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All Journal As-syifaa Jurnal Farmasi

Rachmat Kosman

Fakultas Farmasi Universitas Muslim Indonesia

Author-ID : 2645009

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL BUAH BELIMBING WULUH (Averrhoa bilimbi L.) ASAL KOTA WATAMPONE St. Maryam; Saidah Juniasti; Rachmat Kosman
As-Syifaa Jurnal Farmasi Vol 7, No 1 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

It has been conducted the research on Assay of Antibacterial Activity of Ethanolic Extract of Wuluh Starfruit (Averrhoa bilimbi L.) The aim of this research is to determine the antibacterial activity. The initial screening assay conducted on several bacteria including Escheria coli, Pseudomonas aeruginosa, Salmonella typhi, Bacillus subtilis, Staphylococcus aureus, Streptococcus mutans, Vibrio cholerae, Shigella dysenteriae. Then, assay on the Minimum Inhibition Concentration (MIC) was carried out with some variations of concentration: 0,05%; 0,1%; 0,2%; 0,4%; 0,8%; and 1,6%. Test result of MIC was then followed by MKC test (Minimum Kill Concentration) using NA medium. The results showed that on concentration 0,4%; 0,8%; and 1,6% inhibit the growth of bacteria tested. Antibacterial activity of ethanolic extract of wuluh starfruit (Averrhoa bilimbi L.) was conducted by using the diffusion agat method. The result showed that the lowest concentration 0,4% ethanolic extract of wuluh starfruit (Averrhoa bilimbi L.) inhibit the growth of bacteria Shigella dysenteriae, Salmonella typhi, Pseudomonas aeruginosa, Vibrio cholerae, Escherichia coli and Staphylococcus aureus.

PERBANDINGAN EFEKTIVITAS HIPOGLIKEMIK OBAT METFORMIN PATEN DAN GENERIK BERLOGO BERDASARKAN PENURUNAN KADAR GLUKOSA DARAH MENCIT (Mus musculus) JANTAN YANG DIINDUKSI ALOKSAN Aulia Wati; Rachmat Kosman; Assajadda Lizikri
As-Syifaa Jurnal Farmasi Vol 6, No 1 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Diabetes mellitus (DM) is a group of chronic diseases characterized by increased sugar levels in the blood as a result of disturbances in the body's metabolic system. Comparative studies have been conducted hypoglycemic effect of patent metformin and generic branded metformin to the diabetic male mice with the aim to determine the effect of the patent and the generic branded drug metformin drug in lowering blood glucose levels. This study used male mice were divided into three treatment groups, group I was given Na. CMC as a control, the group II was given generic branded metformin and the group III was given patent metformin. Measurement of blood glucose levels before and after induction of alloxan 120 mg/kgbw intraperitoneally, and for 6 hours after drug administration with measurements every 90 minutes interval. The data obtained were analyzed by ANOVA. The results showed the patents metformin drug have no significantly different effects compared to the generic branded metformin drug.

ISOLASI DAN IDENTIFIKASI BEBERAPA KOMPONEN KIMIA EKSTRAK DIETIL ETER STANDAR HERBA Oxalis corniculata L. Herwin Herwin; Rachmat Kosman; Muzakkir Baits
As-Syifaa Jurnal Farmasi Vol 6, No 1 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

A research have been conducted about isolation and identification some chemicals components in diethyl ether standard ekstract of Oxalis corniculata L. herb from Mamuju of West Sulawesi with purpose isolation and identification some chemicals components standard ekstract diethyl ether Oxalis corniculata L. herb based on fitochemistri parameters on the way kualitatife dan kuantitatife. Based on isolation with fitochemistri parameters of kuantitatife that standard diethyl ether ekstract 38 gram. Based on isolation and identification some chemical components obtained that dietyl ether ekstract of thin layer cromatography obtained chemicals components flavanoid at Rf 0.47 value with reagent Antimo (III) cloride, components alcaloids at Rf 0.86 value with reagents chemicals dragendorf, components chemicals steroids at Rf 0.90 with reagents chemicals Liebermann-Bouchard and kualitatife analisis at specific parameter in organoleptic that colour ekstract green, aromatis, smell, a tick form idication obtained alcaloids, steroids and flavanoids.

