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HUBUNGAN JENIS TERAPI DENGAN KUALITAS HIDUP PASIEN GLAUKOMA Johanes Jethro Nugroho; Fifin Luthfia Rahmi; Trilaksana Nugroho
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 8, No 2 (2019): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Latar belakang: Glaukoma merupakan salah satu penyakit yang dapat menyebabkan kebutaan yang bersifat irreversible. Pada tahun 2010, jumlah orang yang menderita glaukoma sudut terbuka diperkirakan sebanyak 44 juta orang sedunia dan sebanyak 2,7 juta terdapat di Amerika Serikat. Oleh karena itu membutuhkan penanganan terapi yang tepat. Penanganan kasus glaukoma tidak hanya mencapai target klinis namun juga diharapkan mampu meningkatkan kualitas hidup pasien. Untuk itu perlu adanya pengetahuan mengenai hubungan jenis terapi tertentu dengan kualitas hidup pasien glaukoma. Tujuan: Mengetahui adanya hubungan kualitas hidup pada pasien glaukoma dengan terapi yang diberikan. Metode: Penelitian ini menggunakan desain cross-sectional dengan mengambil data nilai kualitas hidup melalui wawancara pasien RSUP Dr. Kariadi Semarang yang sudah menjalani terapi glaukoma menggunakan kuesioner NEI-VFQ-25 (National Eye Institute Visual Function Questionnaire 25). Terapi glaukoma dibagi menjadi 2 kelompok yaitu, kelompok terapi medikamentosa dan operatif. Data tersebut kemudian disusun dan dilakukan analisis statistik dengan uji Independent-t dan uji Mann Whitney untuk melihat perbedaan nilai kualitas hidup antara jenis terapi medikamentosa dan operatif. Hasil: Terdapat 22 subjek penelitian kelompok terapi medikamentosa dan 23 subjek penelitian kelompok terapi operatif. Rerata nilai Kualitas Hidup kelompok terapi medikamentosa lebih tinggi (75,69 ± 9,48) dibandingkan dengan terapi operatif (71,10 ± 15,91). Namun, secara statistik tidak terdapat perbedaan bermakna antara kedua kelompok dalam hal kualitas hidup (p=0,246). Kesimpulan: Terdapat perbedaan rerata nilai kualitas hidup pada kelompok terapi medikamentosa dibandingkan dengan kelompok terapi operatif. Nilai rerata kualitas hidup pada kelompok terapi medikamentosa lebih tinggi dibandingkan kelompok operatif. Namun, secara statistik tidak signifikan. Kata kunci: Glaukoma, Kualitas Hidup, Terapi Medikamentosa, Terapi Operatif

PENGARUH EKSTRAK KULIT MANGGIS TERHADAP ENZIM KATALASE HEPAR TIKUS TERPAPAR MINYAK JELANTAH Jimmy Setiawan; Trilaksana Nugroho
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 7, No 1 (2018): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Latar Belakang Minyak jelantah merupakan minyak goreng yang digunakan secara berulang dan tidak pernah diganti. Konsumsi minyak jelantah secara terus menerus mengakibatkan menurunnya kadar antioksidan tubuh dan menyebabkan stres oksidatif. Ekstrak kulit manggis memiliki khasiat sebagai antioksidan. Dengan adanya antioksidan tersebut, dapat menurunkan jumlah radikal bebas yang terbentuk dari proses peroksidasi lipid. Enzim katalase yang adalah salah satu dari enzim antioksidan digunakan untuk mengatahui kadar antioksidan pada tikus yang terpapar minyak jelantah.Tujuan Menganalisis pengaruh pemberian ekstrak kulit manggis terhadap kadar katalase hepar tikus terpapar minyak jelantah.Metode Penelitian ini merupakan penelitian eksperimental dengan desain post test only controlled group design. Sampel adalah 24 ekor tikus wistar dibagi menjadi menjadi kelompok konrol satu (K1) diberi pakan standar, kelompok kontrol dua (K2) diberi minyak jelantah, kelompok X1 diberi ekstrak kulit manggis 400 mg/kgBB dan kelompok X2 diberi minyak jelantah dan ekstrak kulit manggis 400 mg/kgBB. Perlakuan dilakukan selama 28 hari dan dilanjutkan dengan pengukuran kadar enzim katalase hepar. Uji statistik menggunakan uji Kruskal-Wallis dengan post hoc Mann-Whitney.Hasil Dengan menggunakan uji Mann-Whitney didapatkan perbedaan signifikan antara kelompok K1 dan K2, K2 dan X1, K2 dan X2, dan X1 dan X2. Sedangkan antara kelompok K1 dan X1, dan K1 dan X2 tidak didapatkan perbedaan yang signifikan.Kesimpulan Ekstrak kulit manggis menyebabkan peningkatan kadar enzim katalase tikus terpapar minyak jelantah.

