Article Per Year (5 Year)
p-Index From 2020 - 2025
0
P-Index
This Author published in this journals
All Journal Current Biochemistry INDONESIAN JOURNAL OF ESSENTIAL OIL Jurnal Matematika Sains dan Teknologi Jurnal Ilmu Kefarmasian Indonesia
Latifah K Darusman
Institut Pertanian Bogor
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Mathematics Medicine & Pharmacology Public Health Other

Published : 5 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 5 Documents
Search

 1 
MINYAK ATSIRI DAUN ZINGIBERACEAE SEBAGAI ANTIOKSIDAN DAN ANTIGLIKASI Irmanida Batubara; Ummi Zahra; Latifah K Darusman; Akhirudin Maddu
INDONESIAN JOURNAL OF ESSENTIAL OIL Vol 1, No 1 (2016)
Publisher : Institut Atsiri Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (471.507 KB) | DOI: 10.21776/ub.ijeo.2016.001.01.05

Abstract

Daun keluarga Zingiberaceae memiliki aroma khas yang mirip dengan rimpangnya. Oleh karena itu, penelitian ini bertujuan untuk mengisolasi minyak atsiri daun beberapa spesies dari keluarga Zingiberaceae dan menentukan aktivitas minyak atsiri tersebut sebagai antioksidan dan antiglikasi yang berhubungan dengan anti-penuaan. Daun dari 8 spesies yaitu Alpinia galanga, Boesenbergia pandaratum, Curcuma aeruginosa, Curcuma domestica, Curcuma xanthorrhiza, Curcuma zedoaria, Ellettaria cardamomum, dan Zingiber officinale diisolasi minyak atsirinya menggunakan teknik distilasi uap. Minyak yang diperoleh ditentukan kemampuannya sebagai antioksidan menggunakan metode ABTS (2,2’-azino-bis-3-ethylbenzothiazolin-6-sulfonic acid) menggunakan spektrofotometer visual serta kemampuan antiaging melalui aktivitas antiglikasi mengunakan flourimetri. Rendemen minyak dihasilkan mulai dari 0.04 hingga 3.15%. Kapasitas antioksidan tertinggi dengan metode ABTS ditemukan pada minyak atsiri daun Curcuma aeruginosa sebesar 5.10g ekuivalen asam askorbat/ 100 g minyak sedangkan minyak dengan aktivitas antiglikasi terbesar ditemukan pada minyak daun Z. officinale dengan konsentrasi penghambatan 50%, IC50 sebesar 207.95mg/L.  Senyawa kimia pada minyak atsiri daun Z. officinale ditentukan menggunakan metode Kromatografi Gas- Spektrometri Massa dan ditemukan kariofilena sebagai komponen dominannya. Kariofilena mampu bertindak sebagai antiglikasi dengan konsentrasi penghambatan 50% sebesar 113.8 µM. Minyak atsiri dari daun Z officinale berpotensi dikembangkan sebagai antiaging.
PENGOLAHAN LINDI SEBAGAI PUPUK CAIR UNTUK MENDUKUNG PENGEMBANGAN TPA SAMPAH LESTARI Nurhasanah Nurhasanah; Latifah K Darusman; Surjono Hadi Sutjahjo; Bibiana Widiati Lay
Jurnal Matematika Sains dan Teknologi Vol. 11 No. 1 (2010)
Publisher : LPPM Universitas Terbuka

