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All Journal Indonesian Journal of Cardiology Heart Science Journal Occupational and Environmental Medicine Journal of Indonesia
Isman Firdaus
Department Of Cardiology And Vascular Medicine, Faculty Of Medicine, Universitas Indonesia / National Cardiovascular Center Harapan Kita, Jakarta, Indonesia
Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Expert Opinion on the Use of Inclisiran in Post-Acute Coronary Syndrome Patients in Indonesia Dafsah Arifa Juzar; Sunanto Ng; Isman Firdaus; Akhtar Fajar Muzakkir; Bambang Widyantoro; Faisal Habib; Hendry Purnasidha Bagaswoto; Siska Suridanda Danny; Erwinanto Erwinanto; Anwar Santoso
Jurnal Kardiologi Indonesia Online First
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1991

Abstract

Elevated low-density lipoprotein cholesterol (LDL-C) levels are an independent risk factor for the progression of atherosclerotic cardiovascular disease (ASCVD). Achieving substantial LDL-C reduction is recognized as a primary therapeutic goal, particularly for those at the highest risk of future cardiovascular events. Statin-based lipid-lowering therapy remains the cornerstone of secondary prevention in acute coronary syndrome (ACS). However, many high-risk individuals require combination therapy with non-statin agents to achieve guideline-recommended LDL-C targets. A novel, long-acting small interfering RNA (siRNA)-based proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, inclisiran, has emerged as a therapy that provides rapid and sustained LDL-C reduction. Despite these therapeutic advancements, various hurdles continue to hinder optimal lipid management in Indonesia. To address these challenges, an expert meeting involving cardiologists from multiple cities across Indonesia was convened, and the resulting consensus opinion of experts aimed to provide insights into the current hurdles in managing post-ACS and the potential use of inclisiran following high intensity statin or highest tolerated dose statins, with or without ezetimibe, in post-ACS patients in Indonesia.
Co-Authors Adi Utarini Akhtar Fajar Muzakkir Akhtar Fajar Muzakkir Anandita, Faizal Ablansah Andi Alfian Zainuddin Anwar Santoso Ardeno Kristianto Bambang Widyantoro Bambang Widyantoro Bunga Dewanggi Cholid T. Tjahjono Cindy Elfira Boom Dafsah Arifa Juzar Daniel PL Tobing Danny, Siska S. Dewanggi, Bunga Dian Zamroni Dwi Yuda Herdanto Erwinanto Erwinanto Faisal Habib Ganesja H. Harimurti Ganesja M Harimurti Hananto Andriantoro Hanevi Djasri Harmani Kalim Hendiperdana, Mochamad Rizky Hendry Purnasidha Bagaswoto Irmalita Irmalita Irmalita, Irmalita Juzar, Dafsah A. Juzar, Dafsah Arifa Kartika, Gloria Kuntjoro Harimurti Lilihata, Gracia Mochamad Rizky Hendiperdana Muchtaruddin Mansyur Muhammad Munawar Muhammad Munawar Nurfitri, Syafira Poppy S. Roebiono Retno Asti Werdhani Rino A Gani Simanjuntak, Cindya K. Siska Suridanda Danny Sunanto Ng Surya Dharma Tobing, Daniel P.L. Yasmin Tadjoedin Yoga Yuniadi Yoga Yuniadi