Faktor-Faktor yang Berhubungan dengan Perilaku Ibu Terhadap Pemeriksaan Mata di Anak-Anak di Puskesmas Gunungpati Semarang Dedeh Kurniasih; Trilaksana Nugroho; Andhika Guna Dharma
JURNAL IMPLEMENTA HUSADA Vol 1, No 2 (2020)
Publisher : UMSU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jih.v1i2.4627

Introduction: Early years of life are very important in the development of eyes and vision. Each disorder at this stage can cause severe visual impairment or blindness. Eye examination in children is not only the child's right, but also the obligation of the parents to monitor and evaluate it.Objectives: To determine the relationship of socio-demographic factors and knowledge with the behavior of mothers towards eye examinations in children in the Gunung Pati Primary Health Care, Semarang.Methods: This study was an observational analytic with a cross sectional approach. The sample size was 47 respondents. The instrument used was a questionnaire that had previously been tested for validity and reliability. Data were analyzed using SPSS 15.0 statistical test techniques with Chi square test.Results: There was a significantly correlation between the level of education with the behavior of mothers ( p=0.004), and between the knowledge with behavior of mothers towards eye examination in their children (p=0,018). The multivariate analysis showed that the knowledge was the most dominant factor determine the behavior of the mother (p=0.03; OR=5,74; 95% CI=1,12-29,46).Conclusion: Appropriate maternal education and counseling strategies on the basis of eye health examinations and the importance of undergoing regular eye examinations are needed in improving eye health in children.

COENZYME Q10 EFFECT ON NMDA RECEPTOR EXPRESSION AND RETINAL GANGLION CELL DENSITY (Experimental Study in Traumatic Optic Neuropathy Model of Wistar Rat) FRANSISKA BANJARNAHOR; RISKI PRIHATNINGTIAS; TRILAKSANA NUGROHO; HERMAWAN ISTIADI
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/1s6kza05

Abstract Introduction & Objectives : Traumatic optic neuropathy is a visual disturbance condition after acute injury to optic nerve. This injury results in retinal ganglion cells ischemic leading to excitotoxicity and apoptosis. Coenzyme Q10 (CoQ10) is an antioxidant and cofactor in electron transport within mitochondria that inhibits glutamate excitotoxicity and thereby preventing retinal ganglion cell apoptosis. This research aims to prove the effect of coenzyme Q10 on NMDA receptor expression and retinal ganglion cell density in rat model of traumatic optic neuropathy. Methods : This study use post-test only randomized controlled groups design. Traumatic optic neuropathy wistar rats model was made by optic nerve crushed method, then given oral CoQ10 100mg/kgBW after 1 hour for 14 days in treatment group. Retinal histopathological specimen was made with immunohistochemistry and Haematoxyllin-eosin staining and examined under microscope with 400x magnification. Data was verified and statistically analyzed. Results : The NMDA receptor expression in the treatment group was significantly lower than control (p=0.009). The retinal ganglion cell density in the treatment group was significantly higher than control (p=0.009). There was a significant correlation between NMDA receptor expression and retinal ganglion cell density in the treatment group (p = 0.012) with a strong negative correlation direction (r = - 0.652). Conclusion : Administration of CoQ10 in traumatic optic neuropathy model rats affects NMDA receptor expression and retinal ganglion cell density. NMDA receptor expression was lower with higher retinal ganglion cell density in the treatment group. NMDA receptor expression was inversely proportional to retinal ganglion cell density in the treatment group.

