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All Journal Al-Kimia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Katalisator
Anita Lukman
Sekolah Tinggi Ilmu Farmasi Riau
Agriculture, Biological Sciences & Forestry Chemistry Medicine & Pharmacology

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Isolasi dan Uji Aktivitas Antioksidan Metabolit Sekunder dari Ekstrak Etil Asetat Kulit Batang Kangkang Katup (Bauhinia semibifida Roxb) Haiyul Fadhli; Anita Lukman; Robiatun Adawiyah
Al-Kimia Vol 8 No 1 (2020): JUNE
Publisher : Study Program of Chemistry - Alauddin State Islamic University of Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-kimia.v8i1.10152

Abstract

Antioxidant was a compound which possessed an activity as scavenger of free radicals. This study was aimed to examine the antioxidant activity of ethyl acetate fraction and isolated compound from stem barks of Bauhinia semibifida Roxb. Samples extracted by gradual maceration with n-hexane solvent, ethyl acetate and methanol respectively. Isolation was carried out using Vacuum Liquid Chromatrography and purification by column chromatography with Sephadex LH-20. Isolated compound (BS) obtained was ivory crystalline with melting point 163-1650C. The analysis of FT-IR spectra, UV spectra and the result of qualitative test by Liebermann Burchard reagent were is shown positive as a terpenoid. Antioxidant activity were evaluated by using DPPH method for ethyl acetate fraction and isolation compound in serial concentration of 1000; 500; 250; 125; 62,5; 31,25 ug/mL. The result found that ethyl acetate fraction (f4 and f11) of stem barks of Bauhinia semibifida showed antioxidant activity with IC50 value of >1000 ug/mL; 179 ug/mL. In conclusion, F11 from ethyl acetate extract from stem barks of Bauhinia semibifida Roxb. exhibited an activity as scavenger of free radicals from DPPH. Keywords: Antioxidant, Bauhinia semibifida Roxb, IC50, VLC 
PEMANFAATAN PATI PISANG KEPOK (Musa balbisiana L.) TERPRAGELATINASI POSPAT SEBAGAI SUSPENDING AGENT SUSPENSI KLORAMFENIKOL Deni Anggraini; Anita Lukman; Delvi
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 2 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i2.1321

Abstract

Kepok banana (Musa balbisiana L.) natural starch easily undergoes syneresis due to starch retrogradation which can reduce the stability and viscosity of a suspension preparation, so it is necessary to modify starch to overcome this problem. One of the starch modification technologies is chemical modification with crosslinks. Utilization of kepok banana phosphate pregelatinated starch (Musa balbisiana L.) as a suspending agent in chloramphenicol palmitate suspension has been carried out and evaluated for its physicochemical properties and stability during storage. The method of making the suspension is the dispersion method. F1 used 5% kepok banana phosphate pregelatinated starch, F2 (7.5%) and F3 (10%). The results showed that the best formula was F3 with observations of organoleptic, viscosity and flow properties, degree of sedimentation, redispersibility, density, and pH which met the requirements during 4 weeks of storage.
FORMULASI DAN UJI ANTIOKSIDAN SEDIAAN GEL EKSTRAK DAUN MARPUYAN (Rhodamnia Cinerea Jack) Musyirna Rahmah Nst; Deni Anggraini Anggraini; Armon Fernando; Anita Lukman; Rajeb Fadillah
JURNAL KATALISATOR Vol. 8 No. 2 (2023): Jurnal Katalisator Volume 8 No. 2, Oktober 2023
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v8i2.2343

Abstract

Tumbuhan marpuyan merupakan jenis tumbuhan liar banyak tersebar di wilayah Indonesia. Secara empiris, marpuyan dimanfaatkan oleh masyarakat untuk berbagai pengobatan. Daun tumbuhan marpuyan berpotensi sebagai antioksidan. Hasil penelitian terdahulu melaporkan ekstrak etanol daun marpuyan mempunyai aktivitas tabir surya yang kuat. Formulasi sediaan topikal dalam bentuk gel lebih baik  karena memberikan efek nyaman dikulit. Tujuan penelitian ini adalah memformula ekstrak etanol daun marpuyan dalam bentuk sediaan gel dan menentukan aktivitas antioksidan. Formulasi gel ekstrak etanol daun marpuyan 3 variasi konsentrasi yaitu 0,5% (FI), 1% (FII) dan 2% (FIII). Pengujian aktivitas antioksidan dilakukan dengan menggunakan metode DPPH. Evaluasi gel meliputi pengamatan organoleptis, pH, homogenitas, uji stabilitas freeze and thaw, uji daya sebar, uji daya lekat dan uji iritasi. Hasil penelitian menunjukkan gel ekstrak etanol daun marpuyan memiliki aktivitas antioksidan yang sangat kuat pada FII (1%) dan FIII (2%). Hasil uji stabilitas menunjukkan gel gel ekstrak etanol daun marpuyan tidak stabil setelah disimpan 8 minggu dan tidak memenuhi persyaratan uji daya sebar.
Co-Authors Armon Fernando Delvi Deni Anggraini Deni Anggraini Anggraini Haiyul Fadhli Musyirna Rahmah Nasution Rajeb Fadillah Robiatun Adawiyah