI LAPIS TIPIS (KLT) ., Nunung; Luliana, Sri; Apridamayanti, Pratiwi
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 4, No 1 (2019): Jurnal Farmasi Kalbar
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

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Senggani (Melastoma malabathricum L.) merupakan salah satu tanaman yang memiliki berbagai khasiat seperti antioksidan dan antibakteri. Ekstrak daun senggani berdasarkan uji fitokimia diketahui mengandung senyawa alkaloid, saponin, tannin, fenolik, flavonoid dan triterpenoid. Penelitian ini bertujuan untuk mengidentifikasi adanya senyawa flavonoid pada ekstrak daun senggani. Ekstrak daun senggani diperoleh dengan maserasi menggunakan pelarut etanol 96%. Metode yang digunakan adalah kromatografi lapis tipis (KLT) dengan fase diam plat silika gel GF254 dan dua macam fase gerak yaitu kloroform :metanol : etilasetat :air (80:12:6:2) dan etilasetat : asam format : asamasetat :air (100:11:11:26). Hasil penelitian pada ekstrak daun senggani menunjukkan adanya senyawa flavonoid yang ditandai dengan bercak berwarna kuning dan hijau kekuningan setelah disemprot pereaksi AlCl3 5% dengan nilai Rf (0,11 ; 0,26 ; 0.49) dan (0,62 ; 0,85 ; 0,96). Kata Kunci: Ekstrak Daun Senggani (Melastoma malabathricum L.), Kromatografi Lapis Tipis (KLT), Flavonoid.

OPTIMASI PROSES PEMBUATAN MINUMAN SERBUK INSTAN KOMBINASI JAHE (Zingiber officinale Rosc) DAN KENCUR (Kaempferia galanga L.) ., Saraswati; Desnita, Rise; Luliana, Sri
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 4, No 1 (2019): Jurnal Farmasi Kalbar
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

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Pembuatan minuman serbuk instan jahe dan kencur bertujuan untuk memperpanjang usia simpan produk, memudahkan dalam penyajian, dan memperbaiki rasa. Tujuan penelitian ini adalah untuk mengetahui pengaruh lama pengendapan amilum terhadap lama waktu kristalisasi minuman serbuk instan kombinasi jahe dan kencur. Metode: Minuman serbuk instan dibuat menggunakan metode kristalisasi gula dengan empat perlakuan yaitu waktu dekantasi selama 0 menit, 10 menit, 2 jam, dan 6 jam. Hasil: Hasil uji menunjukkan bahwa pembuatan minuman serbuk instan jahe dan kencur tanpa perlakuan dekantasi membutuhkan waktu pembentukan kristal selama 60 menit sedangkan perlakuan dengan dekantasi selama 10 menit, 2 jam, dan 6 jam membutuhkan lama waktu pembentukan kristal yang lebih cepat yaitu selama 30 menit setelah penambahan gula. Kesimpulan: Penelitian ini menunjukkan bahwa proses dekantasi perlu dilakukan dalam pembuatan minuman sebuk instan jahe dan kencur untuk mempercepat waktu kristalisasi, namun lama waktu dekantasi tersebut tidak berpengaruh terhadap lama waktu pembentukan kristal. Kata kunci: jahe, kencur, kristalisasi, minuman serbuk instan, pati