CHARACTERISTIC OF PATIENTS WITH ORBITAL MENINGIOMA IN DR. KARIADI GENERAL HOSPITAL SEMARANG: Oral Presentation - Observational Research - Resident Joko Satrio; Trilaksana Nugroho
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/e2g5dg68

Abstract Introduction & Objectives : Meningioma is a neoplasm arising from arachnoid cap cells in the meninges. They can arise in the orbit as primary or secondary orbital meningioma. The characteristic and risk factors of orbital meningioma are essential to acknowledge. The aim of this study is to describe the characteristic and risk factors of patients with orbital meningioma in Dr.Kariadi Hospital. Methods : A retrospective study was held from the medical record of patients with a diagnosis of meningioma between January 2020-December 2022. The data of 58 patients included age, sex, duration of proptosis, length of proptosis, history of seizure, diplopia, history of contraceptive and trauma, RAPD, fundus examination, and CT-Scan results. Results : Most of the meningioma patients had female 98,27%, 70,68% in the fourth decade of life. The visual acuity of 25,88% of patients >6/18, and 22,41% were blind. Around 72,41% of proptosis occurred ≥ 1 year, 87,93% had signs of headache, only 1,72% underwent seizure, 8,62% had double vision, and 5,17% had a history of head trauma. Relative afferent pupillary defect occurred in 53,44% of the affected eye with 20,68% atrophic papil and 15,51% edema papil. CT-Scan result of 86,2% had sphenoid meningioma, and only 13,79% had optic sheath meningioma. Most of the patients (72,41%) used 3 months cycle hormonal injection contraceptive. Conclusion : The characteristic of orbital meningioma patients in DR.Kariadi Hospital were mostly women in the fourth decade of life, had proptosis and headache as primary signs and 3 months of intramuscular hormonal contraceptives were suspected to have a correlation.

Outcome Evaluation of Eyelid Laceration Surgery in Kariadi General Hospital Semarang: Oral Presentation - Observational Study - Resident NIZAR ARIF LAZUARDI; TRILAKSANA NUGROHO
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/6703hz28

Abstract Introduction & Objectives : Eyelid laceration are common in cases of trauma involving the eye. This study will discuss cases of eyelid lacerations, procedures, and the follow-up of patients who underwent surgery at Kariadi General Hospital Semarang. Methods : This study used an observational analytic design and was conducted retrospectively. All patients who underwent eyelid surgery April 2019 to January 2023. Age, gender, laceration location, mechanism of trauma, canalicular involvement, and surgery were recorded, subjective complaints and patient complications after surgery. Results : Of the 76 patients (94 eyelid lacerations) included in the study, men exhibited a greater vulnerability (56,75%) and mostly aged around 16-<50 years (43, 57%). In terms of the laceration location, it occurred in right lower (39,36%), right upper (35,10%), left lower (13,82%), and left upper (11,70%) eyelids. Blunt trauma (83,78%) was the main mechanism, with motor vehicle accidents leading (40,54%). Canalicular involvement was present in 35 cases (47,29%). All patients underwent surgery, with eyelid repair to all of the patient following by recanalization (39,18%). The most common complaint of patients after surgery in the first week of control was pain (47,29%) followed by a feeling of lump (13,51%). A total of 25 patients (33,78%) stated that they had no complaints. Conclusion : Eyelid lacerations mainly involve young adult people, right lower eyelid. Blunt trauma, particularly motor vehicle accidents, is the main cause. Most of the patients had no complaints in the1 week postoperative control, and they increased in subsequent controls.

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