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L) PADA TIKUS PUTIH (Rattus norvegicus) DIABETES MELITUS YANG DIINDUKSI ALOKSAN DENGAN PARAMETER MALONDIALDEHID (MDA) Safriani Rahman; Rachmat Kosman; Inda Rahmaniar
As-Syifaa Jurnal Farmasi Vol 6, No 1 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Hyperglycemia in Diabetes can caused the excessive production of Reactive Oxygen Species (ROS) in the body that will causes oxidative stress that tissue damage. Oxidative stress can indicated by increasing MDA levels. This research aims to know and determine the concentration ethanol extract of soursop leaves that have antioxidant activity to MDA levels in diabetic rats. 9 white rats were divided into 3 groups. All rats were induced by alloxan 110mg/Kg.BB intraperitoneally. Group I was administered with Na.CMC as a negative control, group II and III were administered with ethanol extract of soursop leaves 2,5% and 5%. Administration were given orally for 12 days orally. Examination of blood glucose and MDA levels conducted before and after the administration. MDA Assay performed with TBA method was based on reaction of MDA-TBA as measured on a spectrophotometer 532 nm wavelength. The results were analysized statistically by using randomized block design (RBD) method. Based on the research has been done, it was showed that the ethanol extract of soursop leaves can lower blood glucose levels of diabetic rats and extract with concentration of 5% has potential as an antioxidant activity that can reduce MDA levels in diabetic rat.

AKTIVITAS ANTIBAKTERI FERMENTAT FUNGI ENDOFIT DAUN KASUMBA TURATE (Carthamus tinctorius L.) ASAL GALESONG TERHADAP BAKTERI UJI PENYEBAB INFEKSI KULIT Rusli Rusli; Rachmat Kosman; Muthmainnah Muthmainnah; Ayyub Harly Nurung
As-Syifaa Jurnal Farmasi Vol 15, No 1 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i1.905

Kasumba turate (Carthamus tinctorius L.) contains phenolic compounds of flavonoids and carotenoids which have antioxidant, antibacterial, antiviral, anti-inflammatory, antiallergic and anticancer activities. This study aims to obtain isolates of endophytic fungi that have potential as antibacterial using the TLC-Bioautography method. This research was conducted by isolating endophytic fungi from the leaves of kasumba turate (Carthamus tinctorius L.) and after that purification and macroscopic tests were carried out and eight pure isolates were obtained. The results of the isolate screening tests with IFDKT 5 and IFDKT 6 codes showed the highest inhibition. Then tested the antibacterial activity by TLC-Bioautography. The isolates with IFDKT code 5 showed five spots were active against Staphylococcus aureus and Pseudomonas aeruginosa (Rf1 0.83; Rf2 0.65; Rf3 0.47; Rf4 0.30; Rf5 0.07), and six spots were active against bacteria Staphylococcus epidermidis (Rf1 0.94; Rf2 0.83; Rf3 0.65; Rf4 0.47; Rf5 0.30, Rf6 0.07). Then, the isolates with code IFDKT 6 showed four active spots against Staphylococcus aureus and Pseudomonas aeruginosa (Rf1 0.80; Rf2 0.58; Rf3 0.40; Rf4 0.10), and five spots were active against Staphylococcus epidermidis (Rf1 0.96; Rf2 0.80; Rf3 0.58; Rf4 0 .40; Rf5 0.10). Therefore, fermentate isolate of the endophytic fungus of kasumba turate leaves (Carthamus tinctorius L.) has the potential to inhibit Staphylococcus aureus, Stahpyloccous epidermidis and Pseudomonas aeruginosa bacteria that cause skin infections

Co-Authors Assajadda Lizikri Aulia Wati Ayyub Harly Nurung Herwin Herwin Inda Rahmaniar Muthmainnah Muthmainnah Muzakkir Baits Rusli Rusli Safriani Rahman Saidah Juniasti St. Maryam

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