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All Journal Medical Journal of Indonesia Jurnal Ilmu Peternakan dan Veteriner Tropis (Journal of Tropical Animal and Veterinary Sciences) Jurnal Veteriner dan Biomedis
Wibisono, Cahyo
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Immunology & microbiology Medicine & Pharmacology Veterinary

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Efek Pemberian Antibiotik Kombinasi Spektinomisin dan Linkomisin Selama Satu dan Dua Minggu terhadap Hematologi Broiler Wibisono, Cahyo; Wijayanti, Agustina Dwi; Fadilla, Mirza Nur
Jurnal Veteriner dan Biomedis Vol. 2 No. 2 (2024): September
Publisher : Sekolah Kedokteran Hewan dan Biomedis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jvetbiomed.2.2.98-105.

Abstract

Pemberian antibiotik sebagai salah satu upaya terapi maupun pencegahan penyakit bakterial pada ayam tentu sangat penting mengingat broiler rentan terhadap penyakit. Salah satu antibiotik yang digunakan di Indonesia adalah kombinasi spektinomisin dan linkomisin. Status kesehatan ayam dapat diketahui melalui kondisi hematologinya. Tujuan penelitian ini untuk mengetahui kondisi hematologi berupa kadar hemoglobin, nilai hematokrit, total eritrosit, dan total leukosit pada broiler yang diberikan antibiotik kombinasi spektinomisin dan linkomisin selama satu dan dua minggu. Penelitian menggunakan 40 ekor Day Old Chicken (DOC) broiler yang terbagi dalam 3 perlakuan yaitu kelompok K (kontrol), kelompok A1 (pemberian antibiotik 1 minggu), dan kelompok A2 (pemberian antibiotik 2 minggu). Antibiotik kombinasi spektinomisin dan linkomisin diberikan secara oral lewat air minum dengan menggunakan dosis terapi sebesar 1,5 gram/ 2 liter mulai hari ke-18 sampai hari ke-24 untuk kelompok A1 dan untuk A2 dilanjutkan sampai hari ke-31. Pengambilan sampel darah dilakukan pada hari ke-32 untuk kelompok A1 dan hari ke-39 untuk kelompok A2 melalui vena brakialis. Sampel digunakan untuk mengukur kadar hemoglobin dengan spektrofotometer, nilai hematokrit dengan hematokrit scale reader, jumlah eritrosit dengan pipet thoma eritrosit “101”, jumlah leukosit dengan pipet eritrosit “11”. Data yang diperoleh dianalisis secara deskriptif dan statistik. Hasil penelitian menunjukkan kadar hemoglobin, nilai hematokrit, jumlah eritrosit, dan jumlah leukosit tidak ada perbedaan signifikan (p > 0,05). Kesimpulan dari pemberian antibiotik kombinasi spektinomisin dan linkomisin selama 1 dan 2 minggu tidak berpengaruh terhadap hematologi broiler.
Parameter combination norfloxacin and tylosin on poultry: A review Wibisono, Cahyo; Pamudya, Kanya Gabriella Sasri; Wijayanti , Agustina Dwi; Widiasih , Dyah Ayu; Tjahajati, Ida; Indarjulianto , Soedarmanto
Jurnal Ilmu Peternakan dan Veteriner Tropis (Journal of Tropical Animal and Veterinary Science) Vol. 15 No. 1 (2025): Jurnal Ilmu Peternakan dan Veteriner Tropis (Journal of Tropical Animal and Ve
Publisher : Fakultas Peternakan Universitas Papua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46549/jipvet.v15i1.489

Abstract

The use of antibiotics is currently one of the most widely used drugs. Various types of antibiotics that have been distributed, both broad spectrum and narrow spectrum, have caused several side effects. One of the side effects currently occurring is antibiotic residue and antimicrobial resistance. Antibiotic residues occur due to remaining drug metabolism residues not being excreted in full. Antimicrobial resistance occurs due to the use of antibiotics at inappropriate doses. If this incident occurs continuously it will have significant global effects which will directly affect human and animal health in the future. Pharmacokinetic studies really need to be carried out to determine the profile of a drug in the body. Pharmacokinetics describes the time course of drug levels in body fluids as a result of absorption, distribution and elimination of the drug after administration to avoid antimicrobial resistance and provides information regarding the pharmacokinetic parameters of the use of the combination of norfloxacin and tyrosin in birds and as well as information regarding the pharmacokinetic description of the combination of norfloxacin and tyrosin in poultry.
Factors contributing to the prevalence of potential drug-drug interactions among hospitalized elderly patients in a tertiary hospital in Eastern Java, Indonesia Faisal, Shah; Khotib, Junaidi; Wibisono, Cahyo; Hamidah, Khusnul Fitri; Utomo, Febriansyah Nur; Zairina, Elida
Medical Journal of Indonesia Vol. 34 No. 3 (2025): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257888

Abstract

BACKGROUND Drug-drug interactions (DDIs) are the primary cause of adverse drug events. However, studies on potential DDIs (pDDIs) in hospitalized older adult patients in Indonesia remain limited. Therefore, this study aimed to investigate the prevalence and potential risk factors of pDDIs in this population. METHODS A prospective observational study assessing the medical profiles of hospitalized elderly patients was conducted at Universitas Airlangga Hospital from September 2023 to February 2024. Patient characteristics were recorded, and Micromedex® Drug-Reax software was used to check the pDDIs. Ethical approval was obtained for this study (No. 078/KEP/2023). Data were analyzed using SPSS software (version 26). RESULTS Of the 409 patients, 41.9% of the prescriptions contained pDDIs. Furthermore, 73 prescriptions (17.1%) had at least one pDDI, with 1–6 interactions per prescription. Of the 369 identified pDDIs, 209 (56.6%) were major interactions. Logistic regression analysis revealed increased odds of pDDIs in patients with previous medication use (adjusted odds ratio [aOR] = 2.254; crude odds ratio (cOR] = 1.771), polypharmacy (aOR = 16.309; cOR = 11.709), circulatory diseases (aOR = 4.082; cOR = 4.788), and genitourinary diseases (aOR = 1.819; cOR = 1.855). Conversely, patients with digestive system diseases had a significantly lower risk (aOR = 0.573; cOR = 0.608). CONCLUSIONS This study found a high prevalence of pDDIs (41.1%) among older hospitalized patients in Indonesia. Modifiable factors, such as polypharmacy and previous medication use, can reduce the risk of pDDIs and avoid adverse events.
Co-Authors Agustina Dwi Wijayanti Elida Zairina Fadilla, Mirza Nur Hamidah, Khusnul Fitri Ida Tjahajati Indarjulianto , Soedarmanto Junaidi Khotib Pamudya, Kanya Gabriella Sasri Shah Faisal Utomo, Febriansyah Nur Widiasih , Dyah Ayu Wijayanti , Agustina Dwi