AKTIVITAS ANTINOSISEPTIF FRAKSI N-HEKSAN DAUN KRATOM (Mitragyna speciosa Korth.) RUTE ORAL PADA MENCIT JANTAN SWISS Amanda Gita Tiaravista; Robiyanto Robiyanto; Sri Luliana
Farmaka Vol 17, No 1 (2019): Farmaka (Februari)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Daun Kratom (Mitragyna speciosa Korth.) diketahui memiliki aktivitas antinosiseptif. Alkaloid mitraginin bertindak melalui reseptor opioid pada reseptor µ-opioid dan δ-opioid. Tujuan penelitian ini untuk mengetahui aktivitas antinosiseptif fraksi n-heksan daun kratom serta dosis yang dapat memberikan efek antinosiseptif pada mencit jantan Swiss. Metode yang digunakan adalah metode hot plate test. Mencit dibagi menjadi lima kelompok, yaitu kelompok kontrol negatif (CMC Na 0,5%), Kontrol positif (Morfin 5,46 mg/kgBB), dosis I (70 mg/kgBB), dosis II (140 mg/kgBB), dan dosis III (280 mg/kgBB). Pengamatan dilakukan tiap 15 menit selama 2 jam degan mencatat waktu latensi yang dilihat dari respon mencit berupa menarik kaki belakang dan melompat. Data rata-rata waktu latensi dianalisis menggunakan One Way ANOVA, menunjukkan bahwa fraksi n-heksan pada dosis III memiliki hasil (p<0,05) dan pada dosis II memiliki hasil (p>0,05) terhadap kontrol positif. Hasil rata-rata AUC pada dosis II sebanding dengan kontrol positif. Hasil persen daya antinosiseptif paling besar dimiliki oleh dosis III yaitu 90%, diikuti oleh dosis II dan dosis I masing-masing sebesar 86% dan 82%. Kesimpulan dari penelitian ini yaitu fraksi n-heksan daun kratom memiliki aktivitas antinosiseptif pada ketiga dosis. Dosis II memilki aktivitas yang sebanding dengan kontrol posisitf serta semakin meningkatnya dosis maka aktivitas antinosiseptifnya juga akan semakin besar.

Improving the in vitro penetration of niacinamide using span 60-based niosomal system in gel formulation Rise Desnita; Sri Luliana; Zainab Kasim
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Niacinamide is one of the components of cosmeceutical products that reported to have skin benefits for the treatment of skin pigmentation, acne and wrinkles. However, the dermal penetration of niacinamide is poor. The carrier system which can be selected to carry the compound through the stratum corneum layer is the niosome system using span 60. This study was aimed to determine the concentration of span 60 that can trap niacinamide optimally and the ability of niosome system span 60 to increase in vitro penetration of niacinamide in gel formulation. The different formulations of nicotinamide niosome were formulated with variance concentrations of Span 60, that is, formula A 100 Î¼mol, formula B 150 Î¼mol, and formula C 200 Î¼mol. The entrapment efficiency testing was conducted using dialysis membrane. The gel formulation was prepared in two formulas, niacinamide niosome gel and niacinamide gel (without niosomes) and tested diffusion using Franz diffusion cell flow-through type. The result show that Formula A provides the most optimum entrapment efficiency of 99.03Â±0.026%. The results of the in vitro skin penetration studies for 8 hours indicate that the niosomal formulation using Span 60 could increase skin penetration with the percent cumulative amount of niacinamide niosomes was 82.87Â±1.6932% compared to niacinamide in gel without noisome system about 70.27Â±5,3212%.

In vitro penetration of alpha arbutin niosome span 60 system in gel preparation Rise Desnita; Sri Luliana; Silvana Anggraini
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Alpha arbutin is a hydrophilic compound which is difficult to pass trough the stratum corneum. One of the effort to increase the penetration of the drug through the stratum corneum is by making in niosome system. This study aims to determine the optimum concentration of span 60 to improve the entrapment efficiency of niosome and investigate the increasing penetration of alpha arbutin using the niosome system in the preparation of the gel in vitro. Niosome consist a mixture of span 60 and cholesterol it made by thin layer hydration method. Concentration of span 60 was varied into three formulas were 100, 150 and 200 ÂµmoL. The formulation of gel was made in two formulas including formulation of niosome alpha arbutin and alpha arbutin in gel. The determination of enterapment efficiency showed that formula 100Âµmol has an optimum enterapment efficiency by 99.09%Â±0.1. The in vitro penetration tests with shed snake skin membrane showed that usage span 60 as a niosome composer could increase penetration of alpha arbutin in gel formulation with cumulative numbers of diffusion in 8 hours was 91.62%Â±2.32 compared to alpha arbutin in gel without niosome system about 73.00%Â±0.94.7.

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