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

A laboratory scale research to obtain environmentally safe effluent and liquid fertilizer from leachate from Final Waste Disposal Site in Galuga owned by Regional Government of Bogor City was conducted from July 2006 through to April 2007. The experiment was initiated by aerating the leachate in 4 difference aeration rates (0, 10, 30 and 70 liters/minute) followed by processing the sediment to product the liquid fertilizer. The experiment of production liquid fertilizer was carried out by adding lime with different dosage into sediment generated from processing by aerating at 70 liters/minute followed by centrifugation process or secher. Further, the liquid fertilizer generated from such experiment was applied to chilis planting (Capsicum annum). The research found that the processing conducted by aerating at the rate 70 liters/minute was the most effective in reducing pollutant from leachate. The addition of 1000 ppm CaO or Ca(OH)2 limes in sediment from aeration is the most effective in depositing the dissolved material compared to the addition of limes in other dosage. Liquid fertilizer generated through the addition of 1000 ppm CaO have the content of N = 375,83 ppm, P = 121,44 ppm, K = 948,11 ppm, Ca = 827,20 ppm, Mg = 959,50 ppm, S = 48,53 ppm, Cu = 8,23 ppm, Zn = 30,02 ppm, Mn = 230,57 ppm, Fe = 320,95 ppm, Pb = 10,34 ppm, Cd = 7,46 ppm and Cr = 2,05 ppm. The use of liquid fertilizer generated by adding 1000 ppm CaO was the most effective in enhancing vegetation growth and production of chili. The non essential elements (Pb, Cd and Cr) in fruits from vegetation given liquid fertilizer produced from such treatment did not exceed tolerable threshold.
Anti-inflammatory Activity of Temulawak Nanocurcuminoid Coated with Palmitic Acid in The Sprague Dawley Rat Rini Novita; Laksmi Ambarsari; Syamsul Falah; Popi Asri Kurniatin; Waras Nurcholis; Latifah K Darusman
Current Biochemistry Vol. 2 No. 2 (2015)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Temulawak or Curcuma xanthorrhiza Roxb, is usually used as traditional medicine (herbal medicine) that has antioxidant, anticancer, antihyperglycemic, anti-inflammatory, hepatoprotective and gastroprotective properties. The main components contained in temulawak responsible for its efficacy as a medicine are xantorhizol and curcuminoid. Curcuminoid has drawbacks, which are difficult to absorb and very quickly metabolized by the body, so that limit its bioavailability. The use of solid lipid nanoparticle carrier system (SLN) in form of palmitic acid, is known to improve the bioavailability of curcuminoid. This study aims to find the effective dose of nanocurcuminoid coated with palmitic acid that can be used as an anti-inflammatory agent. The methods used in this study, include the production of nanocurcuminoid with homogenization and ultrasonication methods, determination of particle size, polydispersity index, entrapment efficiency and anti-inflammatory activity test through rat feet edema. Nanocurcuminoid obtained in this study was 561.53 nm in size, with polydispersity index 0.309 and concentrations of curcuminoid absorbed and entrapment efficiency were 0.61±0.031 mg/mL, 58.93±3.021%, respectively. Anti-inflammatory activity of nanocurcuminoid through treated Sprague Dawley rats, showed that there were no significant difference compared with the positive control, curcuminoid extracts and empty nanoparticle. These results indicate that nanocurcuminoid with 175, 200 and 250 mg/kg.bw in doses, has greater anti-inflammatory activity (31.70%) compared to the other treatments.
Characterization and Toxicity of Temulawak Curcuminoid Nanoparticles Riki Riki; Popi Asri Kurniatin; Laksmi Ambarsari; waras Nurcholis; Latifah K Darusman
Current Biochemistry Vol. 3 No. 1 (2016)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Temulawak exctract contains curcuminoids which have anticancer potential. However, clinical application of curcuminoid has been limited due to its low bioavailability. One of the efforts that can be developed to solve this problem is incorporated curcuminoids into Solid Lipid Nanoparticles (SLN) carriers system. The objective of this study was to characterize dan evaluate anticancer potential of temulawak ethanolic fraction nanoparticles. HPLC method was used to determined curcuminoids content of temulawak ethanolic fraction. Characterization indicators like polydispersity index, particle size, morpholgy, and entrapment efficiency. HPLC chromatogram has shown of curcumin, demethoxycurcumin, and bisdemethoxycurcumin were found in temulawak ethanolic fraction. The particle size of nanoparticles obtained in this study was 648.4 ± 95 nm with polydispersity index value of 0.216. A uniform size distribution of nanoparticles as observed by Transmission Electron Microscopy (TEM). The entrapment efficiency of curcuminoid in nanoparticles was about 29.8%. Based on results of BSLT obtained temulawak extract Lethal Concentration (LC50) value of 213.24 ppm and 828.78 ppm of nanoparticles.
Curcuminoids Content and α-Glucosidase Inhibition of ExtractPromising Lines of Curcuma xanthorrhiza RoxB. WARAS NURCHOLIS; LAKSMI AMBARSARI; GIA PERMASKU; LATIFAH k DARUSMAN; POPI ASRI KURNIATIN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (517.086 KB)

Abstract

Temulawak merupakan salah satu tanaman obat Indonesia yang termasuk dalam keluarga Zingiberaceae. Kurkuminoid merupakan salah satu senyawa bioaktif dalam temulawak yang dilaporkan memiliki aktivitas biologi. Pada penelitian ini dilakukan evaluasi kandungan kurkuminoid dan penghambatan enzim α-glukosidase dari ekstrak empat aksesi temulawak asal Jawa Barat (Sukabumi), Jawa Tengah (Wonogiri dan Karanganyar), Jawa Timur (Ngawi), dan satu ekstrak asal Bogor-Jawa Barat. Simplisia temulawak tersebutdiekstraksi secara bertahap dengan etanol dan n-heksan. Kandungan kurkuminoid diukur dengan menggunakan metode HPLC. Aktivitas penghambatan enzim α-glukosidase dilakukan secara in vitro dengan microplate reader pada 410 nm. Aksesi temulawak asal Wonogiri menunjukkan kandungan kurkuminoid tertinggi, dengan hasil pengukuran antara 35,57- 85,19 mg/g. Nilai IC50 untuk aktivitas penghambatan enzim α-glukosidase antara 333,27̵908,35 μg/mL, dengan IC50 terbaik adalah temulawak aksesi Wonogiri.Berdasarkan penelitian ini, aksesi temulawak asal Wonogiri sangat baik dalam hal kandungan kurkuminoid dan aktivitas penghambatan enzim α-glukosidase dibandingkan dengan aksesi asal Sukabumi, Karanganyar dan Ngawi, maupun dengan varietas asal Bogor.
Co-Authors Akhirudin Maddu Bibiana Widiati Lay GIA PERMASKU Irmanida Batubara LAKSMI AMBARSARI Nurhasanah Nurhasanah Riki Riki Rini Novita Surjono Hadi Sutjahjo Syamsul Falah Ummi Zahra, Ummi Waras Nurcholis